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Leptin dysfunction

MedGen UID:
864716
•Concept ID:
C4016279
•
Finding
Synonym: LEPTIN DYSFUNCTION
 
OMIM®: 164160

Professional guidelines

PubMed

Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis.
Lee KC, Wu PS, Lin HC
Clin Mol Hepatol 2023 Jan;29(1):77-98. Epub 2022 Oct 13 doi: 10.3350/cmh.2022.0237. PMID: 36226471Free PMC Article
Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India.
Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A
Indian J Med Res 2019 Oct;150(4):333-344. doi: 10.4103/ijmr.IJMR_1937_17. PMID: 31823915Free PMC Article
Latest approaches for the treatment of obesity.
Jackson VM, Breen DM, Fortin JP, Liou A, Kuzmiski JB, Loomis AK, Rives ML, Shah B, Carpino PA
Expert Opin Drug Discov 2015;10(8):825-39. Epub 2015 May 12 doi: 10.1517/17460441.2015.1044966. PMID: 25967138

Recent clinical studies

Etiology

Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β.
Hamilton K, Morrow K, Markantoni E, Harvey J
J Neurochem 2023 Nov;167(4):520-537. Epub 2023 Oct 11 doi: 10.1111/jnc.15980. PMID: 37822142
Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.
McGuire MJ, Ishii M
Cell Mol Neurobiol 2016 Mar;36(2):203-17. Epub 2016 Mar 18 doi: 10.1007/s10571-015-0282-7. PMID: 26993509Free PMC Article
Role of high central leptin activity in a scoliosis model created in bipedal amputated mice.
Wu T, Sun X, Zhu Z, Zheng X, Qian B, Zhu F, Cheng JC, Qiu Y
Stud Health Technol Inform 2012;176:31-5. PMID: 22744452

Diagnosis

Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.
McGuire MJ, Ishii M
Cell Mol Neurobiol 2016 Mar;36(2):203-17. Epub 2016 Mar 18 doi: 10.1007/s10571-015-0282-7. PMID: 26993509Free PMC Article

Therapy

Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.
McGuire MJ, Ishii M
Cell Mol Neurobiol 2016 Mar;36(2):203-17. Epub 2016 Mar 18 doi: 10.1007/s10571-015-0282-7. PMID: 26993509Free PMC Article
Role of high central leptin activity in a scoliosis model created in bipedal amputated mice.
Wu T, Sun X, Zhu Z, Zheng X, Qian B, Zhu F, Cheng JC, Qiu Y
Stud Health Technol Inform 2012;176:31-5. PMID: 22744452

Clinical prediction guides

Role of high central leptin activity in a scoliosis model created in bipedal amputated mice.
Wu T, Sun X, Zhu Z, Zheng X, Qian B, Zhu F, Cheng JC, Qiu Y
Stud Health Technol Inform 2012;176:31-5. PMID: 22744452

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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    Reviews

    Related information

    • ClinVar
      Related medical variations
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
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