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Secondary osteoporosis

MedGen UID:
825434
•Concept ID:
C3839589
•
Disease or Syndrome
Synonym: Pathologic osteoporosis
SNOMED CT: Pathologic osteoporosis (703264005); Secondary osteoporosis (703264005)

Definition

Osteoporosis that results from medical conditions or treatments that interfere with the attainment of peak bone mass, contributing to the structural deterioration of bone tissue. [from SNOMEDCT_US]

Professional guidelines

PubMed

Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.
Shevroja E, Reginster JY, Lamy O, Al-Daghri N, Chandran M, Demoux-Baiada AL, Kohlmeier L, Lecart MP, Messina D, Camargos BM, Payer J, Tuzun S, Veronese N, Cooper C, McCloskey EV, Harvey NC
Osteoporos Int 2023 Sep;34(9):1501-1529. Epub 2023 Jul 1 doi: 10.1007/s00198-023-06817-4. PMID: 37393412Free PMC Article
A narrative review of diabetic bone disease: Characteristics, pathogenesis, and treatment.
Wu B, Fu Z, Wang X, Zhou P, Yang Q, Jiang Y, Zhu D
Front Endocrinol (Lausanne) 2022;13:1052592. Epub 2022 Dec 14 doi: 10.3389/fendo.2022.1052592. PMID: 36589835Free PMC Article
Expert panel consensus recommendations for diagnosis and treatment of secondary osteoporosis in children.
Galindo-Zavala R, Bou-Torrent R, Magallares-López B, Mir-Perelló C, Palmou-Fontana N, Sevilla-Pérez B, Medrano-San Ildefonso M, González-Fernández MI, Román-Pascual A, Alcañiz-Rodríguez P, Nieto-Gonzalez JC, López-Corbeto M, Graña-Gil J
Pediatr Rheumatol Online J 2020 Feb 24;18(1):20. doi: 10.1186/s12969-020-0411-9. PMID: 32093703Free PMC Article

Recent clinical studies

Etiology

Osteoporosis in children and adolescents: how to treat and monitor?
Ciancia S, Högler W, Sakkers RJB, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS
Eur J Pediatr 2023 Feb;182(2):501-511. Epub 2022 Dec 6 doi: 10.1007/s00431-022-04743-x. PMID: 36472650
Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis.
Zhang W, Gao R, Rong X, Zhu S, Cui Y, Liu H, Li M
Front Endocrinol (Lausanne) 2022;13:965258. Epub 2022 Sep 6 doi: 10.3389/fendo.2022.965258. PMID: 36147571Free PMC Article
Osteoporosis in children and adolescents: when to suspect and how to diagnose it.
Ciancia S, van Rijn RR, Högler W, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS
Eur J Pediatr 2022 Jul;181(7):2549-2561. Epub 2022 Apr 6 doi: 10.1007/s00431-022-04455-2. PMID: 35384509Free PMC Article
Secondary Osteoporosis.
Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F
Endocr Rev 2022 Mar 9;43(2):240-313. doi: 10.1210/endrev/bnab028. PMID: 34476488
Osteoporosis prevention, diagnosis, and therapy.
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
JAMA 2001 Feb 14;285(6):785-95. doi: 10.1001/jama.285.6.785. PMID: 11176917

Diagnosis

Osteoporosis in children and adolescents: how to treat and monitor?
Ciancia S, Högler W, Sakkers RJB, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS
Eur J Pediatr 2023 Feb;182(2):501-511. Epub 2022 Dec 6 doi: 10.1007/s00431-022-04743-x. PMID: 36472650
Osteoporosis in men.
Vilaca T, Eastell R, Schini M
Lancet Diabetes Endocrinol 2022 Apr;10(4):273-283. Epub 2022 Mar 2 doi: 10.1016/S2213-8587(22)00012-2. PMID: 35247315
Use of bone turnover markers in postmenopausal osteoporosis.
Eastell R, Szulc P
Lancet Diabetes Endocrinol 2017 Nov;5(11):908-923. Epub 2017 Jul 7 doi: 10.1016/S2213-8587(17)30184-5. PMID: 28689768
Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.
Mirza F, Canalis E
Eur J Endocrinol 2015 Sep;173(3):R131-51. Epub 2015 May 13 doi: 10.1530/EJE-15-0118. PMID: 25971649Free PMC Article
Osteoporosis prevention, diagnosis, and therapy.
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy
JAMA 2001 Feb 14;285(6):785-95. doi: 10.1001/jama.285.6.785. PMID: 11176917

Therapy

Osteoporosis in children and adolescents: how to treat and monitor?
Ciancia S, Högler W, Sakkers RJB, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS
Eur J Pediatr 2023 Feb;182(2):501-511. Epub 2022 Dec 6 doi: 10.1007/s00431-022-04743-x. PMID: 36472650
Osteoporosis in children and adolescents: when to suspect and how to diagnose it.
Ciancia S, van Rijn RR, Högler W, Appelman-Dijkstra NM, Boot AM, Sas TCJ, Renes JS
Eur J Pediatr 2022 Jul;181(7):2549-2561. Epub 2022 Apr 6 doi: 10.1007/s00431-022-04455-2. PMID: 35384509Free PMC Article
Osteoporosis in men.
Vilaca T, Eastell R, Schini M
Lancet Diabetes Endocrinol 2022 Apr;10(4):273-283. Epub 2022 Mar 2 doi: 10.1016/S2213-8587(22)00012-2. PMID: 35247315
Secondary Osteoporosis.
Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F
Endocr Rev 2022 Mar 9;43(2):240-313. doi: 10.1210/endrev/bnab028. PMID: 34476488
Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.
Mirza F, Canalis E
Eur J Endocrinol 2015 Sep;173(3):R131-51. Epub 2015 May 13 doi: 10.1530/EJE-15-0118. PMID: 25971649Free PMC Article

Prognosis

Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.
Shevroja E, Reginster JY, Lamy O, Al-Daghri N, Chandran M, Demoux-Baiada AL, Kohlmeier L, Lecart MP, Messina D, Camargos BM, Payer J, Tuzun S, Veronese N, Cooper C, McCloskey EV, Harvey NC
Osteoporos Int 2023 Sep;34(9):1501-1529. Epub 2023 Jul 1 doi: 10.1007/s00198-023-06817-4. PMID: 37393412Free PMC Article
DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis.
Shevroja E, Cafarelli FP, Guglielmi G, Hans D
Endocrine 2021 Oct;74(1):20-28. Epub 2021 Jul 10 doi: 10.1007/s12020-021-02806-x. PMID: 34245432Free PMC Article
Fracture liaison programs.
Geusens P, Bours SPG, Wyers CE, van den Bergh JP
Best Pract Res Clin Rheumatol 2019 Apr;33(2):278-289. Epub 2019 May 16 doi: 10.1016/j.berh.2019.03.016. PMID: 31547983
Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force, Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Kubik M, Landefeld CS, Mangione CM, Phipps MG, Pignone M, Silverstein M, Simon MA, Tseng CW, Wong JB
JAMA 2018 Jun 26;319(24):2521-2531. doi: 10.1001/jama.2018.7498. PMID: 29946735
Use of bone turnover markers in postmenopausal osteoporosis.
Eastell R, Szulc P
Lancet Diabetes Endocrinol 2017 Nov;5(11):908-923. Epub 2017 Jul 7 doi: 10.1016/S2213-8587(17)30184-5. PMID: 28689768

Clinical prediction guides

Bone fragility and osteoporosis in children and young adults.
Formosa MM, Christou MA, Mäkitie O
J Endocrinol Invest 2024 Feb;47(2):285-298. Epub 2023 Sep 5 doi: 10.1007/s40618-023-02179-0. PMID: 37668887Free PMC Article
Osteoporosis in men.
Vilaca T, Eastell R, Schini M
Lancet Diabetes Endocrinol 2022 Apr;10(4):273-283. Epub 2022 Mar 2 doi: 10.1016/S2213-8587(22)00012-2. PMID: 35247315
Secondary Osteoporosis.
Ebeling PR, Nguyen HH, Aleksova J, Vincent AJ, Wong P, Milat F
Endocr Rev 2022 Mar 9;43(2):240-313. doi: 10.1210/endrev/bnab028. PMID: 34476488
Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence.
Charoenngam N
Int J Mol Sci 2021 Oct 1;22(19) doi: 10.3390/ijms221910659. PMID: 34639000Free PMC Article
Use of bone turnover markers in postmenopausal osteoporosis.
Eastell R, Szulc P
Lancet Diabetes Endocrinol 2017 Nov;5(11):908-923. Epub 2017 Jul 7 doi: 10.1016/S2213-8587(17)30184-5. PMID: 28689768

Recent systematic reviews

Update on the clinical use of trabecular bone score (TBS) in the management of osteoporosis: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), and the International Osteoporosis Foundation (IOF) under the auspices of WHO Collaborating Center for Epidemiology of Musculoskeletal Health and Aging.
Shevroja E, Reginster JY, Lamy O, Al-Daghri N, Chandran M, Demoux-Baiada AL, Kohlmeier L, Lecart MP, Messina D, Camargos BM, Payer J, Tuzun S, Veronese N, Cooper C, McCloskey EV, Harvey NC
Osteoporos Int 2023 Sep;34(9):1501-1529. Epub 2023 Jul 1 doi: 10.1007/s00198-023-06817-4. PMID: 37393412Free PMC Article
Clinical efficacy of denosumab, teriparatide, and oral bisphosphonates in the prevention of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis.
Yuan C, Liang Y, Zhu K, Xie W
J Orthop Surg Res 2023 Jun 22;18(1):447. doi: 10.1186/s13018-023-03920-4. PMID: 37349750Free PMC Article
Primary Aldosteronism and Bone Metabolism: A Systematic Review and Meta-Analysis.
Shi S, Lu C, Tian H, Ren Y, Chen T
Front Endocrinol (Lausanne) 2020;11:574151. Epub 2020 Sep 25 doi: 10.3389/fendo.2020.574151. PMID: 33101208Free PMC Article
Denosumab in the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis.
Yanbeiy ZA, Hansen KE
Drug Des Devel Ther 2019;13:2843-2852. Epub 2019 Aug 14 doi: 10.2147/DDDT.S148654. PMID: 31616133Free PMC Article
Bisphosphonate therapy for children and adolescents with secondary osteoporosis.
Ward L, Tricco AC, Phuong P, Cranney A, Barrowman N, Gaboury I, Rauch F, Tugwell P, Moher D
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD005324. doi: 10.1002/14651858.CD005324.pub2. PMID: 17943849Free PMC Article

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