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Congenital velopharyngeal dysfunction

MedGen UID:
825926
•Concept ID:
C3840081
•
Congenital Abnormality
Synonyms: Congenital incomplete closure of velopharyngeal apparatus; Congenital velopharyngeal inadequacy
SNOMED CT: Congenital velopharyngeal dysfunction (700285006); Congenital incomplete closure of velopharyngeal apparatus (700285006); Congenital velopharyngeal inadequacy (700285006)

Professional guidelines

PubMed

Acquired Velopharyngeal Dysfunction: Survey, Literature Review, and Clinical Recommendations.
Guyton KB, Sandage MJ, Bailey D, Haak N, Molt L, Plumb A
Am J Speech Lang Pathol 2018 Nov 21;27(4):1572-1597. doi: 10.1044/2018_AJSLP-17-0222. PMID: 30208483

Recent clinical studies

Etiology

Evidence-Based Practices in Cleft Palate Surgery.
Applebaum SA, Aronson S, Termanini KM, Gosain AK
Plast Reconstr Surg 2024 Feb 1;153(2):448e-461e. Epub 2024 Jan 24 doi: 10.1097/PRS.0000000000011035. PMID: 38266141
Revision Pharyngoplasty in Cleft Palate and Velopharyngeal Insufficiency: Management and Outcomes.
Bruce MK, Zhang C, Vodovotz L, Irgebay Z, Maliha S, Pfaff M, Ford M, Goldstein JA, Losee JE
Ann Plast Surg 2022 May 1;88(3 Suppl 3):S152-S155. doi: 10.1097/SAP.0000000000003198. PMID: 35513313
Cleft Lip and Palate.
Worley ML, Patel KG, Kilpatrick LA
Clin Perinatol 2018 Dec;45(4):661-678. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.006. PMID: 30396411
Developmental trajectories in 22q11.2 deletion.
Swillen A, McDonald-McGinn D
Am J Med Genet C Semin Med Genet 2015 Jun;169(2):172-81. Epub 2015 May 18 doi: 10.1002/ajmg.c.31435. PMID: 25989227Free PMC Article
Surgery for cleft palate and velopharyngeal dysfunction.
Pearson GD, Kirschner RE
Semin Speech Lang 2011 May;32(2):179-90. Epub 2011 Sep 28 doi: 10.1055/s-0031-1277720. PMID: 21959961

Diagnosis

Revision Pharyngoplasty in Cleft Palate and Velopharyngeal Insufficiency: Management and Outcomes.
Bruce MK, Zhang C, Vodovotz L, Irgebay Z, Maliha S, Pfaff M, Ford M, Goldstein JA, Losee JE
Ann Plast Surg 2022 May 1;88(3 Suppl 3):S152-S155. doi: 10.1097/SAP.0000000000003198. PMID: 35513313
Management of submucous cleft palate.
Dean KM, Leeper LK
Curr Opin Otolaryngol Head Neck Surg 2020 Dec;28(6):410-413. doi: 10.1097/MOO.0000000000000673. PMID: 33105231
Cleft Lip and Palate.
Worley ML, Patel KG, Kilpatrick LA
Clin Perinatol 2018 Dec;45(4):661-678. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.006. PMID: 30396411
Acquired Velopharyngeal Dysfunction: Survey, Literature Review, and Clinical Recommendations.
Guyton KB, Sandage MJ, Bailey D, Haak N, Molt L, Plumb A
Am J Speech Lang Pathol 2018 Nov 21;27(4):1572-1597. doi: 10.1044/2018_AJSLP-17-0222. PMID: 30208483
Surgery for cleft palate and velopharyngeal dysfunction.
Pearson GD, Kirschner RE
Semin Speech Lang 2011 May;32(2):179-90. Epub 2011 Sep 28 doi: 10.1055/s-0031-1277720. PMID: 21959961

Therapy

Isolated cleft palate requires different surgical protocols depending on cleft type.
Elander A, Persson C, Lilja J, Mark H
J Plast Surg Hand Surg 2017 Aug;51(4):228-234. Epub 2016 Oct 18 doi: 10.1080/2000656X.2016.1235579. PMID: 27750489
Velopharyngeal function for speech after the Frolova primary palatoplasty technique.
Williams WN, Bzoch KR, Dixon-Wood V, Seagle MB, Nackashi JA, Marks RG, Frolova LE, Serova EA, Gonchakov GV, Shcheslavskiĭ S, Shmel'kova T, Zagirova AF
Cleft Palate Craniofac J 1998 Nov;35(6):481-8. doi: 10.1597/1545-1569_1998_035_0481_vffsat_2.3.co_2. PMID: 9832218
Is pharyngoplasty a risk in velocardiofacial syndrome? An assessment of medially displaced carotid arteries.
Ross DA, Witzel MA, Armstrong DC, Thomson HG
Plast Reconstr Surg 1996 Dec;98(7):1182-90. doi: 10.1097/00006534-199612000-00009. PMID: 8942903
Nasal and paranasal sinus disease in patients with congenital velopharyngeal insufficiency.
Ishikawa Y, Amitani R
Arch Otolaryngol Head Neck Surg 1994 Aug;120(8):861-5. doi: 10.1001/archotol.1994.01880320063014. PMID: 8049050

Prognosis

Adult-onset obstructive sleep apnea and pediatric pharyngoplasty in 22q11.2 deletion syndrome.
Cancelliere S, Heung T, Fischbach S, Klaiman P, Bassett AS
Sleep Med 2023 Apr;104:49-55. Epub 2023 Feb 16 doi: 10.1016/j.sleep.2023.02.010. PMID: 36889031
Cleft Lip and Palate.
Worley ML, Patel KG, Kilpatrick LA
Clin Perinatol 2018 Dec;45(4):661-678. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.006. PMID: 30396411
Acquired Velopharyngeal Dysfunction: Survey, Literature Review, and Clinical Recommendations.
Guyton KB, Sandage MJ, Bailey D, Haak N, Molt L, Plumb A
Am J Speech Lang Pathol 2018 Nov 21;27(4):1572-1597. doi: 10.1044/2018_AJSLP-17-0222. PMID: 30208483
Developmental trajectories in 22q11.2 deletion.
Swillen A, McDonald-McGinn D
Am J Med Genet C Semin Med Genet 2015 Jun;169(2):172-81. Epub 2015 May 18 doi: 10.1002/ajmg.c.31435. PMID: 25989227Free PMC Article
Surgery for cleft palate and velopharyngeal dysfunction.
Pearson GD, Kirschner RE
Semin Speech Lang 2011 May;32(2):179-90. Epub 2011 Sep 28 doi: 10.1055/s-0031-1277720. PMID: 21959961

Clinical prediction guides

Adult-onset obstructive sleep apnea and pediatric pharyngoplasty in 22q11.2 deletion syndrome.
Cancelliere S, Heung T, Fischbach S, Klaiman P, Bassett AS
Sleep Med 2023 Apr;104:49-55. Epub 2023 Feb 16 doi: 10.1016/j.sleep.2023.02.010. PMID: 36889031
Revision Pharyngoplasty in Cleft Palate and Velopharyngeal Insufficiency: Management and Outcomes.
Bruce MK, Zhang C, Vodovotz L, Irgebay Z, Maliha S, Pfaff M, Ford M, Goldstein JA, Losee JE
Ann Plast Surg 2022 May 1;88(3 Suppl 3):S152-S155. doi: 10.1097/SAP.0000000000003198. PMID: 35513313
Surgical interventions in velopharyngeal dysfunction: comparative perceptual speech and nasometric outcomes for three techniques.
Instrum R, Dzioba A, Dworschak-Stokan A, Husein M
J Otolaryngol Head Neck Surg 2022 Feb 4;51(1):3. doi: 10.1186/s40463-021-00548-4. PMID: 35120565Free PMC Article
Acquired Velopharyngeal Dysfunction: Survey, Literature Review, and Clinical Recommendations.
Guyton KB, Sandage MJ, Bailey D, Haak N, Molt L, Plumb A
Am J Speech Lang Pathol 2018 Nov 21;27(4):1572-1597. doi: 10.1044/2018_AJSLP-17-0222. PMID: 30208483
Developmental trajectories in 22q11.2 deletion.
Swillen A, McDonald-McGinn D
Am J Med Genet C Semin Med Genet 2015 Jun;169(2):172-81. Epub 2015 May 18 doi: 10.1002/ajmg.c.31435. PMID: 25989227Free PMC Article

Recent systematic reviews

Acquired Velopharyngeal Dysfunction: Survey, Literature Review, and Clinical Recommendations.
Guyton KB, Sandage MJ, Bailey D, Haak N, Molt L, Plumb A
Am J Speech Lang Pathol 2018 Nov 21;27(4):1572-1597. doi: 10.1044/2018_AJSLP-17-0222. PMID: 30208483

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