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Hyperplastic colonic polyposis

MedGen UID:
868611
•Concept ID:
C4023010
•
Neoplastic Process
HPO: HP:0012183

Definition

Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Hyperplastic colonic polyposis

Conditions with this feature

Polyposis syndrome, hereditary mixed, 2
MedGen UID:
350500
•Concept ID:
C1864730
•
Disease or Syndrome
Hereditary mixed polyposis syndrome-2 (HMPS2) is characterized by colonic polyps of mixed hyperplastic, adenomatous, and occasional juvenile types. Polyposis eventually progresses to colorectal cancer (Cao et al., 2006). For a discussion of genetic heterogeneity of HMPS, see HMPS1 (601228).
See: Condition Record
Polyposis syndrome, hereditary mixed, 2

Professional guidelines

PubMed

Serrated Lesions in Inflammatory Bowel Disease: Genotype-Phenotype Correlation.
Brcic I, Dawson H, Gröchenig HP, Högenauer C, Kashofer K
Int J Surg Pathol 2021 Feb;29(1):46-53. Epub 2020 Oct 8 doi: 10.1177/1066896920963798. PMID: 33030071
Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance.
East JE, Vieth M, Rex DK
Gut 2015 Jun;64(6):991-1000. Epub 2015 Mar 6 doi: 10.1136/gutjnl-2014-309041. PMID: 25748647
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article

Recent clinical studies

Therapy

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
The "Studded" Rectum: Phenotypic Evidence of MYH-Associated Polyposis.
Church J, Kravochuck S
Dis Colon Rectum 2016 Jun;59(6):565-9. doi: 10.1097/DCR.0000000000000575. PMID: 27145315
Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors.
Amaravadi RK, Hamilton KE, Ma X, Piao S, Portillo AD, Nathanson KL, Carlino MS, Long GV, Puzanov I, Xu X, Morrissette JJ, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR
Clin Cancer Res 2015 Dec 1;21(23):5215-21. Epub 2015 Jul 22 doi: 10.1158/1078-0432.CCR-15-0469. PMID: 26202952Free PMC Article
Tobacco smoking and colorectal hyperplastic and adenomatous polyps.
Ji BT, Weissfeld JL, Chow WH, Huang WY, Schoen RE, Hayes RB
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):897-901. doi: 10.1158/1055-9965.EPI-05-0883. PMID: 16702367
Colonic metaplasia in the ileal pouch is associated with inflammation and is not the result of long-term adaptation.
Fruin AB, El-Zammer O, Stucchi AF, O'Brien M, Becker JM
J Gastrointest Surg 2003 Feb;7(2):246-53; discussion 253-4. doi: 10.1016/s1091-255x(02)00191-9. PMID: 12600449

Prognosis

Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.
Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, Leoni G, San Lucas FA, Catanese MT, Mori F, Diodoro MG, You YN, Hawk ET, Roszik J, Scheet P, Kopetz S, Nicosia A, Scarselli E, Lynch PM, McAllister F, Vilar E
JAMA Oncol 2018 Aug 1;4(8):1085-1092. doi: 10.1001/jamaoncol.2018.1482. PMID: 29710228Free PMC Article
Endoscopic and histologic characteristics of serrated lesions.
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome.
Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, Leoni G, San Lucas FA, Catanese MT, Mori F, Diodoro MG, You YN, Hawk ET, Roszik J, Scheet P, Kopetz S, Nicosia A, Scarselli E, Lynch PM, McAllister F, Vilar E
JAMA Oncol 2018 Aug 1;4(8):1085-1092. doi: 10.1001/jamaoncol.2018.1482. PMID: 29710228Free PMC Article
Endoscopic and histologic characteristics of serrated lesions.
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Serrated pathway colorectal cancer in the population: genetic consideration.
Young J, Jenkins M, Parry S, Young B, Nancarrow D, English D, Giles G, Jass J
Gut 2007 Oct;56(10):1453-9. Epub 2007 Jun 12 doi: 10.1136/gut.2007.126870. PMID: 17566021Free PMC Article

Recent systematic reviews

Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

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