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Abnormal metabolic brain imaging by MRS

MedGen UID:
868370
•Concept ID:
C4022764
•
Finding
HPO: HP:0012705

Definition

An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Professional guidelines

PubMed

Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
Altintas O, Niftaliyev E, Asil T
Neurol Res 2018 Dec;40(12):1048-1053. Epub 2018 Sep 12 doi: 10.1080/01616412.2018.1517111. PMID: 30207930
Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.
Chen R, Ravindra VM, Cohen AL, Jensen RL, Salzman KL, Prescot AP, Colman H
Neurosurg Focus 2015 Mar;38(3):E2. doi: 10.3171/2015.1.FOCUS14745. PMID: 25727224

Recent clinical studies

Etiology

Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice.
McLoughlin HS, Gundry K, Rainwater O, Schuster KH, Wellik IG, Zalon AJ, Benneyworth MA, Eberly LE, Öz G
Ann Neurol 2023 Oct;94(4):658-671. Epub 2023 Aug 2 doi: 10.1002/ana.26713. PMID: 37243335Free PMC Article
Magnetic resonance imaging and spectroscopy in late-onset GM2-gangliosidosis.
Rowe OE, Rangaprakash D, Weerasekera A, Godbole N, Haxton E, James PF, Stephen CD, Barry RL, Eichler FS, Ratai EM
Mol Genet Metab 2021 Aug;133(4):386-396. Epub 2021 Jun 24 doi: 10.1016/j.ymgme.2021.06.008. PMID: 34226107Free PMC Article
Role of cerebral glutamate in post-stroke epileptogenesis.
Nicolo JP, O'Brien TJ, Kwan P
Neuroimage Clin 2019;24:102069. Epub 2019 Nov 5 doi: 10.1016/j.nicl.2019.102069. PMID: 31795040Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Glutamate and psychosis risk.
Egerton A, Fusar-Poli P, Stone JM
Curr Pharm Des 2012;18(4):466-78. doi: 10.2174/138161212799316244. PMID: 22239577

Diagnosis

Neuroimaging in primary lateral sclerosis.
Pioro EP, Turner MR, Bede P
Amyotroph Lateral Scler Frontotemporal Degener 2020 Nov;21(sup1):18-27. doi: 10.1080/21678421.2020.1837176. PMID: 33602015
Clinical Features of Machado-Joseph Disease.
Mendonça N, França MC Jr, Gonçalves AF, Januário C
Adv Exp Med Biol 2018;1049:255-273. doi: 10.1007/978-3-319-71779-1_13. PMID: 29427108
Inherited or acquired metabolic disorders.
Eichler F, Ratai E, Carroll JJ, Masdeu JC
Handb Clin Neurol 2016;135:603-636. doi: 10.1016/B978-0-444-53485-9.00029-5. PMID: 27432685
Respiratory chain deficiencies.
Delonlay P, Rötig A, Sarnat HB
Handb Clin Neurol 2013;113:1651-66. doi: 10.1016/B978-0-444-59565-2.00033-2. PMID: 23622386
Magnetic resonance spectroscopy.
Duncan JS
Epilepsia 1996 Jul;37(7):598-605. doi: 10.1111/j.1528-1157.1996.tb00622.x. PMID: 8681890

Therapy

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice.
McLoughlin HS, Gundry K, Rainwater O, Schuster KH, Wellik IG, Zalon AJ, Benneyworth MA, Eberly LE, Öz G
Ann Neurol 2023 Oct;94(4):658-671. Epub 2023 Aug 2 doi: 10.1002/ana.26713. PMID: 37243335Free PMC Article
Elevation of brain gamma-aminobutyric acid levels is associated with vigabatrin-associated brain abnormalities on magnetic resonance imaging.
Ikeda A, Tomiyasu M, Yamamoto A, Tsuyusaki Y, Kawai Y, Tanabe M, Tsuji M, Iai M, Aida N, Goto T
Epilepsy Res 2022 Mar;181:106881. Epub 2022 Feb 7 doi: 10.1016/j.eplepsyres.2022.106881. PMID: 35183975
Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
Clinical Features of Machado-Joseph Disease.
Mendonça N, França MC Jr, Gonçalves AF, Januário C
Adv Exp Med Biol 2018;1049:255-273. doi: 10.1007/978-3-319-71779-1_13. PMID: 29427108

Prognosis

Magnetic Resonance Spectroscopy Studies of Brain Energy Metabolism in Schizophrenia: Progression from Prodrome to Chronic Psychosis.
Stein A, Zhu C, Du F, Öngür D
Curr Psychiatry Rep 2023 Nov;25(11):659-669. Epub 2023 Oct 9 doi: 10.1007/s11920-023-01457-1. PMID: 37812338
Glutamine Imaging: A New Avenue for Glioma Management.
Ekici S, Nye JA, Neill SG, Allen JW, Shu HK, Fleischer CC
AJNR Am J Neuroradiol 2022 Jan;43(1):11-18. Epub 2021 Nov 4 doi: 10.3174/ajnr.A7333. PMID: 34737183Free PMC Article
Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
MRI-based methods to detect placental and fetal brain abnormalities in utero.
Girardi G
J Reprod Immunol 2016 Apr;114:86-91. Epub 2015 Jul 2 doi: 10.1016/j.jri.2015.05.008. PMID: 26187242

Clinical prediction guides

Susceptibility-Weighted Imaging and Magnetic Resonance Spectroscopy in Concussion.
Kirov II, Whitlow CT, Zamora C
Neuroimaging Clin N Am 2018 Feb;28(1):91-105. Epub 2017 Oct 27 doi: 10.1016/j.nic.2017.09.007. PMID: 29157856
Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy.
Rapalino O, Ratai EM
Magn Reson Imaging Clin N Am 2016 Nov;24(4):671-686. Epub 2016 Sep 13 doi: 10.1016/j.mric.2016.06.001. PMID: 27742109
Clinical magnetic resonance spectroscopy of the central nervous system.
Ratai EM, Gilberto González R
Handb Clin Neurol 2016;135:93-116. doi: 10.1016/B978-0-444-53485-9.00005-2. PMID: 27432661
MRI-based methods to detect placental and fetal brain abnormalities in utero.
Girardi G
J Reprod Immunol 2016 Apr;114:86-91. Epub 2015 Jul 2 doi: 10.1016/j.jri.2015.05.008. PMID: 26187242
Diffusion tensor imaging and magnetic resonance spectroscopy in traumatic brain injury: a review of recent literature.
Xiong KL, Zhu YS, Zhang WG
Brain Imaging Behav 2014 Dec;8(4):487-96. doi: 10.1007/s11682-013-9288-2. PMID: 24449140

Recent systematic reviews

Brain mechanisms underlying catatonia: A systematic review.
Cattarinussi G, Gugliotta AA, Hirjak D, Wolf RC, Sambataro F
Schizophr Res 2024 Jan;263:194-207. Epub 2022 Nov 18 doi: 10.1016/j.schres.2022.11.002. PMID: 36404217
Aggression in borderline personality disorder: A systematic review of neuroimaging studies.
Chu J, Zheng K, Yi J
Prog Neuropsychopharmacol Biol Psychiatry 2022 Mar 8;113:110472. Epub 2021 Nov 4 doi: 10.1016/j.pnpbp.2021.110472. PMID: 34742774
Migraine and magnetic resonance spectroscopy: a systematic review.
Younis S, Hougaard A, Vestergaard MB, Larsson HBW, Ashina M
Curr Opin Neurol 2017 Jun;30(3):246-262. doi: 10.1097/WCO.0000000000000436. PMID: 28240609
Imaging-based neurochemistry in schizophrenia: a systematic review and implications for dysfunctional long-term potentiation.
Salavati B, Rajji TK, Price R, Sun Y, Graff-Guerrero A, Daskalakis ZJ
Schizophr Bull 2015 Jan;41(1):44-56. Epub 2014 Sep 22 doi: 10.1093/schbul/sbu132. PMID: 25249654Free PMC Article
A systematic review of Magnetic Resonance Imaging and Spectroscopy in brain injury after drowning.
Nucci-da-Silva MP, Amaro E Jr
Brain Inj 2009 Aug;23(9):707-14. doi: 10.1080/02699050903123351. PMID: 19636995

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