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APOLIPOPROTEIN A-I (MILANO)

MedGen UID:
864267
•Concept ID:
C4015830
•
Finding
OMIM®: 107680

Professional guidelines

PubMed

Recombinant apolipoprotein A-IMilano for the treatment of cardiovascular diseases.
Calabresi L, Sirtori CR, Paoletti R, Franceschini G
Curr Atheroscler Rep 2006 Mar;8(2):163-7. doi: 10.1007/s11883-006-0054-4. PMID: 16510051

Recent clinical studies

Etiology

Microarray analysis identifies human apoA-I(Milano) and apoA-II as determinants of the liver gene expression related to lipid and energy metabolism.
Ganzetti GS, Parolini C
Exp Cell Res 2023 Dec 1;433(1):113826. Epub 2023 Oct 18 doi: 10.1016/j.yexcr.2023.113826. PMID: 37858836
Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials.
Kühnast S, Fiocco M, van der Hoorn JW, Princen HM, Jukema JW
Eur J Pharmacol 2015 Sep 15;763(Pt A):48-63. Epub 2015 May 16 doi: 10.1016/j.ejphar.2015.03.089. PMID: 25989133
ETC-216 for coronary artery disease.
Nicholls SJ, Uno K, Kataoka Y, Nissen SE
Expert Opin Biol Ther 2011 Mar;11(3):387-94. Epub 2011 Jan 28 doi: 10.1517/14712598.2011.557061. PMID: 21271950
Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model.
Parolini C, Chiesa G, Gong E, Caligari S, Cortese MM, Koga T, Forte TM, Rubin EM
Atherosclerosis 2005 Dec;183(2):222-9. Epub 2005 Apr 21 doi: 10.1016/j.atherosclerosis.2005.03.008. PMID: 16285990
Recombinant apolipoprotein A-I(Milano): a novel agent for the induction of regression of atherosclerotic plaques.
Chiesa G, Sirtori CR
Ann Med 2003;35(4):267-73. doi: 10.1080/07853890310005281. PMID: 12846269

Diagnosis

A unique protease-sensitive high density lipoprotein particle containing the apolipoprotein A-I(Milano) dimer effectively promotes ATP-binding Cassette A1-mediated cell cholesterol efflux.
Favari E, Gomaraschi M, Zanotti I, Bernini F, Lee-Rueckert M, Kovanen PT, Sirtori CR, Franceschini G, Calabresi L
J Biol Chem 2007 Feb 23;282(8):5125-32. Epub 2006 Dec 12 doi: 10.1074/jbc.M609336200. PMID: 17164237
A model structure for the heterodimer apoA-IMilano-apoA-II supports its peculiar susceptibility to proteolysis.
Rocco AG, Mollica L, Gianazza E, Calabresi L, Franceschini G, Sirtori CR, Eberini I
Biophys J 2006 Oct 15;91(8):3043-9. Epub 2006 Aug 4 doi: 10.1529/biophysj.106.085886. PMID: 16891368Free PMC Article
Limited proteolysis of a disulfide-linked apoA-I dimer in reconstituted HDL.
Calabresi L, Tedeschi G, Treu C, Ronchi S, Galbiati D, Airoldi S, Sirtori CR, Marcel Y, Franceschini G
J Lipid Res 2001 Jun;42(6):935-42. PMID: 11369801
Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study.
Sirtori CR, Calabresi L, Franceschini G, Baldassarre D, Amato M, Johansson J, Salvetti M, Monteduro C, Zulli R, Muiesan ML, Agabiti-Rosei E
Circulation 2001 Apr 17;103(15):1949-54. doi: 10.1161/01.cir.103.15.1949. PMID: 11306522
Cell cholesterol efflux to reconstituted high-density lipoproteins containing the apolipoprotein A-IMilano dimer.
Calabresi L, Canavesi M, Bernini F, Franceschini G
Biochemistry 1999 Dec 7;38(49):16307-14. doi: 10.1021/bi991246n. PMID: 10587455

Therapy

A Compendium of the Biological Effects of Apolipoprotein A-I(Milano).
Parolini C
J Pharmacol Exp Ther 2020 Jan;372(1):54-62. Epub 2019 Oct 24 doi: 10.1124/jpet.119.261719. PMID: 31649050
ETC-216 for coronary artery disease.
Nicholls SJ, Uno K, Kataoka Y, Nissen SE
Expert Opin Biol Ther 2011 Mar;11(3):387-94. Epub 2011 Jan 28 doi: 10.1517/14712598.2011.557061. PMID: 21271950
Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention.
Navab M, Anantharamaiah GM, Reddy ST, Fogelman AM
Nat Clin Pract Cardiovasc Med 2006 Oct;3(10):540-7. doi: 10.1038/ncpcardio0661. PMID: 16990839
Recombinant apolipoprotein A-I(Milano): a novel agent for the induction of regression of atherosclerotic plaques.
Chiesa G, Sirtori CR
Ann Med 2003;35(4):267-73. doi: 10.1080/07853890310005281. PMID: 12846269
Apolipoprotein A-I(Milano): current perspectives.
Chiesa G, Sirtori CR
Curr Opin Lipidol 2003 Apr;14(2):159-63. doi: 10.1097/00041433-200304000-00007. PMID: 12642784

Prognosis

Raising high-density lipoprotein cholesterol: innovative strategies against an old adversary.
Kazi D, Farmer JA
Curr Atheroscler Rep 2005 Mar;7(2):88-94. doi: 10.1007/s11883-005-0029-x. PMID: 15727722
Molecular characterization of native and recombinant apolipoprotein A-IMilano dimer. The introduction of an interchain disulfide bridge remarkably alters the physicochemical properties of apolipoprotein A-I.
Calabresi L, Vecchio G, Longhi R, Gianazza E, Palm G, Wadensten H, Hammarström A, Olsson A, Karlström A, Sejlitz T
J Biol Chem 1994 Dec 23;269(51):32168-74. PMID: 7798214

Clinical prediction guides

A Compendium of the Biological Effects of Apolipoprotein A-I(Milano).
Parolini C
J Pharmacol Exp Ther 2020 Jan;372(1):54-62. Epub 2019 Oct 24 doi: 10.1124/jpet.119.261719. PMID: 31649050
MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216.
Reijers JAA, Kallend DG, Malone KE, Jukema JW, Wijngaard PLJ, Burggraaf J, Moerland M
Cardiovasc Drugs Ther 2017 Aug;31(4):381-389. doi: 10.1007/s10557-017-6746-x. PMID: 28844118Free PMC Article
ApoA-I Milano/phospholipid complexes emerging pharmacological strategies and medications for the prevention of atherosclerotic plaque progression.
Kaul S, Shah PK
Curr Drug Targets Cardiovasc Haematol Disord 2005 Dec;5(6):471-9. doi: 10.2174/156800605774962004. PMID: 16503867
Apolipoprotein A-I and the molecular variant apoA-I(Milano): evaluation of the antiatherogenic effects in knock-in mouse model.
Parolini C, Chiesa G, Gong E, Caligari S, Cortese MM, Koga T, Forte TM, Rubin EM
Atherosclerosis 2005 Dec;183(2):222-9. Epub 2005 Apr 21 doi: 10.1016/j.atherosclerosis.2005.03.008. PMID: 16285990
Denaturation of apolipoprotein A-I and the monomer form of apolipoprotein A-I(Milano).
Suurkuusk M, Hallén D
Eur J Biochem 1999 Oct 1;265(1):346-52. doi: 10.1046/j.1432-1327.1999.00739.x. PMID: 10491191

Recent systematic reviews

Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising: A systematic review and meta-analysis of relevant preclinical studies and clinical trials.
Kühnast S, Fiocco M, van der Hoorn JW, Princen HM, Jukema JW
Eur J Pharmacol 2015 Sep 15;763(Pt A):48-63. Epub 2015 May 16 doi: 10.1016/j.ejphar.2015.03.089. PMID: 25989133

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