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Anterior wedging of L1

MedGen UID:
870239
•Concept ID:
C4024677
•
Anatomical Abnormality
HPO: HP:0008432

Definition

An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior wedging of L1

Conditions with this feature

Mucopolysaccharidosis type 6
MedGen UID:
44514
•Concept ID:
C0026709
•
Disease or Syndrome
Mucopolysaccharidosis type VI (MPS6) is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Clinical features and severity are variable, but usually include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism. Intelligence is usually normal (Azevedo et al., 2004).
See: Condition Record
Mucopolysaccharidosis type 6

Professional guidelines

PubMed

Effect of pamidronate treatment on vertebral deformity in children with primary osteoporosis. A pilot study using radiographic morphometry.
Sumník Z, Land C, Rieger-Wettengl G, Körber F, Stabrey A, Schoenau E
Horm Res 2004;61(3):137-42. Epub 2003 Dec 15 doi: 10.1159/000075589. PMID: 14676462

Recent clinical studies

Etiology

Closing-opening wedge osteotomy for the treatment of congenital kyphosis in children.
Xu HF, Li C, Ma ZS, Wu ZX, Sha J, Diwu WL, Yan YB, Liu ZC, Fan ZZ, Huang LY
J Orthop Surg (Hong Kong) 2022 Sep-Dec;30(3):10225536221118600. doi: 10.1177/10225536221118600. PMID: 36120861
Wedging of vertebral bodies at the thoracolumbar spine in healthy individuals on whole body MRI screening: correlation with disc degeneration and disc herniation.
Kim J, Park HJ, Kim MS, Kim JN, Choi YJ, Rho MH, Park JY
Acta Radiol 2022 Jul;63(7):958-963. Epub 2021 Jun 9 doi: 10.1177/02841851211024005. PMID: 34107750
Bone Remodeling and Disc Morphology in the Distal Unfused Spine After Spinal Fusion in Adolescent Idiopathic Scoliosis.
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Wedge Hemivertebra Forward-Shifting Technique for Treatment of Congenital Kyphosis: Case Report, Technical Note, and Literature Review.
Guo J, Guo Q, Li J, Fang Z, Liao H, Xiong W, Li F
World Neurosurg 2019 Feb;122:11-15. Epub 2018 Sep 8 doi: 10.1016/j.wneu.2018.08.234. PMID: 30205229
A morphometric analysis of all lumbar intervertebral discs and vertebral bodies in degenerative spondylolisthesis.
Abu-Leil S, Floman Y, Bronstein Y, Masharawi Y
Eur Spine J 2016 Aug;25(8):2535-45. Epub 2016 Jun 27 doi: 10.1007/s00586-016-4673-3. PMID: 27349752

Diagnosis

3D U-Net Neural Network Architecture-Assisted LDCT to Acquire Vertebral Morphology Parameters: A Vertebral Morphology Comprehensive Analysis in a Chinese Population.
Ma D, Wang Y, Zhang X, Su D, Ma M, Qian B, Yang X, Gao J, Wu Y
Calcif Tissue Int 2024 Oct;115(4):362-372. Epub 2024 Jul 17 doi: 10.1007/s00223-024-01255-8. PMID: 39017691
Primary small cell carcinoma of the urinary bladder.
Qayoom S, Chakrabarti D, Khan F, Goel MM
BMJ Case Rep 2019 Sep 30;12(9) doi: 10.1136/bcr-2019-230185. PMID: 31570346Free PMC Article
Nonoperative management of pediatric aortic injury with seat belt syndrome.
Parrish DW, Barnhorst A, Trebska-McGowan K, Amendola M, Haynes JH
Ann Vasc Surg 2015 Aug;29(6):1316.e1-6. Epub 2015 May 28 doi: 10.1016/j.avsg.2015.02.019. PMID: 26028461
Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging.
Matsumoto M, Okada E, Kaneko Y, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Takahata T
Surg Radiol Anat 2011 Apr;33(3):223-8. Epub 2010 Nov 23 doi: 10.1007/s00276-010-0746-x. PMID: 21104252
Vertebral measurements for assessment of osteoporosis.
Ito M, Hayashi K, Yamada M, Nakamura T
Br J Radiol 1994 Aug;67(800):759-63. doi: 10.1259/0007-1285-67-800-759. PMID: 8087480

Therapy

Finite element analysis of wedge and biconcave deformity in four different height restoration after augmentation of osteoporotic vertebral compression fractures.
Zuo XH, Chen YB, Xie P, Zhang WD, Xue XY, Zhang QX, Shan B, Zhang XB, Bao HG, Si YN
J Orthop Surg Res 2021 Feb 15;16(1):138. doi: 10.1186/s13018-021-02225-8. PMID: 33588890Free PMC Article
Bone Remodeling and Disc Morphology in the Distal Unfused Spine After Spinal Fusion in Adolescent Idiopathic Scoliosis.
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
A morphometric analysis of all lumbar intervertebral discs and vertebral bodies in degenerative spondylolisthesis.
Abu-Leil S, Floman Y, Bronstein Y, Masharawi Y
Eur Spine J 2016 Aug;25(8):2535-45. Epub 2016 Jun 27 doi: 10.1007/s00586-016-4673-3. PMID: 27349752
Nonoperative management of pediatric aortic injury with seat belt syndrome.
Parrish DW, Barnhorst A, Trebska-McGowan K, Amendola M, Haynes JH
Ann Vasc Surg 2015 Aug;29(6):1316.e1-6. Epub 2015 May 28 doi: 10.1016/j.avsg.2015.02.019. PMID: 26028461
A new PMHS model for lumbar spine injuries during vertical acceleration.
Stemper BD, Storvik SG, Yoganandan N, Baisden JL, Fijalkowski RJ, Pintar FA, Shender BS, Paskoff GR
J Biomech Eng 2011 Aug;133(8):081002. doi: 10.1115/1.4004655. PMID: 21950895

Prognosis

Primary small cell carcinoma of the urinary bladder.
Qayoom S, Chakrabarti D, Khan F, Goel MM
BMJ Case Rep 2019 Sep 30;12(9) doi: 10.1136/bcr-2019-230185. PMID: 31570346Free PMC Article
Bone Remodeling and Disc Morphology in the Distal Unfused Spine After Spinal Fusion in Adolescent Idiopathic Scoliosis.
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Risk factor analysis for predicting vertebral body re-collapse after posterior instrumented fusion in thoracolumbar burst fracture.
Jang HD, Bang C, Lee JC, Soh JW, Choi SW, Cho HK, Shin BJ
Spine J 2018 Feb;18(2):285-293. Epub 2017 Jul 20 doi: 10.1016/j.spinee.2017.07.168. PMID: 28735766
Infantile developmental thoracolumbar kyphosis with segmental subluxation of the spine.
Tsirikos AI, McMaster MJ
J Bone Joint Surg Br 2010 Mar;92(3):430-5. doi: 10.1302/0301-620X.92B3.23075. PMID: 20190317
Anterior-posterior surgery versus posterior closing wedge osteotomy in posttraumatic kyphosis with neurologic compromised osteoporotic fracture.
Suk SI, Kim JH, Lee SM, Chung ER, Lee JH
Spine (Phila Pa 1976) 2003 Sep 15;28(18):2170-5. doi: 10.1097/01.BRS.0000090889.45158.5A. PMID: 14501932

Clinical prediction guides

Closing-opening wedge osteotomy for the treatment of congenital kyphosis in children.
Xu HF, Li C, Ma ZS, Wu ZX, Sha J, Diwu WL, Yan YB, Liu ZC, Fan ZZ, Huang LY
J Orthop Surg (Hong Kong) 2022 Sep-Dec;30(3):10225536221118600. doi: 10.1177/10225536221118600. PMID: 36120861
Bone Remodeling and Disc Morphology in the Distal Unfused Spine After Spinal Fusion in Adolescent Idiopathic Scoliosis.
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Wedging of vertebral bodies at the thoracolumbar junction in asymptomatic healthy subjects on magnetic resonance imaging.
Matsumoto M, Okada E, Kaneko Y, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Takahata T
Surg Radiol Anat 2011 Apr;33(3):223-8. Epub 2010 Nov 23 doi: 10.1007/s00276-010-0746-x. PMID: 21104252
Effect of anterior wedging of L1 on the measurement of lumbar lordosis: comparison of two roentgenological methods.
Worrill NA, Peterson CK
J Manipulative Physiol Ther 1997 Sep;20(7):459-67. PMID: 9310901
Injuries of the thoracolumbar junction. Clinical and radiological results in 149 patients.
Härkönen M, Kataja M, Keski-Nisula L, Paakkala T, Pätiälä H, Rokkanen P
Arch Orthop Trauma Surg (1978) 1979 Jun 29;94(1):35-41. doi: 10.1007/BF00448091. PMID: 485790

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