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Cataract 41(CTRCT41)

MedGen UID:
811742
•Concept ID:
C3805412
•
Disease or Syndrome
Synonyms: CATARACT 41, CONGENITAL NUCLEAR TYPE; CTRCT41
 
Gene (location): WFS1 (4p16.1)
 
Monarch Initiative: MONDO:0007287
OMIM®: 116400

Definition

Cataract is an opacification of the lens or lens capsule in the eye and is the most common cause of childhood blindness in the world, with an incidence of 1 to 3 per 10,000 live births. If untreated in infancy or childhood, it frequently causes visual impairment and can result in irreversible amblyopia. Nuclear cataract refers to opacification within the embryonal and/or fetal nuclei of the lens (summary by Berry et al., 2013). [from OMIM]

Clinical features

From HPO
Nuclear cataract
MedGen UID:
140274
•Concept ID:
C0392557
•
Finding
A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Neonatal classic galactosemia-diagnosis, clinical profile and molecular characteristics in unscreened Turkish population.
Çelik M, Akdeniz O, Ozbek MN, Kirbiyik O
J Trop Pediatr 2022 Oct 6;68(6) doi: 10.1093/tropej/fmac098. PMID: 36375035

Recent clinical studies

Etiology

Cataract surgery in neovascular AMD: impact on visual acuity and disease activity.
Tang HY, Rosén M, Granstam E
BMC Ophthalmol 2023 Jun 16;23(1):276. doi: 10.1186/s12886-023-03028-7. PMID: 37328798Free PMC Article
Association Between Cataract Extraction and Development of Dementia.
Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes MS, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK, Larson EB
JAMA Intern Med 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. PMID: 34870676Free PMC Article
Risk of Cataract in Intermediate Uveitis.
Minkus CL, Pistilli M, Dreger KA, Fitzgerald TD, Payal AR, Begum H, Kaçmaz RO, Jabs DA, Nussenblatt RB, Rosenbaum JT, Levy-Clarke GA, Sen HN, Suhler EB, Thorne JE, Bhatt NP, Foster CS, Buchanich JM, Kempen JH; Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Research Group
Am J Ophthalmol 2021 Sep;229:200-209. Epub 2021 Mar 10 doi: 10.1016/j.ajo.2021.02.032. PMID: 33713679Free PMC Article
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Radiation cataract.
Kleiman NJ
Ann ICRP 2012 Oct-Dec;41(3-4):80-97. Epub 2012 Aug 22 doi: 10.1016/j.icrp.2012.06.018. PMID: 23089007

Diagnosis

Association Between Cataract Extraction and Development of Dementia.
Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes MS, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK, Larson EB
JAMA Intern Med 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. PMID: 34870676Free PMC Article
Incontinentia pigmenti in adults.
Scheuerle AE
Am J Med Genet A 2019 Aug;179(8):1415-1419. Epub 2019 May 22 doi: 10.1002/ajmg.a.61205. PMID: 31119873
An Evaluation of the IOLMaster 700.
Bullimore MA, Slade S, Yoo P, Otani T
Eye Contact Lens 2019 Mar;45(2):117-123. doi: 10.1097/ICL.0000000000000552. PMID: 30325761
Objective measurement of accommodation.
Kohnen T
J Cataract Refract Surg 2015 Mar;41(3):485-6. doi: 10.1016/j.jcrs.2015.02.003. PMID: 25804576
Radiation cataract.
Kleiman NJ
Ann ICRP 2012 Oct-Dec;41(3-4):80-97. Epub 2012 Aug 22 doi: 10.1016/j.icrp.2012.06.018. PMID: 23089007

Therapy

Association Between Cataract Extraction and Development of Dementia.
Lee CS, Gibbons LE, Lee AY, Yanagihara RT, Blazes MS, Lee ML, McCurry SM, Bowen JD, McCormick WC, Crane PK, Larson EB
JAMA Intern Med 2022 Feb 1;182(2):134-141. doi: 10.1001/jamainternmed.2021.6990. PMID: 34870676Free PMC Article
Efficient use of ultrasound in cataract surgery.
Bu JJ, Chung J, Afshari NA
Curr Opin Ophthalmol 2022 Jan 1;33(1):41-46. doi: 10.1097/ICU.0000000000000821. PMID: 34854827
Small eyes-big problems.
Srinivasan S
J Cataract Refract Surg 2015 Nov;41(11):2345-6. doi: 10.1016/j.jcrs.2015.10.058. PMID: 26703480
Radiation cataract.
Kleiman NJ
Ann ICRP 2012 Oct-Dec;41(3-4):80-97. Epub 2012 Aug 22 doi: 10.1016/j.icrp.2012.06.018. PMID: 23089007
Interventions for preventing falls in older people living in the community.
Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007146. doi: 10.1002/14651858.CD007146.pub3. PMID: 22972103Free PMC Article

Prognosis

Dual Sensory Impairment as a Predictor of Loneliness and Isolation in Older Adults: National Cohort Study.
Wang Q, Zhang S, Wang Y, Zhao D, Zhou C
JMIR Public Health Surveill 2022 Nov 14;8(11):e39314. doi: 10.2196/39314. PMID: 36374533Free PMC Article
The Risks and Benefits of Myopia Control.
Bullimore MA, Ritchey ER, Shah S, Leveziel N, Bourne RRA, Flitcroft DI
Ophthalmology 2021 Nov;128(11):1561-1579. Epub 2021 May 4 doi: 10.1016/j.ophtha.2021.04.032. PMID: 33961969
Risk of Cataract in Intermediate Uveitis.
Minkus CL, Pistilli M, Dreger KA, Fitzgerald TD, Payal AR, Begum H, Kaçmaz RO, Jabs DA, Nussenblatt RB, Rosenbaum JT, Levy-Clarke GA, Sen HN, Suhler EB, Thorne JE, Bhatt NP, Foster CS, Buchanich JM, Kempen JH; Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study Research Group
Am J Ophthalmol 2021 Sep;229:200-209. Epub 2021 Mar 10 doi: 10.1016/j.ajo.2021.02.032. PMID: 33713679Free PMC Article
Posterior capsule striae.
Vasavada AR, Trivedi RH
J Cataract Refract Surg 1999 Nov;25(11):1527-31. doi: 10.1016/s0886-3350(99)00197-2. PMID: 10569170
Hallerman-Streiff syndrome.
Nicholson AD, Menon S
J Postgrad Med 1995 Jan-Mar;41(1):22-3. PMID: 10740699

Clinical prediction guides

Dual Sensory Impairment as a Predictor of Loneliness and Isolation in Older Adults: National Cohort Study.
Wang Q, Zhang S, Wang Y, Zhao D, Zhou C
JMIR Public Health Surveill 2022 Nov 14;8(11):e39314. doi: 10.2196/39314. PMID: 36374533Free PMC Article
A role for music in cataract surgery: a systematic review.
Dahshan D, Kuzbel J, Verma V
Int Ophthalmol 2021 Dec;41(12):4209-4215. Epub 2021 Jul 26 doi: 10.1007/s10792-021-01986-9. PMID: 34312781
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Impact of cataract surgery in reducing visual impairment: a review.
Khandekar R, Sudhan A, Jain BK, Deshpande M, Dole K, Shah M, Shah S
Middle East Afr J Ophthalmol 2015 Jan-Mar;22(1):80-5. doi: 10.4103/0974-9233.148354. PMID: 25624679Free PMC Article
Radiation cataract.
Kleiman NJ
Ann ICRP 2012 Oct-Dec;41(3-4):80-97. Epub 2012 Aug 22 doi: 10.1016/j.icrp.2012.06.018. PMID: 23089007

Recent systematic reviews

Cataract surgery and IOP: a systematic review of randomised controlled trials.
Brízido M, Rodrigues PF, Almeida AC, Abegão Pinto L
Graefes Arch Clin Exp Ophthalmol 2023 May;261(5):1257-1266. Epub 2022 Nov 28 doi: 10.1007/s00417-022-05911-3. PMID: 36441227
Early vitrectomy for exogenous endophthalmitis following surgery.
Muqit MM, Mehat M, Bunce C, Bainbridge JW
Cochrane Database Syst Rev 2022 Nov 18;11(11):CD013760. doi: 10.1002/14651858.CD013760.pub2. PMID: 36398614Free PMC Article
A role for music in cataract surgery: a systematic review.
Dahshan D, Kuzbel J, Verma V
Int Ophthalmol 2021 Dec;41(12):4209-4215. Epub 2021 Jul 26 doi: 10.1007/s10792-021-01986-9. PMID: 34312781
Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis.
Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, Ramin S, Khabazkhoob M
Eye (Lond) 2020 Aug;34(8):1357-1370. Epub 2020 Feb 13 doi: 10.1038/s41433-020-0806-3. PMID: 32055021Free PMC Article
Interventions for preventing falls in older people living in the community.
Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007146. doi: 10.1002/14651858.CD007146.pub3. PMID: 22972103Free PMC Article

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