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Small cell carcinoma of the ovary, hypercalcemic type

MedGen UID:
862153
•Concept ID:
C4013716
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Small cell carcinoma of the ovary, hypercalcemic type

Professional guidelines

PubMed

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Rare non-epithelial ovarian neoplasms: Pathology, genetics and treatment.
Foulkes WD, Gore M, McCluggage WG
Gynecol Oncol 2016 Jul;142(1):190-198. Epub 2016 Apr 19 doi: 10.1016/j.ygyno.2016.04.005. PMID: 27079213

Recent clinical studies

Etiology

Small Cell Carcinoma of Ovary, Hypercalcemic Type: A Rare Case Report.
Coşkun Ç, Kurucu N, Usubutun A, Soyer T, Ozcan HN, Çelik Ertaş NB, Kutluk T
J Pediatr Adolesc Gynecol 2023 Apr;36(2):112-115. Epub 2022 Oct 12 doi: 10.1016/j.jpag.2022.10.004. PMID: 36243275
Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis.
Auguste A, Blanc-Durand F, Deloger M, Le Formal A, Bareja R, Wilkes DC, Richon C, Brunn B, Caron O, Devouassoux-Shisheboran M, Gouy S, Morice P, Bentivegna E, Sboner A, Elemento O, Rubin MA, Pautier P, Genestie C, Cyrta J, Leary A
Cells 2020 Jun 19;9(6) doi: 10.3390/cells9061496. PMID: 32575483Free PMC Article
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT).
Lang JD, Hendricks WPD
Methods Mol Biol 2018;1706:367-379. doi: 10.1007/978-1-4939-7471-9_20. PMID: 29423809
Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): A review of 47 cases.
Callegaro-Filho D, Gershenson DM, Nick AM, Munsell MF, Ramirez PT, Eifel PJ, Euscher ED, Marques RM, Nicolau SM, Schmeler KM
Gynecol Oncol 2016 Jan;140(1):53-7. Epub 2015 Nov 4 doi: 10.1016/j.ygyno.2015.11.004. PMID: 26546963Free PMC Article

Diagnosis

MR imaging diagnosis of small-cell carcinoma of the ovary, hypercalcemic type: A case report and literature review.
Li X, Liu Z, Chen J, Hao H, Fan D, Huang W
Medicine (Baltimore) 2024 Aug 9;103(32):e39226. doi: 10.1097/MD.0000000000039226. PMID: 39121266Free PMC Article
Case Report of Small Cell Carcinoma of the Ovary, Hypercalcemic Type (Ovarian Rhabdoid Tumor) with SMARCB1 Mutation: A Literature Review of a Rare and Aggressive Condition.
Simões MFE, da Costa AABA, Silva TN, Fernandes L, Bovolim G, Torrezan GT, Carraro DM, Baiocchi G, Menezes ANO, Santana Dos Santos E, De Brot L
Curr Oncol 2022 Jan 18;29(2):411-422. doi: 10.3390/curroncol29020037. PMID: 35200537Free PMC Article
Pembrolizumab-Induced Thyroiditis.
Imblum BA, Baloch ZW, Fraker D, LiVolsi VA
Endocr Pathol 2019 Jun;30(2):163-167. doi: 10.1007/s12022-019-9579-2. PMID: 31111437
Hereditary SWI/SNF complex deficiency syndromes.
Agaimy A, Foulkes WD
Semin Diagn Pathol 2018 May;35(3):193-198. Epub 2018 Feb 1 doi: 10.1053/j.semdp.2018.01.002. PMID: 29397238
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review.
Korivi BR, Javadi S, Faria S, Sagebiel T, Garg N, Patnana M, Prasad SR
Curr Probl Diagn Radiol 2018 Sep;47(5):333-339. Epub 2017 Sep 1 doi: 10.1067/j.cpradiol.2017.08.004. PMID: 28943050

Therapy

Clinical characteristics and status of treatment of small-cell carcinoma of the ovary, hypercalcemic type in the Chinese population: a meta-analysis.
Zheng K, Gao Y, Xu C, Kang Y
J Gynecol Oncol 2024 Jul;35(4):e96. Epub 2024 Apr 17 doi: 10.3802/jgo.2024.35.e96. PMID: 38710530Free PMC Article
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Pembrolizumab-Induced Thyroiditis.
Imblum BA, Baloch ZW, Fraker D, LiVolsi VA
Endocr Pathol 2019 Jun;30(2):163-167. doi: 10.1007/s12022-019-9579-2. PMID: 31111437
SWI/SNF Complexes in Ovarian Cancer: Mechanistic Insights and Therapeutic Implications.
Fukumoto T, Magno E, Zhang R
Mol Cancer Res 2018 Dec;16(12):1819-1825. Epub 2018 Jul 23 doi: 10.1158/1541-7786.MCR-18-0368. PMID: 30037854Free PMC Article
Refractory Small Cell Carcinoma of the Ovary - Hypercalcemic Type (SCCOHT) Treated with Romidepsin and Topotecan: A Case Report and Review of the Literature.
Rao V, Bauer F, Vredenburgh JJ
Conn Med 2016 Oct;80(9):529-532. PMID: 29772136

Prognosis

Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis.
Auguste A, Blanc-Durand F, Deloger M, Le Formal A, Bareja R, Wilkes DC, Richon C, Brunn B, Caron O, Devouassoux-Shisheboran M, Gouy S, Morice P, Bentivegna E, Sboner A, Elemento O, Rubin MA, Pautier P, Genestie C, Cyrta J, Leary A
Cells 2020 Jun 19;9(6) doi: 10.3390/cells9061496. PMID: 32575483Free PMC Article
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Tischkowitz M, Huang S, Banerjee S, Hague J, Hendricks WPD, Huntsman DG, Lang JD, Orlando KA, Oza AM, Pautier P, Ray-Coquard I, Trent JM, Witcher M, Witkowski L, McCluggage WG, Levine DA, Foulkes WD, Weissman BE
Clin Cancer Res 2020 Aug 1;26(15):3908-3917. Epub 2020 Mar 10 doi: 10.1158/1078-0432.CCR-19-3797. PMID: 32156746Free PMC Article
Hereditary SWI/SNF complex deficiency syndromes.
Agaimy A, Foulkes WD
Semin Diagn Pathol 2018 May;35(3):193-198. Epub 2018 Feb 1 doi: 10.1053/j.semdp.2018.01.002. PMID: 29397238
Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Clinical and Imaging Review.
Korivi BR, Javadi S, Faria S, Sagebiel T, Garg N, Patnana M, Prasad SR
Curr Probl Diagn Radiol 2018 Sep;47(5):333-339. Epub 2017 Sep 1 doi: 10.1067/j.cpradiol.2017.08.004. PMID: 28943050
Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): A review of 47 cases.
Callegaro-Filho D, Gershenson DM, Nick AM, Munsell MF, Ramirez PT, Eifel PJ, Euscher ED, Marques RM, Nicolau SM, Schmeler KM
Gynecol Oncol 2016 Jan;140(1):53-7. Epub 2015 Nov 4 doi: 10.1016/j.ygyno.2015.11.004. PMID: 26546963Free PMC Article

Clinical prediction guides

Clinical characteristics and status of treatment of small-cell carcinoma of the ovary, hypercalcemic type in the Chinese population: a meta-analysis.
Zheng K, Gao Y, Xu C, Kang Y
J Gynecol Oncol 2024 Jul;35(4):e96. Epub 2024 Apr 17 doi: 10.3802/jgo.2024.35.e96. PMID: 38710530Free PMC Article
Histologic and genomic features of breast cancers with alterations affecting the SWI/SNF (SMARC) genes.
Schwartz CJ, Pareja F, da Silva EM, Selenica P, Ross DS, Weigelt B, Brogi E, Reis-Filho JS, Wen HY
Mod Pathol 2021 Oct;34(10):1850-1859. Epub 2021 Jun 2 doi: 10.1038/s41379-021-00837-3. PMID: 34079072Free PMC Article
Hereditary SWI/SNF complex deficiency syndromes.
Agaimy A, Foulkes WD
Semin Diagn Pathol 2018 May;35(3):193-198. Epub 2018 Feb 1 doi: 10.1053/j.semdp.2018.01.002. PMID: 29397238
Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.
Fahiminiya S, Witkowski L, Nadaf J, Carrot-Zhang J, Goudie C, Hasselblatt M, Johann P, Kool M, Lee RS, Gayden T, Roberts CW, Biegel JA, Jabado N, Majewski J, Foulkes WD
Oncotarget 2016 Jan 12;7(2):1732-40. doi: 10.18632/oncotarget.6459. PMID: 26646792Free PMC Article
Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type.
Conlon N, Silva A, Guerra E, Jelinic P, Schlappe BA, Olvera N, Mueller JJ, Tornos C, Jungbluth AA, Young RH, Oliva E, Levine D, Soslow RA
Am J Surg Pathol 2016 Mar;40(3):395-403. doi: 10.1097/PAS.0000000000000558. PMID: 26645725Free PMC Article

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