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STATINS, RESPONSE TO

MedGen UID:
1829432
•Concept ID:
C3549252
•
Organism Function
OMIM®: 620410

Definition

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties. [GOC:hp] [from GO]

Professional guidelines

PubMed

Heterogeneity of treatment response to beta-blockers in the treatment of portal hypertension: A systematic review.
Alsaeid M, Sung S, Bai W, Tam M, Wong YJ, Cortes J, Cobo E, Gonzalez JA, Abraldes JG
Hepatol Commun 2024 Feb 1;8(2) Epub 2024 Jan 29 doi: 10.1097/HC9.0000000000000321. PMID: 38285880Free PMC Article
Treatment and Response to Statins: Gender-related Differences.
Raparelli V, Pannitteri G, Todisco T, Toriello F, Napoleone L, Manfredini R, Basili S
Curr Med Chem 2017;24(24):2628-2638. doi: 10.2174/0929867324666161118094711. PMID: 28552051
An Evidence-Based Guide to Cholesterol-Lowering Guidelines.
Waters DD, Boekholdt SM
Can J Cardiol 2017 Mar;33(3):343-349. Epub 2016 Oct 24 doi: 10.1016/j.cjca.2016.10.019. PMID: 28034582

Recent systematic reviews

Pravastatin for lowering lipids.
Adams SP, Alaeiilkhchi N, Tasnim S, Wright JM
Cochrane Database Syst Rev 2023 Sep 18;9(9):CD013673. doi: 10.1002/14651858.CD013673.pub2. PMID: 37721222Free PMC Article
Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.
Cai T, Abel L, Langford O, Monaghan G, Aronson JK, Stevens RJ, Lay-Flurrie S, Koshiaris C, McManus RJ, Hobbs FDR, Sheppard JP
BMJ 2021 Jul 14;374:n1537. doi: 10.1136/bmj.n1537. PMID: 34261627Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Fluvastatin for lowering lipids.
Adams SP, Sekhon SS, Tsang M, Wright JM
Cochrane Database Syst Rev 2018 Mar 6;3(3):CD012282. doi: 10.1002/14651858.CD012282.pub2. PMID: 29508377Free PMC Article
Lipid-lowering efficacy of rosuvastatin.
Adams SP, Sekhon SS, Wright JM
Cochrane Database Syst Rev 2014 Nov 21;2014(11):CD010254. doi: 10.1002/14651858.CD010254.pub2. PMID: 25415541Free PMC Article

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