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SUPEROXIDE DISMUTASE 2 POLYMORPHISM

MedGen UID:
864660
•Concept ID:
C4016223
•
Finding
OMIM®: 147460

Professional guidelines

PubMed

SOD2 genetic polymorphism (rs4880) has no impact on 6-month response to antidepressant treatment and inflammatory biomarkers in depressed patients.
Ait Tayeb AEK, Becquemont L, El-Asmar K, Mahmoudi K, Colle R, Trabado S, Gressier F, Feve B, Corruble E, Verstuyft C
Basic Clin Pharmacol Toxicol 2020 Mar;126(3):289-295. Epub 2020 Jan 29 doi: 10.1111/bcpt.13385. PMID: 31904901
Association between Manganese Superoxide Dismutase (MnSOD Val-9Ala) genotypes with the risk of generalized aggressive periodontitis disease.
Kazemi E, Moradi MT, Yari K, Mousavi SA, Kahrizi D
Cell Mol Biol (Noisy-le-grand) 2015 Dec 19;61(8):49-52. PMID: 26718428
Superoxide Dismutase and Catalase Genotypes in Pediatric Migraine Patients.
Saygi S, Erol İ, Alehan F, Yalçın YY, Kubat G, Ataç FB
J Child Neurol 2015 Oct;30(12):1586-90. Epub 2015 Mar 27 doi: 10.1177/0883073815575366. PMID: 25818327

Recent clinical studies

Etiology

Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
Sobot V, Stamenkovic M, Simic T, Jerotic D, Djokic M, Jaksic V, Bozic M, Milic J, Savic-Radojevic A, Djukic T
Exp Eye Res 2022 Jan;214:108863. Epub 2021 Nov 24 doi: 10.1016/j.exer.2021.108863. PMID: 34826418
Genetic associated complications of type 2 diabetes mellitus.
Wong YH, Wong SH, Wong XT, Yap QY, Yip KY, Wong LZ, Chellappan DK, Bhattamisra SK, Candasamy M
Panminerva Med 2022 Jun;64(2):274-288. Epub 2021 Oct 5 doi: 10.23736/S0031-0808.21.04285-3. PMID: 34609116
Association of pre-eclampsia with SOD2 Ala16Val polymorphism among mother-father-infant triads.
Luo ZC, Julien P, Wei SQ, Audibert F, Fraser WD; Maternal and Infant Research on Oxidative Stress (MIROS) study group
Int J Gynaecol Obstet 2018 Aug;142(2):221-227. Epub 2018 May 30 doi: 10.1002/ijgo.12528. PMID: 29745991
Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?
Seibold P, Hall P, Schoof N, Nevanlinna H, Heikkinen T, Benner A, Liu J, Schmezer P, Popanda O, Flesch-Janys D, Chang-Claude J
Breast 2013 Oct;22(5):817-23. Epub 2013 Mar 13 doi: 10.1016/j.breast.2013.02.008. PMID: 23489758
Genes and nonalcoholic fatty liver disease.
Wilfred de Alwis NM, Day CP
Curr Diab Rep 2008 Apr;8(2):156-63. doi: 10.1007/s11892-008-0027-9. PMID: 18445359

Diagnosis

Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.
Sobot V, Stamenkovic M, Simic T, Jerotic D, Djokic M, Jaksic V, Bozic M, Milic J, Savic-Radojevic A, Djukic T
Exp Eye Res 2022 Jan;214:108863. Epub 2021 Nov 24 doi: 10.1016/j.exer.2021.108863. PMID: 34826418
Genetic associated complications of type 2 diabetes mellitus.
Wong YH, Wong SH, Wong XT, Yap QY, Yip KY, Wong LZ, Chellappan DK, Bhattamisra SK, Candasamy M
Panminerva Med 2022 Jun;64(2):274-288. Epub 2021 Oct 5 doi: 10.23736/S0031-0808.21.04285-3. PMID: 34609116
Genetic variants in N6-methyladenosine are associated with bladder cancer risk in the Chinese population.
Liu H, Gu J, Jin Y, Yuan Q, Ma G, Du M, Ge Y, Qin C, Lv Q, Fu G, Wang M, Chu H, Yuan L, Zhang Z
Arch Toxicol 2021 Jan;95(1):299-309. Epub 2020 Sep 22 doi: 10.1007/s00204-020-02911-2. PMID: 32964246
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J 2011 Dec;11(6):437-43. Epub 2010 Jul 20 doi: 10.1038/tpj.2010.62. PMID: 20644561
Genetic predictors of adverse radiotherapy effects: the Gene-PARE project.
Ho AY, Atencio DP, Peters S, Stock RG, Formenti SC, Cesaretti JA, Green S, Haffty B, Drumea K, Leitzin L, Kuten A, Azria D, Ozsahin M, Overgaard J, Andreassen CN, Trop CS, Park J, Rosenstein BS
Int J Radiat Oncol Biol Phys 2006 Jul 1;65(3):646-55. doi: 10.1016/j.ijrobp.2006.03.006. PMID: 16751059

Therapy

Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study.
Luo H, Fang YJ, Zhang X, Feng XL, Zhang NQ, Abulimiti A, Huang CY, Zhang CX
Nutr Cancer 2021;73(9):1621-1630. Epub 2020 Aug 11 doi: 10.1080/01635581.2020.1804950. PMID: 32777945
The effects of rosuvastatin on lipid-lowering, inflammatory, antioxidant and fibrinolytics blood biomarkers are influenced by Val16Ala superoxide dismutase manganese-dependent gene polymorphism.
Duarte T, da Cruz IB, Barbisan F, Capelleto D, Moresco RN, Duarte MM
Pharmacogenomics J 2016 Nov;16(6):501-506. Epub 2016 Feb 16 doi: 10.1038/tpj.2015.91. PMID: 26882122
Manganese superoxide dismutase and breast cancer recurrence: a Danish clinical registry-based case-control study, and a meta-analysis.
Cronin-Fenton DP, Christensen M, Lash TL, Ahern TP, Pedersen L, Garne JP, Ewertz M, Autrup H, Sørensen HT, Hamilton-Dutoit S
PLoS One 2014;9(1):e87450. Epub 2014 Jan 31 doi: 10.1371/journal.pone.0087450. PMID: 24498107Free PMC Article
Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?
Faure C, Leveille P, Dupont C, Julia C, Chavatte-Palmer P; Alifert Group, Sutton A, Levy R
Antioxid Redox Signal 2014 Aug 1;21(4):565-9. Epub 2014 Feb 25 doi: 10.1089/ars.2014.5831. PMID: 24444339
Genetic predictors of adverse radiotherapy effects: the Gene-PARE project.
Ho AY, Atencio DP, Peters S, Stock RG, Formenti SC, Cesaretti JA, Green S, Haffty B, Drumea K, Leitzin L, Kuten A, Azria D, Ozsahin M, Overgaard J, Andreassen CN, Trop CS, Park J, Rosenstein BS
Int J Radiat Oncol Biol Phys 2006 Jul 1;65(3):646-55. doi: 10.1016/j.ijrobp.2006.03.006. PMID: 16751059

Prognosis

Genetic variants in N6-methyladenosine are associated with bladder cancer risk in the Chinese population.
Liu H, Gu J, Jin Y, Yuan Q, Ma G, Du M, Ge Y, Qin C, Lv Q, Fu G, Wang M, Chu H, Yuan L, Zhang Z
Arch Toxicol 2021 Jan;95(1):299-309. Epub 2020 Sep 22 doi: 10.1007/s00204-020-02911-2. PMID: 32964246
Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer.
Ahmed MW, Mahjabeen I, Gul S, Khursheed A, Mehmood A, Kayani MA
Future Oncol 2019 Nov;15(33):3819-3829. Epub 2019 Oct 25 doi: 10.2217/fon-2019-0365. PMID: 31651195
Association of pre-eclampsia with SOD2 Ala16Val polymorphism among mother-father-infant triads.
Luo ZC, Julien P, Wei SQ, Audibert F, Fraser WD; Maternal and Infant Research on Oxidative Stress (MIROS) study group
Int J Gynaecol Obstet 2018 Aug;142(2):221-227. Epub 2018 May 30 doi: 10.1002/ijgo.12528. PMID: 29745991
Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?
Seibold P, Hall P, Schoof N, Nevanlinna H, Heikkinen T, Benner A, Liu J, Schmezer P, Popanda O, Flesch-Janys D, Chang-Claude J
Breast 2013 Oct;22(5):817-23. Epub 2013 Mar 13 doi: 10.1016/j.breast.2013.02.008. PMID: 23489758
Genetic predictors of adverse radiotherapy effects: the Gene-PARE project.
Ho AY, Atencio DP, Peters S, Stock RG, Formenti SC, Cesaretti JA, Green S, Haffty B, Drumea K, Leitzin L, Kuten A, Azria D, Ozsahin M, Overgaard J, Andreassen CN, Trop CS, Park J, Rosenstein BS
Int J Radiat Oncol Biol Phys 2006 Jul 1;65(3):646-55. doi: 10.1016/j.ijrobp.2006.03.006. PMID: 16751059

Clinical prediction guides

Genetic variants in N6-methyladenosine are associated with bladder cancer risk in the Chinese population.
Liu H, Gu J, Jin Y, Yuan Q, Ma G, Du M, Ge Y, Qin C, Lv Q, Fu G, Wang M, Chu H, Yuan L, Zhang Z
Arch Toxicol 2021 Jan;95(1):299-309. Epub 2020 Sep 22 doi: 10.1007/s00204-020-02911-2. PMID: 32964246
Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case-control association study.
Gentschew L, Flachsbart F, Kleindorp R, Badarinarayan N, Schreiber S, Nebel A
Biogerontology 2013 Dec;14(6):719-27. Epub 2013 Oct 22 doi: 10.1007/s10522-013-9470-3. PMID: 24146173
A search to identify genetic risk factors for endometriosis.
Rotman C, Fischel L, Cortez G, Greiss H, Rana N, Rinehart J, Coulam CB
Am J Reprod Immunol 2013 Jan;69(1):92-5. Epub 2012 Nov 20 doi: 10.1111/aji.12034. PMID: 23167810
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J 2011 Dec;11(6):437-43. Epub 2010 Jul 20 doi: 10.1038/tpj.2010.62. PMID: 20644561
Genetic predictors of adverse radiotherapy effects: the Gene-PARE project.
Ho AY, Atencio DP, Peters S, Stock RG, Formenti SC, Cesaretti JA, Green S, Haffty B, Drumea K, Leitzin L, Kuten A, Azria D, Ozsahin M, Overgaard J, Andreassen CN, Trop CS, Park J, Rosenstein BS
Int J Radiat Oncol Biol Phys 2006 Jul 1;65(3):646-55. doi: 10.1016/j.ijrobp.2006.03.006. PMID: 16751059

Recent systematic reviews

Systematic Review of Candidate Single-nucleotide Polymorphisms as Biomarkers for Responsiveness to Neoadjuvant Chemoradiation for Rectal Cancer.
Maring ED, Tawadros PS, Steer CJ, Lee JT
Anticancer Res 2015 Jul;35(7):3761-6. PMID: 26124319
No association between SOD2 Val16Ala polymorphism and breast cancer susceptibility: a meta-analysis based on 9,710 cases and 11,041 controls.
Ma X, Chen C, Xiong H, Fan J, Li Y, Lin H, Xu R, Huang G, Xu B
Breast Cancer Res Treat 2010 Jul;122(2):509-14. Epub 2010 Jan 6 doi: 10.1007/s10549-009-0725-2. PMID: 20052533

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