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Coronary microvascular dysfunction

MedGen UID:
784228
•Concept ID:
C3696962
•
Disease or Syndrome
Synonym: Microvascular ischemia of myocardium
SNOMED CT: Microvascular ischemia of myocardium (697976003); Coronary microvascular dysfunction (697976003)

Professional guidelines

PubMed

Comprehensive Management of ANOCA, Part 1-Definition, Patient Population, and Diagnosis: JACC State-of-the-Art Review.
Samuels BA, Shah SM, Widmer RJ, Kobayashi Y, Miner SES, Taqueti VR, Jeremias A, Albadri A, Blair JA, Kearney KE, Wei J, Park K, Barseghian El-Farra A, Holoshitz N, Janaszek KB, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds HR, Savage MP, Smilowitz NR, Sutton NR, Sweeny JM, Toleva O, Henry TD, Moses JW, Fearon WF, Tremmel JA; Microvascular Network (MVN)
J Am Coll Cardiol 2023 Sep 19;82(12):1245-1263. doi: 10.1016/j.jacc.2023.06.043. PMID: 37704315
Treatment of coronary microvascular dysfunction.
Bairey Merz CN, Pepine CJ, Shimokawa H, Berry C
Cardiovasc Res 2020 Mar 1;116(4):856-870. doi: 10.1093/cvr/cvaa006. PMID: 32087007Free PMC Article
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990

Recent clinical studies

Etiology

Inflammation in Coronary Microvascular Dysfunction.
Sagris M, Theofilis P, Antonopoulos AS, Oikonomou E, Paschaliori C, Galiatsatos N, Tsioufis K, Tousoulis D
Int J Mol Sci 2021 Dec 15;22(24) doi: 10.3390/ijms222413471. PMID: 34948272Free PMC Article
Acute Myocardial Infarction in Young Individuals.
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M
Mayo Clin Proc 2020 Jan;95(1):136-156. doi: 10.1016/j.mayocp.2019.05.001. PMID: 31902409
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review.
Taqueti VR, Di Carli MF
J Am Coll Cardiol 2018 Nov 27;72(21):2625-2641. doi: 10.1016/j.jacc.2018.09.042. PMID: 30466521Free PMC Article
Coronary microvascular dysfunction.
Camici PG, Crea F
N Engl J Med 2007 Feb 22;356(8):830-40. doi: 10.1056/NEJMra061889. PMID: 17314342

Diagnosis

Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases: JACC State-of-the-Art Review.
Del Buono MG, Montone RA, Camilli M, Carbone S, Narula J, Lavie CJ, Niccoli G, Crea F
J Am Coll Cardiol 2021 Sep 28;78(13):1352-1371. doi: 10.1016/j.jacc.2021.07.042. PMID: 34556322Free PMC Article
Acute Myocardial Infarction in Young Individuals.
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M
Mayo Clin Proc 2020 Jan;95(1):136-156. doi: 10.1016/j.mayocp.2019.05.001. PMID: 31902409
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review.
Taqueti VR, Di Carli MF
J Am Coll Cardiol 2018 Nov 27;72(21):2625-2641. doi: 10.1016/j.jacc.2018.09.042. PMID: 30466521Free PMC Article
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990

Therapy

Treatment of coronary microvascular dysfunction.
Bairey Merz CN, Pepine CJ, Shimokawa H, Berry C
Cardiovasc Res 2020 Mar 1;116(4):856-870. doi: 10.1093/cvr/cvaa006. PMID: 32087007Free PMC Article
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Sex-Specific Physiology and Cardiovascular Disease.
Shufelt CL, Pacheco C, Tweet MS, Miller VM
Adv Exp Med Biol 2018;1065:433-454. doi: 10.1007/978-3-319-77932-4_27. PMID: 30051400Free PMC Article
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge.
Heusch G, Gersh BJ
Eur Heart J 2017 Mar 14;38(11):774-784. doi: 10.1093/eurheartj/ehw224. PMID: 27354052

Prognosis

Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases: JACC State-of-the-Art Review.
Del Buono MG, Montone RA, Camilli M, Carbone S, Narula J, Lavie CJ, Niccoli G, Crea F
J Am Coll Cardiol 2021 Sep 28;78(13):1352-1371. doi: 10.1016/j.jacc.2021.07.042. PMID: 34556322Free PMC Article
Acute Myocardial Infarction in Young Individuals.
Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, Singh M
Mayo Clin Proc 2020 Jan;95(1):136-156. doi: 10.1016/j.mayocp.2019.05.001. PMID: 31902409
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Coronary Microvascular Disease Pathogenic Mechanisms and Therapeutic Options: JACC State-of-the-Art Review.
Taqueti VR, Di Carli MF
J Am Coll Cardiol 2018 Nov 27;72(21):2625-2641. doi: 10.1016/j.jacc.2018.09.042. PMID: 30466521Free PMC Article
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990

Clinical prediction guides

Rethinking False Positive Exercise Electrocardiographic Stress Tests by Assessing Coronary Microvascular Function.
Sinha A, Dutta U, Demir OM, De Silva K, Ellis H, Belford S, Ogden M, Li Kam Wa M, Morgan HP, Shah AM, Chiribiri A, Webb AJ, Marber M, Rahman H, Perera D
J Am Coll Cardiol 2024 Jan 16;83(2):291-299. doi: 10.1016/j.jacc.2023.10.034. PMID: 38199706Free PMC Article
Treatment of coronary microvascular dysfunction.
Bairey Merz CN, Pepine CJ, Shimokawa H, Berry C
Cardiovasc Res 2020 Mar 1;116(4):856-870. doi: 10.1093/cvr/cvaa006. PMID: 32087007Free PMC Article
Experimental animal models of coronary microvascular dysfunction.
Sorop O, van de Wouw J, Chandler S, Ohanyan V, Tune JD, Chilian WM, Merkus D, Bender SB, Duncker DJ
Cardiovasc Res 2020 Mar 1;116(4):756-770. doi: 10.1093/cvr/cvaa002. PMID: 31926020Free PMC Article
Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.
Konijnenberg LSF, Damman P, Duncker DJ, Kloner RA, Nijveldt R, van Geuns RM, Berry C, Riksen NP, Escaned J, van Royen N
Cardiovasc Res 2020 Mar 1;116(4):787-805. doi: 10.1093/cvr/cvz301. PMID: 31710673Free PMC Article
Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF.
Shah SJ, Lam CSP, Svedlund S, Saraste A, Hage C, Tan RS, Beussink-Nelson L, Ljung Faxén U, Fermer ML, Broberg MA, Gan LM, Lund LH
Eur Heart J 2018 Oct 1;39(37):3439-3450. doi: 10.1093/eurheartj/ehy531. PMID: 30165580Free PMC Article

Recent systematic reviews

Impact of coronary microvascular dysfunction in heart failure with preserved ejection fraction: a meta-analysis.
D'Amario D, Laborante R, Bianchini E, Ciliberti G, Paglianiti DA, Galli M, Restivo A, Stolfo D, Vergallo R, Rosano GMC, Crea F, Lam CSP, Lund LH, Metra M, Patti G, Savarese G
ESC Heart Fail 2024 Aug;11(4):2063-2075. Epub 2024 Mar 28 doi: 10.1002/ehf2.14626. PMID: 38549197Free PMC Article
Coronary Microvascular Dysfunction in Patients with Congenital Heart Disease.
Vanreusel I, Segers VFM, Craenenbroeck EV, Berendoncks AV
Curr Cardiol Rev 2023;19(4):e190123212886. doi: 10.2174/1573403X19666230119112634. PMID: 36658708Free PMC Article
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R; Coronary Flow Outcomes Reviewing Committee
Eur Heart J 2022 Apr 19;43(16):1582-1593. doi: 10.1093/eurheartj/ehab775. PMID: 34849697Free PMC Article
Angiogenic CD34 Stem Cell Therapy in Coronary Microvascular Repair-A Systematic Review.
Rai B, Shukla J, Henry TD, Quesada O
Cells 2021 May 8;10(5) doi: 10.3390/cells10051137. PMID: 34066713Free PMC Article
Coronary microvascular dysfunction, microvascular angina, and treatment strategies.
Marinescu MA, Löffler AI, Ouellette M, Smith L, Kramer CM, Bourque JM
JACC Cardiovasc Imaging 2015 Feb;8(2):210-20. doi: 10.1016/j.jcmg.2014.12.008. PMID: 25677893Free PMC Article

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