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Diabetic embryopathy

MedGen UID:
823266
Concept ID:
C3830518
Disease or Syndrome
Synonyms: Diabetic Embryopathy; diabetic embryopathy
SNOMED CT: Diabetic embryopathy (716020005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016018
Orphanet: ORPHA1926

Definition

Congenital anomalies or fetal/neonatal complications in an infant that are linked to diabetes in the mother. In infants of women with established insulin-dependent diabetes mellitus, the risk of congenital malformations is 10 times higher than that in the general population, and the rate of stillbirths is five times higher than that in the general population. Macrosomia is also a common problem among infants of women with established insulin-dependent diabetes mellitus. Excess mortality among infants of women with preexisting insulin-dependent diabetes mellitus is predominantly due to congenital malformations. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic embryopathy

Professional guidelines

PubMed

Reece EA, Homko CJ, Hagay Z
Obstet Gynecol Clin North Am 1996 Mar;23(1):11-28. doi: 10.1016/s0889-8545(05)70242-4. PMID: 8684774
Reece EA, Homko CJ
J Assoc Acad Minor Phys 1994;5(3):87-97. PMID: 7949826
Reece EA, Hobbins JC
Obstet Gynecol Surv 1986 Jun;41(6):325-35. PMID: 2423939

Recent clinical studies

Etiology

Kokhanov A
Neoreviews 2022 May 1;23(5):e319-e327. doi: 10.1542/neo.23-5-e319. PMID: 35490182
Aboughalia H, Pathak P, Basavalingu D, Chapman T, Revzin MV, Sienas LE, Deutsch GH, Katz DS, Moshiri M
Radiographics 2022 Jan-Feb;42(1):302-319. Epub 2021 Dec 2 doi: 10.1148/rg.210164. PMID: 34855544
Loeken MR
Curr Diab Rep 2020 Sep 12;20(10):54. doi: 10.1007/s11892-020-01338-4. PMID: 32918152Free PMC Article
Dong D, Reece EA, Lin X, Wu Y, AriasVillela N, Yang P
Am J Obstet Gynecol 2016 Feb;214(2):192-202. Epub 2015 Sep 30 doi: 10.1016/j.ajog.2015.09.082. PMID: 26432466Free PMC Article
Salbaum JM, Kappen C
Birth Defects Res A Clin Mol Teratol 2011 Aug;91(8):770-80. Epub 2011 May 2 doi: 10.1002/bdra.20807. PMID: 21538816Free PMC Article

Diagnosis

Gajagowni S, Nair P, Bapat AC, Vachharajani AJ
Neoreviews 2022 Oct 1;23(10):e677-e688. doi: 10.1542/neo.23-10-e677. PMID: 36180736
Kokhanov A
Neoreviews 2022 May 1;23(5):e319-e327. doi: 10.1542/neo.23-5-e319. PMID: 35490182
Lubinsky M
Am J Med Genet A 2017 Jan;173(1):151-156. Epub 2016 Sep 22 doi: 10.1002/ajmg.a.37985. PMID: 27717162
Kousseff BG
Curr Opin Pediatr 1999 Aug;11(4):348-52. doi: 10.1097/00008480-199908000-00014. PMID: 10439209
Goto MP, Goldman AS
Curr Opin Pediatr 1994 Aug;6(4):486-91. doi: 10.1097/00008480-199408000-00023. PMID: 7951674

Therapy

Han L, Jiang Z, Zheng X, Qiu J, Hu Y, Li X
Chem Pharm Bull (Tokyo) 2019;67(7):648-653. doi: 10.1248/cpb.c18-01013. PMID: 31257320
Singh CK, Kumar A, Lavoie HA, Dipette DJ, Singh US
Exp Biol Med (Maywood) 2013 May;238(5):482-90. Epub 2013 May 29 doi: 10.1177/1535370212473704. PMID: 23436883Free PMC Article
Reece EA
Curr Diab Rep 2012 Feb;12(1):24-32. doi: 10.1007/s11892-011-0251-6. PMID: 22167469
Ornoy A
Reprod Toxicol 2007 Jul;24(1):31-41. Epub 2007 Apr 27 doi: 10.1016/j.reprotox.2007.04.004. PMID: 17548185
Zhao Z, Reece EA
J Soc Gynecol Investig 2005 Dec;12(8):549-57. doi: 10.1016/j.jsgi.2005.07.005. PMID: 16325743

Prognosis

Guo H, Zhang Q, Li R, Seshadri VD
Appl Biochem Biotechnol 2023 Feb;195(2):801-815. Epub 2022 Oct 3 doi: 10.1007/s12010-022-04100-6. PMID: 36190644
Orbain MM, Johnson J, Nance A, Romeo AN, Silver MA, Martinez L, Leen-Mitchell M, Carey JC
Birth Defects Res 2021 Jan 15;113(2):152-160. Epub 2020 Nov 23 doi: 10.1002/bdr2.1843. PMID: 33226174
Woo JS, Perez-Rosendahl M, Haydel D, Perens G, Fishbein MC
Pediatr Dev Pathol 2015 Jan-Feb;18(1):71-5. Epub 2014 Nov 11 doi: 10.2350/14-07-1532-CR.1. PMID: 25386687
Rodriguez MM
Fetal Pediatr Pathol 2004 Jul-Aug;23(4):211-29. doi: 10.1080/15227950490923453. PMID: 16095033
Reece EA, Homko CJ
J Assoc Acad Minor Phys 1994;5(3):87-97. PMID: 7949826

Clinical prediction guides

Yang P, Reece EA, Wang F, Gabbay-Benziv R
Am J Obstet Gynecol 2015 May;212(5):569-79. Epub 2014 Nov 27 doi: 10.1016/j.ajog.2014.11.036. PMID: 25434839Free PMC Article
Singh CK, Kumar A, Lavoie HA, Dipette DJ, Singh US
Exp Biol Med (Maywood) 2013 May;238(5):482-90. Epub 2013 May 29 doi: 10.1177/1535370212473704. PMID: 23436883Free PMC Article
Ornoy A
Reprod Toxicol 2007 Jul;24(1):31-41. Epub 2007 Apr 27 doi: 10.1016/j.reprotox.2007.04.004. PMID: 17548185
Chugh SS, Wallner EI, Kanwar YS
Semin Nephrol 2003 Nov;23(6):583-92. doi: 10.1053/s0270-9295(03)00136-0. PMID: 14631566
Smoak IW
Front Biosci 2002 Jan 1;7:d307-18. doi: 10.2741/A776. PMID: 11779716

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