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Breakthrough Infections

MedGen UID:
1807883
Concept ID:
C3666010
Disease or Syndrome
Synonym: Breakthrough Infection

Definition

Infections by the same infectious agent (e.g., virus, fungus) occurring during exposure to prophylaxis, vaccine and treatment. [from MeSH]

Professional guidelines

PubMed

Walker J, Edwards WS, Hall NM, Pappas PG
Transpl Infect Dis 2023 Nov;25 Suppl 1:e14175. Epub 2023 Oct 21 doi: 10.1111/tid.14175. PMID: 37864814
Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Lancet Infect Dis 2021 Aug;21(8):e246-e257. Epub 2021 Feb 16 doi: 10.1016/S1473-3099(20)30784-2. PMID: 33606997
Kontoyiannis DP, Lewis RE
Cold Spring Harb Perspect Med 2014 Nov 6;5(4) doi: 10.1101/cshperspect.a019737. PMID: 25377139Free PMC Article

Recent clinical studies

Etiology

Höft MA, Burgers WA, Riou C
Cell Mol Immunol 2024 Feb;21(2):184-196. Epub 2023 Oct 11 doi: 10.1038/s41423-023-01087-w. PMID: 37821620Free PMC Article
Neely SR, Hao F
Vaccine 2023 Dec 18;41(52):7689-7694. Epub 2023 Nov 22 doi: 10.1016/j.vaccine.2023.11.032. PMID: 37996290
Kared H, Alirezaylavasani A, Lund KP, Chopra A, Tietze L, de Matos Kasahara T, Goll GL, Grødeland G, Kaarbø M, Reisæter AV, Hovd M, Heldal K, Vaage JT, Lund-Johansen F, Midtvedt K, Åsberg A, Munthe LA
EBioMedicine 2023 Nov;97:104833. Epub 2023 Oct 14 doi: 10.1016/j.ebiom.2023.104833. PMID: 37844534Free PMC Article
Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK
Lancet Infect Dis 2023 May;23(5):e167-e174. Epub 2022 Dec 16 doi: 10.1016/S1473-3099(22)00641-7. PMID: 36535276Free PMC Article
Stefan N
Nat Rev Endocrinol 2022 Feb;18(2):75-76. doi: 10.1038/s41574-021-00608-9. PMID: 34873287Free PMC Article

Diagnosis

Xia S, Wang L, Jiao F, Yu X, Xu W, Huang Z, Li X, Wang Q, Zhu Y, Man Q, Jiang S, Lu L
Emerg Microbes Infect 2023 Dec;12(1):2178241. doi: 10.1080/22221751.2023.2178241. PMID: 36748716Free PMC Article
Wang L, Wang W, Xu R, Berger NA
Best Pract Res Clin Haematol 2022 Sep;35(3):101384. Epub 2022 Sep 29 doi: 10.1016/j.beha.2022.101384. PMID: 36494154Free PMC Article
Spinelli MA, Grinsztejn B, Landovitz RJ
Curr Opin HIV AIDS 2022 Jul 1;17(4):186-191. Epub 2022 Mar 4 doi: 10.1097/COH.0000000000000733. PMID: 35762372Free PMC Article
Abu-Raddad LJ, Chemaitelly H, Ayoub HH, Tang P, Coyle P, Hasan MR, Yassine HM, Benslimane FM, Al-Khatib HA, Al-Kanaani Z, Al-Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul-Rahim HF, Nasrallah GK, Al-Kuwari MG, Butt AA, Al-Romaihi HE, Al-Khal A, Al-Thani MH, Bertollini R
Nat Commun 2022 Jan 27;13(1):532. doi: 10.1038/s41467-022-28199-7. PMID: 35087035Free PMC Article
Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Lancet Infect Dis 2021 Aug;21(8):e246-e257. Epub 2021 Feb 16 doi: 10.1016/S1473-3099(20)30784-2. PMID: 33606997

Therapy

Boutin CA, Durocher F, Beauchemin S, Ziegler D, Abou Chakra CN, Dufresne SF
Clin Infect Dis 2024 Jul 19;79(1):151-160. doi: 10.1093/cid/ciae203. PMID: 38752732Free PMC Article
Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK
Lancet Infect Dis 2023 May;23(5):e167-e174. Epub 2022 Dec 16 doi: 10.1016/S1473-3099(22)00641-7. PMID: 36535276Free PMC Article
Stefan N
Nat Rev Endocrinol 2022 Feb;18(2):75-76. doi: 10.1038/s41574-021-00608-9. PMID: 34873287Free PMC Article
Gupta RK, Topol EJ
Science 2021 Dec 24;374(6575):1561-1562. Epub 2021 Dec 23 doi: 10.1126/science.abl8487. PMID: 34941414
Romanò L, Paladini S, Galli C, Raimondo G, Pollicino T, Zanetti AR
Hum Vaccin Immunother 2015;11(1):53-7. Epub 2014 Nov 1 doi: 10.4161/hv.34306. PMID: 25483515Free PMC Article

Prognosis

Weber T, Dähling S, Rose S, Affeldt P, Vanshylla K, Ullrich L, Gieselmann L, Teipel F, Gruell H, Di Cristanziano V, Kim DS, Georgiou G, Koch M, Kreer C, Klein F
Sci Immunol 2023 Nov 17;8(89):eadk5845. doi: 10.1126/sciimmunol.adk5845. PMID: 37976348
Mehta G, Riva A, Ballester MP, Uson E, Pujadas M, Carvalho-Gomes Â, Sahuco I, Bono A, D'Amico F, Viganò R, Diago E, Lanseros BT, Inglese E, Vazquez DM, Sharma R, Tsou HLP, Harris N, Broekhoven A, Kikkert M, Morales SPT, Myeni SK, Riveiro-Barciela M, Palom A, Zeni N, Brocca A, Cussigh A, Cmet S, Escudero-García D, Stocco M, Natola LA, Ieluzzi D, Paon V, Sangiovanni A, Farina E, di Benedetto C, Sánchez-Torrijos Y, Lucena-Varela A, Román E, Sánchez E, Sánchez-Aldehuelo R, López-Cardona J, Canas-Perez I, Eastgate C, Jeyanesan D, Morocho AE, Di Cola S, Lapenna L, Zaccherini G, Bongiovanni D, Zanaga P, Sayaf K, Hossain S, Crespo J, Robles-Díaz M, Madejón A, Degroote H, Fernández J, Korenjak M, Verhelst X, García-Samaniego J, Andrade RJ, Iruzubieta P, Wright G, Caraceni P, Merli M, Patel VC, Gander A, Albillos A, Soriano G, Donato MF, Sacerdoti D, Toniutto P, Buti M, Duvoux C, Grossi PA, Berg T, Polak WG, Puoti M, Bosch-Comas A, Belli L, Burra P, Russo FP, Coenraad M, Calleja JL, Perricone G, Berenguer M, Claria J, Moreau R, Arroyo V, Angeli P, Sánchez C, Ampuero J, Piano S, Chokshi S, Jalan R; COBALT Consortium
Hepatol Commun 2023 Nov 1;7(11) Epub 2023 Oct 18 doi: 10.1097/HC9.0000000000000273. PMID: 37870985Free PMC Article
Wang H, Liu C, Xie X, Niu M, Wang Y, Cheng X, Zhang B, Zhang D, Liu M, Sun R, Ma Y, Ma S, Wang H, Zhu G, Lu Y, Huang B, Su P, Chen X, Zhao J, Wang H, Shen L, Fu L, Huang Q, Yang Y, Wang H, Wu C, Ge W, Chen C, Huo Q, Wang Q, Wang Y, Geng L, Xie Y, Xie Y, Liu L, Qi J, Chen H, Wu J, Jiang E, Jiang W, Wang X, Shen Z, Guo T, Zhou J, Zhu P, Cheng T
Immunity 2023 Jun 13;56(6):1410-1428.e8. Epub 2023 May 16 doi: 10.1016/j.immuni.2023.05.007. PMID: 37257450Free PMC Article
Cao Y, Jian F, Wang J, Yu Y, Song W, Yisimayi A, Wang J, An R, Chen X, Zhang N, Wang Y, Wang P, Zhao L, Sun H, Yu L, Yang S, Niu X, Xiao T, Gu Q, Shao F, Hao X, Xu Y, Jin R, Shen Z, Wang Y, Xie XS
Nature 2023 Feb;614(7948):521-529. Epub 2022 Dec 19 doi: 10.1038/s41586-022-05644-7. PMID: 36535326Free PMC Article
Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Lancet Infect Dis 2021 Aug;21(8):e246-e257. Epub 2021 Feb 16 doi: 10.1016/S1473-3099(20)30784-2. PMID: 33606997

Clinical prediction guides

Ramirez SI, Faraji F, Hills LB, Lopez PG, Goodwin B, Stacey HD, Sutton HJ, Hastie KM, Saphire EO, Kim HJ, Mashoof S, Yan CH, DeConde AS, Levi G, Crotty S
Nature 2024 Aug;632(8025):630-636. Epub 2024 Jul 31 doi: 10.1038/s41586-024-07748-8. PMID: 39085605
Cai C, Gao Y, Adamo S, Rivera-Ballesteros O, Hansson L, Österborg A, Bergman P, Sandberg JK, Ljunggren HG, Björkström NK, Strålin K, Llewellyn-Lacey S, Price DA, Qin C, Grifoni A, Weiskopf D, Wherry EJ, Sette A, Aleman S, Buggert M
Sci Immunol 2023 Dec 8;8(90):eadh0687. doi: 10.1126/sciimmunol.adh0687. PMID: 38064569Free PMC Article
Mehta G, Riva A, Ballester MP, Uson E, Pujadas M, Carvalho-Gomes Â, Sahuco I, Bono A, D'Amico F, Viganò R, Diago E, Lanseros BT, Inglese E, Vazquez DM, Sharma R, Tsou HLP, Harris N, Broekhoven A, Kikkert M, Morales SPT, Myeni SK, Riveiro-Barciela M, Palom A, Zeni N, Brocca A, Cussigh A, Cmet S, Escudero-García D, Stocco M, Natola LA, Ieluzzi D, Paon V, Sangiovanni A, Farina E, di Benedetto C, Sánchez-Torrijos Y, Lucena-Varela A, Román E, Sánchez E, Sánchez-Aldehuelo R, López-Cardona J, Canas-Perez I, Eastgate C, Jeyanesan D, Morocho AE, Di Cola S, Lapenna L, Zaccherini G, Bongiovanni D, Zanaga P, Sayaf K, Hossain S, Crespo J, Robles-Díaz M, Madejón A, Degroote H, Fernández J, Korenjak M, Verhelst X, García-Samaniego J, Andrade RJ, Iruzubieta P, Wright G, Caraceni P, Merli M, Patel VC, Gander A, Albillos A, Soriano G, Donato MF, Sacerdoti D, Toniutto P, Buti M, Duvoux C, Grossi PA, Berg T, Polak WG, Puoti M, Bosch-Comas A, Belli L, Burra P, Russo FP, Coenraad M, Calleja JL, Perricone G, Berenguer M, Claria J, Moreau R, Arroyo V, Angeli P, Sánchez C, Ampuero J, Piano S, Chokshi S, Jalan R; COBALT Consortium
Hepatol Commun 2023 Nov 1;7(11) Epub 2023 Oct 18 doi: 10.1097/HC9.0000000000000273. PMID: 37870985Free PMC Article
Wang H, Liu C, Xie X, Niu M, Wang Y, Cheng X, Zhang B, Zhang D, Liu M, Sun R, Ma Y, Ma S, Wang H, Zhu G, Lu Y, Huang B, Su P, Chen X, Zhao J, Wang H, Shen L, Fu L, Huang Q, Yang Y, Wang H, Wu C, Ge W, Chen C, Huo Q, Wang Q, Wang Y, Geng L, Xie Y, Xie Y, Liu L, Qi J, Chen H, Wu J, Jiang E, Jiang W, Wang X, Shen Z, Guo T, Zhou J, Zhu P, Cheng T
Immunity 2023 Jun 13;56(6):1410-1428.e8. Epub 2023 May 16 doi: 10.1016/j.immuni.2023.05.007. PMID: 37257450Free PMC Article
Irrgang P, Gerling J, Kocher K, Lapuente D, Steininger P, Habenicht K, Wytopil M, Beileke S, Schäfer S, Zhong J, Ssebyatika G, Krey T, Falcone V, Schülein C, Peter AS, Nganou-Makamdop K, Hengel H, Held J, Bogdan C, Überla K, Schober K, Winkler TH, Tenbusch M
Sci Immunol 2023 Jan 27;8(79):eade2798. doi: 10.1126/sciimmunol.ade2798. PMID: 36548397Free PMC Article

Recent systematic reviews

Boutin CA, Durocher F, Beauchemin S, Ziegler D, Abou Chakra CN, Dufresne SF
Clin Infect Dis 2024 Jul 19;79(1):151-160. doi: 10.1093/cid/ciae203. PMID: 38752732Free PMC Article
Fitzgerald N, Coltart H, Dominguez L, Flanagan K, Gilleece Y
HIV Med 2023 Jul;24(7):765-776. Epub 2023 Apr 23 doi: 10.1111/hiv.13458. PMID: 37088558
Whitehouse ER, Mandra A, Bonwitt J, Beasley EA, Taliano J, Rao AK
Lancet Infect Dis 2023 May;23(5):e167-e174. Epub 2022 Dec 16 doi: 10.1016/S1473-3099(22)00641-7. PMID: 36535276Free PMC Article
Lee CJ, Woo W, Kim AY, Yon DK, Lee SW, Koyanagi A, Kim MS, Tizaoui K, Dragioti E, Radua J, Lee S, Smith L, Il Shin J
J Med Virol 2022 Sep;94(9):4234-4245. Epub 2022 Jun 1 doi: 10.1002/jmv.27871. PMID: 35588301Free PMC Article
Zhang M, Liang Y, Yu D, Du B, Cheng W, Li L, Yu Z, Luo S, Zhang Y, Wang H, Zhang X, Zhang W
Int J Biol Sci 2022;18(2):889-900. Epub 2022 Jan 1 doi: 10.7150/ijbs.68973. PMID: 35002532Free PMC Article

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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