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Radiation Damage

MedGen UID:
821164
•Concept ID:
C3828416
•
Disease or Syndrome

Definition

Injury resulting from exposure to ionizing radiation. [from NCI]

Professional guidelines

PubMed

Mental health and psychosocial consequences linked to radiation emergencies-increasingly recognised concerns.
Lagergren Lindberg M, Hedman C, Lindberg K, Valentin J, Stenke L
J Radiol Prot 2022 Jul 13;42(3) doi: 10.1088/1361-6498/ac7d19. PMID: 35767945
Clinical Evaluation and Management of Radiation Fibrosis Syndrome.
Stubblefield MD
Phys Med Rehabil Clin N Am 2017 Feb;28(1):89-100. doi: 10.1016/j.pmr.2016.08.003. PMID: 27913002
Management of radiation proctitis.
Sarin A, Safar B
Gastroenterol Clin North Am 2013 Dec;42(4):913-25. doi: 10.1016/j.gtc.2013.08.004. PMID: 24280407

Recent clinical studies

Etiology

CLASSIFICATION OF MEDICAL EQUIPMENT FOR ANTI-RADIATION PROTECTION.
Bazyka DA, Lytvynenko OO, Lytvynenko OO
Probl Radiac Med Radiobiol 2022 Dec;27:84-106. doi: 10.33145/2304-8336-2022-27-84-106. PMID: 36582082
The Eyes Have It.
Machan L
Tech Vasc Interv Radiol 2018 Mar;21(1):21-25. Epub 2017 Dec 16 doi: 10.1053/j.tvir.2017.12.005. PMID: 29471996
Identifying and quantifying radiation damage at the atomic level.
Gerstel M, Deane CM, Garman EF
J Synchrotron Radiat 2015 Mar;22(2):201-12. Epub 2015 Feb 14 doi: 10.1107/S1600577515002131. PMID: 25723922Free PMC Article
Gene therapy for radioprotection.
Everett WH, Curiel DT
Cancer Gene Ther 2015 Mar;22(4):172-80. Epub 2015 Feb 27 doi: 10.1038/cgt.2015.8. PMID: 25721205Free PMC Article
Radiation-induced hypopituitarism.
Darzy KH
Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):342-53. doi: 10.1097/MED.0b013e3283631820. PMID: 23807607

Diagnosis

Immune Dysfunction from Radiation Exposure.
Hollingsworth BA, Aldrich JT, Case CM Jr, DiCarlo AL, Hoffman CM, Jakubowski AA, Liu Q, Loelius SG, PrabhuDas M, Winters TA, Cassatt DR
Radiat Res 2023 Oct;200(4):396-416. Epub 2023 Sep 13 doi: 10.1667/rade-22-00004.1. PMID: 38152282Free PMC Article
Radiation Damage in Biomolecules and Cells.
Carante MP, Ballarini F
Int J Mol Sci 2020 Nov 1;21(21) doi: 10.3390/ijms21218188. PMID: 33139616Free PMC Article
Management of radiation proctitis.
Sarin A, Safar B
Gastroenterol Clin North Am 2013 Dec;42(4):913-25. doi: 10.1016/j.gtc.2013.08.004. PMID: 24280407
Radiation-induced hypopituitarism.
Darzy KH
Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):342-53. doi: 10.1097/MED.0b013e3283631820. PMID: 23807607
Radiation retinopathy.
Brown GC, Shields JA, Sanborn G, Augsburger JJ, Savino PJ, Schatz NJ
Ophthalmology 1982 Dec;89(12):1494-501. doi: 10.1016/s0161-6420(82)34611-4. PMID: 7162794

Therapy

Crossed Pathways for Radiation-Induced and Immunotherapy-Related Lung Injury.
Zhang Z, Zhou J, Verma V, Liu X, Wu M, Yu J, Chen D
Front Immunol 2021;12:774807. Epub 2021 Dec 1 doi: 10.3389/fimmu.2021.774807. PMID: 34925345Free PMC Article
Application of Radiosensitizers in Cancer Radiotherapy.
Gong L, Zhang Y, Liu C, Zhang M, Han S
Int J Nanomedicine 2021;16:1083-1102. Epub 2021 Feb 12 doi: 10.2147/IJN.S290438. PMID: 33603370Free PMC Article
The Eyes Have It.
Machan L
Tech Vasc Interv Radiol 2018 Mar;21(1):21-25. Epub 2017 Dec 16 doi: 10.1053/j.tvir.2017.12.005. PMID: 29471996
Cancer Radiosensitizers.
Wang H, Mu X, He H, Zhang XD
Trends Pharmacol Sci 2018 Jan;39(1):24-48. Epub 2017 Dec 7 doi: 10.1016/j.tips.2017.11.003. PMID: 29224916
Recent developments in radiosensitization.
Linam J, Yang LX
Anticancer Res 2015 May;35(5):2479-85. PMID: 25964520

Prognosis

Modern Fat Grafting Techniques to the Face and Neck.
Azoury SC, Shakir S, Bucky LP, Percec I
Plast Reconstr Surg 2021 Oct 1;148(4):620e-633e. doi: 10.1097/PRS.0000000000008405. PMID: 34550946
Long and short non-coding RNA and radiation response: a review.
May JM, Bylicky M, Chopra S, Coleman CN, Aryankalayil MJ
Transl Res 2021 Jul;233:162-179. Epub 2021 Feb 11 doi: 10.1016/j.trsl.2021.02.005. PMID: 33582242Free PMC Article
Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms.
Wei J, Wang B, Wang H, Meng L, Zhao Q, Li X, Xin Y, Jiang X
Oxid Med Cell Longev 2019;2019:3010342. Epub 2019 Nov 12 doi: 10.1155/2019/3010342. PMID: 31781332Free PMC Article
Epigenetics of malignant melanoma.
Moran B, Silva R, Perry AS, Gallagher WM
Semin Cancer Biol 2018 Aug;51:80-88. Epub 2017 Oct 23 doi: 10.1016/j.semcancer.2017.10.006. PMID: 29074395
Radiation and pregnancy.
Sternberg J
Can Med Assoc J 1973 Jul 7;109(1):51-7. PMID: 4577600Free PMC Article

Clinical prediction guides

Strategies to Mitigate Chemotherapy and Radiation Toxicities That Affect Eating.
Anderson PM, Thomas SM, Sartoski S, Scott JG, Sobilo K, Bewley S, Salvador LK, Salazar-Abshire M
Nutrients 2021 Dec 8;13(12) doi: 10.3390/nu13124397. PMID: 34959948Free PMC Article
Modern Fat Grafting Techniques to the Face and Neck.
Azoury SC, Shakir S, Bucky LP, Percec I
Plast Reconstr Surg 2021 Oct 1;148(4):620e-633e. doi: 10.1097/PRS.0000000000008405. PMID: 34550946
Epigenetics of malignant melanoma.
Moran B, Silva R, Perry AS, Gallagher WM
Semin Cancer Biol 2018 Aug;51:80-88. Epub 2017 Oct 23 doi: 10.1016/j.semcancer.2017.10.006. PMID: 29074395
Rationale for chemoradiotherapy.
Nishimura Y
Int J Clin Oncol 2004 Dec;9(6):414-20. doi: 10.1007/s10147-004-0443-z. PMID: 15616871
DNA damage and repair.
Ward JF
Basic Life Sci 1991;58:403-15; discussion 415-21. doi: 10.1007/978-1-4684-7627-9_15. PMID: 1811480

Recent systematic reviews

Dosimetric parameters and radiotherapy simulation methods used in preclinical studies of radiation damage to the dentition: a systematic review.
Pedroso CM, Normando AGC, Pérez-de-Oliveira ME, Palmier NR, Guerra ENS, Epstein JB, Lopes MA, Ribeiro ACP, Brandão TB, Bensadoun RJ, Marta GN, de Goes MF, Santos-Silva AR
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 May;135(5):614-625. Epub 2022 Dec 23 doi: 10.1016/j.oooo.2022.12.005. PMID: 36725442
Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as Radioprotector.
González A, Atienza V, Montoro A, Soriano JM
Nutrients 2020 Apr 19;12(4) doi: 10.3390/nu12041143. PMID: 32325828Free PMC Article
Prevention from radiation damage by natural products.
Fischer N, Seo EJ, Efferth T
Phytomedicine 2018 Aug 1;47:192-200. Epub 2017 Nov 13 doi: 10.1016/j.phymed.2017.11.005. PMID: 30166104
Omentum for Mammary Disorders: A 30-Year Systematic Review.
Claro F Jr, Sarian LO, Pinto-Neto AM
Ann Surg Oncol 2015 Aug;22(8):2540-50. Epub 2015 Jan 9 doi: 10.1245/s10434-014-4328-8. PMID: 25572679
Systematic review: anal and rectal changes after radiotherapy for prostate cancer.
Krol R, Smeenk RJ, van Lin EN, Yeoh EE, Hopman WP
Int J Colorectal Dis 2014 Mar;29(3):273-83. Epub 2013 Oct 23 doi: 10.1007/s00384-013-1784-8. PMID: 24150230

Supplemental Content

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