U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atlantoaxial abnormality

MedGen UID:
871145
•Concept ID:
C4025617
•
Anatomical Abnormality
HPO: HP:0003413

Definition

An anomaly of the atlantoaxial joint, i.e., of the joint between the first (atlas) and second (axis) cervical vertebrae. [from HPO]

Professional guidelines

PubMed

Evaluating Airway Management in Patients With Trisomy 21 in the PICU and Cardiac ICU: A Retrospective Cohort Study.
Wilsterman EJ Jr, Nellis ME, Panisello J, Al-Subu A, Breuer R, Kimura D, Krawiec C, Mallory PP, Nett S, Owen E, Parsons SJ, Sanders RC Jr, Garcia-Marcinkiewicz A, Napolitano N, Shults J, Nadkarni VM, Nishisaki A; National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Pediatr Crit Care Med 2024 Apr 1;25(4):335-343. Epub 2023 Dec 7 doi: 10.1097/PCC.0000000000003418. PMID: 38059735Free PMC Article
Medical Care of Adults With Down Syndrome: A Clinical Guideline.
Tsou AY, Bulova P, Capone G, Chicoine B, Gelaro B, Harville TO, Martin BA, McGuire DE, McKelvey KD, Peterson M, Tyler C, Wells M, Whitten MS; Global Down Syndrome Foundation Medical Care Guidelines for Adults with Down Syndrome Workgroup
JAMA 2020 Oct 20;324(15):1543-1556. doi: 10.1001/jama.2020.17024. PMID: 33079159
Epidemiology, diagnosis, and treatment of neck pain.
Cohen SP
Mayo Clin Proc 2015 Feb;90(2):284-99. doi: 10.1016/j.mayocp.2014.09.008. PMID: 25659245

Recent clinical studies

Etiology

Medical Care of Adults With Down Syndrome: A Clinical Guideline.
Tsou AY, Bulova P, Capone G, Chicoine B, Gelaro B, Harville TO, Martin BA, McGuire DE, McKelvey KD, Peterson M, Tyler C, Wells M, Whitten MS; Global Down Syndrome Foundation Medical Care Guidelines for Adults with Down Syndrome Workgroup
JAMA 2020 Oct 20;324(15):1543-1556. doi: 10.1001/jama.2020.17024. PMID: 33079159
Miniplate-Augmented Interlaminar Fusion in C1-C2 Screwing.
Huang PJ, Lin JH, Chiang YH
World Neurosurg 2020 Jun;138:e634-e641. Epub 2020 Mar 13 doi: 10.1016/j.wneu.2020.03.023. PMID: 32173550
Neurological and spinal manifestations of the Ehlers-Danlos syndromes.
Henderson FC Sr, Austin C, Benzel E, Bolognese P, Ellenbogen R, Francomano CA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):195-211. Epub 2017 Feb 21 doi: 10.1002/ajmg.c.31549. PMID: 28220607
Mucopolysaccharide disorders in orthopaedic surgery.
White KK, Sousa T
J Am Acad Orthop Surg 2013 Jan;21(1):12-22. doi: 10.5435/JAAOS-21-01-12. PMID: 23281467
Down syndrome.
Hayes A, Batshaw ML
Pediatr Clin North Am 1993 Jun;40(3):523-35. doi: 10.1016/s0031-3955(16)38548-0. PMID: 8493063

Diagnosis

Medical Care of Adults With Down Syndrome: A Clinical Guideline.
Tsou AY, Bulova P, Capone G, Chicoine B, Gelaro B, Harville TO, Martin BA, McGuire DE, McKelvey KD, Peterson M, Tyler C, Wells M, Whitten MS; Global Down Syndrome Foundation Medical Care Guidelines for Adults with Down Syndrome Workgroup
JAMA 2020 Oct 20;324(15):1543-1556. doi: 10.1001/jama.2020.17024. PMID: 33079159
Familial Os Odontoideum.
Prasad A, Shah A, Sasane S, Goel A
World Neurosurg 2020 Sep;141:215-218. Epub 2020 Jun 18 doi: 10.1016/j.wneu.2020.06.102. PMID: 32565378
Neurological and spinal manifestations of the Ehlers-Danlos syndromes.
Henderson FC Sr, Austin C, Benzel E, Bolognese P, Ellenbogen R, Francomano CA, Ireton C, Klinge P, Koby M, Long D, Patel S, Singman EL, Voermans NC
Am J Med Genet C Semin Med Genet 2017 Mar;175(1):195-211. Epub 2017 Feb 21 doi: 10.1002/ajmg.c.31549. PMID: 28220607
Epidemiology, diagnosis, and treatment of neck pain.
Cohen SP
Mayo Clin Proc 2015 Feb;90(2):284-99. doi: 10.1016/j.mayocp.2014.09.008. PMID: 25659245
Down syndrome.
Hayes A, Batshaw ML
Pediatr Clin North Am 1993 Jun;40(3):523-35. doi: 10.1016/s0031-3955(16)38548-0. PMID: 8493063

Therapy

Clinical Features of Kawasaki Disease With Atlantoaxial Rotatory Fixation.
Michihata N, Suzuki T, Honda A, Oka I, Yoshikawa T, Saito K, Matsui H, Fushimi K, Yasunaga H
Pediatr Infect Dis J 2022 Aug 1;41(8):626-630. Epub 2022 Jul 13 doi: 10.1097/INF.0000000000003571. PMID: 35544743
Subaxial lordosis loss and influence factors after posterior atlantoaxial fusion.
Liu S, Liu B, Liang G, Chen Q, Wang H, Lin Y
J Orthop Surg Res 2022 Mar 28;17(1):183. doi: 10.1186/s13018-022-03077-6. PMID: 35346286Free PMC Article
Iatrogenic neurological injury in children with trisomy 21.
Husnudinov RE, Ibrahim GM, Propst EJ, Wolter NE
Int J Pediatr Otorhinolaryngol 2018 Nov;114:36-43. Epub 2018 Aug 27 doi: 10.1016/j.ijporl.2018.08.029. PMID: 30262364
Outcome comparison of atlantoaxial fusion with transarticular screws and screw-rod constructs: meta-analysis and review of literature.
Elliott RE, Tanweer O, Boah A, Morsi A, Ma T, Frempong-Boadu A, Smith ML
J Spinal Disord Tech 2014 Feb;27(1):11-28. doi: 10.1097/BSD.0b013e318277da19. PMID: 23128387
Fusions at the craniovertebral junction.
Ahmed R, Traynelis VC, Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1209-24. Epub 2008 Apr 4 doi: 10.1007/s00381-008-0607-7. PMID: 18389260

Prognosis

Radiologic Features of Atlas Occipitalization and Its Clinical Implications.
Yan J, Qiu C, Fu L, Liu X, Zheng Y
Spine (Phila Pa 1976) 2023 Jul 1;48(13):962-968. Epub 2023 Mar 15 doi: 10.1097/BRS.0000000000004626. PMID: 36940257
Transoral Odontoidectomy - Our Experience in A Limited-Resource Setup.
Rehman RU, Akhtar MS, Bibi A, Shah SM, Khan S, Kashif M
World Neurosurg 2022 Sep;165:27-44. Epub 2022 Jun 11 doi: 10.1016/j.wneu.2022.06.024. PMID: 35700863
Miniplate-Augmented Interlaminar Fusion in C1-C2 Screwing.
Huang PJ, Lin JH, Chiang YH
World Neurosurg 2020 Jun;138:e634-e641. Epub 2020 Mar 13 doi: 10.1016/j.wneu.2020.03.023. PMID: 32173550
Spondylo-epi-metaphyseal dysplasia.
Cormier-Daire V
Best Pract Res Clin Rheumatol 2008 Mar;22(1):33-44. doi: 10.1016/j.berh.2007.12.009. PMID: 18328979
Down syndrome.
Hayes A, Batshaw ML
Pediatr Clin North Am 1993 Jun;40(3):523-35. doi: 10.1016/s0031-3955(16)38548-0. PMID: 8493063

Clinical prediction guides

Evolving Concepts of Craniovertebral and Spinal Instability.
Goel A, Vutha R, Shah A
Adv Tech Stand Neurosurg 2023;46:125-147. doi: 10.1007/978-3-031-28202-7_7. PMID: 37318573
Clinical and Radiographic Features of the Atlantoaxial Dislocation Associated With Kashin-Beck Disease.
Wang Y, Song C, Ji Y, Xia J, Chen C, Haque M, Zhuang J, Zhou C, Zu J, Li X, Yan J
World Neurosurg 2023 Mar;171:e1-e7. Epub 2022 Aug 29 doi: 10.1016/j.wneu.2022.08.108. PMID: 36049725
Subaxial lordosis loss and influence factors after posterior atlantoaxial fusion.
Liu S, Liu B, Liang G, Chen Q, Wang H, Lin Y
J Orthop Surg Res 2022 Mar 28;17(1):183. doi: 10.1186/s13018-022-03077-6. PMID: 35346286Free PMC Article
Outcome comparison of atlantoaxial fusion with transarticular screws and screw-rod constructs: meta-analysis and review of literature.
Elliott RE, Tanweer O, Boah A, Morsi A, Ma T, Frempong-Boadu A, Smith ML
J Spinal Disord Tech 2014 Feb;27(1):11-28. doi: 10.1097/BSD.0b013e318277da19. PMID: 23128387
Craniocervical fusions in children.
Menezes AH
J Neurosurg Pediatr 2012 Jun;9(6):573-85. doi: 10.3171/2012.2.PEDS11371. PMID: 22656246

Recent systematic reviews

Systematic review of the nonsurgical management of atlantoaxial rotatory fixation in childhood.
Sae-Huang M, Borg A, Hill CS
J Neurosurg Pediatr 2020 Oct 9;27(1):108-119. doi: 10.3171/2020.6.PEDS20396. PMID: 33036001
Outcomes of Surgical Correction of Atlantoaxial Instability in Patients with Down Syndrome: Systematic Review and Meta-Analysis.
Hofler RC, Pecoraro N, Jones GA
World Neurosurg 2019 Jun;126:e125-e135. Epub 2019 Feb 18 doi: 10.1016/j.wneu.2019.01.267. PMID: 30790735
Juvenile chronic arthritis and the craniovertebral junction in the paediatric patient: review of the literature and management considerations.
Wolfs JF, Arts MP, Peul WC
Adv Tech Stand Neurosurg 2014;41:143-56. doi: 10.1007/978-3-319-01830-0_7. PMID: 24309924
Grisel's syndrome in otolaryngology: a systematic review.
Karkos PD, Benton J, Leong SC, Mushi E, Sivaji N, Assimakopoulos DA
Int J Pediatr Otorhinolaryngol 2007 Dec;71(12):1823-7. Epub 2007 Aug 13 doi: 10.1016/j.ijporl.2007.07.002. PMID: 17706297
Down syndrome and craniovertebral instability. Topic review and treatment recommendations.
Brockmeyer D
Pediatr Neurosurg 1999 Aug;31(2):71-7. doi: 10.1159/000028837. PMID: 10592475

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...