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Spitzoid melanoma

MedGen UID:
1713307
•Concept ID:
C3495721
•
Neoplastic Process
Synonyms: Malignant Spitz Tumor; Spitz Melanoma; Spitzoid Melanoma; spitzoid melanoma
 
Monarch Initiative: MONDO:0850101

Definition

A melanoma that shares histopathologic and clinical features with atypical Spitz nevus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpitzoid melanoma

Professional guidelines

PubMed

Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment.
Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A
Actas Dermosifiliogr (Engl Ed) 2020 Jan 2;111(1):20-25. Epub 2019 Nov 15 doi: 10.1016/j.ad.2019.02.010. PMID: 31739993
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829

Recent clinical studies

Etiology

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Tumors of the Skin.
Menezes FD, Mooi WJ
Surg Pathol Clin 2017 Jun;10(2):281-298. Epub 2017 Mar 31 doi: 10.1016/j.path.2017.01.004. PMID: 28477881
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Diagnosis

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Therapy

A case of severe nivolumab-induced lichen planus pemphigoides in a child with metastatic spitzoid melanoma.
Mueller KA, Cordisco MR, Scott GA, Plovanich ME
Pediatr Dermatol 2023 Jan;40(1):154-156. Epub 2022 Jul 26 doi: 10.1111/pde.15097. PMID: 35882548
The role of routine imaging in pediatric cutaneous melanoma.
Halalsheh H, Kaste SC, Navid F, Bahrami A, Shulkin BL, Rao B, Kunkel M, Artz N, Pappo A
Pediatr Blood Cancer 2018 Dec;65(12):e27412. Epub 2018 Aug 19 doi: 10.1002/pbc.27412. PMID: 30124237Free PMC Article
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ
Int J Cancer 2016 Feb 15;138(4):881-90. Epub 2015 Sep 8 doi: 10.1002/ijc.29825. PMID: 26314551Free PMC Article
A case of spitzoid melanoma with lymph node metastasis in a child.
Kim JY, Choi JE, Ahn HH, Kye YC, Seo SH
J Korean Med Sci 2012 Apr;27(4):454-7. Epub 2012 Mar 21 doi: 10.3346/jkms.2012.27.4.454. PMID: 22468113Free PMC Article
Statistical analysis of the concordance of immunohistochemical stains with the final diagnosis in spitzoid neoplasms.
Puri PK, Ferringer TC, Tyler WB, Wilson ML, Kirchner HL, Elston DM
Am J Dermatopathol 2011 Feb;33(1):72-7. doi: 10.1097/DAD.0b013e3181da3841. PMID: 20700039

Prognosis

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829
Spitz nevi, atypical spitzoid neoplasms, and spitzoid melanoma.
Zedek DC, McCalmont TH
Clin Lab Med 2011 Jun;31(2):311-20. doi: 10.1016/j.cll.2011.03.008. PMID: 21549244
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Clinical prediction guides

PRAME immunohistochemistry of spitzoid neoplasms.
Koh SS, Lau SK, Scapa JV, Cassarino DS
J Cutan Pathol 2022 Aug;49(8):709-716. Epub 2022 May 24 doi: 10.1111/cup.14245. PMID: 35488519
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ
Int J Cancer 2016 Feb 15;138(4):881-90. Epub 2015 Sep 8 doi: 10.1002/ijc.29825. PMID: 26314551Free PMC Article
Atypical Spitz Tumors: A Diagnostic Challenge.
Harms KL, Lowe L, Fullen DR, Harms PW
Arch Pathol Lab Med 2015 Oct;139(10):1263-70. doi: 10.5858/arpa.2015-0207-RA. PMID: 26414472

Recent systematic reviews

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255

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