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Parietal hypometabolism in FDG PET

MedGen UID:
868400
Concept ID:
C4022794
Finding
HPO: HP:0012662

Definition

Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParietal hypometabolism in FDG PET

Conditions with this feature

Alzheimer disease 4
MedGen UID:
376072
Concept ID:
C1847200
Disease or Syndrome
Alzheimer's disease is a degenerative disease of the brain that causes dementia, which is a gradual loss of memory, judgment, and ability to function. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood.\n\nMemory loss is the most common sign of Alzheimer's disease. Forgetfulness may be subtle at first, but the loss of memory worsens over time until it interferes with most aspects of daily living. Even in familiar settings, a person with Alzheimer's disease may get lost or become confused. Routine tasks such as preparing meals, doing laundry, and performing other household chores can be challenging. Additionally, it may become difficult to recognize people and name objects. Affected people increasingly require help with dressing, eating, and personal care.\n\nAs the disorder progresses, some people with Alzheimer's disease experience personality and behavioral changes and have trouble interacting in a socially appropriate manner. Other common symptoms include agitation, restlessness, withdrawal, and loss of language skills. People with Alzheimer's disease usually require total care during the advanced stages of the disease.\n\nIndividuals with Alzheimer's disease usually survive 8 to 10 years after the appearance of symptoms, but the course of the disease can range from 1 to 25 years. Survival is usually shorter in individuals diagnosed after age 80 than in those diagnosed at a younger age. In Alzheimer's disease, death usually results from pneumonia, malnutrition, or general body wasting (inanition).\n\nAlzheimer's disease can be classified as early-onset or late-onset. The signs and symptoms of the early-onset form appear between a person's thirties and mid-sixties, while the late-onset form appears during or after a person's mid-sixties. The early-onset form of Alzheimer's disease is much less common than the late-onset form, accounting for less than 10 percent of all cases of Alzheimer's disease.

Professional guidelines

PubMed

Iasevoli F, D'Ambrosio L, Ciccarelli M, Barone A, Gaudieri V, Cocozza S, Pontillo G, Brunetti A, Cuocolo A, de Bartolomeis A, Pappatà S
Schizophr Bull 2023 Mar 15;49(2):474-485. doi: 10.1093/schbul/sbac147. PMID: 36268829Free PMC Article
Ercoli LM, Small GW, Siddarth P, Kepe V, Huang SC, Miller KJ, Lavretsky H, Bookheimer SY, Barrio JR, Silverman DH
Int J Geriatr Psychiatry 2012 Oct;27(10):1017-27. Epub 2012 Mar 1 doi: 10.1002/gps.2816. PMID: 22383132Free PMC Article
Carbon M, Su S, Dhawan V, Raymond D, Bressman S, Eidelberg D
Neurology 2004 Apr 27;62(8):1384-90. doi: 10.1212/01.wnl.0000120541.97467.fe. PMID: 15111678

Recent clinical studies

Etiology

Caminiti SP, De Francesco S, Tondo G, Galli A, Redolfi A, Perani D; Alzheimer's Disease Neuroimaging Initiative; Interceptor Project
Alzheimers Dement 2024 Jan;20(1):159-172. Epub 2023 Jul 28 doi: 10.1002/alz.13385. PMID: 37505996Free PMC Article
Tsagkaris S, Yau EKC, McClelland V, Papandreou A, Siddiqui A, Lumsden DE, Kaminska M, Guedj E, Hammers A, Lin JP
Brain 2023 Jun 1;146(6):2512-2523. doi: 10.1093/brain/awac439. PMID: 36445406Free PMC Article
Shir D, Graff-Radford J, Machulda MM, Pham NTT, Jack CR Jr, Lowe VJ, Whitwell JL, Josephs KA
Eur J Neurol 2022 Jul;29(7):2138-2143. Epub 2022 Mar 30 doi: 10.1111/ene.15327. PMID: 35298068Free PMC Article
Strom A, Iaccarino L, Edwards L, Lesman-Segev OH, Soleimani-Meigooni DN, Pham J, Baker SL, Landau SM, Jagust WJ, Miller BL, Rosen HJ, Gorno-Tempini ML, Rabinovici GD, La Joie R; Alzheimer’s Disease Neuroimaging Initiative
Brain 2022 Apr 18;145(2):713-728. doi: 10.1093/brain/awab294. PMID: 34373896Free PMC Article
Muccioli L, Farolfi A, Pondrelli F, d'Orsi G, Michelucci R, Freri E, Canafoglia L, Licchetta L, Toni F, Bonfiglioli R, Civollani S, Pettinato C, Maietti E, Marotta G, Fanti S, Tinuper P, Bisulli F
Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1576-1584. Epub 2019 Dec 19 doi: 10.1007/s00259-019-04647-3. PMID: 31858178

Diagnosis

Mirbod M, Ayubcha C, Redden HWK, Teichner E, Subtirelu RC, Patel R, Raynor W, Werner T, Alavi A, Revheim ME
Ann Nucl Med 2024 Sep;38(9):673-687. Epub 2024 Jul 19 doi: 10.1007/s12149-024-01958-w. PMID: 39028529Free PMC Article
Tsagkaris S, Yau EKC, McClelland V, Papandreou A, Siddiqui A, Lumsden DE, Kaminska M, Guedj E, Hammers A, Lin JP
Brain 2023 Jun 1;146(6):2512-2523. doi: 10.1093/brain/awac439. PMID: 36445406Free PMC Article
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
Muccioli L, Farolfi A, Pondrelli F, d'Orsi G, Michelucci R, Freri E, Canafoglia L, Licchetta L, Toni F, Bonfiglioli R, Civollani S, Pettinato C, Maietti E, Marotta G, Fanti S, Tinuper P, Bisulli F
Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1576-1584. Epub 2019 Dec 19 doi: 10.1007/s00259-019-04647-3. PMID: 31858178
Kato T, Inui Y, Nakamura A, Ito K
Ageing Res Rev 2016 Sep;30:73-84. Epub 2016 Feb 11 doi: 10.1016/j.arr.2016.02.003. PMID: 26876244

Therapy

Iasevoli F, D'Ambrosio L, Ciccarelli M, Barone A, Gaudieri V, Cocozza S, Pontillo G, Brunetti A, Cuocolo A, de Bartolomeis A, Pappatà S
Schizophr Bull 2023 Mar 15;49(2):474-485. doi: 10.1093/schbul/sbac147. PMID: 36268829Free PMC Article
Townsend L, Pillinger T, Selvaggi P, Veronese M, Turkheimer F, Howes O
Psychol Med 2023 Aug;53(11):4880-4897. Epub 2022 Jun 22 doi: 10.1017/S003329172200174X. PMID: 35730361Free PMC Article
Provost K, La Joie R, Strom A, Iaccarino L, Edwards L, Mellinger TJ, Pham J, Baker SL, Miller BL, Jagust WJ, Rabinovici GD
J Cereb Blood Flow Metab 2021 Sep;41(9):2329-2343. Epub 2021 Mar 10 doi: 10.1177/0271678X211001216. PMID: 33691512Free PMC Article
Ha SW, Yang YS, Song IU, Chung YA, Oh JK, Chung SW
Acta Radiol 2015 Apr;56(4):482-6. Epub 2014 Apr 29 doi: 10.1177/0284185114531414. PMID: 24782572
Molchan SE, Matochik JA, Zametkin AJ, Szymanski HV, Cantillon M, Cohen RM, Sunderland T
Neuropsychopharmacology 1994 May;10(3):191-8. doi: 10.1038/npp.1994.21. PMID: 7916916

Prognosis

Caminiti SP, De Francesco S, Tondo G, Galli A, Redolfi A, Perani D; Alzheimer's Disease Neuroimaging Initiative; Interceptor Project
Alzheimers Dement 2024 Jan;20(1):159-172. Epub 2023 Jul 28 doi: 10.1002/alz.13385. PMID: 37505996Free PMC Article
Zhu HY, Tang YX, Xiao L, Wen SR, Wu YX, Yang ZQ, Zhou L, Xiao B, Feng L, Hu S
CNS Neurosci Ther 2023 Sep;29(9):2656-2665. Epub 2023 Apr 5 doi: 10.1111/cns.14209. PMID: 37017415Free PMC Article
Booth S, Park KW, Lee CS, Ko JH
J Clin Invest 2022 Oct 17;132(20) doi: 10.1172/JCI157074. PMID: 36040832Free PMC Article
Levin F, Ferreira D, Lange C, Dyrba M, Westman E, Buchert R, Teipel SJ, Grothe MJ; Alzheimer’s Disease Neuroimaging Initiative
Alzheimers Res Ther 2021 Feb 19;13(1):49. doi: 10.1186/s13195-021-00785-9. PMID: 33608059Free PMC Article
Kato T, Inui Y, Nakamura A, Ito K
Ageing Res Rev 2016 Sep;30:73-84. Epub 2016 Feb 11 doi: 10.1016/j.arr.2016.02.003. PMID: 26876244

Clinical prediction guides

Singh NA, Goodrich AW, Graff-Radford J, Machulda MM, Sintini I, Carlos AF, Robinson CG, Reid RI, Lowe VJ, Jack CR Jr, Petersen RC, Boeve BF, Josephs KA, Kantarci K, Whitwell JL
Neuroimage 2024 Apr 15;290:120564. Epub 2024 Mar 3 doi: 10.1016/j.neuroimage.2024.120564. PMID: 38442778Free PMC Article
Tsagkaris S, Yau EKC, McClelland V, Papandreou A, Siddiqui A, Lumsden DE, Kaminska M, Guedj E, Hammers A, Lin JP
Brain 2023 Jun 1;146(6):2512-2523. doi: 10.1093/brain/awac439. PMID: 36445406Free PMC Article
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
Shir D, Graff-Radford J, Machulda MM, Pham NTT, Jack CR Jr, Lowe VJ, Whitwell JL, Josephs KA
Eur J Neurol 2022 Jul;29(7):2138-2143. Epub 2022 Mar 30 doi: 10.1111/ene.15327. PMID: 35298068Free PMC Article
Kato T, Inui Y, Nakamura A, Ito K
Ageing Res Rev 2016 Sep;30:73-84. Epub 2016 Feb 11 doi: 10.1016/j.arr.2016.02.003. PMID: 26876244

Recent systematic reviews

Mirbod M, Ayubcha C, Redden HWK, Teichner E, Subtirelu RC, Patel R, Raynor W, Werner T, Alavi A, Revheim ME
Ann Nucl Med 2024 Sep;38(9):673-687. Epub 2024 Jul 19 doi: 10.1007/s12149-024-01958-w. PMID: 39028529Free PMC Article
Townsend L, Pillinger T, Selvaggi P, Veronese M, Turkheimer F, Howes O
Psychol Med 2023 Aug;53(11):4880-4897. Epub 2022 Jun 22 doi: 10.1017/S003329172200174X. PMID: 35730361Free PMC Article
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
Muccioli L, Farolfi A, Pondrelli F, d'Orsi G, Michelucci R, Freri E, Canafoglia L, Licchetta L, Toni F, Bonfiglioli R, Civollani S, Pettinato C, Maietti E, Marotta G, Fanti S, Tinuper P, Bisulli F
Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1576-1584. Epub 2019 Dec 19 doi: 10.1007/s00259-019-04647-3. PMID: 31858178
Mohamed W, Ahuja N, Shah A
J Neurol Sci 2012 Jun 15;317(1-2):6-12. Epub 2012 Mar 11 doi: 10.1016/j.jns.2012.02.016. PMID: 22414800

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