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Anterior wedging of L1

MedGen UID:
870239
Concept ID:
C4024677
Anatomical Abnormality
HPO: HP:0008432

Definition

An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front). [from HPO]

Term Hierarchy

Conditions with this feature

Mucopolysaccharidosis type 6
MedGen UID:
44514
Concept ID:
C0026709
Disease or Syndrome
Mucopolysaccharidosis type VI (MPS6) is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Clinical features and severity are variable, but usually include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism. Intelligence is usually normal (Azevedo et al., 2004).

Professional guidelines

PubMed

Sumník Z, Land C, Rieger-Wettengl G, Körber F, Stabrey A, Schoenau E
Horm Res 2004;61(3):137-42. Epub 2003 Dec 15 doi: 10.1159/000075589. PMID: 14676462

Recent clinical studies

Etiology

Xu HF, Li C, Ma ZS, Wu ZX, Sha J, Diwu WL, Yan YB, Liu ZC, Fan ZZ, Huang LY
J Orthop Surg (Hong Kong) 2022 Sep-Dec;30(3):10225536221118600. doi: 10.1177/10225536221118600. PMID: 36120861
Kim J, Park HJ, Kim MS, Kim JN, Choi YJ, Rho MH, Park JY
Acta Radiol 2022 Jul;63(7):958-963. Epub 2021 Jun 9 doi: 10.1177/02841851211024005. PMID: 34107750
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Guo J, Guo Q, Li J, Fang Z, Liao H, Xiong W, Li F
World Neurosurg 2019 Feb;122:11-15. Epub 2018 Sep 8 doi: 10.1016/j.wneu.2018.08.234. PMID: 30205229
Abu-Leil S, Floman Y, Bronstein Y, Masharawi Y
Eur Spine J 2016 Aug;25(8):2535-45. Epub 2016 Jun 27 doi: 10.1007/s00586-016-4673-3. PMID: 27349752

Diagnosis

Ma D, Wang Y, Zhang X, Su D, Ma M, Qian B, Yang X, Gao J, Wu Y
Calcif Tissue Int 2024 Oct;115(4):362-372. Epub 2024 Jul 17 doi: 10.1007/s00223-024-01255-8. PMID: 39017691
Qayoom S, Chakrabarti D, Khan F, Goel MM
BMJ Case Rep 2019 Sep 30;12(9) doi: 10.1136/bcr-2019-230185. PMID: 31570346Free PMC Article
Parrish DW, Barnhorst A, Trebska-McGowan K, Amendola M, Haynes JH
Ann Vasc Surg 2015 Aug;29(6):1316.e1-6. Epub 2015 May 28 doi: 10.1016/j.avsg.2015.02.019. PMID: 26028461
Matsumoto M, Okada E, Kaneko Y, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Takahata T
Surg Radiol Anat 2011 Apr;33(3):223-8. Epub 2010 Nov 23 doi: 10.1007/s00276-010-0746-x. PMID: 21104252
Ito M, Hayashi K, Yamada M, Nakamura T
Br J Radiol 1994 Aug;67(800):759-63. doi: 10.1259/0007-1285-67-800-759. PMID: 8087480

Therapy

Zuo XH, Chen YB, Xie P, Zhang WD, Xue XY, Zhang QX, Shan B, Zhang XB, Bao HG, Si YN
J Orthop Surg Res 2021 Feb 15;16(1):138. doi: 10.1186/s13018-021-02225-8. PMID: 33588890Free PMC Article
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Abu-Leil S, Floman Y, Bronstein Y, Masharawi Y
Eur Spine J 2016 Aug;25(8):2535-45. Epub 2016 Jun 27 doi: 10.1007/s00586-016-4673-3. PMID: 27349752
Parrish DW, Barnhorst A, Trebska-McGowan K, Amendola M, Haynes JH
Ann Vasc Surg 2015 Aug;29(6):1316.e1-6. Epub 2015 May 28 doi: 10.1016/j.avsg.2015.02.019. PMID: 26028461
Stemper BD, Storvik SG, Yoganandan N, Baisden JL, Fijalkowski RJ, Pintar FA, Shender BS, Paskoff GR
J Biomech Eng 2011 Aug;133(8):081002. doi: 10.1115/1.4004655. PMID: 21950895

Prognosis

Qayoom S, Chakrabarti D, Khan F, Goel MM
BMJ Case Rep 2019 Sep 30;12(9) doi: 10.1136/bcr-2019-230185. PMID: 31570346Free PMC Article
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Jang HD, Bang C, Lee JC, Soh JW, Choi SW, Cho HK, Shin BJ
Spine J 2018 Feb;18(2):285-293. Epub 2017 Jul 20 doi: 10.1016/j.spinee.2017.07.168. PMID: 28735766
Tsirikos AI, McMaster MJ
J Bone Joint Surg Br 2010 Mar;92(3):430-5. doi: 10.1302/0301-620X.92B3.23075. PMID: 20190317
Suk SI, Kim JH, Lee SM, Chung ER, Lee JH
Spine (Phila Pa 1976) 2003 Sep 15;28(18):2170-5. doi: 10.1097/01.BRS.0000090889.45158.5A. PMID: 14501932

Clinical prediction guides

Xu HF, Li C, Ma ZS, Wu ZX, Sha J, Diwu WL, Yan YB, Liu ZC, Fan ZZ, Huang LY
J Orthop Surg (Hong Kong) 2022 Sep-Dec;30(3):10225536221118600. doi: 10.1177/10225536221118600. PMID: 36120861
Pasha S, Smith L, Sankar WN
Spine Deform 2019 Sep;7(5):746-753. doi: 10.1016/j.jspd.2018.12.004. PMID: 31495475Free PMC Article
Matsumoto M, Okada E, Kaneko Y, Ichihara D, Watanabe K, Chiba K, Toyama Y, Fujiwara H, Momoshima S, Nishiwaki Y, Hashimoto T, Takahata T
Surg Radiol Anat 2011 Apr;33(3):223-8. Epub 2010 Nov 23 doi: 10.1007/s00276-010-0746-x. PMID: 21104252
Worrill NA, Peterson CK
J Manipulative Physiol Ther 1997 Sep;20(7):459-67. PMID: 9310901
Härkönen M, Kataja M, Keski-Nisula L, Paakkala T, Pätiälä H, Rokkanen P
Arch Orthop Trauma Surg (1978) 1979 Jun 29;94(1):35-41. doi: 10.1007/BF00448091. PMID: 485790

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