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Decreased sialylation of O-linked protein glycosylation

MedGen UID:
868529
•Concept ID:
C4022928
•
Finding
HPO: HP:0012363

Definition

An reduced addition of sialic acids to O-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased sialylation of O-linked protein glycosylation

Recent clinical studies

Etiology

Alteration of the goat milk glycoproteins N/O-glycome at different lactation stages.
Lu Y, Li C, Liu J, Huang W, Yang Y, Jia Y, Liu T, Huang L, Wang Z
Food Chem 2021 Apr 16;342:128221. Epub 2020 Oct 12 doi: 10.1016/j.foodchem.2020.128221. PMID: 33092920
RNA interference-mediated silencing of ppGalNAc-T1 and ppGalNAc-T2 inhibits invasion and increases chemosensitivity potentially by reducing terminal α2,3 sialylation and MMP14 expression in triple‑negative breast cancer cells.
Qiu H, Xu X, Liu M, Wang Z, Yuan Y, Liu C, Xu L, Wu S
Mol Med Rep 2017 Jun;15(6):3724-3734. Epub 2017 Apr 7 doi: 10.3892/mmr.2017.6449. PMID: 28393207
Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity.
Jin C, Ekwall AK, Bylund J, Björkman L, Estrella RP, Whitelock JM, Eisler T, Bokarewa M, Karlsson NG
J Biol Chem 2012 Oct 19;287(43):35922-33. Epub 2012 Aug 28 doi: 10.1074/jbc.M112.363119. PMID: 22930755Free PMC Article
MUC1 glycoforms in breast cancer--cell line T47D as a model for carcinoma-associated alterations of 0-glycosylation.
Hanisch FG, Stadie TR, Deutzmann F, Peter-Katalinic J
Eur J Biochem 1996 Feb 15;236(1):318-27. doi: 10.1111/j.1432-1033.1996.00318.x. PMID: 8617281

Diagnosis

RNA interference-mediated silencing of ppGalNAc-T1 and ppGalNAc-T2 inhibits invasion and increases chemosensitivity potentially by reducing terminal α2,3 sialylation and MMP14 expression in triple‑negative breast cancer cells.
Qiu H, Xu X, Liu M, Wang Z, Yuan Y, Liu C, Xu L, Wu S
Mol Med Rep 2017 Jun;15(6):3724-3734. Epub 2017 Apr 7 doi: 10.3892/mmr.2017.6449. PMID: 28393207
Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.
van Schooten CJ, Denis CV, Lisman T, Eikenboom JC, Leebeek FW, Goudemand J, Fressinaud E, van den Berg HM, de Groot PG, Lenting PJ
Blood 2007 Mar 15;109(6):2430-7. Epub 2006 Nov 7 doi: 10.1182/blood-2006-06-032706. PMID: 17090649
Role of O-linked carbohydrate chains on leukocyte cell membranes in platelet-induced leukocyte activation.
Nagata K, Tsuji T, Hanai N, Irimura T
J Biol Chem 1994 Sep 16;269(37):23290-5. PMID: 7521876
Cancer-associated carbohydrates identified by monoclonal antibodies.
Sell S
Hum Pathol 1990 Oct;21(10):1003-19. doi: 10.1016/0046-8177(90)90250-9. PMID: 2210723
Biosynthesis and glycosylation of the human complement regulatory protein decay-accelerating factor.
Lublin DM, Krsek-Staples J, Pangburn MK, Atkinson JP
J Immunol 1986 Sep 1;137(5):1629-35. PMID: 2427577

Therapy

Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy.
Leoyklang P, Malicdan MC, Yardeni T, Celeste F, Ciccone C, Li X, Jiang R, Gahl WA, Carrillo-Carrasco N, He M, Huizing M
Biomark Med 2014;8(5):641-52. doi: 10.2217/bmm.14.2. PMID: 25123033Free PMC Article
Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies.
Chik JH, Zhou J, Moh ES, Christopherson R, Clarke SJ, Molloy MP, Packer NH
J Proteomics 2014 Aug 28;108:146-62. Epub 2014 May 17 doi: 10.1016/j.jprot.2014.05.002. PMID: 24840470
Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity.
Jin C, Ekwall AK, Bylund J, Björkman L, Estrella RP, Whitelock JM, Eisler T, Bokarewa M, Karlsson NG
J Biol Chem 2012 Oct 19;287(43):35922-33. Epub 2012 Aug 28 doi: 10.1074/jbc.M112.363119. PMID: 22930755Free PMC Article
Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.
van Schooten CJ, Denis CV, Lisman T, Eikenboom JC, Leebeek FW, Goudemand J, Fressinaud E, van den Berg HM, de Groot PG, Lenting PJ
Blood 2007 Mar 15;109(6):2430-7. Epub 2006 Nov 7 doi: 10.1182/blood-2006-06-032706. PMID: 17090649
Differential effect of GalNAcalpha-O-bn on intracellular trafficking in enterocytic HT-29 and Caco-2 cells: correlation with the glycosyltransferase expression pattern.
Gouyer V, Leteurtre E, Delmotte P, Steelant WF, Krzewinski-Recchi MA, Zanetta JP, Lesuffleur T, Trugnan G, Delannoy P, Huet G
J Cell Sci 2001 Apr;114(Pt 8):1455-71. doi: 10.1242/jcs.114.8.1455. PMID: 11282022

Prognosis

Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy.
Leoyklang P, Malicdan MC, Yardeni T, Celeste F, Ciccone C, Li X, Jiang R, Gahl WA, Carrillo-Carrasco N, He M, Huizing M
Biomark Med 2014;8(5):641-52. doi: 10.2217/bmm.14.2. PMID: 25123033Free PMC Article
Cancer-associated carbohydrates identified by monoclonal antibodies.
Sell S
Hum Pathol 1990 Oct;21(10):1003-19. doi: 10.1016/0046-8177(90)90250-9. PMID: 2210723

Clinical prediction guides

Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages.
Delannoy CP, Rombouts Y, Groux-Degroote S, Holst S, Coddeville B, Harduin-Lepers A, Wuhrer M, Elass-Rochard E, Guérardel Y
J Proteome Res 2017 Jan 6;16(1):156-169. Epub 2016 Jul 8 doi: 10.1021/acs.jproteome.6b00161. PMID: 27351377
O-glycosylation of α-1-acid glycoprotein of human milk is lactation stage related.
Orczyk-Pawiłowicz M, Berghausen-Mazur M, Hirnle L, Kątnik-Prastowska I
Breastfeed Med 2015 Jun;10(5):270-6. doi: 10.1089/bfm.2015.0049. PMID: 26057552Free PMC Article
MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase.
Solatycka A, Owczarek T, Piller F, Piller V, Pula B, Wojciech L, Podhorska-Okolow M, Dziegiel P, Ugorski M
Glycobiology 2012 Aug;22(8):1042-54. Epub 2012 Apr 25 doi: 10.1093/glycob/cws075. PMID: 22534569
Over-expression of ST3Gal-I promotes mammary tumorigenesis.
Picco G, Julien S, Brockhausen I, Beatson R, Antonopoulos A, Haslam S, Mandel U, Dell A, Pinder S, Taylor-Papadimitriou J, Burchell J
Glycobiology 2010 Oct;20(10):1241-50. Epub 2010 Jun 8 doi: 10.1093/glycob/cwq085. PMID: 20534593Free PMC Article
Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.
van Schooten CJ, Denis CV, Lisman T, Eikenboom JC, Leebeek FW, Goudemand J, Fressinaud E, van den Berg HM, de Groot PG, Lenting PJ
Blood 2007 Mar 15;109(6):2430-7. Epub 2006 Nov 7 doi: 10.1182/blood-2006-06-032706. PMID: 17090649

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