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Neuropathic pain

MedGen UID:
811414
Concept ID:
C3714625
Finding
Synonym: Neuropathic Pain
SNOMED CT: Neuropathic pain (247398009)
 
HPO: HP:6000040

Definition

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its structure and function so that pain occurs spontaneously and responses to noxious and innocuous stimuli are pathologically amplified. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuropathic pain

Professional guidelines

PubMed

Allam AK, Sharma H, Larkin MB, Viswanathan A
Neurol Clin 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550
Chimenti RL, Frey-Law LA, Sluka KA
Phys Ther 2018 May 1;98(5):302-314. doi: 10.1093/ptj/pzy030. PMID: 29669091Free PMC Article
Baron R, Binder A, Wasner G
Lancet Neurol 2010 Aug;9(8):807-19. doi: 10.1016/S1474-4422(10)70143-5. PMID: 20650402

Recent clinical studies

Etiology

Rosner J, de Andrade DC, Davis KD, Gustin SM, Kramer JLK, Seal RP, Finnerup NB
Nat Rev Dis Primers 2023 Dec 21;9(1):73. doi: 10.1038/s41572-023-00484-9. PMID: 38129427
Yildirim P, Gultekin A
Spine (Phila Pa 1976) 2022 May 15;47(10):711-719. Epub 2022 Jan 11 doi: 10.1097/BRS.0000000000004316. PMID: 35019882
Devigili G, Cazzato D, Lauria G
Expert Rev Neurother 2020 Sep;20(9):967-980. Epub 2020 Jul 23 doi: 10.1080/14737175.2020.1794825. PMID: 32654574
Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Nurmikko T, Perrot S, Raja SN, Rice ASC, Rowbotham MC, Schug S, Simpson DM, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ, Barke A, Rief W, Treede RD; Classification Committee of the Neuropathic Pain Special Interest Group (NeuPSIG)
Pain 2019 Jan;160(1):53-59. doi: 10.1097/j.pain.0000000000001365. PMID: 30586071Free PMC Article
Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS
Pain 2016 Aug;157(8):1599-1606. doi: 10.1097/j.pain.0000000000000492. PMID: 27115670Free PMC Article

Diagnosis

Moisset X, Bouhassira D, Attal N
Rev Neurol (Paris) 2021 Sep;177(7):834-837. Epub 2021 Jul 28 doi: 10.1016/j.neurol.2021.07.004. PMID: 34332778
Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD, Evers S, First M, Giamberardino MA, Hansson P, Kaasa S, Korwisi B, Kosek E, Lavand'homme P, Nicholas M, Nurmikko T, Perrot S, Raja SN, Rice ASC, Rowbotham MC, Schug S, Simpson DM, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ, Barke A, Rief W, Treede RD; Classification Committee of the Neuropathic Pain Special Interest Group (NeuPSIG)
Pain 2019 Jan;160(1):53-59. doi: 10.1097/j.pain.0000000000001365. PMID: 30586071Free PMC Article
Bouhassira D
Rev Neurol (Paris) 2019 Jan-Feb;175(1-2):16-25. Epub 2018 Oct 29 doi: 10.1016/j.neurol.2018.09.016. PMID: 30385075
Cohen SP, Mao J
BMJ 2014 Feb 5;348:f7656. doi: 10.1136/bmj.f7656. PMID: 24500412
Baron R, Binder A, Wasner G
Lancet Neurol 2010 Aug;9(8):807-19. doi: 10.1016/S1474-4422(10)70143-5. PMID: 20650402

Therapy

Shi DD, Guo JA, Hoffman HI, Su J, Mino-Kenudson M, Barth JL, Schenkel JM, Loeffler JS, Shih HA, Hong TS, Wo JY, Aguirre AJ, Jacks T, Zheng L, Wen PY, Wang TC, Hwang WL
Lancet Oncol 2022 Feb;23(2):e62-e74. doi: 10.1016/S1470-2045(21)00596-9. PMID: 35114133Free PMC Article
Cavalli E, Mammana S, Nicoletti F, Bramanti P, Mazzon E
Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419838383. doi: 10.1177/2058738419838383. PMID: 30900486Free PMC Article
Onakpoya IJ, Thomas ET, Lee JJ, Goldacre B, Heneghan CJ
BMJ Open 2019 Jan 21;9(1):e023600. doi: 10.1136/bmjopen-2018-023600. PMID: 30670513Free PMC Article
Tardiolo G, Bramanti P, Mazzon E
Molecules 2018 Dec 13;23(12) doi: 10.3390/molecules23123305. PMID: 30551603Free PMC Article
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M
Lancet Neurol 2015 Feb;14(2):162-73. Epub 2015 Jan 7 doi: 10.1016/S1474-4422(14)70251-0. PMID: 25575710Free PMC Article

Prognosis

Palmer SC, Tendal B, Mustafa RA, Vandvik PO, Li S, Hao Q, Tunnicliffe D, Ruospo M, Natale P, Saglimbene V, Nicolucci A, Johnson DW, Tonelli M, Rossi MC, Badve SV, Cho Y, Nadeau-Fredette AC, Burke M, Faruque LI, Lloyd A, Ahmad N, Liu Y, Tiv S, Millard T, Gagliardi L, Kolanu N, Barmanray RD, McMorrow R, Raygoza Cortez AK, White H, Chen X, Zhou X, Liu J, Rodríguez AF, González-Colmenero AD, Wang Y, Li L, Sutanto S, Solis RC, Díaz González-Colmenero F, Rodriguez-Gutierrez R, Walsh M, Guyatt G, Strippoli GFM
BMJ 2021 Jan 13;372:m4573. doi: 10.1136/bmj.m4573. PMID: 33441402Free PMC Article
Baba M, Matsui N, Kuroha M, Wasaki Y, Ohwada S
J Diabetes Investig 2019 Sep;10(5):1299-1306. Epub 2019 Feb 28 doi: 10.1111/jdi.13013. PMID: 30672128Free PMC Article
Galeotti N
Oncotarget 2017 Feb 21;8(8):12546-12547. doi: 10.18632/oncotarget.15091. PMID: 28179580Free PMC Article
Ben-Aroya Z, Edwards L
Semin Cutan Med Surg 2015 Dec;34(4):192-8. doi: 10.12788/j.sder.2015.0181. PMID: 26650698
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N
Pain 2014 Apr;155(4):654-662. Epub 2013 Nov 26 doi: 10.1016/j.pain.2013.11.013. PMID: 24291734

Clinical prediction guides

Raymond TJ
FP Essent 2023 Oct;533:27-40. PMID: 37812531
Helito CP, Moreira FS, Santiago MAM, Medeiros LFB, Giglio PN, da Silva AGM, Gobbi RG, Pécora JR
Clinics (Sao Paulo) 2023;78:100287. Epub 2023 Sep 29 doi: 10.1016/j.clinsp.2023.100287. PMID: 37778166Free PMC Article
Ucar M, Cebicci MA, Koca I, Arik HO
Eur Rev Med Pharmacol Sci 2022 Aug;26(15):5422-5425. doi: 10.26355/eurrev_202208_29410. PMID: 35993637
Moisset X, Pagé MG
Rev Neurol (Paris) 2021 Sep;177(7):843-848. Epub 2021 Aug 9 doi: 10.1016/j.neurol.2021.07.011. PMID: 34384628
Zivi I, Maffia S, Ferrari V, Zarucchi A, Molatore K, Maestri R, Frazzitta G
Clin Rehabil 2018 May;32(5):663-670. Epub 2017 Dec 13 doi: 10.1177/0269215517746716. PMID: 29232980Free PMC Article

Recent systematic reviews

McDonagh MS, Morasco BJ, Wagner J, Ahmed AY, Fu R, Kansagara D, Chou R
Ann Intern Med 2022 Aug;175(8):1143-1153. Epub 2022 Jun 7 doi: 10.7326/M21-4520. PMID: 35667066
Grossman S, Tan H, Gadiwalla Y
Br J Oral Maxillofac Surg 2022 Jun;60(5):e677-e690. Epub 2021 Jun 23 doi: 10.1016/j.bjoms.2021.06.005. PMID: 35305839
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, Lanteri-Minet M, Lefaucheur JP, Mick G, Piano V, Pickering G, Piquet E, Regis C, Salvat E, Attal N
Rev Neurol (Paris) 2020 May;176(5):325-352. Epub 2020 Apr 7 doi: 10.1016/j.neurol.2020.01.361. PMID: 32276788
Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W
Cochrane Database Syst Rev 2018 Mar 7;3(3):CD012182. doi: 10.1002/14651858.CD012182.pub2. PMID: 29513392Free PMC Article
Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M
Lancet Neurol 2015 Feb;14(2):162-73. Epub 2015 Jan 7 doi: 10.1016/S1474-4422(14)70251-0. PMID: 25575710Free PMC Article

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