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Abnormal substantia nigra morphology

MedGen UID:
868012
•Concept ID:
C4022403
•
Anatomical Abnormality
Synonym: Abnormality of the substantia nigra
 
HPO: HP:0045007

Definition

A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry. [from HPO]

Professional guidelines

PubMed

Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease.
Takeshige-Amano H, Hatano T, Kamagata K, Andica C, Ogawa T, Shindo A, Uchida W, Sako W, Saiki S, Shimo Y, Oyama G, Umemura A, Ito M, Hori M, Aoki S, Hattori N
J Neurol Sci 2024 Feb 15;457:122883. Epub 2024 Jan 13 doi: 10.1016/j.jns.2024.122883. PMID: 38246127
Technological prospection: patents mapping involving compounds for the treatment of L-DOPA-induced dyskinesias.
Barroso SDS, Lopes LES, Santos KS, Gomes MZ
Expert Opin Ther Pat 2019 Dec;29(12):979-985. Epub 2019 Nov 13 doi: 10.1080/13543776.2019.1690453. PMID: 31694421
Progressive supranuclear palsy: clinical features, pathophysiology and management.
Rajput A, Rajput AH
Drugs Aging 2001;18(12):913-25. doi: 10.2165/00002512-200118120-00003. PMID: 11888346

Recent clinical studies

Therapy

Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.
Todd G, Pearson-Dennett V, Wilcox RA, Chau MT, Thoirs K, Thewlis D, Vogel AP, White JM
Parkinsonism Relat Disord 2016 Apr;25:27-32. Epub 2016 Feb 21 doi: 10.1016/j.parkreldis.2016.02.019. PMID: 26923520
Illicit stimulant use is associated with abnormal substantia nigra morphology in humans.
Todd G, Noyes C, Flavel SC, Della Vedova CB, Spyropoulos P, Chatterton B, Berg D, White JM
PLoS One 2013;8(2):e56438. Epub 2013 Feb 13 doi: 10.1371/journal.pone.0056438. PMID: 23418568Free PMC Article
Neuroprotection and dopamine agonists.
Schapira AH
Neurology 2002 Feb 26;58(4 Suppl 1):S9-18. doi: 10.1212/wnl.58.suppl_1.s9. PMID: 11909981
Parkinsonism. Multiple system atrophy.
Wenning GK, Quinn NP
Baillieres Clin Neurol 1997 Apr;6(1):187-204. PMID: 9426875
Hallervorden-Spatz syndrome and brain iron metabolism.
Swaiman KF
Arch Neurol 1991 Dec;48(12):1285-93. doi: 10.1001/archneur.1991.00530240091029. PMID: 1845035

Prognosis

Dysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson's disease.
Lu J, Xu Y, Quan Z, Chen Z, Sun Z, Qing H
Neuroscience 2017 Dec 4;365:70-82. Epub 2017 Sep 28 doi: 10.1016/j.neuroscience.2017.09.033. PMID: 28964753
Parkinson's disease dementia and potential therapeutic strategies.
Caviness JN, Lue L, Adler CH, Walker DG
CNS Neurosci Ther 2011 Feb;17(1):32-44. Epub 2010 Dec 28 doi: 10.1111/j.1755-5949.2010.00216.x. PMID: 21199444Free PMC Article
Transcranial sonography in restless legs syndrome.
Godau J, Sojer M
Int Rev Neurobiol 2010;90:199-215. doi: 10.1016/S0074-7742(10)90015-9. PMID: 20692504
Stages in the development of Parkinson's disease-related pathology.
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K
Cell Tissue Res 2004 Oct;318(1):121-34. Epub 2004 Aug 24 doi: 10.1007/s00441-004-0956-9. PMID: 15338272
Neuroprotection and dopamine agonists.
Schapira AH
Neurology 2002 Feb 26;58(4 Suppl 1):S9-18. doi: 10.1212/wnl.58.suppl_1.s9. PMID: 11909981

Clinical prediction guides

Plasma exosomes impair microglial degradation of α-synuclein through V-ATPase subunit V1G1.
Li Y, Wang Y, Kou L, Yin S, Chi X, Sun Y, Wu J, Jin Z, Zhou Q, Zou W, Wang T, Xia Y
CNS Neurosci Ther 2024 May;30(5):e14738. doi: 10.1111/cns.14738. PMID: 38702933Free PMC Article
Macroscopic findings of brain with dementia.
Hashizume Y
Neuropathology 2022 Oct;42(5):353-366. Epub 2022 Apr 21 doi: 10.1111/neup.12785. PMID: 35451141
Transcranial sonography in restless legs syndrome.
Godau J, Sojer M
Int Rev Neurobiol 2010;90:199-215. doi: 10.1016/S0074-7742(10)90015-9. PMID: 20692504
Stages in the development of Parkinson's disease-related pathology.
Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K
Cell Tissue Res 2004 Oct;318(1):121-34. Epub 2004 Aug 24 doi: 10.1007/s00441-004-0956-9. PMID: 15338272
The adrenal medulla and Parkinson's disease.
Stoddard SL
Rev Neurosci 1994 Oct-Dec;5(4):293-307. doi: 10.1515/revneuro.1994.5.4.293. PMID: 7697198

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