U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of the intrinsic pathway

MedGen UID:
869188
•Concept ID:
C4023610
•
Anatomical Abnormality
HPO: HP:0010989

Definition

An abnormality of the intrinsic pathway (also known as the contact activation pathway) of the coagulation cascade. [from HPO]

Professional guidelines

PubMed

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.
Vucic S, Stanley Chen KH, Kiernan MC, Hallett M, Benninger DH, Di Lazzaro V, Rossini PM, Benussi A, Berardelli A, Currà A, Krieg SM, Lefaucheur JP, Long Lo Y, Macdonell RA, Massimini M, Rosanova M, Picht T, Stinear CM, Paulus W, Ugawa Y, Ziemann U, Chen R
Clin Neurophysiol 2023 Jun;150:131-175. Epub 2023 Mar 29 doi: 10.1016/j.clinph.2023.03.010. PMID: 37068329Free PMC Article
Clinical Evaluation of Bleeding and Bruising in Primary Care.
Neutze D, Roque J
Am Fam Physician 2016 Feb 15;93(4):279-86. PMID: 26926815
Diagnosis, pathophysiology, and treatment of photophobia.
Katz BJ, Digre KB
Surv Ophthalmol 2016 Jul-Aug;61(4):466-77. Epub 2016 Feb 12 doi: 10.1016/j.survophthal.2016.02.001. PMID: 26875996

Recent clinical studies

Etiology

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Santoro RC, Molinari AC, Leotta M, Martini T
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061169. PMID: 37374373Free PMC Article
Implementation of the WHO integrated care for older people (ICOPE) programme in clinical practice: a prospective study.
Tavassoli N, de Souto Barreto P, Berbon C, Mathieu C, de Kerimel J, Lafont C, Takeda C, Carrie I, Piau A, Jouffrey T, Andrieu S, Nourhashemi F, Beard JR, Soto Martin ME, Vellas B
Lancet Healthy Longev 2022 Jun;3(6):e394-e404. Epub 2022 Jun 9 doi: 10.1016/S2666-7568(22)00097-6. PMID: 36098317
Lamin A involvement in ageing processes.
Cenni V, Capanni C, Mattioli E, Schena E, Squarzoni S, Bacalini MG, Garagnani P, Salvioli S, Franceschi C, Lattanzi G
Ageing Res Rev 2020 Sep;62:101073. Epub 2020 May 21 doi: 10.1016/j.arr.2020.101073. PMID: 32446955
Coagulation Testing in the Core Laboratory.
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Diagnosis

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Santoro RC, Molinari AC, Leotta M, Martini T
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061169. PMID: 37374373Free PMC Article
Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.
Vucic S, Stanley Chen KH, Kiernan MC, Hallett M, Benninger DH, Di Lazzaro V, Rossini PM, Benussi A, Berardelli A, Currà A, Krieg SM, Lefaucheur JP, Long Lo Y, Macdonell RA, Massimini M, Rosanova M, Picht T, Stinear CM, Paulus W, Ugawa Y, Ziemann U, Chen R
Clin Neurophysiol 2023 Jun;150:131-175. Epub 2023 Mar 29 doi: 10.1016/j.clinph.2023.03.010. PMID: 37068329Free PMC Article
Coagulation Testing in the Core Laboratory.
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL
Chest 2017 Jan;151(1):181-192. Epub 2016 Sep 16 doi: 10.1016/j.chest.2016.09.001. PMID: 27645688Free PMC Article
Diagnosis, pathophysiology, and treatment of photophobia.
Katz BJ, Digre KB
Surv Ophthalmol 2016 Jul-Aug;61(4):466-77. Epub 2016 Feb 12 doi: 10.1016/j.survophthal.2016.02.001. PMID: 26875996

Therapy

Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!
Santoro RC, Molinari AC, Leotta M, Martini T
Medicina (Kaunas) 2023 Jun 17;59(6) doi: 10.3390/medicina59061169. PMID: 37374373Free PMC Article
Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Blümel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, Wölfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, Stühler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S
J Immunother Cancer 2023 Jan;11(1) doi: 10.1136/jitc-2022-005871. PMID: 36639156Free PMC Article
The Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina.
Oshitari T
Int J Mol Sci 2021 Aug 22;22(16) doi: 10.3390/ijms22169050. PMID: 34445756Free PMC Article
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis.
Dubin C, Del Duca E, Guttman-Yassky E
Expert Rev Clin Immunol 2021 Aug;17(8):835-852. Epub 2021 Jul 21 doi: 10.1080/1744666X.2021.1940962. PMID: 34106037
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Prognosis

The current advances of lncRNAs in breast cancer immunobiology research.
Fonseca-Montaño MA, Vázquez-Santillán KI, Hidalgo-Miranda A
Front Immunol 2023;14:1194300. Epub 2023 Jun 5 doi: 10.3389/fimmu.2023.1194300. PMID: 37342324Free PMC Article
Architects of Pituitary Tumour Growth.
Sabatino ME, Grondona E, De Paul AL
Front Endocrinol (Lausanne) 2022;13:924942. Epub 2022 Jun 28 doi: 10.3389/fendo.2022.924942. PMID: 35837315Free PMC Article
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
Peng J, Sun BF, Chen CY, Zhou JY, Chen YS, Chen H, Liu L, Huang D, Jiang J, Cui GS, Yang Y, Wang W, Guo D, Dai M, Guo J, Zhang T, Liao Q, Liu Y, Zhao YL, Han DL, Zhao Y, Yang YG, Wu W
Cell Res 2019 Sep;29(9):725-738. Epub 2019 Jul 4 doi: 10.1038/s41422-019-0195-y. PMID: 31273297Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
HLA-B27 misfolding and ankylosing spondylitis.
Colbert RA, Tran TM, Layh-Schmitt G
Mol Immunol 2014 Jan;57(1):44-51. Epub 2013 Aug 30 doi: 10.1016/j.molimm.2013.07.013. PMID: 23993278Free PMC Article

Clinical prediction guides

Architects of Pituitary Tumour Growth.
Sabatino ME, Grondona E, De Paul AL
Front Endocrinol (Lausanne) 2022;13:924942. Epub 2022 Jun 28 doi: 10.3389/fendo.2022.924942. PMID: 35837315Free PMC Article
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma.
Peng J, Sun BF, Chen CY, Zhou JY, Chen YS, Chen H, Liu L, Huang D, Jiang J, Cui GS, Yang Y, Wang W, Guo D, Dai M, Guo J, Zhang T, Liao Q, Liu Y, Zhao YL, Han DL, Zhao Y, Yang YG, Wu W
Cell Res 2019 Sep;29(9):725-738. Epub 2019 Jul 4 doi: 10.1038/s41422-019-0195-y. PMID: 31273297Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Fantastic nuclear envelope herniations and where to find them.
Thaller DJ, Patrick Lusk C
Biochem Soc Trans 2018 Aug 20;46(4):877-889. Epub 2018 Jul 19 doi: 10.1042/BST20170442. PMID: 30026368Free PMC Article
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.
EFSA GMO Panel Working Group on Animal Feeding Trials
Food Chem Toxicol 2008 Mar;46 Suppl 1:S2-70. Epub 2008 Feb 13 doi: 10.1016/j.fct.2008.02.008. PMID: 18328408

Recent systematic reviews

Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review.
Menezes Júnior ADS, França-E-Silva ALG, Oliveira JM, Silva DMD
Int J Mol Sci 2023 Dec 30;25(1) doi: 10.3390/ijms25010535. PMID: 38203704Free PMC Article
Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis.
Liu J, Cao L, Li H, Gao Y, Bu X, Liang K, Bao W, Zhang S, Qiu H, Li X, Hu X, Lu L, Zhang L, Hu X, Huang X, Gong Q
Neurosci Biobehav Rev 2022 Apr;135:104574. Epub 2022 Feb 10 doi: 10.1016/j.neubiorev.2022.104574. PMID: 35151769
The association between first-episode psychosis and abnormal glycaemic control: systematic review and meta-analysis.
Perry BI, McIntosh G, Weich S, Singh S, Rees K
Lancet Psychiatry 2016 Nov;3(11):1049-1058. Epub 2016 Oct 5 doi: 10.1016/S2215-0366(16)30262-0. PMID: 27720402
Cognition and resting-state functional connectivity in schizophrenia.
Sheffield JM, Barch DM
Neurosci Biobehav Rev 2016 Feb;61:108-20. Epub 2015 Dec 14 doi: 10.1016/j.neubiorev.2015.12.007. PMID: 26698018Free PMC Article
Spontaneous movement disorders in antipsychotic-naive patients with first-episode psychoses: a systematic review.
Pappa S, Dazzan P
Psychol Med 2009 Jul;39(7):1065-76. Epub 2008 Nov 12 doi: 10.1017/S0033291708004716. PMID: 19000340

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...