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Multiple digital exostoses

MedGen UID:
870708
•Concept ID:
C4025162
•
Neoplastic Process
HPO: HP:0005655

Definition

Multiple exostoses originating in the fingers and toes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple digital exostoses

Conditions with this feature

Metachondromatosis
MedGen UID:
98377
•Concept ID:
C0410530
•
Disease or Syndrome
Metachondromatosis is characterized by exostoses (osteochondromas), commonly of the hands and feet, and enchondromas of long bone metaphyses and iliac crests (summary by Sobreira et al., 2010).
See: Condition Record
Metachondromatosis

Recent clinical studies

Etiology

Determining the factors influencing the symptoms related to naviculo-medial cuneiform coalition.
Choi JY, Chun KA, Lee DJ, Cho ST, Suh JS
J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019832719. doi: 10.1177/2309499019832719. PMID: 30827191
Chest wall osteochondroma in children: a case series of surgical management.
Bakhshi H, Kushare I, Murphy MO, Gaynor JW, Dormans JP
J Pediatr Orthop 2014 Oct-Nov;34(7):733-7. doi: 10.1097/BPO.0000000000000153. PMID: 25210940
Successful operative management of an asymptomatic chest lesion in hereditary multiple exostosis.
Pelc HJ, Walker J, Davies G
J Pediatr Orthop B 2013 Sep;22(5):505-8. doi: 10.1097/BPB.0b013e32835875d2. PMID: 23907180
An unusual complication of pubic exostosis.
Mnif H, Zrig M, Koubaa M, Zammel N, Abid A
Orthop Traumatol Surg Res 2009 Apr;95(2):151-3. Epub 2009 Mar 24 doi: 10.1016/j.otsr.2009.02.003. PMID: 19321394
Chondrosarcoma arising in osteochondroma.
Garrison RC, Unni KK, McLeod RA, Pritchard DJ, Dahlin DC
Cancer 1982 May 1;49(9):1890-7. doi: 10.1002/1097-0142(19820501)49:9<1890::aid-cncr2820490923>3.0.co;2-u. PMID: 7074587

Diagnosis

Surgical Management of Thoracic Multiple Exostoses.
Kanthasamy S, Aresu G, Peryt A, Coonar AS
Ann Thorac Surg 2020 May;109(5):e361-e362. Epub 2019 Oct 4 doi: 10.1016/j.athoracsur.2019.08.088. PMID: 31589851
Osteochondroma of acromioclavicular joint.
Baig MN, O'Malley S, Fenelon C, Kaar K
BMJ Case Rep 2019 Aug 22;12(8) doi: 10.1136/bcr-2019-230246. PMID: 31444263Free PMC Article
Multiple hereditary exostoses: A pseudoaneurysm masquerading as tumor.
Trivedi H, Link TM, O'Donnell RJ, Horvai AE, Motamedi D
J Radiol Case Rep 2016 Aug;10(8):50-59. Epub 2016 Aug 31 doi: 10.3941/jrcr.v10i8.2849. PMID: 27761193Free PMC Article
Multiple Hereditary Exostoses.
DuBose CO
Radiol Technol 2016 Jan-Feb;87(3):305-21. quiz 322-5. PMID: 26721841
Sarcomatous transformation in diaphyseal aclasis.
Shah ZK, Peh WC, Wong Y, Shek TW, Davies AM
Australas Radiol 2007 Apr;51(2):110-9. doi: 10.1111/j.1440-1673.2007.01679.x. PMID: 17419854

Therapy

Spontaneous absorption of osteophytic calcification associated with chronic dural tear and ventral spinal CSF leak.
Rohatgi VK, Robbins MS, Schievink WI, Chazen JL
Neuroradiol J 2024 Apr;37(2):257-260. Epub 2023 Jun 30 doi: 10.1177/19714009231187360. PMID: 37387398Free PMC Article
A Novel Cause of Acute Coronary Syndrome Due to Dynamic Extrinsic Coronary Artery Compression by a Rib Exostosis: Multimodality Imaging Diagnosis.
Rodrigues JC, Mathias HC, Lyen SM, Mcalindon E, Bucciarelli-Ducci C, Batchelor TJ, Hamilton MC, Manghat NE
Can J Cardiol 2015 Oct;31(10):1303.e9-1303.e11. Epub 2015 May 16 doi: 10.1016/j.cjca.2015.05.008. PMID: 26255213
Selective computed tomography-guided perisciatic injection as a diagnostic tool in multiple hereditary exostoses.
Tenenbaum S, Arzi H, Shabshin N, Liberman B, Caspi I
Orthopedics 2012 Sep;35(9):e1446-8. doi: 10.3928/01477447-20120822-38. PMID: 22955418
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report.
Pandya NK, Auerbach JD, Baldwin K, Lackman RD, Chin KR
Spine (Phila Pa 1976) 2006 Nov 15;31(24):E920-4. doi: 10.1097/01.brs.0000245926.30594.bf. PMID: 17108823

Prognosis

Chest wall osteochondroma in children: a case series of surgical management.
Bakhshi H, Kushare I, Murphy MO, Gaynor JW, Dormans JP
J Pediatr Orthop 2014 Oct-Nov;34(7):733-7. doi: 10.1097/BPO.0000000000000153. PMID: 25210940
Successful operative management of an asymptomatic chest lesion in hereditary multiple exostosis.
Pelc HJ, Walker J, Davies G
J Pediatr Orthop B 2013 Sep;22(5):505-8. doi: 10.1097/BPB.0b013e32835875d2. PMID: 23907180
An unusual complication of pubic exostosis.
Mnif H, Zrig M, Koubaa M, Zammel N, Abid A
Orthop Traumatol Surg Res 2009 Apr;95(2):151-3. Epub 2009 Mar 24 doi: 10.1016/j.otsr.2009.02.003. PMID: 19321394
Dedifferentiated chondrosarcoma in patients with multiple osteochondromatosis: report of a case and review of the literature.
Kilpatrick SE, Pike EJ, Ward WG, Pope TL
Skeletal Radiol 1997 Jun;26(6):370-4. doi: 10.1007/s002560050250. PMID: 9229421
Malignant transformation of a multiple cartilaginous exostosis--a case report.
Willms R, Hartwig CH, Böhm P, Sell S
Int Orthop 1997;21(2):133-6. doi: 10.1007/s002640050136. PMID: 9195270Free PMC Article

Clinical prediction guides

Multiple long bone cysts revealed by MRI in trichorhinophalangeal syndrome type II predisposing to pathological fractures.
Konala P, Kiely N, Noakes C, Blair E, Cassar-Pullicino VN
Pediatr Radiol 2017 Jul;47(8):1016-1021. Epub 2017 May 10 doi: 10.1007/s00247-017-3839-4. PMID: 28493010
Hip-Spine Syndrome: Is There an Association Between Markers for Cam Deformity and Osteoarthritis of the Lumbar Spine?
Gebhart JJ, Weinberg DS, Conry KT, Morris WZ, Sasala LM, Liu RW
Arthroscopy 2016 Nov;32(11):2243-2248. Epub 2016 Jun 11 doi: 10.1016/j.arthro.2016.04.025. PMID: 27296870
Congenital bizarre parosteal osteochondromatous proliferation in unusual location and age: a case report.
Sökücü S, Aycan OE, Arıkan Y, Kabukçuoğlu YS
Acta Orthop Traumatol Turc 2016;50(1):120-4. doi: 10.3944/AOTT.2016.13.0141. PMID: 26854060
Prevalence and severity of external auditory exostoses in breath-hold divers.
Sheard PW, Doherty M
J Laryngol Otol 2008 Nov;122(11):1162-7. Epub 2008 Mar 18 doi: 10.1017/S0022215108001850. PMID: 18346299
Secondary chondrosarcoma in osteochondroma: report of 107 patients.
Ahmed AR, Tan TS, Unni KK, Collins MS, Wenger DE, Sim FH
Clin Orthop Relat Res 2003 Jun;(411):193-206. doi: 10.1097/01.blo.0000069888.31220.2b. PMID: 12782876

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