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Harmful use of ketamine

MedGen UID:
1381393
•Concept ID:
C3824685
•
Mental or Behavioral Dysfunction
Synonym: Ketamine abuse
SNOMED CT: Harmful use of ketamine (724713006); Ketamine abuse (724713006)

Professional guidelines

PubMed

Spanning Treatment Modalities: Psychotherapy, Psychopharmacology, and Neuromodulation.
Kalin NH
Am J Psychiatry 2022 Feb;179(2):75-78. doi: 10.1176/appi.ajp.2021.21121218. PMID: 35105160
Scientific Advances Supporting New and Improved Treatment Strategies in Psychiatry.
Kalin NH
Am J Psychiatry 2021 May 1;178(5):365-368. doi: 10.1176/appi.ajp.2021.21030290. PMID: 33979538
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S
Am J Psychiatry 2021 May 1;178(5):383-399. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20081251. PMID: 33726522Free PMC Article

Recent clinical studies

Etiology

Tusi: a new ketamine concoction complicating the drug landscape.
Palamar JJ
Am J Drug Alcohol Abuse 2023 Sep 3;49(5):546-550. Epub 2023 May 10 doi: 10.1080/00952990.2023.2207716. PMID: 37162319Free PMC Article
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S
Am J Psychiatry 2021 May 1;178(5):383-399. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20081251. PMID: 33726522Free PMC Article
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients.
Dixit D, Endicott J, Burry L, Ramos L, Yeung SY, Devabhakthuni S, Chan C, Tobia A, Bulloch MN
Pharmacotherapy 2016 Jul;36(7):797-822. Epub 2016 Jun 30 doi: 10.1002/phar.1770. PMID: 27196747
Development of a rational scale to assess the harm of drugs of potential misuse.
Nutt D, King LA, Saulsbury W, Blakemore C
Lancet 2007 Mar 24;369(9566):1047-53. doi: 10.1016/S0140-6736(07)60464-4. PMID: 17382831

Diagnosis

Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review.
Burback L, Brémault-Phillips S, Nijdam MJ, McFarlane A, Vermetten E
Curr Neuropharmacol 2024;22(4):557-635. doi: 10.2174/1570159X21666230428091433. PMID: 37132142Free PMC Article
Trends in Illicit Ketamine Seizures in the US From 2017 to 2022.
Palamar JJ, Wilkinson ST, Carr TH, Rutherford C, Cottler LB
JAMA Psychiatry 2023 Jul 1;80(7):750-751. doi: 10.1001/jamapsychiatry.2023.1423. PMID: 37223891Free PMC Article
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Ketamine-induced cholangiopathy.
Lui KL, Lee WK, Li MK
Hong Kong Med J 2014 Feb;20(1):78.e1-e2. doi: 10.12809/hkmj133796. PMID: 24473697
Ketamine-associated vesicopathy.
Chen YC, Chen YL, Huang GS, Wu CJ
QJM 2012 Oct;105(10):1023-4. Epub 2011 Sep 14 doi: 10.1093/qjmed/hcr170. PMID: 21920995

Therapy

Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review.
Burback L, Brémault-Phillips S, Nijdam MJ, McFarlane A, Vermetten E
Curr Neuropharmacol 2024;22(4):557-635. doi: 10.2174/1570159X21666230428091433. PMID: 37132142Free PMC Article
Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.
McIntyre RS, Rosenblat JD, Nemeroff CB, Sanacora G, Murrough JW, Berk M, Brietzke E, Dodd S, Gorwood P, Ho R, Iosifescu DV, Lopez Jaramillo C, Kasper S, Kratiuk K, Lee JG, Lee Y, Lui LMW, Mansur RB, Papakostas GI, Subramaniapillai M, Thase M, Vieta E, Young AH, Zarate CA Jr, Stahl S
Am J Psychiatry 2021 May 1;178(5):383-399. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20081251. PMID: 33726522Free PMC Article
Ketamine beyond anesthesia: Antidepressant effects and abuse potential.
Trujillo KA, Iñiguez SD
Behav Brain Res 2020 Sep 15;394:112841. Epub 2020 Jul 31 doi: 10.1016/j.bbr.2020.112841. PMID: 32739287Free PMC Article
Neonatal pain management.
Carter BS, Brunkhorst J
Semin Perinatol 2017 Mar;41(2):111-116. Epub 2017 Jan 26 doi: 10.1053/j.semperi.2016.11.001. PMID: 28131321
Development of a rational scale to assess the harm of drugs of potential misuse.
Nutt D, King LA, Saulsbury W, Blakemore C
Lancet 2007 Mar 24;369(9566):1047-53. doi: 10.1016/S0140-6736(07)60464-4. PMID: 17382831

Prognosis

Mechanisms of SSRI Therapy and Discontinuation.
Sharp T, Collins H
Curr Top Behav Neurosci 2024;66:21-47. doi: 10.1007/7854_2023_452. PMID: 37955823
Alcohol Withdrawal Syndrome in Neurocritical Care Unit: Assessment and Treatment Challenges.
Farrokh S, Roels C, Owusu KA, Nelson SE, Cook AM
Neurocrit Care 2021 Apr;34(2):593-607. Epub 2020 Aug 13 doi: 10.1007/s12028-020-01061-8. PMID: 32794143
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications.
Cosci F, Chouinard G
Psychother Psychosom 2020;89(5):283-306. Epub 2020 Apr 7 doi: 10.1159/000506868. PMID: 32259826
Rates and Correlates of Syphilis Reinfection in Men Who Have Sex with Men.
Jain J, Santos GM, Scheer S, Gibson S, Crouch PC, Kohn R, Chang W, Carrico AW
LGBT Health 2017 Jun;4(3):232-236. Epub 2016 Dec 19 doi: 10.1089/lgbt.2016.0095. PMID: 27991843
New drugs of abuse.
Graeme KA
Emerg Med Clin North Am 2000 Nov;18(4):625-36. doi: 10.1016/s0733-8627(05)70150-4. PMID: 11130930

Clinical prediction guides

Mechanisms of SSRI Therapy and Discontinuation.
Sharp T, Collins H
Curr Top Behav Neurosci 2024;66:21-47. doi: 10.1007/7854_2023_452. PMID: 37955823
Alcohol Withdrawal Syndrome in Neurocritical Care Unit: Assessment and Treatment Challenges.
Farrokh S, Roels C, Owusu KA, Nelson SE, Cook AM
Neurocrit Care 2021 Apr;34(2):593-607. Epub 2020 Aug 13 doi: 10.1007/s12028-020-01061-8. PMID: 32794143
Prediction error, ketamine and psychosis: An updated model.
Corlett PR, Honey GD, Fletcher PC
J Psychopharmacol 2016 Nov;30(11):1145-1155. Epub 2016 May 25 doi: 10.1177/0269881116650087. PMID: 27226342Free PMC Article
Ketamine-associated bladder dysfunction.
Tsai TH, Cha TL, Lin CM, Tsao CW, Tang SH, Chuang FP, Wu ST, Sun GH, Yu DS, Chang SY
Int J Urol 2009 Oct;16(10):826-9. Epub 2009 Jul 29 doi: 10.1111/j.1442-2042.2009.02361.x. PMID: 19659678
Development of a rational scale to assess the harm of drugs of potential misuse.
Nutt D, King LA, Saulsbury W, Blakemore C
Lancet 2007 Mar 24;369(9566):1047-53. doi: 10.1016/S0140-6736(07)60464-4. PMID: 17382831

Recent systematic reviews

The Pharmacological Management of Ketamine Use Disorder: A Systematic Review.
Roberts E, Sanderson E, Guerrini I
J Addict Med 2024 Sep-Oct 01;18(5):574-579. Epub 2024 Jun 26 doi: 10.1097/ADM.0000000000001340. PMID: 38922637
Overdoses and deaths related to the use of ketamine and its analogues: a systematic review.
Chaves TV, Wilffert B, Sanchez ZM
Am J Drug Alcohol Abuse 2023 Mar 4;49(2):141-150. Epub 2022 Nov 21 doi: 10.1080/00952990.2022.2132506. PMID: 36410032
Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies.
Breeksema JJ, Niemeijer AR, Krediet E, Vermetten E, Schoevers RA
CNS Drugs 2020 Sep;34(9):925-946. doi: 10.1007/s40263-020-00748-y. PMID: 32803732Free PMC Article
Chemsex behaviours among men who have sex with men: A systematic review of the literature.
Maxwell S, Shahmanesh M, Gafos M
Int J Drug Policy 2019 Jan;63:74-89. Epub 2018 Dec 1 doi: 10.1016/j.drugpo.2018.11.014. PMID: 30513473
Patterns of use and toxicity of new para-halogenated substituted cathinones: 4-CMC (clephedrone), 4-CEC (4-chloroethcatinone) and 4-BMC (brephedrone).
Grifell M, Ventura M, Carbón X, Quintana P, Galindo L, Palma Á, Fornis I, Gil C, Farre M, Torrens M
Hum Psychopharmacol 2017 May;32(3) doi: 10.1002/hup.2621. PMID: 28657185

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