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Orthostatic tachycardia

MedGen UID:
866749
•Concept ID:
C4021099
•
Finding
Synonym: Postural tachycardia
 
HPO: HP:0012173

Definition

An increase in heart rate with standing of 30 beats per minute or more. [from HPO]

Conditions with this feature

Neurocirculatory asthenia
MedGen UID:
283928
•Concept ID:
C1535893
•
Finding
A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart palpitations, sweating, anxiety, lightheadedness, hyperpnea, anxiety, and blurred vision.
See: Condition Record
Neurocirculatory asthenia

Professional guidelines

PubMed

Dysautonomia: Diagnosis and Management.
Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.
Fedorowski A
J Intern Med 2019 Apr;285(4):352-366. Epub 2018 Nov 23 doi: 10.1111/joim.12852. PMID: 30372565
Exercise and non-pharmacological treatment of POTS.
Fu Q, Levine BD
Auton Neurosci 2018 Dec;215:20-27. Epub 2018 Jul 4 doi: 10.1016/j.autneu.2018.07.001. PMID: 30001836Free PMC Article

Recent clinical studies

Etiology

Long COVID: major findings, mechanisms and recommendations.
Davis HE, McCorkell L, Vogel JM, Topol EJ
Nat Rev Microbiol 2023 Mar;21(3):133-146. Epub 2023 Jan 13 doi: 10.1038/s41579-022-00846-2. PMID: 36639608Free PMC Article
Long COVID: mechanisms, risk factors and recovery.
Astin R, Banerjee A, Baker MR, Dani M, Ford E, Hull JH, Lim PB, McNarry M, Morten K, O'Sullivan O, Pretorius E, Raman B, Soteropoulos DS, Taquet M, Hall CN
Exp Physiol 2023 Jan;108(1):12-27. Epub 2022 Nov 22 doi: 10.1113/EP090802. PMID: 36412084Free PMC Article
Dysautonomia: Diagnosis and Management.
Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments.
Yong SJ
Infect Dis (Lond) 2021 Oct;53(10):737-754. Epub 2021 May 22 doi: 10.1080/23744235.2021.1924397. PMID: 34024217Free PMC Article
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR
Annu Rev Med 2020 Jan 27;71:235-248. Epub 2019 Aug 14 doi: 10.1146/annurev-med-041818-011630. PMID: 31412221

Diagnosis

Dysautonomia: Diagnosis and Management.
Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Postural Orthostatic Tachycardia Syndrome (POTS): An Update for Clinical Practice.
Sebastian SA, Co EL, Panthangi V, Jain E, Ishak A, Shah Y, Vasavada A, Padda I
Curr Probl Cardiol 2022 Dec;47(12):101384. Epub 2022 Aug 31 doi: 10.1016/j.cpcardiol.2022.101384. PMID: 36055438
Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment.
Olshansky B, Cannom D, Fedorowski A, Stewart J, Gibbons C, Sutton R, Shen WK, Muldowney J, Chung TH, Feigofsky S, Nayak H, Calkins H, Benditt DG
Prog Cardiovasc Dis 2020 May-Jun;63(3):263-270. Epub 2020 Mar 25 doi: 10.1016/j.pcad.2020.03.010. PMID: 32222376Free PMC Article
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR
Annu Rev Med 2020 Jan 27;71:235-248. Epub 2019 Aug 14 doi: 10.1146/annurev-med-041818-011630. PMID: 31412221
Postural Orthostatic Tachycardia Syndrome: JACC Focus Seminar.
Bryarly M, Phillips LT, Fu Q, Vernino S, Levine BD
J Am Coll Cardiol 2019 Mar 19;73(10):1207-1228. doi: 10.1016/j.jacc.2018.11.059. PMID: 30871704

Therapy

Postural Orthostatic Tachycardia Syndrome (POTS): An Update for Clinical Practice.
Sebastian SA, Co EL, Panthangi V, Jain E, Ishak A, Shah Y, Vasavada A, Padda I
Curr Probl Cardiol 2022 Dec;47(12):101384. Epub 2022 Aug 31 doi: 10.1016/j.cpcardiol.2022.101384. PMID: 36055438
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR
Annu Rev Med 2020 Jan 27;71:235-248. Epub 2019 Aug 14 doi: 10.1146/annurev-med-041818-011630. PMID: 31412221
Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.
Fedorowski A
J Intern Med 2019 Apr;285(4):352-366. Epub 2018 Nov 23 doi: 10.1111/joim.12852. PMID: 30372565
Exercise and non-pharmacological treatment of POTS.
Fu Q, Levine BD
Auton Neurosci 2018 Dec;215:20-27. Epub 2018 Jul 4 doi: 10.1016/j.autneu.2018.07.001. PMID: 30001836Free PMC Article
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article

Prognosis

Arrhythmias in COVID-19.
Pandat S, Zhu Z, Fuentes-Rojas S, Schurmann P
Methodist Debakey Cardiovasc J 2021;17(5):73-82. Epub 2021 Dec 15 doi: 10.14797/mdcvj.1039. PMID: 34992725Free PMC Article
Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment.
Olshansky B, Cannom D, Fedorowski A, Stewart J, Gibbons C, Sutton R, Shen WK, Muldowney J, Chung TH, Feigofsky S, Nayak H, Calkins H, Benditt DG
Prog Cardiovasc Dis 2020 May-Jun;63(3):263-270. Epub 2020 Mar 25 doi: 10.1016/j.pcad.2020.03.010. PMID: 32222376Free PMC Article
Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.
Fedorowski A
J Intern Med 2019 Apr;285(4):352-366. Epub 2018 Nov 23 doi: 10.1111/joim.12852. PMID: 30372565
Exercise and non-pharmacological treatment of POTS.
Fu Q, Levine BD
Auton Neurosci 2018 Dec;215:20-27. Epub 2018 Jul 4 doi: 10.1016/j.autneu.2018.07.001. PMID: 30001836Free PMC Article

Clinical prediction guides

Postacute Sequelae of SARS-CoV-2 in Children.
Rao S, Gross RS, Mohandas S, Stein CR, Case A, Dreyer B, Pajor NM, Bunnell HT, Warburton D, Berg E, Overdevest JB, Gorelik M, Milner J, Saxena S, Jhaveri R, Wood JC, Rhee KE, Letts R, Maughan C, Guthe N, Castro-Baucom L, Stockwell MS
Pediatrics 2024 Mar 1;153(3) doi: 10.1542/peds.2023-062570. PMID: 38321938Free PMC Article
Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial.
Stavrakis S, Chakraborty P, Farhat K, Whyte S, Morris L, Abideen Asad ZU, Karfonta B, Anjum J, Matlock HG, Cai X, Yu X
JACC Clin Electrophysiol 2024 Feb;10(2):346-355. Epub 2023 Nov 22 doi: 10.1016/j.jacep.2023.10.015. PMID: 37999672Free PMC Article
Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases.
Gyöngyösi M, Alcaide P, Asselbergs FW, Brundel BJJM, Camici GG, Martins PDC, Ferdinandy P, Fontana M, Girao H, Gnecchi M, Gollmann-Tepeköylü C, Kleinbongard P, Krieg T, Madonna R, Paillard M, Pantazis A, Perrino C, Pesce M, Schiattarella GG, Sluijter JPG, Steffens S, Tschöpe C, Van Linthout S, Davidson SM
Cardiovasc Res 2023 Mar 31;119(2):336-356. doi: 10.1093/cvr/cvac115. PMID: 35875883Free PMC Article
Arrhythmias in COVID-19.
Pandat S, Zhu Z, Fuentes-Rojas S, Schurmann P
Methodist Debakey Cardiovasc J 2021;17(5):73-82. Epub 2021 Dec 15 doi: 10.14797/mdcvj.1039. PMID: 34992725Free PMC Article
Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment.
Olshansky B, Cannom D, Fedorowski A, Stewart J, Gibbons C, Sutton R, Shen WK, Muldowney J, Chung TH, Feigofsky S, Nayak H, Calkins H, Benditt DG
Prog Cardiovasc Dis 2020 May-Jun;63(3):263-270. Epub 2020 Mar 25 doi: 10.1016/j.pcad.2020.03.010. PMID: 32222376Free PMC Article

Recent systematic reviews

Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis.
Yong SJ, Halim A, Liu S, Halim M, Alshehri AA, Alshahrani MA, Alshahrani MM, Alfaraj AH, Alburaiky LM, Khamis F, Muzaheed, AlShehail BM, Alfaresi M, Al Azmi R, Albayat H, Al Kaabi NA, Alhajri M, Al Amri KAS, Alsalman J, Algosaibi SA, Al Fares MA, Almanaa TN, Almutawif YA, Mohapatra RK, Rabaan AA
Auton Neurosci 2023 Dec;250:103132. Epub 2023 Nov 23 doi: 10.1016/j.autneu.2023.103132. PMID: 38000119
Cardiovascular Adaptations of Space Travel: A Systematic Review.
Sharma SN, Meller LLT, Sharma AN, Amsterdam EA
Cardiology 2023;148(5):434-440. Epub 2023 Jun 10 doi: 10.1159/000531466. PMID: 37302388Free PMC Article
Postural Orthostatic Tachycardia Syndrome After COVID-19: A Systematic Review of Therapeutic Interventions.
Abbate G, De Iulio B, Thomas G, Priday A, Biondi-Zoccai G, Markley R, Abbate A
J Cardiovasc Pharmacol 2023 Jul 1;82(1):23-31. doi: 10.1097/FJC.0000000000001432. PMID: 37094584
Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.
Wu REY, Khan FM, Hockin BCD, Lobban TCA, Sanatani S, Claydon VE
Clin Auton Res 2022 Jun;32(3):185-203. Epub 2022 Jun 10 doi: 10.1007/s10286-022-00868-z. PMID: 35689118Free PMC Article
Pediatric Syncope: A Systematic Review.
Zavala R, Metais B, Tuckfield L, DelVecchio M, Aronoff S
Pediatr Emerg Care 2020 Sep;36(9):442-445. doi: 10.1097/PEC.0000000000002149. PMID: 32530839Free PMC Article

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