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Aspirin exacerbated respiratory disease

MedGen UID:
835312
•Concept ID:
C3853540
•
Disease or Syndrome
Synonyms: AERD - aspirin exacerbated respiratory disease; Samter syndrome; Samter triad
SNOMED CT: Aspirin exacerbated respiratory disease (10692681000119108); AERD - aspirin exacerbated respiratory disease (10692681000119108); Samter syndrome (10692681000119108); Samter triad (10692681000119108)

Professional guidelines

PubMed

The chronic rhinosinusitis practice parameter.
Kim SL, Rank MA, Peters AT
Ann Allergy Asthma Immunol 2023 Sep;131(3):307-310. Epub 2022 Dec 17 doi: 10.1016/j.anai.2022.12.022. PMID: 37667905
European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, Terezinha Anselmo-Lima W, Bachert C, Baroody F, von Buchwald C, Cervin A, Cohen N, Constantinidis J, De Gabory L, Desrosiers M, Diamant Z, Douglas RG, Gevaert PH, Hafner A, Harvey RJ, Joos GF, Kalogjera L, Knill A, Kocks JH, Landis BN, Limpens J, Lebeer S, Lourenco O, Meco C, Matricardi PM, O'Mahony L, Philpott CM, Ryan D, Schlosser R, Senior B, Smith TL, Teeling T, Tomazic PV, Wang DY, Wang D, Zhang L, Agius AM, Ahlstrom-Emanuelsson C, Alabri R, Albu S, Alhabash S, Aleksic A, Aloulah M, Al-Qudah M, Alsaleh S, Baban MA, Baudoin T, Balvers T, Battaglia P, Bedoya JD, Beule A, Bofares KM, Braverman I, Brozek-Madry E, Richard B, Callejas C, Carrie S, Caulley L, Chussi D, de Corso E, Coste A, El Hadi U, Elfarouk A, Eloy PH, Farrokhi S, Felisati G, Ferrari MD, Fishchuk R, Grayson W, Goncalves PM, Grdinic B, Grgic V, Hamizan AW, Heinichen JV, Husain S, Ping TI, Ivaska J, Jakimovska F, Jovancevic L, Kakande E, Kamel R, Karpischenko S, Kariyawasam HH, Kawauchi H, Kjeldsen A, Klimek L, Krzeski A, Kopacheva Barsova G, Kim SW, Lal D, Letort JJ, Lopatin A, Mahdjoubi A, Mesbahi A, Netkovski J, Nyenbue Tshipukane D, Obando-Valverde A, Okano M, Onerci M, Ong YK, Orlandi R, Otori N, Ouennoughy K, Ozkan M, Peric A, Plzak J, Prokopakis E, Prepageran N, Psaltis A, Pugin B, Raftopulos M, Rombaux P, Riechelmann H, Sahtout S, Sarafoleanu CC, Searyoh K, Rhee CS, Shi J, Shkoukani M, Shukuryan AK, Sicak M, Smyth D, Sindvongs K, Soklic Kosak T, Stjarne P, Sutikno B, Steinsvag S, Tantilipikorn P, Thanaviratananich S, Tran T, Urbancic J, Valiulius A, Vasquez de Aparicio C, Vicheva D, Virkkula PM, Vicente G, Voegels R, Wagenmann MM, Wardani RS, Welge-Lussen A, Witterick I, Wright E, Zabolotniy D, Zsolt B, Zwetsloot CP
Rhinology 2020 Feb 20;58(Suppl S29):1-464. doi: 10.4193/Rhin20.600. PMID: 32077450
Aspirin exacerbated respiratory disease (AERD) treatment revisited.
Kennedy DW
Int Forum Allergy Rhinol 2019 Dec;9(12):1399-1400. doi: 10.1002/alr.22496. PMID: 31816200

Recent clinical studies

Etiology

Recent Updates in Understanding NSAID Hypersensitivity.
Minaldi E, Cahill K
Curr Allergy Asthma Rep 2023 Mar;23(3):181-188. Epub 2023 Feb 9 doi: 10.1007/s11882-023-01064-3. PMID: 36757490
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article
Japanese guidelines for adult asthma 2020.
Nakamura Y, Tamaoki J, Nagase H, Yamaguchi M, Horiguchi T, Hozawa S, Ichinose M, Iwanaga T, Kondo R, Nagata M, Yokoyama A, Tohda Y; Japanese Society of Allergology
Allergol Int 2020 Oct;69(4):519-548. Epub 2020 Sep 4 doi: 10.1016/j.alit.2020.08.001. PMID: 32893125
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375

Diagnosis

Recent Updates in Understanding NSAID Hypersensitivity.
Minaldi E, Cahill K
Curr Allergy Asthma Rep 2023 Mar;23(3):181-188. Epub 2023 Feb 9 doi: 10.1007/s11882-023-01064-3. PMID: 36757490
Japanese guidelines for adult asthma 2020.
Nakamura Y, Tamaoki J, Nagase H, Yamaguchi M, Horiguchi T, Hozawa S, Ichinose M, Iwanaga T, Kondo R, Nagata M, Yokoyama A, Tohda Y; Japanese Society of Allergology
Allergol Int 2020 Oct;69(4):519-548. Epub 2020 Sep 4 doi: 10.1016/j.alit.2020.08.001. PMID: 32893125
Phenotypes of Chronic Rhinosinusitis.
Cho SH, Hamilos DL, Han DH, Laidlaw TM
J Allergy Clin Immunol Pract 2020 May;8(5):1505-1511. doi: 10.1016/j.jaip.2019.12.021. PMID: 32389275Free PMC Article
European Position Paper on Rhinosinusitis and Nasal Polyps 2020.
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, Terezinha Anselmo-Lima W, Bachert C, Baroody F, von Buchwald C, Cervin A, Cohen N, Constantinidis J, De Gabory L, Desrosiers M, Diamant Z, Douglas RG, Gevaert PH, Hafner A, Harvey RJ, Joos GF, Kalogjera L, Knill A, Kocks JH, Landis BN, Limpens J, Lebeer S, Lourenco O, Meco C, Matricardi PM, O'Mahony L, Philpott CM, Ryan D, Schlosser R, Senior B, Smith TL, Teeling T, Tomazic PV, Wang DY, Wang D, Zhang L, Agius AM, Ahlstrom-Emanuelsson C, Alabri R, Albu S, Alhabash S, Aleksic A, Aloulah M, Al-Qudah M, Alsaleh S, Baban MA, Baudoin T, Balvers T, Battaglia P, Bedoya JD, Beule A, Bofares KM, Braverman I, Brozek-Madry E, Richard B, Callejas C, Carrie S, Caulley L, Chussi D, de Corso E, Coste A, El Hadi U, Elfarouk A, Eloy PH, Farrokhi S, Felisati G, Ferrari MD, Fishchuk R, Grayson W, Goncalves PM, Grdinic B, Grgic V, Hamizan AW, Heinichen JV, Husain S, Ping TI, Ivaska J, Jakimovska F, Jovancevic L, Kakande E, Kamel R, Karpischenko S, Kariyawasam HH, Kawauchi H, Kjeldsen A, Klimek L, Krzeski A, Kopacheva Barsova G, Kim SW, Lal D, Letort JJ, Lopatin A, Mahdjoubi A, Mesbahi A, Netkovski J, Nyenbue Tshipukane D, Obando-Valverde A, Okano M, Onerci M, Ong YK, Orlandi R, Otori N, Ouennoughy K, Ozkan M, Peric A, Plzak J, Prokopakis E, Prepageran N, Psaltis A, Pugin B, Raftopulos M, Rombaux P, Riechelmann H, Sahtout S, Sarafoleanu CC, Searyoh K, Rhee CS, Shi J, Shkoukani M, Shukuryan AK, Sicak M, Smyth D, Sindvongs K, Soklic Kosak T, Stjarne P, Sutikno B, Steinsvag S, Tantilipikorn P, Thanaviratananich S, Tran T, Urbancic J, Valiulius A, Vasquez de Aparicio C, Vicheva D, Virkkula PM, Vicente G, Voegels R, Wagenmann MM, Wardani RS, Welge-Lussen A, Witterick I, Wright E, Zabolotniy D, Zsolt B, Zwetsloot CP
Rhinology 2020 Feb 20;58(Suppl S29):1-464. doi: 10.4193/Rhin20.600. PMID: 32077450
Classification of asthma.
Padem N, Saltoun C
Allergy Asthma Proc 2019 Nov 1;40(6):385-388. doi: 10.2500/aap.2019.40.4253. PMID: 31690376

Therapy

Chronic Rhinosinusitis With Nasal Polyps: Quality of Life in the Biologics Era.
Mullol J, Azar A, Buchheit KM, Hopkins C, Bernstein JA
J Allergy Clin Immunol Pract 2022 Jun;10(6):1434-1453.e9. Epub 2022 Mar 16 doi: 10.1016/j.jaip.2022.03.002. PMID: 35306180
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
Japanese guidelines for adult asthma 2020.
Nakamura Y, Tamaoki J, Nagase H, Yamaguchi M, Horiguchi T, Hozawa S, Ichinose M, Iwanaga T, Kondo R, Nagata M, Yokoyama A, Tohda Y; Japanese Society of Allergology
Allergol Int 2020 Oct;69(4):519-548. Epub 2020 Sep 4 doi: 10.1016/j.alit.2020.08.001. PMID: 32893125
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Aspirin-Exacerbated Respiratory Disease.
White AA, Stevenson DD
N Engl J Med 2018 Sep 13;379(11):1060-1070. doi: 10.1056/NEJMra1712125. PMID: 30207919

Prognosis

Mepolizumab Reduces Systemic Corticosteroid Use in Chronic Rhinosinusitis With Nasal Polyps.
Chupp G, Alobid I, Lugogo NL, Kariyawasam HH, Bourdin A, Chaker AM, Smith SG, Sousa AR, Mayer B, Chan RH, Matucci A
J Allergy Clin Immunol Pract 2023 Nov;11(11):3504-3512.e2. Epub 2023 Aug 14 doi: 10.1016/j.jaip.2023.08.015. PMID: 37586475
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Eosinophilic Drug Allergy.
Kuruvilla M, Khan DA
Clin Rev Allergy Immunol 2016 Apr;50(2):228-39. doi: 10.1007/s12016-015-8491-x. PMID: 26006718
Other asthma considerations.
Aguilar PR, Walgama ES, Ryan MW
Otolaryngol Clin North Am 2014 Feb;47(1):147-60. Epub 2013 Nov 1 doi: 10.1016/j.otc.2013.08.015. PMID: 24286688
Identifying asthma triggers.
McCarty JC, Ferguson BJ
Otolaryngol Clin North Am 2014 Feb;47(1):109-18. doi: 10.1016/j.otc.2013.08.012. PMID: 24286684Free PMC Article

Clinical prediction guides

Mast cells control lung type 2 inflammation via prostaglandin E(2)-driven soluble ST2.
Alhallak K, Nagai J, Zaleski K, Marshall S, Salloum T, Derakhshan T, Hayashi H, Feng C, Kratchmarov R, Lai J, Kuchibhotla V, Nishida A, Balestrieri B, Laidlaw T, Dwyer DF, Boyce JA
Immunity 2024 Jun 11;57(6):1274-1288.e6. Epub 2024 May 30 doi: 10.1016/j.immuni.2024.05.003. PMID: 38821053Free PMC Article
A comparative analysis of endoscopic sinus surgery versus biologics for treatment of chronic rhinosinusitis with nasal polyposis.
Miglani A, Soler ZM, Smith TL, Mace JC, Schlosser RJ
Int Forum Allergy Rhinol 2023 Feb;13(2):116-128. Epub 2022 Sep 4 doi: 10.1002/alr.23059. PMID: 35980852Free PMC Article
Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation.
Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK, Barrett NA, Boyce JA
Sci Immunol 2021 Feb 26;6(56) doi: 10.1126/sciimmunol.abb7221. PMID: 33637594Free PMC Article
Inflammatory heterogeneity in aspirin-exacerbated respiratory disease.
Scott WC, Cahill KN, Milne GL, Li P, Sheng Q, Huang LC, Dennis S, Snyder J, Bauer AM, Chandra RK, Chowdhury NI, Turner JH
J Allergy Clin Immunol 2021 Apr;147(4):1318-1328.e5. Epub 2020 Nov 12 doi: 10.1016/j.jaci.2020.11.001. PMID: 33189729Free PMC Article

Recent systematic reviews

Biologic Therapy in Pediatric Chronic Rhinosinusitis: A Systematic Review.
Rahavi-Ezabadi S, Zhou S, Lee SE, Ference E, Magit A, Leuin S, Mohamed K, Rezaei N, Patel VA
Otolaryngol Head Neck Surg 2024 Jul;171(1):35-44. Epub 2024 Mar 15 doi: 10.1002/ohn.717. PMID: 38488239
Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486
Meta-analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease.
Chaaban MR, Moffatt D, Wright AE, Cowthran JA, Hsu ES, Kuo YF
Otolaryngol Head Neck Surg 2021 Jan;164(1):11-18. Epub 2020 Jun 23 doi: 10.1177/0194599820932137. PMID: 32571140
Aspirin desensitization therapy in aspirin-exacerbated respiratory disease: a systematic review.
Larivée N, Chin CJ
Int Forum Allergy Rhinol 2020 Apr;10(4):450-464. Epub 2020 Jan 16 doi: 10.1002/alr.22520. PMID: 31951112
Aspirin desensitization for aspirin-exacerbated respiratory disease (Samter's Triad): a systematic review of the literature.
Xu JJ, Sowerby L, Rotenberg BW
Int Forum Allergy Rhinol 2013 Nov;3(11):915-20. Epub 2013 Jul 16 doi: 10.1002/alr.21202. PMID: 23861151

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