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Tolbutamide response

MedGen UID:: 865155
•Concept ID:: C4016718
•: Finding

Synonym:	Tolbutamide poor metabolizer
Drug:	Tolbutamide MedGen UID: 21577 •Concept ID: C0040374 • Pharmacologic Substance A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by CYPC29. [from NCI] Tolbutamide

Gene (location): Gene(s) directly associated with this condition or phenotype.	G6PD (Xq28)

OMIM®:	601130

Professional guidelines

PubMed

Traditional pharmacological management of non-insulin-dependent diabetes.

Tattersall R
Clin Invest Med 1995 Aug;18(4):288-95. PMID: 8549015

Oral hypoglycemic agents in the treatment of type II diabetes.

Tal A
Am Fam Physician 1993 Nov 1;48(6):1089-95. PMID: 8237731

Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.

Pohl JE, Thurston H, Davis D, Morgan MY
Br Med J 1972 Jun 3;2(5813):568-70. doi: 10.1136/bmj.2.5813.568. PMID: 5032785 Free PMC Article

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Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

Recent clinical studies

Diagnosis

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

Pearson ER, Badman MK, Lockwood CR, Clark PM, Ellard S, Bingham C, Hattersley AT
Diabetes Care 2004 May;27(5):1102-7. doi: 10.2337/diacare.27.5.1102. PMID: 15111528

Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.

Lippiat JD, Albinson SL, Ashcroft FM
Diabetes 2002 Dec;51 Suppl 3:S377-80. doi: 10.2337/diabetes.51.2007.s377. PMID: 12475778

Diabetes mellitus--current criteria for laboratory diagnosis.

Alexander RW
Calif Med 1969 Feb;110(2):107-13. PMID: 5805334 Free PMC Article

The intravenous tolbutamide response test. Initial observations.

WHITEHOUSE FW, LOWRIE WL
J Mich State Med Soc 1960 Oct;59:1540-42. PMID: 13784885

A new diagnostic procedure for mild diabetes mellitus; evaluation of an intravenous tolbutamide response test.

UNGER RH, MADISON LL
Diabetes 1958 Nov-Dec;7(6):455-61. doi: 10.2337/diab.7.6.455. PMID: 13597739

See all (10)

Therapy

Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.

Sato T, Miura Y, Saito T, Ito M, Kokubun M, Sakuma H, Adachi M, Yoshinaga K
Tohoku J Exp Med 1979 Jan;127(1):97-8. doi: 10.1620/tjem.127.97. PMID: 760255

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Clinical prediction guides

Effect of tolbutamide on plasma catecholamine in insulin dependent diabetics.

Sato T, Miura Y, Saito T, Ito M, Kokubun M, Sakuma H, Adachi M, Yoshinaga K
Tohoku J Exp Med 1979 Jan;127(1):97-8. doi: 10.1620/tjem.127.97. PMID: 760255

The intravenous tolbutamide response test. Initial observations.

WHITEHOUSE FW, LOWRIE WL
J Mich State Med Soc 1960 Oct;59:1540-42. PMID: 13784885

See all (2)

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Tolbutamide response

Professional guidelines

PubMed

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

Recent clinical studies

Diagnosis

Therapy

Clinical prediction guides

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