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Bone mineral density quantitative trait locus 17(BMND17)

MedGen UID:
811539
Concept ID:
C3714987
Finding
Synonym: BMND17
 
Gene (location): LGR4 (11p14.1)
 
OMIM®: 615311

Recent clinical studies

Etiology

Trajanoska K, Seppala LJ, Medina-Gomez C, Hsu YH, Zhou S, van Schoor NM, de Groot LCPGM, Karasik D, Richards JB, Kiel DP, Uitterlinden AG, Perry JRB, van der Velde N, Day FR, Rivadeneira F
Commun Biol 2020 Sep 30;3(1):543. doi: 10.1038/s42003-020-01256-x. PMID: 32999390Free PMC Article
Zhai Y, Yu L, Shao Y, Wang J
Biosci Rep 2020 Apr 30;40(4) doi: 10.1042/BSR20193185. PMID: 32266926Free PMC Article
Shaffer JR, Kammerer CM, Bruder JM, Cole SA, Dyer TD, Almasy L, Maccluer JW, Blangero J, Bauer RL, Mitchell BD
Calcif Tissue Int 2009 Feb;84(2):75-84. Epub 2008 Dec 9 doi: 10.1007/s00223-008-9197-3. PMID: 19067020Free PMC Article
Mullin BH, Prince RL, Dick IM, Hart DJ, Spector TD, Dudbridge F, Wilson SG
Am J Hum Genet 2008 Jun;82(6):1262-9. Epub 2008 May 22 doi: 10.1016/j.ajhg.2008.04.016. PMID: 18499081Free PMC Article
Ralston SH
Curr Opin Rheumatol 2005 Jul;17(4):475-9. doi: 10.1097/01.bor.0000166385.62851.92. PMID: 15956846

Diagnosis

Orwoll ES, Belknap JK, Klein RF
J Bone Miner Res 2001 Nov;16(11):1962-71. doi: 10.1359/jbmr.2001.16.11.1962. PMID: 11697792

Therapy

Richardson TG, Richmond RC, North TL, Hemani G, Davey Smith G, Sharp GC, Relton CL
Int J Epidemiol 2019 Jun 1;48(3):887-898. doi: 10.1093/ije/dyz119. PMID: 31257439Free PMC Article
Oei L, Estrada K, Duncan EL, Christiansen C, Liu CT, Langdahl BL, Obermayer-Pietsch B, Riancho JA, Prince RL, van Schoor NM, McCloskey E, Hsu YH, Evangelou E, Ntzani E, Evans DM, Alonso N, Husted LB, Valero C, Hernandez JL, Lewis JR, Kaptoge SK, Zhu K, Cupples LA, Medina-Gómez C, Vandenput L, Kim GS, Hun Lee S, Castaño-Betancourt MC, Oei EH, Martinez J, Daroszewska A, van der Klift M, Mellström D, Herrera L, Karlsson MK, Hofman A, Ljunggren Ö, Pols HA, Stolk L, van Meurs JB, Ioannidis JP, Zillikens MC, Lips P, Karasik D, Uitterlinden AG, Styrkarsdottir U, Brown MA, Koh JM, Richards JB, Reeve J, Ohlsson C, Ralston SH, Kiel DP, Rivadeneira F
Bone 2014 Feb;59:20-7. PMID: 24516880Free PMC Article
Karasik D, Myers RH, Cupples LA, Hannan MT, Gagnon DR, Herbert A, Kiel DP
J Bone Miner Res 2002 Sep;17(9):1718-27. doi: 10.1359/jbmr.2002.17.9.1718. PMID: 12211443

Prognosis

Zhai Y, Yu L, Shao Y, Wang J
Biosci Rep 2020 Apr 30;40(4) doi: 10.1042/BSR20193185. PMID: 32266926Free PMC Article
Richardson TG, Richmond RC, North TL, Hemani G, Davey Smith G, Sharp GC, Relton CL
Int J Epidemiol 2019 Jun 1;48(3):887-898. doi: 10.1093/ije/dyz119. PMID: 31257439Free PMC Article
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, Mellström D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NL, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-Gómez C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw KT, Lehtimäki T, Liu Y, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HA, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner AR, Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AW, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlsson C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F
Nat Genet 2012 Apr 15;44(5):491-501. doi: 10.1038/ng.2249. PMID: 22504420Free PMC Article
Xu FH, Liu YJ, Deng H, Huang QY, Zhao LJ, Shen H, Liu YZ, Dvornyk V, Conway T, Li JL, Davies KM, Recker RR, Deng HW
Bone 2004 Sep;35(3):777-84. doi: 10.1016/j.bone.2004.05.007. PMID: 15336616

Clinical prediction guides

Trajanoska K, Seppala LJ, Medina-Gomez C, Hsu YH, Zhou S, van Schoor NM, de Groot LCPGM, Karasik D, Richards JB, Kiel DP, Uitterlinden AG, Perry JRB, van der Velde N, Day FR, Rivadeneira F
Commun Biol 2020 Sep 30;3(1):543. doi: 10.1038/s42003-020-01256-x. PMID: 32999390Free PMC Article
Zhai Y, Yu L, Shao Y, Wang J
Biosci Rep 2020 Apr 30;40(4) doi: 10.1042/BSR20193185. PMID: 32266926Free PMC Article
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, Mellström D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NL, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-Gómez C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw KT, Lehtimäki T, Liu Y, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HA, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner AR, Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AW, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlsson C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F
Nat Genet 2012 Apr 15;44(5):491-501. doi: 10.1038/ng.2249. PMID: 22504420Free PMC Article
Li HY, Kung WC, Huang QY
J Bone Miner Metab 2011 Jan;29(1):80-7. Epub 2010 Jul 6 doi: 10.1007/s00774-010-0195-y. PMID: 20607328
Shaffer JR, Kammerer CM, Bruder JM, Cole SA, Dyer TD, Almasy L, Maccluer JW, Blangero J, Bauer RL, Mitchell BD
Calcif Tissue Int 2009 Feb;84(2):75-84. Epub 2008 Dec 9 doi: 10.1007/s00223-008-9197-3. PMID: 19067020Free PMC Article

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