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Umbilical Cord Occlusion

MedGen UID:
820481
•Concept ID:
C3827733
•
Disease or Syndrome

Definition

Blockage of blood flow in the umbilical vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUmbilical Cord Occlusion

Professional guidelines

PubMed

Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Miller SL, Bennet L, Sutherland AE, Pham Y, McDonald C, Castillo-Melendez M, Allison BJ, Mihelakis J, Nitsos I, Boyd BJ, Hirst JJ, Walker DW, Hunt RW, Jenkin G, Wong F, Malhotra A, Fahey MC, Yawno T
Ann Neurol 2022 Dec;92(6):1066-1079. Epub 2022 Sep 26 doi: 10.1002/ana.26493. PMID: 36054160Free PMC Article
Selective intrauterine growth restriction (SIUGR) type II: proposed subclassification to guide surgical management.
Chmait RH, Chon AH, Korst LM, Stephen Y, Llanes A, Ouzounian JG
J Matern Fetal Neonatal Med 2022 Mar;35(6):1184-1191. Epub 2020 Mar 31 doi: 10.1080/14767058.2020.1745177. PMID: 32233709
Management and perinatal outcome of selective intrauterine growth restriction in monochorionic pregnancies.
Sukhwani M, Antolín E, Herrero B, Rodríguez R, de la Calle M, López F, Bartha JL
J Matern Fetal Neonatal Med 2021 Dec;34(23):3838-3843. Epub 2019 Dec 3 doi: 10.1080/14767058.2019.1698030. PMID: 31766901

Recent clinical studies

Etiology

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).
Gregoraci A, Carbonell M, Linde A, Goya M, Maiz N, Gabriel P, Villena Y, Bérgamo S, Beneitez D, Montserrat I, Céspedes MC, Vargas M, Castillo F, Carreras E
Eur J Obstet Gynecol Reprod Biol 2023 Oct;289:203-207. Epub 2023 Aug 23 doi: 10.1016/j.ejogrb.2023.08.376. PMID: 37696147
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Miller SL, Bennet L, Sutherland AE, Pham Y, McDonald C, Castillo-Melendez M, Allison BJ, Mihelakis J, Nitsos I, Boyd BJ, Hirst JJ, Walker DW, Hunt RW, Jenkin G, Wong F, Malhotra A, Fahey MC, Yawno T
Ann Neurol 2022 Dec;92(6):1066-1079. Epub 2022 Sep 26 doi: 10.1002/ana.26493. PMID: 36054160Free PMC Article
Perinatal outcomes after selective feticide via umbilical cord occlusion in complicated monochorionic pregnancies: A systematic review and meta-analysis.
Wu T, Chen Z, Yin X, Shi H, Niu J, Xie J, Wei Y, Wang X
Prenat Diagn 2022 Jan;42(1):37-48. Epub 2021 Nov 2 doi: 10.1002/pd.6064. PMID: 34699084
Short-Term Flow Changes in Monochorionic Survivor Twins after Ultrasound-Guided Umbilical Cord Occlusion.
Schou KV, Ekelund CK, Jensen LN, Nørgaard LN, Søgaard K, Rode L, Tabor A, Sundberg K
Fetal Diagn Ther 2020;47(1):45-53. Epub 2019 Jun 13 doi: 10.1159/000500021. PMID: 31195393
Umbilical Cord Occlusion via Laser Coagulation in Monochorionic Multifetal Gestations before and after 20 Weeks of Gestation.
King JR, Conturie CL, Ouzounian JG, Korst LM, Llanes A, Chmait RH
Fetal Diagn Ther 2017;42(1):9-16. Epub 2016 Aug 31 doi: 10.1159/000448948. PMID: 27577884

Diagnosis

Management and perinatal outcome of selective intrauterine growth restriction in monochorionic pregnancies.
Sukhwani M, Antolín E, Herrero B, Rodríguez R, de la Calle M, López F, Bartha JL
J Matern Fetal Neonatal Med 2021 Dec;34(23):3838-3843. Epub 2019 Dec 3 doi: 10.1080/14767058.2019.1698030. PMID: 31766901
Severe fetal anemia after umbilical cord occlusion leading to severe neurological injury in monochorionic twins.
Bartha JL, Duyos I, de la Calle M, Herrero B, Rodriguez R, Antolín E
J Matern Fetal Neonatal Med 2021 Jun;34(12):2030-2032. Epub 2019 Aug 11 doi: 10.1080/14767058.2019.1651284. PMID: 31401894
Long-Term Neurodevelopmental Outcome of Monochorionic Twins after Laser Therapy or Umbilical Cord Occlusion for Twin-Twin Transfusion Syndrome.
Schou KV, Lando AV, Ekelund CK, Jensen LN, Jørgensen C, Nørgaard LN, Rode L, Søgaard K, Tabor A, Sundberg K
Fetal Diagn Ther 2019;46(1):20-27. Epub 2018 Aug 27 doi: 10.1159/000491787. PMID: 30149379
Operative fetoscopy in complicated monochorionic twins: current status and future direction.
Chmait RH, Quintero RA
Curr Opin Obstet Gynecol 2008 Apr;20(2):169-74. doi: 10.1097/GCO.0b013e3282f52f72. PMID: 18388818
Selective feticide in monoamniotic twin pregnancies by umbilical cord occlusion and transection.
Middeldorp JM, Klumper FJ, Oepkes D, Lopriore E, Kanhai HH, Vandenbussche FP
Fetal Diagn Ther 2008;23(2):121-5. Epub 2007 Nov 26 doi: 10.1159/000111591. PMID: 18046069

Therapy

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).
Gregoraci A, Carbonell M, Linde A, Goya M, Maiz N, Gabriel P, Villena Y, Bérgamo S, Beneitez D, Montserrat I, Céspedes MC, Vargas M, Castillo F, Carreras E
Eur J Obstet Gynecol Reprod Biol 2023 Oct;289:203-207. Epub 2023 Aug 23 doi: 10.1016/j.ejogrb.2023.08.376. PMID: 37696147
Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury.
Lear CA, Lear BA, Davidson JO, Sae-Jiw J, Lloyd JM, Dhillon SK, Gunn AJ, Bennet L
Brain 2023 Apr 19;146(4):1453-1466. doi: 10.1093/brain/awac331. PMID: 36087304Free PMC Article
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Miller SL, Bennet L, Sutherland AE, Pham Y, McDonald C, Castillo-Melendez M, Allison BJ, Mihelakis J, Nitsos I, Boyd BJ, Hirst JJ, Walker DW, Hunt RW, Jenkin G, Wong F, Malhotra A, Fahey MC, Yawno T
Ann Neurol 2022 Dec;92(6):1066-1079. Epub 2022 Sep 26 doi: 10.1002/ana.26493. PMID: 36054160Free PMC Article
Perinatal outcomes after selective feticide via umbilical cord occlusion in complicated monochorionic pregnancies: A systematic review and meta-analysis.
Wu T, Chen Z, Yin X, Shi H, Niu J, Xie J, Wei Y, Wang X
Prenat Diagn 2022 Jan;42(1):37-48. Epub 2021 Nov 2 doi: 10.1002/pd.6064. PMID: 34699084
Umbilical Cord Occlusion via Laser Coagulation in Monochorionic Multifetal Gestations before and after 20 Weeks of Gestation.
King JR, Conturie CL, Ouzounian JG, Korst LM, Llanes A, Chmait RH
Fetal Diagn Ther 2017;42(1):9-16. Epub 2016 Aug 31 doi: 10.1159/000448948. PMID: 27577884

Prognosis

First-trimester biomarkers and ultrasound biometries in relation to growth discordance in monochorionic diamniotic twins.
Løppke FB, Schou KV, Ekelund CK, Rode L, Tabor A, Sundberg K
J Matern Fetal Neonatal Med 2023 Dec;36(1):2184223. doi: 10.1080/14767058.2023.2184223. PMID: 36889742
Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E
Dev Neurosci 2022;44(4-5):277-294. Epub 2022 May 19 doi: 10.1159/000525150. PMID: 35588703Free PMC Article
Management and perinatal outcome of selective intrauterine growth restriction in monochorionic pregnancies.
Sukhwani M, Antolín E, Herrero B, Rodríguez R, de la Calle M, López F, Bartha JL
J Matern Fetal Neonatal Med 2021 Dec;34(23):3838-3843. Epub 2019 Dec 3 doi: 10.1080/14767058.2019.1698030. PMID: 31766901
Selective intrauterine growth restriction in monochorionic diamniotic twin pregnancies.
Bennasar M, Eixarch E, Martinez JM, Gratacós E
Semin Fetal Neonatal Med 2017 Dec;22(6):376-382. Epub 2017 May 20 doi: 10.1016/j.siny.2017.05.001. PMID: 28532678
Cord occlusion techniques for selective termination in monochorionic twins.
Challis D, Gratacos E, Deprest JA
J Perinat Med 1999;27(5):327-38. doi: 10.1515/JPM.1999.046. PMID: 10642953

Clinical prediction guides

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).
Gregoraci A, Carbonell M, Linde A, Goya M, Maiz N, Gabriel P, Villena Y, Bérgamo S, Beneitez D, Montserrat I, Céspedes MC, Vargas M, Castillo F, Carreras E
Eur J Obstet Gynecol Reprod Biol 2023 Oct;289:203-207. Epub 2023 Aug 23 doi: 10.1016/j.ejogrb.2023.08.376. PMID: 37696147
Tumour necrosis factor blockade after asphyxia in foetal sheep ameliorates cystic white matter injury.
Lear CA, Lear BA, Davidson JO, Sae-Jiw J, Lloyd JM, Dhillon SK, Gunn AJ, Bennet L
Brain 2023 Apr 19;146(4):1453-1466. doi: 10.1093/brain/awac331. PMID: 36087304Free PMC Article
Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.
Mike JK, Wu KY, White Y, Pathipati P, Ndjamen B, Hutchings RS, Losser C, Vento C, Arellano K, Vanhatalo O, Ostrin S, Windsor C, Ha J, Alhassen Z, Goudy BD, Vali P, Lakshminrusimha S, Gobburu JVS, Long-Boyle J, Chen P, Wu YW, Fineman JR, Ferriero DM, Maltepe E
Dev Neurosci 2022;44(4-5):277-294. Epub 2022 May 19 doi: 10.1159/000525150. PMID: 35588703Free PMC Article
Short-Term Flow Changes in Monochorionic Survivor Twins after Ultrasound-Guided Umbilical Cord Occlusion.
Schou KV, Ekelund CK, Jensen LN, Nørgaard LN, Søgaard K, Rode L, Tabor A, Sundberg K
Fetal Diagn Ther 2020;47(1):45-53. Epub 2019 Jun 13 doi: 10.1159/000500021. PMID: 31195393
The endocrine control of the onset of thermogenesis at birth.
Gunn TR, Gluckman PD
Baillieres Clin Endocrinol Metab 1989 Nov;3(3):869-86. doi: 10.1016/s0950-351x(89)80057-6. PMID: 2698159

Recent systematic reviews

Perinatal outcomes after selective feticide via umbilical cord occlusion in complicated monochorionic pregnancies: A systematic review and meta-analysis.
Wu T, Chen Z, Yin X, Shi H, Niu J, Xie J, Wei Y, Wang X
Prenat Diagn 2022 Jan;42(1):37-48. Epub 2021 Nov 2 doi: 10.1002/pd.6064. PMID: 34699084
Umbilical cord occlusion for selective feticide in complicated monochorionic twins: a systematic review of literature.
Rossi AC, D'Addario V
Am J Obstet Gynecol 2009 Feb;200(2):123-9. doi: 10.1016/j.ajog.2008.08.039. PMID: 19185099

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