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Obesity, early-onset, susceptibility to

MedGen UID:
864778
•Concept ID:
C4016341
•
Finding
Synonym: OBESITY, EARLY-ONSET, SUSCEPTIBILITY TO
 
OMIM®: 176830

Professional guidelines

PubMed

Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.
Soliman AT, Alaaraj N, De Sanctis V, Hamed N, Alyafei F, Ahmed S
Acta Biomed 2023 Dec 5;94(6):e2023222. doi: 10.23750/abm.v94i6.15316. PMID: 38054666Free PMC Article
Understanding susceptibility and targeting treatment in non-alcoholic fatty liver disease in children; moving the fulcrum.
Fitzpatrick E
Proc Nutr Soc 2019 Aug;78(3):362-371. Epub 2019 Feb 8 doi: 10.1017/S0029665118002914. PMID: 30732664
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article

Recent clinical studies

Etiology

Is early-onset cancer an emerging global epidemic? Current evidence and future implications.
Ugai T, Sasamoto N, Lee HY, Ando M, Song M, Tamimi RM, Kawachi I, Campbell PT, Giovannucci EL, Weiderpass E, Rebbeck TR, Ogino S
Nat Rev Clin Oncol 2022 Oct;19(10):656-673. Epub 2022 Sep 6 doi: 10.1038/s41571-022-00672-8. PMID: 36068272Free PMC Article
Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review.
Gómez-Roig MD, Pascal R, Cahuana MJ, García-Algar O, Sebastiani G, Andreu-Fernández V, Martínez L, Rodríguez G, Iglesia I, Ortiz-Arrabal O, Mesa MD, Cabero MJ, Guerra L, Llurba E, Domínguez C, Zanini MJ, Foraster M, Larqué E, Cabañas F, Lopez-Azorín M, Pérez A, Loureiro B, Pallás-Alonso CR, Escuder-Vieco D, Vento M
Fetal Diagn Ther 2021;48(4):245-257. Epub 2021 Mar 18 doi: 10.1159/000514884. PMID: 33735860
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S
Nat Rev Clin Oncol 2021 Apr;18(4):230-243. Epub 2020 Nov 20 doi: 10.1038/s41571-020-00445-1. PMID: 33219329Free PMC Article
The two-stage placental model of preeclampsia: An update.
Staff AC
J Reprod Immunol 2019 Sep;134-135:1-10. Epub 2019 Jul 8 doi: 10.1016/j.jri.2019.07.004. PMID: 31301487
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article

Diagnosis

Current Treatments for Patients with Genetic Obesity.
Faccioli N, Poitou C, Clément K, Dubern B
J Clin Res Pediatr Endocrinol 2023 May 29;15(2):108-119. Epub 2023 May 16 doi: 10.4274/jcrpe.galenos.2023.2023-3-2. PMID: 37191347Free PMC Article
Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Is early-onset cancer an emerging global epidemic? Current evidence and future implications.
Ugai T, Sasamoto N, Lee HY, Ando M, Song M, Tamimi RM, Kawachi I, Campbell PT, Giovannucci EL, Weiderpass E, Rebbeck TR, Ogino S
Nat Rev Clin Oncol 2022 Oct;19(10):656-673. Epub 2022 Sep 6 doi: 10.1038/s41571-022-00672-8. PMID: 36068272Free PMC Article
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S
Nat Rev Clin Oncol 2021 Apr;18(4):230-243. Epub 2020 Nov 20 doi: 10.1038/s41571-020-00445-1. PMID: 33219329Free PMC Article
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article

Therapy

Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis.
Perez-Cornago A, Smith-Byrne K, Hazelwood E, Watling CZ, Martin S, Frayling T, Lewis S, Martin RM, Yaghootkar H, Travis RC, Key TJ
Cancer Med 2023 Aug;12(15):16482-16489. Epub 2023 Jun 12 doi: 10.1002/cam4.6220. PMID: 37305903Free PMC Article
Current Treatments for Patients with Genetic Obesity.
Faccioli N, Poitou C, Clément K, Dubern B
J Clin Res Pediatr Endocrinol 2023 May 29;15(2):108-119. Epub 2023 May 16 doi: 10.4274/jcrpe.galenos.2023.2023-3-2. PMID: 37191347Free PMC Article
Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review.
Gómez-Roig MD, Pascal R, Cahuana MJ, García-Algar O, Sebastiani G, Andreu-Fernández V, Martínez L, Rodríguez G, Iglesia I, Ortiz-Arrabal O, Mesa MD, Cabero MJ, Guerra L, Llurba E, Domínguez C, Zanini MJ, Foraster M, Larqué E, Cabañas F, Lopez-Azorín M, Pérez A, Loureiro B, Pallás-Alonso CR, Escuder-Vieco D, Vento M
Fetal Diagn Ther 2021;48(4):245-257. Epub 2021 Mar 18 doi: 10.1159/000514884. PMID: 33735860
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S
Nat Rev Clin Oncol 2021 Apr;18(4):230-243. Epub 2020 Nov 20 doi: 10.1038/s41571-020-00445-1. PMID: 33219329Free PMC Article
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article

Prognosis

Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Is early-onset cancer an emerging global epidemic? Current evidence and future implications.
Ugai T, Sasamoto N, Lee HY, Ando M, Song M, Tamimi RM, Kawachi I, Campbell PT, Giovannucci EL, Weiderpass E, Rebbeck TR, Ogino S
Nat Rev Clin Oncol 2022 Oct;19(10):656-673. Epub 2022 Sep 6 doi: 10.1038/s41571-022-00672-8. PMID: 36068272Free PMC Article
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y, Ng K, Ogino S
Nat Rev Clin Oncol 2021 Apr;18(4):230-243. Epub 2020 Nov 20 doi: 10.1038/s41571-020-00445-1. PMID: 33219329Free PMC Article
Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.
Mantovani G, Bastepe M, Monk D, de Sanctis L, Thiele S, Usardi A, Ahmed SF, Bufo R, Choplin T, De Filippo G, Devernois G, Eggermann T, Elli FM, Freson K, García Ramirez A, Germain-Lee EL, Groussin L, Hamdy N, Hanna P, Hiort O, Jüppner H, Kamenický P, Knight N, Kottler ML, Le Norcy E, Lecumberri B, Levine MA, Mäkitie O, Martin R, Martos-Moreno GÁ, Minagawa M, Murray P, Pereda A, Pignolo R, Rejnmark L, Rodado R, Rothenbuhler A, Saraff V, Shoemaker AH, Shore EM, Silve C, Turan S, Woods P, Zillikens MC, Perez de Nanclares G, Linglart A
Nat Rev Endocrinol 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0. PMID: 29959430Free PMC Article
HLA-Cw6 and psoriasis.
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309

Clinical prediction guides

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome.
Song Y, Wade H, Zhang B, Xu W, Wu R, Li S, Su Q
Nutrients 2023 Jun 6;15(12) doi: 10.3390/nu15122643. PMID: 37375547Free PMC Article
Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer.
Ahmad Kendong SM, Raja Ali RA, Nawawi KNM, Ahmad HF, Mokhtar NM
Front Cell Infect Microbiol 2021;11:744606. Epub 2021 Dec 13 doi: 10.3389/fcimb.2021.744606. PMID: 34966694Free PMC Article
The two-stage placental model of preeclampsia: An update.
Staff AC
J Reprod Immunol 2019 Sep;134-135:1-10. Epub 2019 Jul 8 doi: 10.1016/j.jri.2019.07.004. PMID: 31301487
HLA-Cw6 and psoriasis.
Chen L, Tsai TF
Br J Dermatol 2018 Apr;178(4):854-862. Epub 2018 Mar 2 doi: 10.1111/bjd.16083. PMID: 29072309

Recent systematic reviews

Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.
Soliman AT, Alaaraj N, De Sanctis V, Hamed N, Alyafei F, Ahmed S
Acta Biomed 2023 Dec 5;94(6):e2023222. doi: 10.23750/abm.v94i6.15316. PMID: 38054666Free PMC Article

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