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Abnormal circulating leptin concentration

MedGen UID:
870878
•Concept ID:
C4025339
•
Finding
Synonym: Abnormality of circulating leptin level
 
HPO: HP:0004361

Definition

An abnormal concentration of leptin in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating leptin concentration

Professional guidelines

PubMed

Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729

Recent clinical studies

Etiology

The causal impact of gut microbiota on circulating adipokine concentrations: a two-sample Mendelian randomization study.
Zhang T, Liu J, Liu X, Wang Q, Zhang H
Hormones (Athens) 2024 Dec;23(4):789-799. Epub 2024 Apr 2 doi: 10.1007/s42000-024-00553-y. PMID: 38564143
Leptin, Obesity, and Hypertension: A Review of Pathogenetic Mechanisms.
Lu SC, Akanji AO
Metab Syndr Relat Disord 2020 Nov;18(9):399-405. Epub 2020 Sep 1 doi: 10.1089/met.2020.0065. PMID: 32876506
Adiponectin and leptin concentrations in dichorionic twins with discordant and concordant growth.
Mazaki-Tovi S, Kanety H, Pariente C, Hemi R, Yinon Y, Wiser A, Schiff E, Sivan E
J Clin Endocrinol Metab 2009 Mar;94(3):892-8. Epub 2008 Dec 9 doi: 10.1210/jc.2008-2118. PMID: 19066299
Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease.
Mak RH, Cheung W, Cone RD, Marks DL
Pediatr Nephrol 2005 Mar;20(3):427-31. Epub 2005 Jan 21 doi: 10.1007/s00467-004-1789-1. PMID: 15662537
Androgens and coronary artery disease.
Wu FC, von Eckardstein A
Endocr Rev 2003 Apr;24(2):183-217. doi: 10.1210/er.2001-0025. PMID: 12700179

Diagnosis

The causal impact of gut microbiota on circulating adipokine concentrations: a two-sample Mendelian randomization study.
Zhang T, Liu J, Liu X, Wang Q, Zhang H
Hormones (Athens) 2024 Dec;23(4):789-799. Epub 2024 Apr 2 doi: 10.1007/s42000-024-00553-y. PMID: 38564143
The characteristics of elevated blood pressure in abdominal obesity correspond to primary hypertension: a cross-sectional study.
Taurio J, Hautaniemi EJ, Koskela JK, Eräranta A, Hämäläinen M, Tikkakoski A, Kettunen JA, Kähönen M, Niemelä O, Moilanen E, Mustonen J, Pörsti I
BMC Cardiovasc Disord 2023 Mar 27;23(1):161. doi: 10.1186/s12872-023-03150-w. PMID: 36973671Free PMC Article
Effects of DHEA on metabolic and endocrine functions of adipose tissue.
Karbowska J, Kochan Z
Horm Mol Biol Clin Investig 2013 Aug;14(2):65-74. doi: 10.1515/hmbci-2013-0009. PMID: 25436721
Lack of association of apoE ε4 allele with insulin resistance.
Ragogna F, Lattuada G, Ruotolo G, Luzi L, Perseghin G
Acta Diabetol 2012 Feb;49(1):25-32. Epub 2011 Feb 3 doi: 10.1007/s00592-011-0255-3. PMID: 21290252
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Therapy

The causal impact of gut microbiota on circulating adipokine concentrations: a two-sample Mendelian randomization study.
Zhang T, Liu J, Liu X, Wang Q, Zhang H
Hormones (Athens) 2024 Dec;23(4):789-799. Epub 2024 Apr 2 doi: 10.1007/s42000-024-00553-y. PMID: 38564143
Circulating Levels of Nesfatin-1 and Spexin in Children with Prader-Willi Syndrome during Growth Hormone Treatment and Dietary Intervention.
Gajewska J, Szamotulska K, Klemarczyk W, Chełchowska M, Strucińska M, Ambroszkiewicz J
Nutrients 2023 Mar 1;15(5) doi: 10.3390/nu15051240. PMID: 36904239Free PMC Article
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729
Androgens and coronary artery disease.
Wu FC, von Eckardstein A
Endocr Rev 2003 Apr;24(2):183-217. doi: 10.1210/er.2001-0025. PMID: 12700179
Fructose, weight gain, and the insulin resistance syndrome.
Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ
Am J Clin Nutr 2002 Nov;76(5):911-22. doi: 10.1093/ajcn/76.5.911. PMID: 12399260

Prognosis

Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS.
Fu J, Li Y, Esangbedo IC, Li G, Feng D, Li L, Xu L, Han L, Li M, Li C, Gao S, Li M, Willi SM
J Am Heart Assoc 2018 Dec 4;7(23):e009169. doi: 10.1161/JAHA.118.009169. PMID: 30571596Free PMC Article
Circulating levels of adiponectin and leptin at 23-25 weeks of pregnancy in women with impaired placentation and in those with established fetal growth restriction.
Savvidou MD, Sotiriadis A, Kaihura C, Nicolaides KH, Sattar N
Clin Sci (Lond) 2008 Oct;115(7):219-24. doi: 10.1042/CS20070409. PMID: 18211260
Leptin and cellular and innate immunity in abstinent alcoholics and controls.
Motivala SJ, Dang J, Obradovic T, Meadows GG, Butch AW, Irwin MR
Alcohol Clin Exp Res 2003 Nov;27(11):1819-24. doi: 10.1097/01.ALC.0000093741.21492.02. PMID: 14634499
Leptin concentrations in GH deficiency: the effect of GH insensitivity.
Marzullo P, Buckway C, Pratt KL, Colao A, Guevara-Aguirre J, Rosenfeld RG
J Clin Endocrinol Metab 2002 Feb;87(2):540-5. doi: 10.1210/jcem.87.2.8229. PMID: 11836282
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

Clinical prediction guides

The causal impact of gut microbiota on circulating adipokine concentrations: a two-sample Mendelian randomization study.
Zhang T, Liu J, Liu X, Wang Q, Zhang H
Hormones (Athens) 2024 Dec;23(4):789-799. Epub 2024 Apr 2 doi: 10.1007/s42000-024-00553-y. PMID: 38564143
Leptin and reproductive dysfunction in obese men.
Almabhouh FA, Md Mokhtar AH, Malik IA, Aziz NAAA, Durairajanayagam D, Singh HJ
Andrologia 2020 Feb;52(1):e13433. Epub 2019 Nov 27 doi: 10.1111/and.13433. PMID: 31773771
Androgens and coronary artery disease.
Wu FC, von Eckardstein A
Endocr Rev 2003 Apr;24(2):183-217. doi: 10.1210/er.2001-0025. PMID: 12700179
Fructose, weight gain, and the insulin resistance syndrome.
Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ
Am J Clin Nutr 2002 Nov;76(5):911-22. doi: 10.1093/ajcn/76.5.911. PMID: 12399260
Clinical aspects of leptin.
Sinha MK, Caro JF
Vitam Horm 1998;54:1-30. doi: 10.1016/s0083-6729(08)60919-x. PMID: 9529971

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