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Malignant Bowel Obstruction

MedGen UID:
1646288
•Concept ID:
C3888580
•
Anatomical Abnormality

Definition

Obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Bowel Obstruction

Professional guidelines

PubMed

Comprehensive Diagnosis and Management of Malignant Bowel Obstruction: A Review.
Demarest K, Lavu H, Collins E, Batra V
J Pain Palliat Care Pharmacother 2023 Mar;37(1):91-105. Epub 2022 Nov 15 doi: 10.1080/15360288.2022.2106012. PMID: 36377820
MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663

Recent clinical studies

Etiology

Surgical versus non-surgical management for patients with malignant bowel obstruction (S1316): a pragmatic comparative effectiveness trial.
Krouse RS, Anderson GL, Arnold KB, Thomson CA, Nfonsam VN, Al-Kasspooles MF, Walker JL, Sun V, Alvarez Secord A, Han ES, Leon-Takahashi AM, Isla-Ortiz D, Rodgers P, Hendren S, Sanchez Salcedo M, Laryea JA, Graybill WS, Flaherty DC, Mogal H, Miner TJ, Pimiento JM, Kitano M, Badgwell B, Whalen G, Lamont JP, Guevara OA, Senthil MS, Dewdney SB, Silberfein E, Wright JD, Friday B, Fahy B, Anantha Sathyanarayana S, O'Rourke M, Bakitas M, Sloan J, Grant M, Deutsch GB, Deneve JL
Lancet Gastroenterol Hepatol 2023 Oct;8(10):908-918. Epub 2023 Aug 1 doi: 10.1016/S2468-1253(23)00191-7. PMID: 37541263Free PMC Article
MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Malignant Bowel Obstruction Management Over Time: Are We Doing Anything New? A Current Narrative Review.
Shariff F, Bogach J, Guidolin K, Nadler A
Ann Surg Oncol 2022 Mar;29(3):1995-2005. Epub 2021 Oct 18 doi: 10.1245/s10434-021-10922-1. PMID: 34664143
A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663
Octreotide-Associated Neutropenia.
Tse SS, Kish T
Pharmacotherapy 2017 Jun;37(6):e32-e37. doi: 10.1002/phar.1942. PMID: 28488730

Diagnosis

Comprehensive Diagnosis and Management of Malignant Bowel Obstruction: A Review.
Demarest K, Lavu H, Collins E, Batra V
J Pain Palliat Care Pharmacother 2023 Mar;37(1):91-105. Epub 2022 Nov 15 doi: 10.1080/15360288.2022.2106012. PMID: 36377820
Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?
Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, Kim JY, Fong Y
Curr Probl Surg 2018 Sep;55(9):330-379. Epub 2018 Oct 4 doi: 10.1067/j.cpsurg.2018.08.004. PMID: 30526930Free PMC Article
Oral water soluble contrast for malignant bowel obstruction.
Syrmis W, Richard R, Jenkins-Marsh S, Chia SC, Good P
Cochrane Database Syst Rev 2018 Mar 7;3(3):CD012014. doi: 10.1002/14651858.CD012014.pub2. PMID: 29513393Free PMC Article
Octreotide-Associated Neutropenia.
Tse SS, Kish T
Pharmacotherapy 2017 Jun;37(6):e32-e37. doi: 10.1002/phar.1942. PMID: 28488730
Bowel obstruction and peritoneal carcinomatosis in the elderly. A systematic review.
Santangelo ML, Grifasi C, Criscitiello C, Giuliano M, Calogero A, Dodaro C, Incollingo P, Rupealta N, Candida M, Chiacchio G, Riccio E, Pisani A, Tammaro V, Carlomagno N
Aging Clin Exp Res 2017 Feb;29(Suppl 1):73-78. Epub 2016 Nov 11 doi: 10.1007/s40520-016-0656-9. PMID: 27837464

Therapy

Surgical versus non-surgical management for patients with malignant bowel obstruction (S1316): a pragmatic comparative effectiveness trial.
Krouse RS, Anderson GL, Arnold KB, Thomson CA, Nfonsam VN, Al-Kasspooles MF, Walker JL, Sun V, Alvarez Secord A, Han ES, Leon-Takahashi AM, Isla-Ortiz D, Rodgers P, Hendren S, Sanchez Salcedo M, Laryea JA, Graybill WS, Flaherty DC, Mogal H, Miner TJ, Pimiento JM, Kitano M, Badgwell B, Whalen G, Lamont JP, Guevara OA, Senthil MS, Dewdney SB, Silberfein E, Wright JD, Friday B, Fahy B, Anantha Sathyanarayana S, O'Rourke M, Bakitas M, Sloan J, Grant M, Deutsch GB, Deneve JL
Lancet Gastroenterol Hepatol 2023 Oct;8(10):908-918. Epub 2023 Aug 1 doi: 10.1016/S2468-1253(23)00191-7. PMID: 37541263Free PMC Article
When Should the Appropriateness of PEG be Questioned?
Roche KF, Bower KL, Collier B, Neel D, Esry L
Curr Gastroenterol Rep 2023 Jan;25(1):13-19. Epub 2022 Dec 8 doi: 10.1007/s11894-022-00857-2. PMID: 36480136
Medical management of malignant bowel obstruction in patients with advanced cancer: 2021 MASCC guideline update.
Davis M, Hui D, Davies A, Ripamonti C, Capela A, DeFeo G, Del Fabbro E, Bruera E
Support Care Cancer 2021 Dec;29(12):8089-8096. Epub 2021 Aug 14 doi: 10.1007/s00520-021-06438-9. PMID: 34390398
Medical Management of Inoperable Malignant Bowel Obstruction.
Huang X, Xue J, Gao M, Qin Q, Ma T, Li X, Wang H
Ann Pharmacother 2021 Sep;55(9):1134-1145. Epub 2020 Dec 21 doi: 10.1177/1060028020979773. PMID: 33345552
Octreotide-Associated Neutropenia.
Tse SS, Kish T
Pharmacotherapy 2017 Jun;37(6):e32-e37. doi: 10.1002/phar.1942. PMID: 28488730

Prognosis

Surgical versus non-surgical management for patients with malignant bowel obstruction (S1316): a pragmatic comparative effectiveness trial.
Krouse RS, Anderson GL, Arnold KB, Thomson CA, Nfonsam VN, Al-Kasspooles MF, Walker JL, Sun V, Alvarez Secord A, Han ES, Leon-Takahashi AM, Isla-Ortiz D, Rodgers P, Hendren S, Sanchez Salcedo M, Laryea JA, Graybill WS, Flaherty DC, Mogal H, Miner TJ, Pimiento JM, Kitano M, Badgwell B, Whalen G, Lamont JP, Guevara OA, Senthil MS, Dewdney SB, Silberfein E, Wright JD, Friday B, Fahy B, Anantha Sathyanarayana S, O'Rourke M, Bakitas M, Sloan J, Grant M, Deutsch GB, Deneve JL
Lancet Gastroenterol Hepatol 2023 Oct;8(10):908-918. Epub 2023 Aug 1 doi: 10.1016/S2468-1253(23)00191-7. PMID: 37541263Free PMC Article
Comprehensive Diagnosis and Management of Malignant Bowel Obstruction: A Review.
Demarest K, Lavu H, Collins E, Batra V
J Pain Palliat Care Pharmacother 2023 Mar;37(1):91-105. Epub 2022 Nov 15 doi: 10.1080/15360288.2022.2106012. PMID: 36377820
MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Malignant Bowel Obstruction Management Over Time: Are We Doing Anything New? A Current Narrative Review.
Shariff F, Bogach J, Guidolin K, Nadler A
Ann Surg Oncol 2022 Mar;29(3):1995-2005. Epub 2021 Oct 18 doi: 10.1245/s10434-021-10922-1. PMID: 34664143
Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?
Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, Kim JY, Fong Y
Curr Probl Surg 2018 Sep;55(9):330-379. Epub 2018 Oct 4 doi: 10.1067/j.cpsurg.2018.08.004. PMID: 30526930Free PMC Article

Clinical prediction guides

Surgical versus non-surgical management for patients with malignant bowel obstruction (S1316): a pragmatic comparative effectiveness trial.
Krouse RS, Anderson GL, Arnold KB, Thomson CA, Nfonsam VN, Al-Kasspooles MF, Walker JL, Sun V, Alvarez Secord A, Han ES, Leon-Takahashi AM, Isla-Ortiz D, Rodgers P, Hendren S, Sanchez Salcedo M, Laryea JA, Graybill WS, Flaherty DC, Mogal H, Miner TJ, Pimiento JM, Kitano M, Badgwell B, Whalen G, Lamont JP, Guevara OA, Senthil MS, Dewdney SB, Silberfein E, Wright JD, Friday B, Fahy B, Anantha Sathyanarayana S, O'Rourke M, Bakitas M, Sloan J, Grant M, Deutsch GB, Deneve JL
Lancet Gastroenterol Hepatol 2023 Oct;8(10):908-918. Epub 2023 Aug 1 doi: 10.1016/S2468-1253(23)00191-7. PMID: 37541263Free PMC Article
Medical Management of Inoperable Malignant Bowel Obstruction.
Huang X, Xue J, Gao M, Qin Q, Ma T, Li X, Wang H
Ann Pharmacother 2021 Sep;55(9):1134-1145. Epub 2020 Dec 21 doi: 10.1177/1060028020979773. PMID: 33345552
Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?
Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, Kim JY, Fong Y
Curr Probl Surg 2018 Sep;55(9):330-379. Epub 2018 Oct 4 doi: 10.1067/j.cpsurg.2018.08.004. PMID: 30526930Free PMC Article
Oral water soluble contrast for malignant bowel obstruction.
Syrmis W, Richard R, Jenkins-Marsh S, Chia SC, Good P
Cochrane Database Syst Rev 2018 Mar 7;3(3):CD012014. doi: 10.1002/14651858.CD012014.pub2. PMID: 29513393Free PMC Article
Octreotide-Associated Neutropenia.
Tse SS, Kish T
Pharmacotherapy 2017 Jun;37(6):e32-e37. doi: 10.1002/phar.1942. PMID: 28488730

Recent systematic reviews

MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
Home parenteral nutrition for people with inoperable malignant bowel obstruction.
Sowerbutts AM, Lal S, Sremanakova J, Clamp A, Todd C, Jayson GC, Teubner A, Raftery AM, Sutton EJ, Hardy L, Burden S
Cochrane Database Syst Rev 2018 Aug 10;8(8):CD012812. doi: 10.1002/14651858.CD012812.pub2. PMID: 30095168Free PMC Article
Oral water soluble contrast for malignant bowel obstruction.
Syrmis W, Richard R, Jenkins-Marsh S, Chia SC, Good P
Cochrane Database Syst Rev 2018 Mar 7;3(3):CD012014. doi: 10.1002/14651858.CD012014.pub2. PMID: 29513393Free PMC Article
Bowel obstruction and peritoneal carcinomatosis in the elderly. A systematic review.
Santangelo ML, Grifasi C, Criscitiello C, Giuliano M, Calogero A, Dodaro C, Incollingo P, Rupealta N, Candida M, Chiacchio G, Riccio E, Pisani A, Tammaro V, Carlomagno N
Aging Clin Exp Res 2017 Feb;29(Suppl 1):73-78. Epub 2016 Nov 11 doi: 10.1007/s40520-016-0656-9. PMID: 27837464
Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review.
Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML
JAMA Surg 2014 Apr;149(4):383-92. doi: 10.1001/jamasurg.2013.4059. PMID: 24477929Free PMC Article

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