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Intrapartum fever

MedGen UID:
822262
•Concept ID:
C3829514
•
Sign or Symptom
Synonyms: Intrapartum Pyrexia; Maternal fever during labor; Maternal fever during labour
 
HPO: HP:0030245

Definition

The occurrence of maternal fever during labor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntrapartum fever

Professional guidelines

PubMed

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
ACOG Committee Opinion No. 348, November 2006: Umbilical cord blood gas and acid-base analysis.
ACOG Committee on Obstetric Practice
Obstet Gynecol 2006 Nov;108(5):1319-22. doi: 10.1097/00006250-200611000-00058. PMID: 17077266

Recent clinical studies

Etiology

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Severity of intrapartum fever and neonatal outcomes.
Hensel D, Zhang F, Carter EB, Frolova AI, Odibo AO, Kelly JC, Cahill AG, Raghuraman N
Am J Obstet Gynecol 2022 Sep;227(3):513.e1-513.e8. Epub 2022 May 19 doi: 10.1016/j.ajog.2022.05.031. PMID: 35598690
Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.
Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Algert CS, Thornton JG, Crowther CA; PPROMT Collaboration
Lancet 2016 Jan 30;387(10017):444-52. Epub 2015 Nov 10 doi: 10.1016/S0140-6736(15)00724-2. PMID: 26564381

Diagnosis

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Pulse perfusion index for predicting intrapartum fever during epidural analgesia.
Sun C, Ren S, Chen C, Liu Q, Lu P, Xia L, Shao D, Xu J
J Clin Anesth 2022 Sep;80:110852. Epub 2022 Apr 27 doi: 10.1016/j.jclinane.2022.110852. PMID: 35489302
Time- and dose-dependent correlations between patient-controlled epidural analgesia and intrapartum maternal fever.
Zhao BS, Li B, Wang QN, Jia JX, Song XR
BMC Anesthesiol 2021 Jan 29;21(1):31. doi: 10.1186/s12871-021-01249-1. PMID: 33514322Free PMC Article

Therapy

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes.
Abu Shqara R, Glikman D, Jad S, Rechnitzer H, Lowenstein L, Frank Wolf M
Am J Obstet Gynecol 2023 Nov;229(5):540.e1-540.e9. Epub 2023 Jul 4 doi: 10.1016/j.ajog.2023.05.013. PMID: 38051599
Group B Streptococcus in Pregnancy.
Mei JY, Silverman NS
Obstet Gynecol Clin North Am 2023 Jun;50(2):375-387. Epub 2023 Apr 2 doi: 10.1016/j.ogc.2023.02.009. PMID: 37149317
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.
Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Algert CS, Thornton JG, Crowther CA; PPROMT Collaboration
Lancet 2016 Jan 30;387(10017):444-52. Epub 2015 Nov 10 doi: 10.1016/S0140-6736(15)00724-2. PMID: 26564381

Prognosis

Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes.
Abu Shqara R, Glikman D, Jad S, Rechnitzer H, Lowenstein L, Frank Wolf M
Am J Obstet Gynecol 2023 Nov;229(5):540.e1-540.e9. Epub 2023 Jul 4 doi: 10.1016/j.ajog.2023.05.013. PMID: 38051599
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Epidural-related maternal fever: incidence, pathophysiology, outcomes, and management.
Patel S, Ciechanowicz S, Blumenfeld YJ, Sultan P
Am J Obstet Gynecol 2023 May;228(5S):S1283-S1304.e1. Epub 2023 Mar 14 doi: 10.1016/j.ajog.2022.06.026. PMID: 36925412
Inflammation and Epidural-Related Maternal Fever: Proposed Mechanisms.
Sultan P, David AL, Fernando R, Ackland GL
Anesth Analg 2016 May;122(5):1546-53. doi: 10.1213/ANE.0000000000001195. PMID: 27101499
Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.
Morris JM, Roberts CL, Bowen JR, Patterson JA, Bond DM, Algert CS, Thornton JG, Crowther CA; PPROMT Collaboration
Lancet 2016 Jan 30;387(10017):444-52. Epub 2015 Nov 10 doi: 10.1016/S0140-6736(15)00724-2. PMID: 26564381

Clinical prediction guides

Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: maternal and neonatal outcomes.
Abu Shqara R, Glikman D, Jad S, Rechnitzer H, Lowenstein L, Frank Wolf M
Am J Obstet Gynecol 2023 Nov;229(5):540.e1-540.e9. Epub 2023 Jul 4 doi: 10.1016/j.ajog.2023.05.013. PMID: 38051599
Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Nomogram for perinatal prediction of intrapartum fever: a retrospective case-control study.
Jiang Z, Hu X, Zeng H, Wang X, Tan C, Ni C, Dai L, Liu S
BMC Pregnancy Childbirth 2021 Jun 25;21(1):445. doi: 10.1186/s12884-021-03891-6. PMID: 34172031Free PMC Article
Intrapartum fever, epidural analgesia and histologic chorioamnionitis.
Curtin WM, Katzman PJ, Florescue H, Metlay LA, Ural SH
J Perinatol 2015 Jun;35(6):396-400. Epub 2015 Feb 12 doi: 10.1038/jp.2014.235. PMID: 25675051
ACOG Committee Opinion No. 348, November 2006: Umbilical cord blood gas and acid-base analysis.
ACOG Committee on Obstetric Practice
Obstet Gynecol 2006 Nov;108(5):1319-22. doi: 10.1097/00006250-200611000-00058. PMID: 17077266

Recent systematic reviews

Effects of epidural analgesia on intrapartum maternal fever and maternal outcomes: an updated systematic review and meta-analysis.
Lu R, Rong L, Ye L, Xu Y, Wu H
J Matern Fetal Neonatal Med 2024 Dec;37(1):2357168. Epub 2024 May 29 doi: 10.1080/14767058.2024.2357168. PMID: 38812361
Interventions for the prevention or treatment of epidural-related maternal fever: a systematic review and meta-analysis.
Cartledge A, Hind D, Bradburn M, Martyn-St James M, Davenport S, Tung WS, Yung H, Wong J, Wilson M
Br J Anaesth 2022 Oct;129(4):567-580. Epub 2022 Aug 5 doi: 10.1016/j.bja.2022.06.022. PMID: 35934529Free PMC Article
Remifentanil patient-controlled versus epidural analgesia on intrapartum maternal fever: a systematic review and meta-analysis.
Lu G, Yao W, Chen X, Zhang S, Zhou M
BMC Pregnancy Childbirth 2020 Mar 12;20(1):151. doi: 10.1186/s12884-020-2800-y. PMID: 32164593Free PMC Article
Epidural-Related Fever and Maternal and Neonatal Morbidity: A Systematic Review and Meta-Analysis.
Jansen S, Lopriore E, Naaktgeboren C, Sueters M, Limpens J, van Leeuwen E, Bekker V
Neonatology 2020;117(3):259-270. Epub 2020 Jan 28 doi: 10.1159/000504805. PMID: 31991422
Prophylactic versus therapeutic amnioinfusion for oligohydramnios in labour.
Novikova N, Hofmeyr GJ, Essilfie-Appiah G
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD000176. doi: 10.1002/14651858.CD000176.pub2. PMID: 22972040Free PMC Article

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