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Subcortical cerebral atrophy

MedGen UID:
868619
•Concept ID:
C4023018
•
Disease or Syndrome
HPO: HP:0012157

Definition

Atrophy of the cerebral subcortical white and gray matter, termed subcortical atrophy, reflects loss of nerve cells in the basal ganglia or fibers in the deep white matter. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubcortical cerebral atrophy

Professional guidelines

PubMed

Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.
Cheng YW, Liao YC, Chen CH, Chung CP, Fann CSJ, Chang CC, Lee YC, Tang SC
J Am Heart Assoc 2023 Nov 21;12(22):e032689. Epub 2023 Nov 20 doi: 10.1161/JAHA.123.032689. PMID: 37982214Free PMC Article
Extra-motor cerebral changes and manifestations in primary lateral sclerosis.
Finegan E, Shing SLH, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Pender N, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P
Brain Imaging Behav 2021 Oct;15(5):2283-2296. Epub 2021 Jan 7 doi: 10.1007/s11682-020-00421-4. PMID: 33409820
Seoul criteria for PiB(-) subcortical vascular dementia based on clinical and MRI variables.
Kim GH, Lee JH, Seo SW, Ye BS, Cho H, Kim HJ, Noh Y, Yoon CW, Chin JH, Oh SJ, Kim JS, Choe YS, Lee KH, Kim ST, Jeong JH, Na DL
Neurology 2014 Apr 29;82(17):1529-35. Epub 2014 Mar 28 doi: 10.1212/WNL.0000000000000360. PMID: 24682969

Recent clinical studies

Etiology

Differential associations of cortical and subcortical cerebral atrophy with retinal vascular signs in patients with acute stroke.
Baker ML, Wang JJ, Liew G, Hand PJ, De Silva DA, Lindley RI, Mitchell P, Wong MC, Rochtchina E, Wong TY, Wardlaw JM, Hankey GJ; Multi-Centre Retinal Stroke Study Group
Stroke 2010 Oct;41(10):2143-50. Epub 2010 Sep 2 doi: 10.1161/STROKEAHA.110.594317. PMID: 20813998

Clinical prediction guides

Gene localization in a family with X-linked syndromal mental retardation (Prieto syndrome).
Watty A, Prieto F, Beneyto M, Neugebauer M, Gal A
Am J Med Genet 1991 Feb-Mar;38(2-3):234-9. doi: 10.1002/ajmg.1320380213. PMID: 1673297

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