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Adrenocortical tumor, somatic

MedGen UID:
864829
•Concept ID:
C4016392
•
Neoplastic Process
Synonym: Adrenal cortical tumor, somatic
 
OMIM®: 188830

Professional guidelines

PubMed

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.
Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA
Hypertension 2023 Jul;80(7):1555-1567. Epub 2023 May 1 doi: 10.1161/HYPERTENSIONAHA.123.20921. PMID: 37125608Free PMC Article
Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
A Gene-Based Classification of Primary Adrenocortical Hyperplasias.
Hannah-Shmouni F, Stratakis CA
Horm Metab Res 2020 Mar;52(3):133-141. Epub 2020 Mar 25 doi: 10.1055/a-1107-2972. PMID: 32215884

Recent clinical studies

Etiology

Disorders of the adrenal cortex: Genetic and molecular aspects.
Pitsava G, Maria AG, Faucz FR
Front Endocrinol (Lausanne) 2022;13:931389. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.931389. PMID: 36105398Free PMC Article
Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma.
Nazha B, Zhuang TZ, Dada HI, Drusbosky LM, Brown JT, Ravindranathan D, Carthon BC, Kucuk O, Goldman J, Master VA, Bilen MA
Oncologist 2022 Jun 8;27(6):462-468. doi: 10.1093/oncolo/oyac061. PMID: 35462410Free PMC Article
Genomic classification of benign adrenocortical lesions.
Faillot S, Foulonneau T, Néou M, Espiard S, Garinet S, Vaczlavik A, Jouinot A, Rondof W, Septier A, Drougat L, Hécale-Perlemoine K, Ragazzon B, Rizk-Rabin M, Sibony M, Bonnet-Serrano F, Guibourdenche J, Libé R, Groussin L, Dousset B, de Reyniès A, Bertherat J, Assié G
Endocr Relat Cancer 2021 Jan;28(1):79-95. doi: 10.1530/ERC-20-0128. PMID: 33151900
A Gene-Based Classification of Primary Adrenocortical Hyperplasias.
Hannah-Shmouni F, Stratakis CA
Horm Metab Res 2020 Mar;52(3):133-141. Epub 2020 Mar 25 doi: 10.1055/a-1107-2972. PMID: 32215884
Aldosterone-Producing Cell Clusters in Normal and Pathological States.
Omata K, Tomlins SA, Rainey WE
Horm Metab Res 2017 Dec;49(12):951-956. Epub 2017 Dec 4 doi: 10.1055/s-0043-122394. PMID: 29202494Free PMC Article

Diagnosis

Advances in translational research of the rare cancer type adrenocortical carcinoma.
Ghosh C, Hu J, Kebebew E
Nat Rev Cancer 2023 Dec;23(12):805-824. Epub 2023 Oct 19 doi: 10.1038/s41568-023-00623-0. PMID: 37857840
Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults.
Nanba K, Baker JE, Blinder AR, Bick NR, Liu CJ, Lim JS, Wachtel H, Cohen DL, Williams TA, Reincke M, Lyden ML, Bancos I, Young WF, Else T, Giordano TJ, Udager AM, Rainey WE
J Clin Endocrinol Metab 2022 Aug 18;107(9):2473-2482. doi: 10.1210/clinem/dgac408. PMID: 35779252Free PMC Article
Diagnosis and treatment of primary aldosteronism.
Reincke M, Bancos I, Mulatero P, Scholl UI, Stowasser M, Williams TA
Lancet Diabetes Endocrinol 2021 Dec;9(12):876-892. doi: 10.1016/S2213-8587(21)00210-2. PMID: 34798068
Old and new genes in primary aldosteronism.
Boulkroun S, Fernandes-Rosa FL, Zennaro MC
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101375. Epub 2020 Jan 22 doi: 10.1016/j.beem.2020.101375. PMID: 32007424
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203

Therapy

Pharmacogenomic analysis in adrenocortical carcinoma reveals genetic features associated with mitotane sensitivity and potential therapeutics.
Zhang J, Wu L, Su T, Liu H, Jiang L, Jiang Y, Wu Z, Chen L, Li H, Zheng J, Sun Y, Peng H, Han R, Ning G, Ye L, Wang W
Front Endocrinol (Lausanne) 2024;15:1365321. Epub 2024 May 8 doi: 10.3389/fendo.2024.1365321. PMID: 38779454Free PMC Article
Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical Therapy.
Guan Y, Yue S, Chen Y, Pan Y, An L, Du H, Liang C
Cells 2022 Nov 26;11(23) doi: 10.3390/cells11233784. PMID: 36497046Free PMC Article
PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL
J Clin Oncol 2020 Jan 1;38(1):71-80. Epub 2019 Oct 23 doi: 10.1200/JCO.19.01586. PMID: 31644329Free PMC Article
A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma.
Lenzini L, Rossitto G, Maiolino G, Letizia C, Funder JW, Rossi GP
J Clin Endocrinol Metab 2015 Aug;100(8):E1089-95. Epub 2015 Jun 11 doi: 10.1210/jc.2015-2149. PMID: 26066531
Adrenocortical cancer treatment.
Patalano A, Brancato V, Mantero F
Horm Res 2009 Jan;71 Suppl 1:99-104. Epub 2009 Jan 21 doi: 10.1159/000178049. PMID: 19153517

Prognosis

Advances in translational research of the rare cancer type adrenocortical carcinoma.
Ghosh C, Hu J, Kebebew E
Nat Rev Cancer 2023 Dec;23(12):805-824. Epub 2023 Oct 19 doi: 10.1038/s41568-023-00623-0. PMID: 37857840
Disorders of the adrenal cortex: Genetic and molecular aspects.
Pitsava G, Maria AG, Faucz FR
Front Endocrinol (Lausanne) 2022;13:931389. Epub 2022 Aug 29 doi: 10.3389/fendo.2022.931389. PMID: 36105398Free PMC Article
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome.
Santana LS, Guimaraes AG, Almeida MQ
Front Endocrinol (Lausanne) 2022;13:927669. Epub 2022 Jun 23 doi: 10.3389/fendo.2022.927669. PMID: 35813615Free PMC Article
Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma.
Nazha B, Zhuang TZ, Dada HI, Drusbosky LM, Brown JT, Ravindranathan D, Carthon BC, Kucuk O, Goldman J, Master VA, Bilen MA
Oncologist 2022 Jun 8;27(6):462-468. doi: 10.1093/oncolo/oyac061. PMID: 35462410Free PMC Article
PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL
J Clin Oncol 2020 Jan 1;38(1):71-80. Epub 2019 Oct 23 doi: 10.1200/JCO.19.01586. PMID: 31644329Free PMC Article

Clinical prediction guides

Advances in translational research of the rare cancer type adrenocortical carcinoma.
Ghosh C, Hu J, Kebebew E
Nat Rev Cancer 2023 Dec;23(12):805-824. Epub 2023 Oct 19 doi: 10.1038/s41568-023-00623-0. PMID: 37857840
Pathogenesis of Primary Aldosteronism: Impact on Clinical Outcome.
Santana LS, Guimaraes AG, Almeida MQ
Front Endocrinol (Lausanne) 2022;13:927669. Epub 2022 Jun 23 doi: 10.3389/fendo.2022.927669. PMID: 35813615Free PMC Article
Blood-Based Next-Generation Sequencing in Adrenocortical Carcinoma.
Nazha B, Zhuang TZ, Dada HI, Drusbosky LM, Brown JT, Ravindranathan D, Carthon BC, Kucuk O, Goldman J, Master VA, Bilen MA
Oncologist 2022 Jun 8;27(6):462-468. doi: 10.1093/oncolo/oyac061. PMID: 35462410Free PMC Article
The genetics of adrenocortical tumors.
Espiard S, Bertherat J
Endocrinol Metab Clin North Am 2015 Jun;44(2):311-34. doi: 10.1016/j.ecl.2015.02.004. PMID: 26038203
Pathogenesis of adrenocortical cancer.
Bertherat J, Bertagna X
Best Pract Res Clin Endocrinol Metab 2009 Apr;23(2):261-71. doi: 10.1016/j.beem.2008.10.006. PMID: 19500768

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