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Harmful use of ketamine

MedGen UID:
1381393
•Concept ID:
C3824685
•
Mental or Behavioral Dysfunction
Synonym: Ketamine abuse
SNOMED CT: Harmful use of ketamine (724713006); Ketamine abuse (724713006)

Professional guidelines

PubMed

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S
Am J Psychiatry 2021 May 1;178(5):383-399. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20081251. PMID: 33726522Free PMC Article
Ketamine for the treatment of addiction: Evidence and potential mechanisms.
Ivan Ezquerra-Romano I, Lawn W, Krupitsky E, Morgan CJA
Neuropharmacology 2018 Nov;142:72-82. Epub 2018 Jan 12 doi: 10.1016/j.neuropharm.2018.01.017. PMID: 29339294
Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients.
Dixit D, Endicott J, Burry L, Ramos L, Yeung SY, Devabhakthuni S, Chan C, Tobia A, Bulloch MN
Pharmacotherapy 2016 Jul;36(7):797-822. Epub 2016 Jun 30 doi: 10.1002/phar.1770. PMID: 27196747

Recent clinical studies

Etiology

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S
Am J Psychiatry 2021 May 1;178(5):383-399. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20081251. PMID: 33726522Free PMC Article
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients.
Dixit D, Endicott J, Burry L, Ramos L, Yeung SY, Devabhakthuni S, Chan C, Tobia A, Bulloch MN
Pharmacotherapy 2016 Jul;36(7):797-822. Epub 2016 Jun 30 doi: 10.1002/phar.1770. PMID: 27196747
Ketamine for chronic pain: risks and benefits.
Niesters M, Martini C, Dahan A
Br J Clin Pharmacol 2014 Feb;77(2):357-67. doi: 10.1111/bcp.12094. PMID: 23432384Free PMC Article
Development of a rational scale to assess the harm of drugs of potential misuse.
Nutt D, King LA, Saulsbury W, Blakemore C
Lancet 2007 Mar 24;369(9566):1047-53. doi: 10.1016/S0140-6736(07)60464-4. PMID: 17382831

Diagnosis

Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review.
Burback L, Brémault-Phillips S, Nijdam MJ, McFarlane A, Vermetten E
Curr Neuropharmacol 2024;22(4):557-635. doi: 10.2174/1570159X21666230428091433. PMID: 37132142Free PMC Article
Clinical and behavior characteristics of individuals who used ketamine.
Lee TS, Liu YH, Huang YJ, Tang WK, Wang Y, Hu S, Lin CP, Li CR, Hung CC
Sci Rep 2022 Jan 17;12(1):801. doi: 10.1038/s41598-022-04832-9. PMID: 35039593Free PMC Article
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Focus on Adolescent Use of Club Drugs and "Other" Substances.
Williams JF, Lundahl LH
Pediatr Clin North Am 2019 Dec;66(6):1121-1134. doi: 10.1016/j.pcl.2019.08.013. PMID: 31679602
Illegal use patterns, side effects, and analytical methods of ketamine.
Han E, Kwon NJ, Feng LY, Li JH, Chung H
Forensic Sci Int 2016 Nov;268:25-34. Epub 2016 Sep 12 doi: 10.1016/j.forsciint.2016.09.001. PMID: 27685472

Therapy

Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S
Am J Psychiatry 2021 May 1;178(5):383-399. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20081251. PMID: 33726522Free PMC Article
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Ketamine for the treatment of addiction: Evidence and potential mechanisms.
Ivan Ezquerra-Romano I, Lawn W, Krupitsky E, Morgan CJA
Neuropharmacology 2018 Nov;142:72-82. Epub 2018 Jan 12 doi: 10.1016/j.neuropharm.2018.01.017. PMID: 29339294
Ketamine abuse potential and use disorder.
Liu Y, Lin D, Wu B, Zhou W
Brain Res Bull 2016 Sep;126(Pt 1):68-73. Epub 2016 May 31 doi: 10.1016/j.brainresbull.2016.05.016. PMID: 27261367
Development of a rational scale to assess the harm of drugs of potential misuse.
Nutt D, King LA, Saulsbury W, Blakemore C
Lancet 2007 Mar 24;369(9566):1047-53. doi: 10.1016/S0140-6736(07)60464-4. PMID: 17382831

Prognosis

Alcohol Withdrawal Syndrome in Neurocritical Care Unit: Assessment and Treatment Challenges.
Farrokh S, Roels C, Owusu KA, Nelson SE, Cook AM
Neurocrit Care 2021 Apr;34(2):593-607. Epub 2020 Aug 13 doi: 10.1007/s12028-020-01061-8. PMID: 32794143
Characteristics and circumstances of death related to the self-administration of ketamine.
Darke S, Duflou J, Farrell M, Peacock A, Lappin J
Addiction 2021 Feb;116(2):339-345. Epub 2020 Jul 7 doi: 10.1111/add.15154. PMID: 32533718
The potential of (1)H-MRS in CNS drug development.
Egerton A
Psychopharmacology (Berl) 2021 May;238(5):1241-1254. Epub 2019 Sep 5 doi: 10.1007/s00213-019-05344-7. PMID: 31486875Free PMC Article
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Pain management in neurocritical care; an update.
Morad A, Farrokh S, Papangelou A
Curr Opin Crit Care 2018 Apr;24(2):72-79. doi: 10.1097/MCC.0000000000000480. PMID: 29517981

Clinical prediction guides

Alcohol Withdrawal Syndrome in Neurocritical Care Unit: Assessment and Treatment Challenges.
Farrokh S, Roels C, Owusu KA, Nelson SE, Cook AM
Neurocrit Care 2021 Apr;34(2):593-607. Epub 2020 Aug 13 doi: 10.1007/s12028-020-01061-8. PMID: 32794143
The potential of (1)H-MRS in CNS drug development.
Egerton A
Psychopharmacology (Berl) 2021 May;238(5):1241-1254. Epub 2019 Sep 5 doi: 10.1007/s00213-019-05344-7. PMID: 31486875Free PMC Article
Prediction error, ketamine and psychosis: An updated model.
Corlett PR, Honey GD, Fletcher PC
J Psychopharmacol 2016 Nov;30(11):1145-1155. Epub 2016 May 25 doi: 10.1177/0269881116650087. PMID: 27226342Free PMC Article
Ketamine-associated bladder dysfunction.
Tsai TH, Cha TL, Lin CM, Tsao CW, Tang SH, Chuang FP, Wu ST, Sun GH, Yu DS, Chang SY
Int J Urol 2009 Oct;16(10):826-9. Epub 2009 Jul 29 doi: 10.1111/j.1442-2042.2009.02361.x. PMID: 19659678
Development of a rational scale to assess the harm of drugs of potential misuse.
Nutt D, King LA, Saulsbury W, Blakemore C
Lancet 2007 Mar 24;369(9566):1047-53. doi: 10.1016/S0140-6736(07)60464-4. PMID: 17382831

Recent systematic reviews

Overdoses and deaths related to the use of ketamine and its analogues: a systematic review.
Chaves TV, Wilffert B, Sanchez ZM
Am J Drug Alcohol Abuse 2023 Mar 4;49(2):141-150. Epub 2022 Nov 21 doi: 10.1080/00952990.2022.2132506. PMID: 36410032
Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies.
Breeksema JJ, Niemeijer AR, Krediet E, Vermetten E, Schoevers RA
CNS Drugs 2020 Sep;34(9):925-946. doi: 10.1007/s40263-020-00748-y. PMID: 32803732Free PMC Article
Chemsex behaviours among men who have sex with men: A systematic review of the literature.
Maxwell S, Shahmanesh M, Gafos M
Int J Drug Policy 2019 Jan;63:74-89. Epub 2018 Dec 1 doi: 10.1016/j.drugpo.2018.11.014. PMID: 30513473
Excited Delirium: A Systematic Review.
Gonin P, Beysard N, Yersin B, Carron PN
Acad Emerg Med 2018 May;25(5):552-565. Epub 2017 Nov 27 doi: 10.1111/acem.13330. PMID: 28990246
Patterns of use and toxicity of new para-halogenated substituted cathinones: 4-CMC (clephedrone), 4-CEC (4-chloroethcatinone) and 4-BMC (brephedrone).
Grifell M, Ventura M, Carbón X, Quintana P, Galindo L, Palma Á, Fornis I, Gil C, Farre M, Torrens M
Hum Psychopharmacol 2017 May;32(3) doi: 10.1002/hup.2621. PMID: 28657185

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