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Abnormal corpus striatum morphology

MedGen UID:: 869185
•Concept ID:: C4023607
•: Anatomical Abnormality

Synonym:	Abnormality of the striatum

HPO:	HP:0010994

Definition

Abnormality of the striatum, which is the largest nucleus of the basal ganglia, comprising the caudate, putamen and ventral striatum, including the nucleus accumbens. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal corpus striatum morphology

Morphological central nervous system abnormality
- Abnormal brain morphology
  - Abnormal forebrain morphology
    - Abnormal cerebral morphology
      - Abnormal cerebral subcortex morphology
        Abnormal basal ganglia morphology
        Abnormal corpus striatum morphology
        Abnormal caudate nucleus morphology
        Increased caudate lactate level
        Abnormal putamen morphology
        Agenesis of putamen
        Fusion of the caudate and putamen
        T2-hyperintense putaminal rim
        Degeneration of the striatum
        Striatal T2 hyperintensity

Conditions with this feature

Striatal degeneration, autosomal dominant 2

MedGen UID:: 934758
•Concept ID:: C4310791
•: Disease or Syndrome

Autosomal dominant striatal degeneration-2 is a neurologic disorder characterized by hyperkinetic movements, mainly chorea, resulting from dysfunction of the basal ganglia. Although symptoms appear in the first decade, the disorder is not progressive (summary by Mencacci et al., 2016). For a discussion of genetic heterogeneity of ADSD, see ADSD1 (609161).

See: Condition Record

Striatal degeneration, autosomal dominant 2

Professional guidelines

PubMed

Lithium treatment impacts nucleus accumbens shape in bipolar disorder.

Vecchio D, Piras F, Piras F, Banaj N, Janiri D, Simonetti A, Sani G, Spalletta G
Neuroimage Clin 2020;25:102167. Epub 2020 Jan 10 doi: 10.1016/j.nicl.2020.102167. PMID: 31972398 Free PMC Article

Levodopa treatment and dendritic spine pathology.

Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414 Free PMC Article

Surgical treatment of Parkinson's disease.

Obeso JA, Rodríguez MC, Gorospe A, Guridi J, Alvarez L, Macias R
Baillieres Clin Neurol 1997 Apr;6(1):125-45. PMID: 9426872

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Recent clinical studies

Etiology

Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors' Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia.

Sawada T, Barbosa AR, Araujo B, McCord AE, D'Ignazio L, Benjamin KJM, Sheehan B, Zabolocki M, Feltrin A, Arora R, Brandtjen AC, Kleinman JE, Hyde TM, Bardy C, Weinberger DR, Paquola ACM, Erwin JA
Am J Psychiatry 2024 Jun 1;181(6):493-511. Epub 2023 Nov 2 doi: 10.1176/appi.ajp.20220723. PMID: 37915216 Free PMC Article

Increased insula-putamen connectivity in X-linked dystonia-parkinsonism.

Blood AJ, Waugh JL, Münte TF, Heldmann M, Domingo A, Klein C, Breiter HC, Lee LV, Rosales RL, Brüggemann N
Neuroimage Clin 2018;17:835-846. Epub 2017 Oct 28 doi: 10.1016/j.nicl.2017.10.025. PMID: 29527488 Free PMC Article

Postural & striatal deformities in Parkinson`s disease: Are these rare?

Pandey S, Garg H
Indian J Med Res 2016 Jan;143(1):11-7. doi: 10.4103/0971-5916.178577. PMID: 26997007 Free PMC Article

The dopamine hypothesis of schizophrenia: version III--the final common pathway.

Howes OD, Kapur S
Schizophr Bull 2009 May;35(3):549-62. Epub 2009 Mar 26 doi: 10.1093/schbul/sbp006. PMID: 19325164 Free PMC Article

Caudate infarcts.

Caplan LR, Schmahmann JD, Kase CS, Feldmann E, Baquis G, Greenberg JP, Gorelick PB, Helgason C, Hier DB
Arch Neurol 1990 Feb;47(2):133-43. doi: 10.1001/archneur.1990.00530020029011. PMID: 2405818

See all (538)

Diagnosis

Diabetic striatopathy: a case report.

Guan Y, Yuan L, Yuan L
Neurocase 2023 Jun;29(3):90-91. Epub 2024 Feb 17 doi: 10.1080/13554794.2024.2317788. PMID: 38367007

"Diabetic striatopathy": clinical presentations, controversy, pathogenesis, treatments, and outcomes.

Chua CB, Sun CK, Hsu CW, Tai YC, Liang CY, Tsai IT
Sci Rep 2020 Jan 31;10(1):1594. doi: 10.1038/s41598-020-58555-w. PMID: 32005905 Free PMC Article

Parkinson's disease: diagnosis.

Brooks DJ
Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S31-3. doi: 10.1016/S1353-8020(11)70012-8. PMID: 22166447

The dopamine hypothesis of schizophrenia: version III--the final common pathway.

Howes OD, Kapur S
Schizophr Bull 2009 May;35(3):549-62. Epub 2009 Mar 26 doi: 10.1093/schbul/sbp006. PMID: 19325164 Free PMC Article

The corticostriatal pathway in Huntington's disease.

Cepeda C, Wu N, André VM, Cummings DM, Levine MS
Prog Neurobiol 2007 Apr;81(5-6):253-71. Epub 2006 Dec 13 doi: 10.1016/j.pneurobio.2006.11.001. PMID: 17169479 Free PMC Article

See all (531)

Therapy

Potential mechanisms for phencyclidine/ketamine-induced brain structural alterations and behavioral consequences.

Wang C, Inselman A, Liu S, Liu F
Neurotoxicology 2020 Jan;76:213-219. Epub 2019 Dec 5 doi: 10.1016/j.neuro.2019.12.005. PMID: 31812709

Levodopa treatment and dendritic spine pathology.

Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414 Free PMC Article

Exercise effects on depression: Possible neural mechanisms.

Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145 Free PMC Article

Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease.

Obeso JA, Rodríguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M
Mov Disord 2008;23 Suppl 3:S548-59. doi: 10.1002/mds.22062. PMID: 18781672

Parkinsonism. Multiple system atrophy.

Wenning GK, Quinn NP
Baillieres Clin Neurol 1997 Apr;6(1):187-204. PMID: 9426875

See all (192)

Prognosis

Cerebrospinal Fluid-In Gradient of Cortical and Deep Gray Matter Damage in Multiple Sclerosis.

Rubin M, Pagani E, Preziosa P, Meani A, Storelli L, Margoni M, Filippi M, Rocca MA
Neurol Neuroimmunol Neuroinflamm 2024 Jul;11(4):e200271. Epub 2024 Jun 19 doi: 10.1212/NXI.0000000000200271. PMID: 38896808 Free PMC Article

Kernicterus in preterm infants.

Okumura A, Kidokoro H, Shoji H, Nakazawa T, Mimaki M, Fujii K, Oba H, Shimizu T
Pediatrics 2009 Jun;123(6):e1052-8. Epub 2009 May 11 doi: 10.1542/peds.2008-2791. PMID: 19433515

Pallidal stimulation for dystonia.

Lozano AM, Abosch A
Adv Neurol 2004;94:301-8. PMID: 14509687

Arteries of the insula.

Türe U, Yaşargil MG, Al-Mefty O, Yaşargil DC
J Neurosurg 2000 Apr;92(4):676-87. doi: 10.3171/jns.2000.92.4.0676. PMID: 10761659

Glycogenosis type VIII.

Kornfeld M, LeBaron M
J Neuropathol Exp Neurol 1984 Nov;43(6):568-79. doi: 10.1097/00005072-198411000-00002. PMID: 6594438

See all (202)

Clinical prediction guides

Cerebrospinal Fluid-In Gradient of Cortical and Deep Gray Matter Damage in Multiple Sclerosis.

Exercise effects on depression: Possible neural mechanisms.

Gujral S, Aizenstein H, Reynolds CF 3rd, Butters MA, Erickson KI
Gen Hosp Psychiatry 2017 Nov;49:2-10. doi: 10.1016/j.genhosppsych.2017.04.012. PMID: 29122145 Free PMC Article

Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia.

Eskow Jaunarajs KL, Bonsi P, Chesselet MF, Standaert DG, Pisani A
Prog Neurobiol 2015 Apr;127-128:91-107. Epub 2015 Feb 17 doi: 10.1016/j.pneurobio.2015.02.002. PMID: 25697043 Free PMC Article

The impairment of cholesterol metabolism in Huntington disease.

Leoni V, Caccia C
Biochim Biophys Acta 2015 Aug;1851(8):1095-105. Epub 2015 Jan 14 doi: 10.1016/j.bbalip.2014.12.018. PMID: 25596342

Glycogenosis type VIII.

Kornfeld M, LeBaron M
J Neuropathol Exp Neurol 1984 Nov;43(6):568-79. doi: 10.1097/00005072-198411000-00002. PMID: 6594438

See all (436)

Recent systematic reviews

Resting-state fMRI in depressive and (hypo)manic mood states in bipolar disorders: A systematic review.

Claeys EHI, Mantingh T, Morrens M, Yalin N, Stokes PRA
Prog Neuropsychopharmacol Biol Psychiatry 2022 Mar 8;113:110465. Epub 2021 Nov 2 doi: 10.1016/j.pnpbp.2021.110465. PMID: 34736998

Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis.

Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM
Br J Psychiatry 2009 Sep;195(3):194-201. doi: 10.1192/bjp.bp.108.059717. PMID: 19721106

Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies.

Stanfield AC, McIntosh AM, Spencer MD, Philip R, Gaur S, Lawrie SM
Eur Psychiatry 2008 Jun;23(4):289-99. Epub 2007 Aug 31 doi: 10.1016/j.eurpsy.2007.05.006. PMID: 17765485

See all (3)

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Abnormal corpus striatum morphology

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

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Clinical resources

Practice guidelines

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Reviews

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