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Abnormal motor evoked potentials

MedGen UID:
868293
•Concept ID:
C4022687
•
Pathologic Function
HPO: HP:0012896

Definition

An anomaly identified by motor evoked potentials (MEPs). MEPs are measured following single-pulse or repetitive transcranial magnetic stimulation and can be used for the assessment of the excitability of the motor cortex and the integrity of conduction along the central and peripheral motor pathways. [from HPO]

Conditions with this feature

Spinocerebellar ataxia type 29
MedGen UID:
350085
•Concept ID:
C1861732
•
Disease or Syndrome
Spinocerebellar ataxia-29 (SCA29) is an autosomal dominant neurologic disorder characterized by onset in infancy of delayed motor development and mild cognitive delay. Affected individuals develop a very slowly progressive or nonprogressive gait and limb ataxia associated with cerebellar atrophy on brain imaging. Additional variable features include nystagmus, dysarthria, and tremor (summary by Huang et al., 2012). For a general discussion of autosomal dominant spinocerebellar ataxia, see SCA1 (164400).
See: Condition Record
Spinocerebellar ataxia type 29

Professional guidelines

PubMed

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.
Vucic S, Stanley Chen KH, Kiernan MC, Hallett M, Benninger DH, Di Lazzaro V, Rossini PM, Benussi A, Berardelli A, Currà A, Krieg SM, Lefaucheur JP, Long Lo Y, Macdonell RA, Massimini M, Rosanova M, Picht T, Stinear CM, Paulus W, Ugawa Y, Ziemann U, Chen R
Clin Neurophysiol 2023 Jun;150:131-175. Epub 2023 Mar 29 doi: 10.1016/j.clinph.2023.03.010. PMID: 37068329Free PMC Article
Bilateral vestibulopathy: Diagnostic criteria Consensus document of the Classification Committee of the Bárány Society.
Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM, Della Santina CC, Kingma H
J Vestib Res 2017;27(4):177-189. doi: 10.3233/VES-170619. PMID: 29081426Free PMC Article
The contribution of neurophysiology in the diagnosis and management of cervical spondylotic myelopathy: a review.
Nardone R, Höller Y, Brigo F, Frey VN, Lochner P, Leis S, Golaszewski S, Trinka E
Spinal Cord 2016 Oct;54(10):756-766. Epub 2016 May 31 doi: 10.1038/sc.2016.82. PMID: 27241448

Recent clinical studies

Etiology

Motor Evoked Potentials in Newly Diagnosed and Treated Patients With Wilson Disease.
Bembenek JP, Kurczych K, Kłysz B, Smoliński Ł, Litwin T, Członkowska A
J Clin Neurophysiol 2023 Mar 1;40(3):258-262. Epub 2021 Aug 4 doi: 10.1097/WNP.0000000000000882. PMID: 36872503
Diagnostic and Prognostic Relevance of Magnetic Resonance Imaging and Electrophysiological Findings in Acute Spinal Ischemia.
Artemis D, Wolf M, Blahak C, Szabo K, Hennerici MG, Fatar M
J Stroke Cerebrovasc Dis 2017 Mar;26(3):459-464. Epub 2017 Jan 12 doi: 10.1016/j.jstrokecerebrovasdis.2016.12.031. PMID: 28089563
Translumbar and transsacral magnetic neurostimulation for the assessment of neuropathy in fecal incontinence.
Rao SS, Coss-Adame E, Tantiphlachiva K, Attaluri A, Remes-Troche J
Dis Colon Rectum 2014 May;57(5):645-52. doi: 10.1097/DCR.0000000000000069. PMID: 24819106Free PMC Article

Diagnosis

Motor Evoked Potentials in Newly Diagnosed and Treated Patients With Wilson Disease.
Bembenek JP, Kurczych K, Kłysz B, Smoliński Ł, Litwin T, Członkowska A
J Clin Neurophysiol 2023 Mar 1;40(3):258-262. Epub 2021 Aug 4 doi: 10.1097/WNP.0000000000000882. PMID: 36872503
Diagnostic and Prognostic Relevance of Magnetic Resonance Imaging and Electrophysiological Findings in Acute Spinal Ischemia.
Artemis D, Wolf M, Blahak C, Szabo K, Hennerici MG, Fatar M
J Stroke Cerebrovasc Dis 2017 Mar;26(3):459-464. Epub 2017 Jan 12 doi: 10.1016/j.jstrokecerebrovasdis.2016.12.031. PMID: 28089563
Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease.
Fisher KM, Zaaimi B, Williams TL, Baker SN, Baker MR
Brain 2012 Sep;135(Pt 9):2849-64. Epub 2012 Jun 22 doi: 10.1093/brain/aws150. PMID: 22734124Free PMC Article
Atlastin1 mutations are frequent in young-onset autosomal dominant spastic paraplegia.
Dürr A, Camuzat A, Colin E, Tallaksen C, Hannequin D, Coutinho P, Fontaine B, Rossi A, Gil R, Rousselle C, Ruberg M, Stevanin G, Brice A
Arch Neurol 2004 Dec;61(12):1867-72. doi: 10.1001/archneur.61.12.1867. PMID: 15596607
Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis.
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O
Spine (Phila Pa 1976) 2002 May 1;27(9):975-83. doi: 10.1097/00007632-200205010-00019. PMID: 11979174

Therapy

Translumbar and transsacral magnetic neurostimulation for the assessment of neuropathy in fecal incontinence.
Rao SS, Coss-Adame E, Tantiphlachiva K, Attaluri A, Remes-Troche J
Dis Colon Rectum 2014 May;57(5):645-52. doi: 10.1097/DCR.0000000000000069. PMID: 24819106Free PMC Article
Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis.
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O
Spine (Phila Pa 1976) 2002 May 1;27(9):975-83. doi: 10.1097/00007632-200205010-00019. PMID: 11979174

Prognosis

Diagnostic and Prognostic Relevance of Magnetic Resonance Imaging and Electrophysiological Findings in Acute Spinal Ischemia.
Artemis D, Wolf M, Blahak C, Szabo K, Hennerici MG, Fatar M
J Stroke Cerebrovasc Dis 2017 Mar;26(3):459-464. Epub 2017 Jan 12 doi: 10.1016/j.jstrokecerebrovasdis.2016.12.031. PMID: 28089563

Clinical prediction guides

Motor Evoked Potentials in Newly Diagnosed and Treated Patients With Wilson Disease.
Bembenek JP, Kurczych K, Kłysz B, Smoliński Ł, Litwin T, Członkowska A
J Clin Neurophysiol 2023 Mar 1;40(3):258-262. Epub 2021 Aug 4 doi: 10.1097/WNP.0000000000000882. PMID: 36872503
Diagnostic and Prognostic Relevance of Magnetic Resonance Imaging and Electrophysiological Findings in Acute Spinal Ischemia.
Artemis D, Wolf M, Blahak C, Szabo K, Hennerici MG, Fatar M
J Stroke Cerebrovasc Dis 2017 Mar;26(3):459-464. Epub 2017 Jan 12 doi: 10.1016/j.jstrokecerebrovasdis.2016.12.031. PMID: 28089563
Translumbar and transsacral magnetic neurostimulation for the assessment of neuropathy in fecal incontinence.
Rao SS, Coss-Adame E, Tantiphlachiva K, Attaluri A, Remes-Troche J
Dis Colon Rectum 2014 May;57(5):645-52. doi: 10.1097/DCR.0000000000000069. PMID: 24819106Free PMC Article
Atlastin1 mutations are frequent in young-onset autosomal dominant spastic paraplegia.
Dürr A, Camuzat A, Colin E, Tallaksen C, Hannequin D, Coutinho P, Fontaine B, Rossi A, Gil R, Rousselle C, Ruberg M, Stevanin G, Brice A
Arch Neurol 2004 Dec;61(12):1867-72. doi: 10.1001/archneur.61.12.1867. PMID: 15596607
Impaired lumbar movement perception in association with postural stability and motor- and somatosensory-evoked potentials in lumbar spinal stenosis.
Leinonen V, Määttä S, Taimela S, Herno A, Kankaanpää M, Partanen J, Kansanen M, Hänninen O, Airaksinen O
Spine (Phila Pa 1976) 2002 May 1;27(9):975-83. doi: 10.1097/00007632-200205010-00019. PMID: 11979174

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