U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of pain sensation

MedGen UID:
869265
•Concept ID:
C4023691
•
Anatomical Abnormality
HPO: HP:0010832

Definition

Pain is an unpleasant sensation that can range from mild, localized discomfort to agony, whereby the physical part of pain results from nerve stimulation and is often accompanied by an emotional component. This term groups abnormalities in pain sensation presumed to result from abnormalities related to the specific nerve fibers that carry the pain impulses to the brain. [from HPO]

Professional guidelines

PubMed

Management of Chronic Abdominal Distension and Bloating.
Lacy BE, Cangemi D, Vazquez-Roque M
Clin Gastroenterol Hepatol 2021 Feb;19(2):219-231.e1. Epub 2020 Apr 1 doi: 10.1016/j.cgh.2020.03.056. PMID: 32246999
Management of functional neurological disorder.
Gilmour GS, Nielsen G, Teodoro T, Yogarajah M, Coebergh JA, Dilley MD, Martino D, Edwards MJ
J Neurol 2020 Jul;267(7):2164-2172. Epub 2020 Mar 19 doi: 10.1007/s00415-020-09772-w. PMID: 32193596Free PMC Article
Management Options for Irritable Bowel Syndrome.
Camilleri M
Mayo Clin Proc 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596Free PMC Article

Recent clinical studies

Etiology

At the intersection of alcohol use disorder and chronic pain.
Maleki N, Tahaney K, Thompson BL, Oscar-Berman M
Neuropsychology 2019 Sep;33(6):795-807. doi: 10.1037/neu0000558. PMID: 31448947Free PMC Article
Functional imaging of pain.
Peyron R, Fauchon C
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):38-45. Epub 2018 Oct 11 doi: 10.1016/j.neurol.2018.08.006. PMID: 30318262
Congenital corneal anesthesia.
Ramappa M, Chaurasia S, Chakrabarti S, Kaur I
J AAPOS 2014 Oct;18(5):427-32. Epub 2014 Oct 21 doi: 10.1016/j.jaapos.2014.05.011. PMID: 25439301
Current treatments in familial dysautonomia.
Palma JA, Norcliffe-Kaufmann L, Fuente-Mora C, Percival L, Mendoza-Santiesteban C, Kaufmann H
Expert Opin Pharmacother 2014 Dec;15(18):2653-71. Epub 2014 Oct 17 doi: 10.1517/14656566.2014.970530. PMID: 25323828Free PMC Article
Congenital corneal anesthesia.
Ramaesh K, Stokes J, Henry E, Dutton GN, Dhillon B
Surv Ophthalmol 2007 Jan-Feb;52(1):50-60. doi: 10.1016/j.survophthal.2006.10.004. PMID: 17212990

Diagnosis

Annular urticarial lesions.
Örnek S, Zuberbier T, Kocatürk E
Clin Dermatol 2022 Sep-Oct;40(5):480-504. Epub 2022 Jan 1 doi: 10.1016/j.clindermatol.2021.12.010. PMID: 34979264
Neuroanatomical basis of Wallenberg syndrome.
Gasca-González OO, Pérez-Cruz JC, Baldoncini M, Macías-Duvignau MA, Delgado-Reyes L
Cir Cir 2020;88(3):376-382. doi: 10.24875/CIRU.19000801. PMID: 32539005
Pain Neurology.
Wang VC, Mullally WJ
Am J Med 2020 Mar;133(3):273-280. Epub 2019 Aug 13 doi: 10.1016/j.amjmed.2019.07.029. PMID: 31419424
Functional sensory symptoms.
Stone J, Vermeulen M
Handb Clin Neurol 2016;139:271-281. doi: 10.1016/B978-0-12-801772-2.00024-2. PMID: 27719847
Abdominal Pain Mimics.
Palmer J, Pontius E
Emerg Med Clin North Am 2016 May;34(2):409-23. Epub 2016 Mar 22 doi: 10.1016/j.emc.2015.12.007. PMID: 27133252

Therapy

Acute Uncomplicated UTIs in Adults: Rapid Evidence Review.
Kurotschka PK, Gágyor I, Ebell MH
Am Fam Physician 2024 Feb;109(2):167-174. PMID: 38393801
Acroparesthesias: An Overview.
Slouma M, Ben Dhia S, Cheour E, Gharsallah I
Curr Rheumatol Rev 2024;20(2):115-126. doi: 10.2174/0115733971254976230927113202. PMID: 37921132
Management Options for Irritable Bowel Syndrome.
Camilleri M
Mayo Clin Proc 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596Free PMC Article
Refractory Constipation: What is the Clinician to Do?
Staller K
J Clin Gastroenterol 2018 Jul;52(6):490-501. doi: 10.1097/MCG.0000000000001049. PMID: 29794543
Alliaceous migraines.
Roussos AP, Hirsch AR
Headache 2014 Feb;54(2):378-82. Epub 2013 Apr 1 doi: 10.1111/head.12091. PMID: 23551212

Prognosis

Refractory Constipation: What is the Clinician to Do?
Staller K
J Clin Gastroenterol 2018 Jul;52(6):490-501. doi: 10.1097/MCG.0000000000001049. PMID: 29794543
Degenerative Cervical Myelopathy: A Clinical Review.
Gibson J, Nouri A, Krueger B, Lakomkin N, Nasser R, Gimbel D, Cheng J
Yale J Biol Med 2018 Mar;91(1):43-48. Epub 2018 Mar 28 PMID: 29599656Free PMC Article
Functional sensory symptoms.
Stone J, Vermeulen M
Handb Clin Neurol 2016;139:271-281. doi: 10.1016/B978-0-12-801772-2.00024-2. PMID: 27719847
Diagnostic criteria for pudendal neuralgia by pudendal nerve entrapment (Nantes criteria).
Labat JJ, Riant T, Robert R, Amarenco G, Lefaucheur JP, Rigaud J
Neurourol Urodyn 2008;27(4):306-10. doi: 10.1002/nau.20505. PMID: 17828787
Congenital corneal anesthesia.
Ramaesh K, Stokes J, Henry E, Dutton GN, Dhillon B
Surv Ophthalmol 2007 Jan-Feb;52(1):50-60. doi: 10.1016/j.survophthal.2006.10.004. PMID: 17212990

Clinical prediction guides

Functional Dyspepsia: Current Understanding and Future Perspective.
Oshima T
Digestion 2024;105(1):26-33. Epub 2023 Aug 18 doi: 10.1159/000532082. PMID: 37598673
Fibromyalgia syndrome and the eye-A review.
Zdebik N, Zdebik A, Bogusławska J, Przeździecka-Dołyk J, Turno-Kręcicka A
Surv Ophthalmol 2021 Jan-Feb;66(1):132-137. Epub 2020 Jun 5 doi: 10.1016/j.survophthal.2020.05.006. PMID: 32512032
Functional imaging of pain.
Peyron R, Fauchon C
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):38-45. Epub 2018 Oct 11 doi: 10.1016/j.neurol.2018.08.006. PMID: 30318262
Refractory Constipation: What is the Clinician to Do?
Staller K
J Clin Gastroenterol 2018 Jul;52(6):490-501. doi: 10.1097/MCG.0000000000001049. PMID: 29794543
Diagnostic criteria for pudendal neuralgia by pudendal nerve entrapment (Nantes criteria).
Labat JJ, Riant T, Robert R, Amarenco G, Lefaucheur JP, Rigaud J
Neurourol Urodyn 2008;27(4):306-10. doi: 10.1002/nau.20505. PMID: 17828787

Recent systematic reviews

Anti-vascular endothelial growth factor for neovascular glaucoma.
Rittiphairoj T, Roberti G, Michelessi M
Cochrane Database Syst Rev 2023 Apr 3;4(4):CD007920. doi: 10.1002/14651858.CD007920.pub4. PMID: 37010901Free PMC Article
Sensory sensitivity after acquired brain injury: A systematic review.
Thielen H, Tuts N, Welkenhuyzen L, Huenges Wajer IMC, Lafosse C, Gillebert CR
J Neuropsychol 2023 Mar;17(1):1-31. Epub 2022 Jun 30 doi: 10.1111/jnp.12284. PMID: 35773750
Physical and social pains in borderline disorder and neuroanatomical correlates: a systematic review.
Ducasse D, Courtet P, Olié E
Curr Psychiatry Rep 2014 May;16(5):443. doi: 10.1007/s11920-014-0443-2. PMID: 24633938
The effect of tongue-tie division on breastfeeding and speech articulation: a systematic review.
Webb AN, Hao W, Hong P
Int J Pediatr Otorhinolaryngol 2013 May;77(5):635-46. Epub 2013 Mar 26 doi: 10.1016/j.ijporl.2013.03.008. PMID: 23537928
The Charcot foot.
Jeffcoate W, Lima J, Nobrega L
Diabet Med 2000 Apr;17(4):253-8. doi: 10.1046/j.1464-5491.2000.00233.x. PMID: 10821290

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...