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Degeneration of the striatum

MedGen UID:
868026
•Concept ID:
C4022417
•
Disease or Syndrome
HPO: HP:0040140

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDegeneration of the striatum

Conditions with this feature

Autosomal dominant striatal neurodegeneration type 1
MedGen UID:
934775
•Concept ID:
C4310808
•
Disease or Syndrome
Autosomal dominant striatal degeneration is a neurologic disorder characterized by variable movement abnormalities due to dysfunction in the striatal part of the basal ganglia (summary by Kuhlenbaumer et al., 2004). Genetic Heterogeneity of Autosomal Dominant Striatal Degeneration See also ADSD2 (616922), caused by mutation in the PDE10A gene (610652) on chromosome 6q27.
See: Condition Record
Autosomal dominant striatal neurodegeneration type 1

Professional guidelines

PubMed

Advantages of Vasoactive Intestinal Peptide for the Future Treatment of Parkinson's Disease.
Korkmaz OT, Tunçel N
Curr Pharm Des 2018;24(39):4693-4701. doi: 10.2174/1381612825666190111150953. PMID: 30636594
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS
Brain 2018 Jul 1;141(7):1917-1933. doi: 10.1093/brain/awy132. PMID: 29850777Free PMC Article
Treatment strategies for Parkinson's disease.
Yuan H, Zhang ZW, Liang LW, Shen Q, Wang XD, Ren SM, Ma HJ, Jiao SJ, Liu P
Neurosci Bull 2010 Feb;26(1):66-76. doi: 10.1007/s12264-010-0302-z. PMID: 20101274Free PMC Article

Recent clinical studies

Etiology

Nigrostriatal tau pathology in parkinsonism and Parkinson's disease.
Chu Y, Hirst WD, Federoff HJ, Harms AS, Stoessl AJ, Kordower JH
Brain 2024 Feb 1;147(2):444-457. doi: 10.1093/brain/awad388. PMID: 38006313Free PMC Article
Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson's disease.
Jeong SH, Park CJ, Jeong HJ, Sunwoo MK, Ahn SS, Lee SK, Lee PH, Kim YJ, Sohn YH, Chung SJ
J Neurol Neurosurg Psychiatry 2023 Dec;94(12):1047-1055. Epub 2023 Jun 30 doi: 10.1136/jnnp-2023-331170. PMID: 37399288
Nutritional Risk Factors, Microbiota and Parkinson's Disease: What Is the Current Evidence?
Boulos C, Yaghi N, El Hayeck R, Heraoui GN, Fakhoury-Sayegh N
Nutrients 2019 Aug 14;11(8) doi: 10.3390/nu11081896. PMID: 31416163Free PMC Article
Neuropathology of Parkinson disease.
Dickson DW
Parkinsonism Relat Disord 2018 Jan;46 Suppl 1(Suppl 1):S30-S33. Epub 2017 Aug 1 doi: 10.1016/j.parkreldis.2017.07.033. PMID: 28780180Free PMC Article
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.
Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA
J Psychopharmacol 2014 Nov;28(11):1088-98. Epub 2014 Sep 18 doi: 10.1177/0269881114550355. PMID: 25237116

Diagnosis

Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease.
Blagov A, Postnov A, Sukhorukov V, Popov M, Uzokov J, Orekhov A
Front Biosci (Landmark Ed) 2024 Jan 19;29(1):36. doi: 10.31083/j.fbl2901036. PMID: 38287806
Nigrostriatal tau pathology in parkinsonism and Parkinson's disease.
Chu Y, Hirst WD, Federoff HJ, Harms AS, Stoessl AJ, Kordower JH
Brain 2024 Feb 1;147(2):444-457. doi: 10.1093/brain/awad388. PMID: 38006313Free PMC Article
Pathomechanisms of cognitive and behavioral impairment in corticobasal degeneration.
Jellinger KA
J Neural Transm (Vienna) 2023 Dec;130(12):1509-1522. Epub 2023 Sep 2 doi: 10.1007/s00702-023-02691-w. PMID: 37659990
Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease.
Lee JY, Martin-Bastida A, Murueta-Goyena A, Gabilondo I, Cuenca N, Piccini P, Jeon B
Nat Rev Neurol 2022 Apr;18(4):203-220. Epub 2022 Feb 17 doi: 10.1038/s41582-022-00618-9. PMID: 35177849
Stem Cell-Based Therapies for Parkinson Disease.
Liu Z, Cheung HH
Int J Mol Sci 2020 Oct 29;21(21) doi: 10.3390/ijms21218060. PMID: 33137927Free PMC Article

Therapy

Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson's disease.
Jeong SH, Park CJ, Jeong HJ, Sunwoo MK, Ahn SS, Lee SK, Lee PH, Kim YJ, Sohn YH, Chung SJ
J Neurol Neurosurg Psychiatry 2023 Dec;94(12):1047-1055. Epub 2023 Jun 30 doi: 10.1136/jnnp-2023-331170. PMID: 37399288
Nutritional Risk Factors, Microbiota and Parkinson's Disease: What Is the Current Evidence?
Boulos C, Yaghi N, El Hayeck R, Heraoui GN, Fakhoury-Sayegh N
Nutrients 2019 Aug 14;11(8) doi: 10.3390/nu11081896. PMID: 31416163Free PMC Article
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease.
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS
Brain 2018 Jul 1;141(7):1917-1933. doi: 10.1093/brain/awy132. PMID: 29850777Free PMC Article
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.
Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA
J Psychopharmacol 2014 Nov;28(11):1088-98. Epub 2014 Sep 18 doi: 10.1177/0269881114550355. PMID: 25237116
Parkinson's disease.
Wolters EC, Calne DB
CMAJ 1989 Mar 1;140(5):507-14. PMID: 2563667Free PMC Article

Prognosis

Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease.
Lee JY, Martin-Bastida A, Murueta-Goyena A, Gabilondo I, Cuenca N, Piccini P, Jeon B
Nat Rev Neurol 2022 Apr;18(4):203-220. Epub 2022 Feb 17 doi: 10.1038/s41582-022-00618-9. PMID: 35177849
Stem Cell-Based Therapies for Parkinson Disease.
Liu Z, Cheung HH
Int J Mol Sci 2020 Oct 29;21(21) doi: 10.3390/ijms21218060. PMID: 33137927Free PMC Article
Alzheimer disease.
Calderon-Garcidueñas AL, Duyckaerts C
Handb Clin Neurol 2017;145:325-337. doi: 10.1016/B978-0-12-802395-2.00023-7. PMID: 28987180
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.
Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA
J Psychopharmacol 2014 Nov;28(11):1088-98. Epub 2014 Sep 18 doi: 10.1177/0269881114550355. PMID: 25237116
Parkinson's disease.
Wolters EC, Calne DB
CMAJ 1989 Mar 1;140(5):507-14. PMID: 2563667Free PMC Article

Clinical prediction guides

Association of choroid plexus volume with motor symptoms and dopaminergic degeneration in Parkinson's disease.
Jeong SH, Park CJ, Jeong HJ, Sunwoo MK, Ahn SS, Lee SK, Lee PH, Kim YJ, Sohn YH, Chung SJ
J Neurol Neurosurg Psychiatry 2023 Dec;94(12):1047-1055. Epub 2023 Jun 30 doi: 10.1136/jnnp-2023-331170. PMID: 37399288
Age-related Huntington's disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy.
Oh YM, Lee SW, Kim WK, Chen S, Church VA, Cates K, Li T, Zhang B, Dolle RE, Dahiya S, Pak SC, Silverman GA, Perlmutter DH, Yoo AS
Nat Neurosci 2022 Nov;25(11):1420-1433. Epub 2022 Oct 27 doi: 10.1038/s41593-022-01185-4. PMID: 36303071Free PMC Article
Alzheimer disease.
Calderon-Garcidueñas AL, Duyckaerts C
Handb Clin Neurol 2017;145:325-337. doi: 10.1016/B978-0-12-802395-2.00023-7. PMID: 28987180
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J
Nature 2017 Aug 30;548(7669):592-596. doi: 10.1038/nature23664. PMID: 28858313
Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial.
Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA
J Psychopharmacol 2014 Nov;28(11):1088-98. Epub 2014 Sep 18 doi: 10.1177/0269881114550355. PMID: 25237116

Recent systematic reviews

Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies.
López-Cerdán A, Andreu Z, Hidalgo MR, Grillo-Risco R, Català-Senent JF, Soler-Sáez I, Neva-Alejo A, Gordillo F, de la Iglesia-Vayá M, García-García F
Biol Sex Differ 2022 Nov 22;13(1):68. doi: 10.1186/s13293-022-00477-5. PMID: 36414996Free PMC Article
The Potential Roles of Extracellular Vesicles as Biomarkers for Parkinson's Disease: A Systematic Review.
Valencia J, Ferreira M, Merino-Torres JF, Marcilla A, Soriano JM
Int J Mol Sci 2022 Sep 29;23(19) doi: 10.3390/ijms231911508. PMID: 36232833Free PMC Article
The Role of the Cerebellum in Huntington's Disease: a Systematic Review.
Franklin GL, Camargo CHF, Meira AT, Lima NSC, Teive HAG
Cerebellum 2021 Apr;20(2):254-265. Epub 2020 Oct 7 doi: 10.1007/s12311-020-01198-4. PMID: 33029762
Clinicopathological review of pallidonigroluysian atrophy.
Wong JC, Armstrong MJ, Lang AE, Hazrati LN
Mov Disord 2013 Mar;28(3):274-81. Epub 2012 Oct 31 doi: 10.1002/mds.25232. PMID: 23114877
Systematic review of proton magnetic resonance spectroscopy of the striatum in parkinsonian syndromes.
Clarke CE, Lowry M
Eur J Neurol 2001 Nov;8(6):573-7. doi: 10.1046/j.1468-1331.2001.00308.x. PMID: 11784341

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