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Sertoli cell neoplasm

MedGen UID:
866465
•Concept ID:
C4020704
•
Neoplastic Process
Synonym: Sertoli cell neoplasia
 
HPO: HP:0100619

Definition

The presence of a neoplasm of the testis with origin in a Sertoli cell. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSertoli cell neoplasm

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Preservation of Fertility in Testis Cancer Management.
Sineath RC, Mehta A
Urol Clin North Am 2019 Aug;46(3):341-351. Epub 2019 May 29 doi: 10.1016/j.ucl.2019.04.010. PMID: 31277729
Ovarian sex-cord stromal tumours and small cell tumours: Pathological, genetic and management aspects.
Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337

Recent clinical studies

Etiology

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Androgen-Secreting Ovarian Tumors.
Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493
DICER1 Syndrome.
Hořínová V, Drábová K, Nosková H, Bajčiová V, Šoukalová J, Černá L, Hůrková V, Slabý O, Štěrba J
Klin Onkol 2019 Summer;32(Supplementum2):123-127. doi: 10.14735/amko2019S123. PMID: 31409088
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Diagnosis

An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Androgen-Secreting Ovarian Tumors.
Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Ovarian paraganglioma.
Schuldt M, Retamero JA, Tourné M, Nogales FF
Int J Surg Pathol 2015 Apr;23(2):130-3. Epub 2014 Mar 13 doi: 10.1177/1066896914526779. PMID: 24626167

Therapy

INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors.
Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059
Possible fetal determinants of male infertility.
Juul A, Almstrup K, Andersson AM, Jensen TK, Jørgensen N, Main KM, Rajpert-De Meyts E, Toppari J, Skakkebæk NE
Nat Rev Endocrinol 2014 Sep;10(9):553-62. Epub 2014 Jun 17 doi: 10.1038/nrendo.2014.97. PMID: 24935122
Male fertility preservation, where are we in 2014?
Goossens E, Tournaye H
Ann Endocrinol (Paris) 2014 May;75(2):115-7. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.03.011. PMID: 24793992
Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.
Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638Free PMC Article
Testicular tumours.
Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Prognosis

Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Clin Lab Med 2023 Jun;43(2):245-274. doi: 10.1016/j.cll.2023.03.001. PMID: 37169445
Update on Ovarian Sex Cord-Stromal Tumors.
Ordulu Z
Surg Pathol Clin 2022 Jun;15(2):235-258. doi: 10.1016/j.path.2022.02.004. PMID: 35715160
An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article

Clinical prediction guides

Treatment and follow-up of rare testis tumours.
Fankhauser CD, Grogg JB, Rothermundt C, Clarke NW
J Cancer Res Clin Oncol 2022 Mar;148(3):667-671. Epub 2022 Jan 20 doi: 10.1007/s00432-021-03890-2. PMID: 35048196
Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors.
Chen J, Liu Y, Zhang Y, Wang Y, Chen X, Wang Z
Sci Prog 2021 Apr-Jun;104(2):368504211009668. doi: 10.1177/00368504211009668. PMID: 33848213Free PMC Article
Imaging of DICER1 syndrome.
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
DICER1 Syndrome.
Hořínová V, Drábová K, Nosková H, Bajčiová V, Šoukalová J, Černá L, Hůrková V, Slabý O, Štěrba J
Klin Onkol 2019 Summer;32(Supplementum2):123-127. doi: 10.14735/amko2019S123. PMID: 31409088
The nucleolus.
Schwarzacher HG, Wachtler F
Anat Embryol (Berl) 1993 Dec;188(6):515-36. doi: 10.1007/BF00187008. PMID: 8129175

Recent systematic reviews

The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Ovarian Sertoli-Leydig cell tumours: A systematic review of relapsed cases.
Nef J, Huber DE
Eur J Obstet Gynecol Reprod Biol 2021 Aug;263:261-274. Epub 2021 Jun 28 doi: 10.1016/j.ejogrb.2021.06.036. PMID: 34245994
Sertoli Cell Tumors of the Testes: Systematic Literature Review and Meta-Analysis of Outcomes in 435 Patients.
Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680Free PMC Article
Multimorbidity and Genetic Characteristics of DICER1 Syndrome Based on Systematic Review.
Cai S, Zhao W, Nie X, Abbas A, Fu L, Bihi S, Feng G, Liu T, Lv Y, Ma X, Peng X
J Pediatr Hematol Oncol 2017 Jul;39(5):355-361. doi: 10.1097/MPH.0000000000000715. PMID: 27906793
Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.
Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

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