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Childhood Pilomyxoid Astrocytoma

MedGen UID:
859240
•Concept ID:
C3899646
•
Neoplastic Process

Definition

A pilomyxoid astrocytoma that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Pilomyxoid Astrocytoma

Recent clinical studies

Etiology

Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study.
Grønbæk JK, Wibroe M, Toescu S, Frič R, Thomsen BL, Møller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R; CMS study group
Lancet Child Adolesc Health 2021 Nov;5(11):814-824. Epub 2021 Oct 6 doi: 10.1016/S2352-4642(21)00274-1. PMID: 34624241
Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults.
Shoji T, Kanamori M, Saito R, Watanabe Y, Watanabe M, Fujimura M, Ogawa Y, Sonoda Y, Kumabe T, Kure S, Tominaga T
Neurol Med Chir (Tokyo) 2020 Jun 15;60(6):277-285. Epub 2020 May 14 doi: 10.2176/nmc.oa.2019-0208. PMID: 32404575Free PMC Article
Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas.
Snuderl M, Zhang G, Wu P, Jennings TS, Shroff S, Ortenzi V, Jain R, Cohen B, Reidy JJ, Dushay MS, Wisoff JH, Harter DH, Karajannis MA, Fenyo D, Neubert TA, Zagzag D
Am J Pathol 2017 Aug;187(8):1867-1878. Epub 2017 Jun 9 doi: 10.1016/j.ajpath.2017.04.004. PMID: 28606795Free PMC Article
Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution.
Colin C, Padovani L, Chappé C, Mercurio S, Scavarda D, Loundou A, Frassineti F, André N, Bouvier C, Korshunov A, Lena G, Figarella-Branger D
Neuropathol Appl Neurobiol 2013 Oct;39(6):693-705. doi: 10.1111/nan.12013. PMID: 23278243
Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings.
Nakamura OK, Pinho Mda C, Odone Filho V, Rosemberg S
Einstein (Sao Paulo) 2012 Apr-Jun;10(2):236-8. doi: 10.1590/s1679-45082012000200020. PMID: 23052462

Diagnosis

Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults.
Shoji T, Kanamori M, Saito R, Watanabe Y, Watanabe M, Fujimura M, Ogawa Y, Sonoda Y, Kumabe T, Kure S, Tominaga T
Neurol Med Chir (Tokyo) 2020 Jun 15;60(6):277-285. Epub 2020 May 14 doi: 10.2176/nmc.oa.2019-0208. PMID: 32404575Free PMC Article
Temporal lobe angiocentric glioma with oligodendroglioma-like areas: a rare association of an uncommon tumor. A case report with review of literature.
Gupta S, Rangari KV, Mehrotra A, Pal L, Jaisawal AK, Kumar R
Childs Nerv Syst 2020 Mar;36(3):641-646. Epub 2020 Jan 2 doi: 10.1007/s00381-019-04445-0. PMID: 31897632
Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings.
Nakamura OK, Pinho Mda C, Odone Filho V, Rosemberg S
Einstein (Sao Paulo) 2012 Apr-Jun;10(2):236-8. doi: 10.1590/s1679-45082012000200020. PMID: 23052462
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma.
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174

Therapy

Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study.
Grønbæk JK, Wibroe M, Toescu S, Frič R, Thomsen BL, Møller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R; CMS study group
Lancet Child Adolesc Health 2021 Nov;5(11):814-824. Epub 2021 Oct 6 doi: 10.1016/S2352-4642(21)00274-1. PMID: 34624241
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma.
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174

Prognosis

Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study.
Grønbæk JK, Wibroe M, Toescu S, Frič R, Thomsen BL, Møller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R; CMS study group
Lancet Child Adolesc Health 2021 Nov;5(11):814-824. Epub 2021 Oct 6 doi: 10.1016/S2352-4642(21)00274-1. PMID: 34624241
Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults.
Shoji T, Kanamori M, Saito R, Watanabe Y, Watanabe M, Fujimura M, Ogawa Y, Sonoda Y, Kumabe T, Kure S, Tominaga T
Neurol Med Chir (Tokyo) 2020 Jun 15;60(6):277-285. Epub 2020 May 14 doi: 10.2176/nmc.oa.2019-0208. PMID: 32404575Free PMC Article
Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors.
Bozkurt SU, Dagcinar A, Tanrikulu B, Comunoglu N, Meydan BC, Ozek M, Oz B
Childs Nerv Syst 2018 Jan;34(1):107-116. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3633-5. PMID: 29063957
Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution.
Colin C, Padovani L, Chappé C, Mercurio S, Scavarda D, Loundou A, Frassineti F, André N, Bouvier C, Korshunov A, Lena G, Figarella-Branger D
Neuropathol Appl Neurobiol 2013 Oct;39(6):693-705. doi: 10.1111/nan.12013. PMID: 23278243
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma.
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174

Clinical prediction guides

Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study.
Grønbæk JK, Wibroe M, Toescu S, Frič R, Thomsen BL, Møller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R; CMS study group
Lancet Child Adolesc Health 2021 Nov;5(11):814-824. Epub 2021 Oct 6 doi: 10.1016/S2352-4642(21)00274-1. PMID: 34624241
Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors.
Bozkurt SU, Dagcinar A, Tanrikulu B, Comunoglu N, Meydan BC, Ozek M, Oz B
Childs Nerv Syst 2018 Jan;34(1):107-116. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3633-5. PMID: 29063957
A Case Series Characterizing Pilomyxoid Astrocytomas in Childhood.
Rosenfeld A, Etzl M, Lee D, Miller J, Carpenteri D, Shafron D, Kaplan A
J Pediatr Hematol Oncol 2016 Mar;38(2):e63-6. doi: 10.1097/MPH.0000000000000457. PMID: 26886222
Outcome analysis of childhood pilocytic astrocytomas: a retrospective study of 148 cases at a single institution.
Colin C, Padovani L, Chappé C, Mercurio S, Scavarda D, Loundou A, Frassineti F, André N, Bouvier C, Korshunov A, Lena G, Figarella-Branger D
Neuropathol Appl Neurobiol 2013 Oct;39(6):693-705. doi: 10.1111/nan.12013. PMID: 23278243

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