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Fatigable weakness of neck muscles

MedGen UID:
868192
•Concept ID:
C4022584
•
Finding
HPO: HP:0030199

Definition

A type of weakness of a skeletal muscle in the neck that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFatigable weakness of neck muscles

Recent clinical studies

Etiology

Long-term Follow-up and Muscle Imaging Findings in Brachio-Cervical Inflammatory Myopathy.
Lucchini M, Bortolani S, Monforte M, Papacci M, Ricci E, Mirabella M, Tasca G
Neurol Neuroimmunol Neuroinflamm 2021 Jul;8(4) Epub 2021 May 19 doi: 10.1212/NXI.0000000000001016. PMID: 34011678Free PMC Article
Prevalence of Bruxism in Hemifacial-Spasm Patients.
Ella B, Guillaud E, Langbour N, Guehl D, Burbaud P
J Prosthodont 2017 Jun;26(4):280-283. Epub 2015 Nov 20 doi: 10.1111/jopr.12394. PMID: 26588188
An endurance-strength training regime is effective in reducing myoelectric manifestations of cervical flexor muscle fatigue in females with chronic neck pain.
Falla D, Jull G, Hodges P, Vicenzino B
Clin Neurophysiol 2006 Apr;117(4):828-37. Epub 2006 Feb 21 doi: 10.1016/j.clinph.2005.12.025. PMID: 16490395
Myasthenic syndrome of snake envenomation: a clinical and neurophysiological study.
Sanmuganathan PS
Postgrad Med J 1998 Oct;74(876):596-9. doi: 10.1136/pgmj.74.876.596. PMID: 10211352Free PMC Article

Diagnosis

MuSK not MNGIE: Atypical MuSK-antibody myasthenia presenting as a genetic disorder.
Thebault S, Gibbs E, Bourque P, McKim D, Rakhra K, Breiner A, Frykman H, Warman-Chardon J
Neuromuscul Disord 2021 Dec;31(12):1279-1281. Epub 2021 Sep 6 doi: 10.1016/j.nmd.2021.08.014. PMID: 34690051
Long-term Follow-up and Muscle Imaging Findings in Brachio-Cervical Inflammatory Myopathy.
Lucchini M, Bortolani S, Monforte M, Papacci M, Ricci E, Mirabella M, Tasca G
Neurol Neuroimmunol Neuroinflamm 2021 Jul;8(4) Epub 2021 May 19 doi: 10.1212/NXI.0000000000001016. PMID: 34011678Free PMC Article
The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations.
Rodríguez Cruz PM, Cossins J, Estephan EP, Munell F, Selby K, Hirano M, Maroofin R, Mehrjardi MYV, Chow G, Carr A, Manzur A, Robb S, Munot P, Wei Liu W, Banka S, Fraser H, De Goede C, Zanoteli E, Conti Reed U, Sage A, Gratacos M, Macaya A, Dusl M, Senderek J, Töpf A, Hofer M, Knight R, Ramdas S, Jayawant S, Lochmüller H, Palace J, Beeson D
Brain 2019 Jun 1;142(6):1547-1560. doi: 10.1093/brain/awz107. PMID: 31081514Free PMC Article
Prevalence of Bruxism in Hemifacial-Spasm Patients.
Ella B, Guillaud E, Langbour N, Guehl D, Burbaud P
J Prosthodont 2017 Jun;26(4):280-283. Epub 2015 Nov 20 doi: 10.1111/jopr.12394. PMID: 26588188
The thoracic outlet syndrome in athletes.
Nichols AW
J Am Board Fam Pract 1996 Sep-Oct;9(5):346-55. PMID: 8884673

Therapy

Myasthenia gravis.
Silvestri NJ, Wolfe GI
Semin Neurol 2012 Jul;32(3):215-26. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329200. PMID: 23117946
An endurance-strength training regime is effective in reducing myoelectric manifestations of cervical flexor muscle fatigue in females with chronic neck pain.
Falla D, Jull G, Hodges P, Vicenzino B
Clin Neurophysiol 2006 Apr;117(4):828-37. Epub 2006 Feb 21 doi: 10.1016/j.clinph.2005.12.025. PMID: 16490395
The otolaryngologic presentation of myasthenia gravis.
Carpenter RJ 3rd, McDonald TJ, Howard FM Jr
Laryngoscope 1979 Jun;89(6 Pt 1):922-8. doi: 10.1288/00005537-197906000-00008. PMID: 449537

Prognosis

MuSK not MNGIE: Atypical MuSK-antibody myasthenia presenting as a genetic disorder.
Thebault S, Gibbs E, Bourque P, McKim D, Rakhra K, Breiner A, Frykman H, Warman-Chardon J
Neuromuscul Disord 2021 Dec;31(12):1279-1281. Epub 2021 Sep 6 doi: 10.1016/j.nmd.2021.08.014. PMID: 34690051
Long-term Follow-up and Muscle Imaging Findings in Brachio-Cervical Inflammatory Myopathy.
Lucchini M, Bortolani S, Monforte M, Papacci M, Ricci E, Mirabella M, Tasca G
Neurol Neuroimmunol Neuroinflamm 2021 Jul;8(4) Epub 2021 May 19 doi: 10.1212/NXI.0000000000001016. PMID: 34011678Free PMC Article
The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations.
Rodríguez Cruz PM, Cossins J, Estephan EP, Munell F, Selby K, Hirano M, Maroofin R, Mehrjardi MYV, Chow G, Carr A, Manzur A, Robb S, Munot P, Wei Liu W, Banka S, Fraser H, De Goede C, Zanoteli E, Conti Reed U, Sage A, Gratacos M, Macaya A, Dusl M, Senderek J, Töpf A, Hofer M, Knight R, Ramdas S, Jayawant S, Lochmüller H, Palace J, Beeson D
Brain 2019 Jun 1;142(6):1547-1560. doi: 10.1093/brain/awz107. PMID: 31081514Free PMC Article

Clinical prediction guides

Immunotherapies in MuSK-positive Myasthenia Gravis; an IgG4 antibody-mediated disease.
Vakrakou AG, Karachaliou E, Chroni E, Zouvelou V, Tzanetakos D, Salakou S, Papadopoulou M, Tzartos S, Voumvourakis K, Kilidireas C, Giannopoulos S, Tsivgoulis G, Tzartos J
Front Immunol 2023;14:1212757. Epub 2023 Jul 26 doi: 10.3389/fimmu.2023.1212757. PMID: 37564637Free PMC Article
Peak expiratory flow and the single-breath count test as markers of respiratory function in patients with myasthenia gravis.
Aguirre F, Fernández RN, Arrejoría RM, Manin A, Cores VE, Sivori M, Villa AM
Neurologia (Engl Ed) 2023 Jul-Aug;38(6):405-411. Epub 2022 Jul 14 doi: 10.1016/j.nrleng.2020.09.006. PMID: 35842128
An endurance-strength training regime is effective in reducing myoelectric manifestations of cervical flexor muscle fatigue in females with chronic neck pain.
Falla D, Jull G, Hodges P, Vicenzino B
Clin Neurophysiol 2006 Apr;117(4):828-37. Epub 2006 Feb 21 doi: 10.1016/j.clinph.2005.12.025. PMID: 16490395

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