U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Autoimmune uveitis

MedGen UID:
1843501
•Concept ID:
C3888523
•
Disease or Syndrome
Synonyms: autoimmune uveitis; autoimmune uveitis (disease)
 
Monarch Initiative: MONDO:0031012

Definition

An autoimmune form of uveitis (disease). [from MONDO]

Professional guidelines

PubMed

SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis.
Pandey R, Bakay M, Hakonarson H
Front Immunol 2023;14:1271102. Epub 2023 Oct 26 doi: 10.3389/fimmu.2023.1271102. PMID: 38022642Free PMC Article
Cyclosporine: A Historical Perspective on Its Role in the Treatment of Noninfectious Uveitis.
Smith WM
J Ocul Pharmacol Ther 2017 May;33(4):247-262. Epub 2017 Mar 13 doi: 10.1089/jop.2016.0155. PMID: 28287852
A Review of the Course and Treatment of Non-Infectious Uveitis during Pregnancy.
Grotting LA, Papaliodis GN
Semin Ophthalmol 2017;32(1):75-81. Epub 2016 Nov 2 doi: 10.1080/08820538.2016.1228402. PMID: 27805464

Recent clinical studies

Etiology

Sleep loss potentiates Th17-cell pathogenicity and promotes autoimmune uveitis.
Liu X, Su Y, Huang Z, Lv J, Gu C, Li Z, Tao T, Liu Y, Jiang Q, Duan R, Chen B, Ju R, Wang X, Zheng Y, Su W
Clin Transl Med 2023 May;13(5):e1250. doi: 10.1002/ctm2.1250. PMID: 37132178Free PMC Article
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Tolerance Induction in Relation to the Eye.
Gery I, Caspi RR
Front Immunol 2018;9:2304. Epub 2018 Oct 9 doi: 10.3389/fimmu.2018.02304. PMID: 30356688Free PMC Article
The Role of αA-Crystallin in Experimental Autoimmune Uveitis.
Wang L, Zhang L, Wang ZF, Huang ZX, Hu X, Gong L, Tang X, Liu F, Luo Z, Ji W, Hu WF, Woodward Z, Zhu J, Liu YZ, Nguyen QD, Li DW
Curr Mol Med 2015;15(6):558-64. doi: 10.2174/1566524015666150731101146. PMID: 26238368
Rat models of autoimmune uveitis.
Wildner G, Diedrichs-Mohring M, Thurau SR
Ophthalmic Res 2008;40(3-4):141-4. Epub 2008 Apr 18 doi: 10.1159/000119865. PMID: 18421228

Diagnosis

COVID-19 Developed During Systemic Steroid Therapy for Vogt-Koyanagi-Harada Disease: A Case Report.
Niidome S, Usui Y, Tsubota K, Sugawara R, Goto H
Ocul Immunol Inflamm 2023 Aug;31(6):1305-1309. Epub 2023 Apr 21 doi: 10.1080/09273948.2023.2200488. PMID: 37084286
Assessment of the Anti-inflammatory Effects of NORFLO® ORO in Acute Relapses of HLA-B27-associated Autoimmune Uveitis: A Multicenter, Randomized, Placebo-controlled, Double-blind Clinical Study.
Allegri P, Cimino L, Davis JL, Tugal-Tutkun I; Norflo Oro study group
Ocul Immunol Inflamm 2023 Apr;31(3):526-535. Epub 2022 Mar 30 doi: 10.1080/09273948.2022.2039210. PMID: 35353651
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Checkpoint inhibitor-induced uveitis: a case series.
Conrady CD, Larochelle M, Pecen P, Palestine A, Shakoor A, Singh A
Graefes Arch Clin Exp Ophthalmol 2018 Jan;256(1):187-191. Epub 2017 Oct 27 doi: 10.1007/s00417-017-3835-2. PMID: 29080102
Identification of Hnrph3 as an autoantigen for acute anterior uveitis.
Kim Y, Caberoy NB, Alvarado G, Davis JL, Feuer WJ, Li W
Clin Immunol 2011 Jan;138(1):60-6. Epub 2010 Oct 12 doi: 10.1016/j.clim.2010.09.008. PMID: 20943442Free PMC Article

Therapy

Checkpoint inhibitor-induced uveitis: a case series.
Conrady CD, Larochelle M, Pecen P, Palestine A, Shakoor A, Singh A
Graefes Arch Clin Exp Ophthalmol 2018 Jan;256(1):187-191. Epub 2017 Oct 27 doi: 10.1007/s00417-017-3835-2. PMID: 29080102
Biologic agents in experimental autoimmune uveitis.
Giuliari GP, Sadaka A, Hinkle DM
Int Ophthalmol 2014 Feb;34(1):145-56. Epub 2013 Mar 14 doi: 10.1007/s10792-013-9756-0. PMID: 23494482
Rat models of autoimmune uveitis.
Wildner G, Diedrichs-Mohring M, Thurau SR
Ophthalmic Res 2008;40(3-4):141-4. Epub 2008 Apr 18 doi: 10.1159/000119865. PMID: 18421228
Cyclosporine A delivery to the eye: a pharmaceutical challenge.
Lallemand F, Felt-Baeyens O, Besseghir K, Behar-Cohen F, Gurny R
Eur J Pharm Biopharm 2003 Nov;56(3):307-18. doi: 10.1016/s0939-6411(03)00138-3. PMID: 14602172
Treatment of autoimmune uveitis.
Whitcup SM, Nussenblatt RB
Ann N Y Acad Sci 1993 Nov 30;696:307-18. doi: 10.1111/j.1749-6632.1993.tb17166.x. PMID: 8109836

Prognosis

Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease.
Ye Z, Wu C, Zhang N, Du L, Cao Q, Huang X, Tang J, Wang Q, Li F, Zhou C, Xu Q, Xiong X, Kijlstra A, Qin N, Yang P
Gut Microbes 2020 May 3;11(3):539-555. Epub 2020 Jan 13 doi: 10.1080/19490976.2019.1700754. PMID: 31928124Free PMC Article
Current developments in pediatric systemic sclerosis.
Foeldvari I
Curr Rheumatol Rep 2009 Apr;11(2):97-102. doi: 10.1007/s11926-009-0014-4. PMID: 19296881
Rat models of autoimmune uveitis.
Wildner G, Diedrichs-Mohring M, Thurau SR
Ophthalmic Res 2008;40(3-4):141-4. Epub 2008 Apr 18 doi: 10.1159/000119865. PMID: 18421228
Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis.
Yoshimura T, Sonoda KH, Miyazaki Y, Iwakura Y, Ishibashi T, Yoshimura A, Yoshida H
Int Immunol 2008 Feb;20(2):209-14. Epub 2007 Dec 21 doi: 10.1093/intimm/dxm135. PMID: 18156624
S-antigen: preparation and characterization of site-specific monoclonal antibodies.
Donoso LA, Gregerson DS, Smith L, Robertson S, Knospe V, Vrabec T, Kalsow CM
Curr Eye Res 1990 Apr;9(4):343-55. doi: 10.3109/02713689008999622. PMID: 1692780

Clinical prediction guides

Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis: Insights From Single-Cell Analysis.
Huang Z, Jiang Q, Chen J, Liu X, Gu C, Tao T, Lv J, Li Z, Li Z, Su W
Invest Ophthalmol Vis Sci 2023 Sep 1;64(12):28. doi: 10.1167/iovs.64.12.28. PMID: 37713206Free PMC Article
Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease.
Ye Z, Wu C, Zhang N, Du L, Cao Q, Huang X, Tang J, Wang Q, Li F, Zhou C, Xu Q, Xiong X, Kijlstra A, Qin N, Yang P
Gut Microbes 2020 May 3;11(3):539-555. Epub 2020 Jan 13 doi: 10.1080/19490976.2019.1700754. PMID: 31928124Free PMC Article
PD-1(+) melanocortin receptor dependent-Treg cells prevent autoimmune disease.
Muhammad F, Wang D, Montieth A, Lee S, Preble J, Foster CS, Larson TA, Ding K, Dvorak JD, Lee DJ
Sci Rep 2019 Nov 15;9(1):16941. doi: 10.1038/s41598-019-53297-w. PMID: 31729418Free PMC Article
Resolution of uveitis.
Wildner G, Diedrichs-Möhring M
Semin Immunopathol 2019 Nov;41(6):727-736. Epub 2019 Oct 7 doi: 10.1007/s00281-019-00758-z. PMID: 31591678
Renal tubular function in cyclosporine-treated patients.
Palestine AG, Austin HA 3rd, Nussenblatt RB
Am J Med 1986 Sep;81(3):419-24. doi: 10.1016/0002-9343(86)90292-5. PMID: 3752142

Recent systematic reviews

Systematic review of studies comparing infliximab and adalimumab in autoimmune uveitis.
Mase O, Qasem M, Beare N
BMJ Open Ophthalmol 2023 Jun;8(1) Epub 2023 Jun 14 doi: 10.1136/bmjophth-2023-001303. PMID: 37493653Free PMC Article
Microbiome and Behçet's disease: a systematic review.
Joubert M, André M, Barnich N, Billard E
Clin Exp Rheumatol 2023 Oct;41(10):2093-2104. Epub 2023 Jun 7 doi: 10.55563/clinexprheumatol/zbt4gx. PMID: 37382445
Systematic review on the effectiveness of immunosuppressants and biological therapies in the treatment of autoimmune posterior uveitis.
Pato E, Muñoz-Fernández S, Francisco F, Abad MA, Maese J, Ortiz A, Carmona L; Uveitis Working Group from Spanish Society of Rheumatology
Semin Arthritis Rheum 2011 Feb;40(4):314-23. Epub 2010 Jul 24 doi: 10.1016/j.semarthrit.2010.05.008. PMID: 20656330

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...