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Persistent ductus arteriosus

MedGen UID:
758778
•Concept ID:
C3495549
•
Congenital Abnormality

Definition

abnormal persistence of an open lumen in the ductus arteriosus after birth, the direction of flow being from the aorta to the pulmonary artery, resulting in recirculation of arterial blood through the lungs. [from CRISP]

Professional guidelines

PubMed

Management of persistent ductus arteriosus in very premature neonates. Results of the French TRIOCAPI trial, perspectives for clinicians, and subsequent studies on this topic.
Cambonie G, Clyman RI, Rozé JC
Arch Pediatr 2021 Oct;28(7):501-503. Epub 2021 Sep 9 doi: 10.1016/j.arcped.2021.07.002. PMID: 34511277
Novel treatment criteria for persistent ductus arteriosus in neonates.
Nagasawa H, Terazawa D, Kohno Y, Yamamoto Y, Kondo M, Sugawara M, Koyama T, Miura R
Pediatr Neonatol 2014 Aug;55(4):250-5. Epub 2013 Dec 25 doi: 10.1016/j.pedneo.2013.10.009. PMID: 24373670
Risk factors for persistent ductus arteriosus patency during indomethacin treatment.
Chorne N, Jegatheesan P, Lin E, Shi R, Clyman RI
J Pediatr 2007 Dec;151(6):629-34. Epub 2007 Aug 6 doi: 10.1016/j.jpeds.2007.05.007. PMID: 18035143

Recent clinical studies

Etiology

Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the "Connection Trial".
Neu J, Ashley P, Chowdhary V, Lampland A, Porcelli P, Rothstein R, Slancheva B, Kronström A, Rastad J, Strömberg S, Thuresson M; Connection Study Group
Am J Perinatol 2024 May;41(S 01):e2717-e2726. Epub 2023 Sep 8 doi: 10.1055/s-0043-1774314. PMID: 37683670
Maternal Overweight and Obesity and Risk of Congenital Heart Defects.
Persson M, Razaz N, Edstedt Bonamy AK, Villamor E, Cnattingius S
J Am Coll Cardiol 2019 Jan 8;73(1):44-53. doi: 10.1016/j.jacc.2018.10.050. PMID: 30621950
Transcatheter closure of persistent ductus arteriosus in adults.
Bentham JR, Thomson JD, Gibbs JL
J Interv Cardiol 2012 Oct;25(5):501-4. Epub 2012 Jun 7 doi: 10.1111/j.1540-8183.2012.00749.x. PMID: 22672406
Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition.
Bancalari E, Claure N, Sosenko IR
Semin Neonatol 2003 Feb;8(1):63-71. doi: 10.1016/s1084-2756(02)00192-6. PMID: 12667831
Flying and congenital heart disease.
Macartney FJ
Eur Heart J 1984 Mar;5 Suppl A:147-54. doi: 10.1093/eurheartj/5.suppl_a.147. PMID: 6373275

Diagnosis

PATENT DUCTUS ARTERIOSUS CLOSURE: EXPERIENCE FROM A TERTIARY REFERRAL CENTER.
Faim DRO, Tiago JAM, Castelo RJS, Francisco ASS, Alves RR, Pires AMGS
Rev Paul Pediatr 2020;39:e2020013. Epub 2020 Nov 27 doi: 10.1590/1984-0462/2021/39/2020013. PMID: 33263696Free PMC Article
Maternal Overweight and Obesity and Risk of Congenital Heart Defects.
Persson M, Razaz N, Edstedt Bonamy AK, Villamor E, Cnattingius S
J Am Coll Cardiol 2019 Jan 8;73(1):44-53. doi: 10.1016/j.jacc.2018.10.050. PMID: 30621950
Right ductus arteriosus: facts and theory.
Bronshtein M, Zimmer EZ, Blazer S, Blumenfeld Z
Eur J Obstet Gynecol Reprod Biol 2011 Dec;159(2):282-8. Epub 2011 Sep 16 doi: 10.1016/j.ejogrb.2011.07.047. PMID: 21925785
Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition.
Bancalari E, Claure N, Sosenko IR
Semin Neonatol 2003 Feb;8(1):63-71. doi: 10.1016/s1084-2756(02)00192-6. PMID: 12667831
Flying and congenital heart disease.
Macartney FJ
Eur Heart J 1984 Mar;5 Suppl A:147-54. doi: 10.1093/eurheartj/5.suppl_a.147. PMID: 6373275

Therapy

Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the "Connection Trial".
Neu J, Ashley P, Chowdhary V, Lampland A, Porcelli P, Rothstein R, Slancheva B, Kronström A, Rastad J, Strömberg S, Thuresson M; Connection Study Group
Am J Perinatol 2024 May;41(S 01):e2717-e2726. Epub 2023 Sep 8 doi: 10.1055/s-0043-1774314. PMID: 37683670
Management of persistent ductus arteriosus in very premature neonates. Results of the French TRIOCAPI trial, perspectives for clinicians, and subsequent studies on this topic.
Cambonie G, Clyman RI, Rozé JC
Arch Pediatr 2021 Oct;28(7):501-503. Epub 2021 Sep 9 doi: 10.1016/j.arcped.2021.07.002. PMID: 34511277
PATENT DUCTUS ARTERIOSUS CLOSURE: EXPERIENCE FROM A TERTIARY REFERRAL CENTER.
Faim DRO, Tiago JAM, Castelo RJS, Francisco ASS, Alves RR, Pires AMGS
Rev Paul Pediatr 2020;39:e2020013. Epub 2020 Nov 27 doi: 10.1590/1984-0462/2021/39/2020013. PMID: 33263696Free PMC Article
Novel treatment criteria for persistent ductus arteriosus in neonates.
Nagasawa H, Terazawa D, Kohno Y, Yamamoto Y, Kondo M, Sugawara M, Koyama T, Miura R
Pediatr Neonatol 2014 Aug;55(4):250-5. Epub 2013 Dec 25 doi: 10.1016/j.pedneo.2013.10.009. PMID: 24373670
Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition.
Bancalari E, Claure N, Sosenko IR
Semin Neonatol 2003 Feb;8(1):63-71. doi: 10.1016/s1084-2756(02)00192-6. PMID: 12667831

Prognosis

Thoracoscopy Versus Open Surgery for Persistent Ductus Arteriosus and Vascular Ring Anomaly in Neonates and Infants.
Muller CO, Ali L, Matta R, Montalva L, Michelet D, Soudee S, Bonnard A
J Laparoendosc Adv Surg Tech A 2018 Aug;28(8):1008-1011. Epub 2018 Mar 14 doi: 10.1089/lap.2017.0340. PMID: 29641371
Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition.
Bancalari E, Claure N, Sosenko IR
Semin Neonatol 2003 Feb;8(1):63-71. doi: 10.1016/s1084-2756(02)00192-6. PMID: 12667831
Fetal and neonatal effects of treatment with angiotensin-converting enzyme inhibitors in pregnancy.
Hanssens M, Keirse MJ, Vankelecom F, Van Assche FA
Obstet Gynecol 1991 Jul;78(1):128-35. PMID: 2047053
Flying and congenital heart disease.
Macartney FJ
Eur Heart J 1984 Mar;5 Suppl A:147-54. doi: 10.1093/eurheartj/5.suppl_a.147. PMID: 6373275
Persistent ductus arteriosus.
Lancet 1968 Apr 27;1(7548):903-4. PMID: 4171502

Clinical prediction guides

Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the "Connection Trial".
Neu J, Ashley P, Chowdhary V, Lampland A, Porcelli P, Rothstein R, Slancheva B, Kronström A, Rastad J, Strömberg S, Thuresson M; Connection Study Group
Am J Perinatol 2024 May;41(S 01):e2717-e2726. Epub 2023 Sep 8 doi: 10.1055/s-0043-1774314. PMID: 37683670
Facilitated tucking during early neonatologist-performed echocardiography in very preterm neonates.
Gautheyrou L, Durand S, Jourdes E, De Jonckheere J, Combes C, Cambonie G
Acta Paediatr 2018 Dec;107(12):2079-2085. Epub 2018 Sep 21 doi: 10.1111/apa.14555. PMID: 30144169
Maturation of Platelet Function During Murine Fetal Development In Vivo.
Margraf A, Nussbaum C, Rohwedder I, Klapproth S, Kurz ARM, Florian A, Wiebking V, Pircher J, Pruenster M, Immler R, Dietzel S, Kremer L, Kiefer F, Moser M, Flemmer AW, Quackenbush E, von Andrian UH, Sperandio M
Arterioscler Thromb Vasc Biol 2017 Jun;37(6):1076-1086. Epub 2017 Apr 20 doi: 10.1161/ATVBAHA.116.308464. PMID: 28428216
Using benchmarking to identify inter-centre differences in persistent ductus arteriosus treatment: can we improve outcome?
Jansen EJS, Dijkman KP, van Lingen RA, de Vries WB, Vijlbrief DC, de Boode WP, Andriessen P
Cardiol Young 2017 Oct;27(8):1488-1496. Epub 2017 Apr 12 doi: 10.1017/S104795111700052X. PMID: 28399954
A conservative treatment of patent ductus arteriosus in very low birth weight infants.
Letshwiti JB, Semberova J, Pichova K, Dempsey EM, Franklin OM, Miletin J
Early Hum Dev 2017 Jan;104:45-49. Epub 2016 Dec 30 doi: 10.1016/j.earlhumdev.2016.12.008. PMID: 28042972

Recent systematic reviews

Catheter-Related Arterial Thrombosis in Neonates and Children: A Systematic Review.
Rizzi M, Goldenberg N, Bonduel M, Revel-Vilk S, Amankwah E, Albisetti M
Thromb Haemost 2018 Jun;118(6):1058-1066. Epub 2018 Apr 25 doi: 10.1055/s-0038-1642635. PMID: 29695022

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