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Multiple sclerosis, susceptibility to 1(MS1)

MedGen UID:
854774
•Concept ID:
C3888106
•
Finding
Synonym: Multiple sclerosis susceptibility 1
 
Monarch Initiative: MONDO:0021571
OMIM®: 126200; 142857

Professional guidelines

PubMed

Multilocus evaluation of genetic predictors of multiple sclerosis.
Timasheva Y, Nasibullin TR, Tuktarova IA, Erdman VV, Galiullin TR, Zaplakhova OV, Bakhtiiarova KZ
Gene 2022 Jan 30;809:146008. Epub 2021 Oct 14 doi: 10.1016/j.gene.2021.146008. PMID: 34656742
Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment.
Mizuguchi M, Ohsawa M, Kashii H, Sato A
Int J Mol Sci 2021 Jun 22;22(13) doi: 10.3390/ijms22136677. PMID: 34206526Free PMC Article
Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States.
Au KS, Williams AT, Roach ES, Batchelor L, Sparagana SP, Delgado MR, Wheless JW, Baumgartner JE, Roa BB, Wilson CM, Smith-Knuppel TK, Cheung MY, Whittemore VH, King TM, Northrup H
Genet Med 2007 Feb;9(2):88-100. doi: 10.1097/gim.0b013e31803068c7. PMID: 17304050

Curated

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Therapy

Vitamin D: immune function, inflammation, infections and auto-immunity.
Johnson CR, Thacher TD
Paediatr Int Child Health 2023 Nov;43(4):29-39. Epub 2023 Mar 1 doi: 10.1080/20469047.2023.2171759. PMID: 36857810
Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice: A Scoping Review.
Louis S, Carlson AK, Suresh A, Rim J, Mays M, Ontaneda D, Dhawan A
Neurology 2023 Mar 7;100(10):474-483. Epub 2022 Nov 16 doi: 10.1212/WNL.0000000000201630. PMID: 36384657Free PMC Article
The Effect of Peripheral Immune Cell Counts on the Risk of Multiple Sclerosis: A Mendelian Randomization Study.
He D, Liu L, Shen D, Zou P, Cui L
Front Immunol 2022;13:867693. Epub 2022 May 10 doi: 10.3389/fimmu.2022.867693. PMID: 35619713Free PMC Article
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases.
Yang Y, Musco H, Simpson-Yap S, Zhu Z, Wang Y, Lin X, Zhang J, Taylor B, Gratten J, Zhou Y
Nat Commun 2021 Sep 24;12(1):5641. doi: 10.1038/s41467-021-25768-0. PMID: 34561436Free PMC Article
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.
Olsson T, Barcellos LF, Alfredsson L
Nat Rev Neurol 2017 Jan;13(1):25-36. Epub 2016 Dec 9 doi: 10.1038/nrneurol.2016.187. PMID: 27934854

Prognosis

Multiple sclerosis progression: time for a new mechanism-driven framework.
Kuhlmann T, Moccia M, Coetzee T, Cohen JA, Correale J, Graves J, Marrie RA, Montalban X, Yong VW, Thompson AJ, Reich DS; International Advisory Committee on Clinical Trials in Multiple Sclerosis
Lancet Neurol 2023 Jan;22(1):78-88. Epub 2022 Nov 18 doi: 10.1016/S1474-4422(22)00289-7. PMID: 36410373Free PMC Article
Preclinical Autoimmune Disease: a Comparison of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Multiple Sclerosis and Type 1 Diabetes.
Frazzei G, van Vollenhoven RF, de Jong BA, Siegelaar SE, van Schaardenburg D
Front Immunol 2022;13:899372. Epub 2022 Jun 30 doi: 10.3389/fimmu.2022.899372. PMID: 35844538Free PMC Article
The Effect of Peripheral Immune Cell Counts on the Risk of Multiple Sclerosis: A Mendelian Randomization Study.
He D, Liu L, Shen D, Zou P, Cui L
Front Immunol 2022;13:867693. Epub 2022 May 10 doi: 10.3389/fimmu.2022.867693. PMID: 35619713Free PMC Article
Gut Microbiota Composition Is Related to AD Pathology.
Verhaar BJH, Hendriksen HMA, de Leeuw FA, Doorduijn AS, van Leeuwenstijn M, Teunissen CE, Barkhof F, Scheltens P, Kraaij R, van Duijn CM, Nieuwdorp M, Muller M, van der Flier WM
Front Immunol 2021;12:794519. Epub 2022 Jan 31 doi: 10.3389/fimmu.2021.794519. PMID: 35173707Free PMC Article
Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.
Mennuni S, Rubattu S, Pierelli G, Tocci G, Fofi C, Volpe M
J Hum Hypertens 2014 Feb;28(2):74-9. Epub 2013 Jun 27 doi: 10.1038/jhh.2013.55. PMID: 23803592

Clinical prediction guides

Locus for severity implicates CNS resilience in progression of multiple sclerosis.
International Multiple Sclerosis Genetics Consortium; MultipleMS Consortium
Nature 2023 Jul;619(7969):323-331. Epub 2023 Jun 28 doi: 10.1038/s41586-023-06250-x. PMID: 37380766Free PMC Article
Multiple sclerosis progression: time for a new mechanism-driven framework.
Kuhlmann T, Moccia M, Coetzee T, Cohen JA, Correale J, Graves J, Marrie RA, Montalban X, Yong VW, Thompson AJ, Reich DS; International Advisory Committee on Clinical Trials in Multiple Sclerosis
Lancet Neurol 2023 Jan;22(1):78-88. Epub 2022 Nov 18 doi: 10.1016/S1474-4422(22)00289-7. PMID: 36410373Free PMC Article
Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Shams H, Shao X, Santaniello A, Kirkish G, Harroud A, Ma Q, Isobe N; University of California San Francisco MS-EPIC Team, Schaefer CA, McCauley JL, Cree BAC, Didonna A, Baranzini SE, Patsopoulos NA, Hauser SL, Barcellos LF, Henry RG, Oksenberg JR
Brain 2023 Feb 13;146(2):645-656. doi: 10.1093/brain/awac092. PMID: 35253861Free PMC Article
The Effect of Peripheral Immune Cell Counts on the Risk of Multiple Sclerosis: A Mendelian Randomization Study.
He D, Liu L, Shen D, Zou P, Cui L
Front Immunol 2022;13:867693. Epub 2022 May 10 doi: 10.3389/fimmu.2022.867693. PMID: 35619713Free PMC Article
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases.
Yang Y, Musco H, Simpson-Yap S, Zhu Z, Wang Y, Lin X, Zhang J, Taylor B, Gratten J, Zhou Y
Nat Commun 2021 Sep 24;12(1):5641. doi: 10.1038/s41467-021-25768-0. PMID: 34561436Free PMC Article

Recent systematic reviews

The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis.
De Silvestri A, Capittini C, Mallucci G, Bergamaschi R, Rebuffi C, Pasi A, Martinetti M, Tinelli C
Dis Markers 2019;2019:1409069. Epub 2019 Nov 6 doi: 10.1155/2019/1409069. PMID: 31781296Free PMC Article
Association between VDR polymorphisms and multiple sclerosis: systematic review and updated meta-analysis of case-control studies.
Zhang YJ, Zhang L, Chen SY, Yang GJ, Huang XL, Duan Y, Yang LJ, Ye DQ, Wang J
Neurol Sci 2018 Feb;39(2):225-234. Epub 2017 Nov 6 doi: 10.1007/s10072-017-3175-3. PMID: 29110148
MtDNA T4216C variation in multiple sclerosis: a systematic review and meta-analysis.
Andalib S, Emamhadi M, Yousefzadeh-Chabok S, Salari A, Sigaroudi AE, Vafaee MS
Acta Neurol Belg 2016 Dec;116(4):439-443. Epub 2016 Jul 25 doi: 10.1007/s13760-016-0675-5. PMID: 27457485
Association between vitamin D receptor polymorphisms and multiple sclerosis: systematic review and meta-analysis of case-control studies.
Tizaoui K, Kaabachi W, Hamzaoui A, Hamzaoui K
Cell Mol Immunol 2015 Mar;12(2):243-52. Epub 2014 Jul 7 doi: 10.1038/cmi.2014.47. PMID: 24998351Free PMC Article
Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review.
Benamer HT, Ahmed ES, Al-Din AS, Grosset DG
J Neurol Sci 2009 Mar 15;278(1-2):1-4. Epub 2009 Jan 9 doi: 10.1016/j.jns.2008.12.001. PMID: 19135686

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

    Reviews

    Related information

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