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Bacteremia caused by Gram-negative bacteria

MedGen UID:
782273
•Concept ID:
C3495091
•
Disease or Syndrome
SNOMED CT: Bacteremia caused by Gram-negative bacteria (501000119108)

Professional guidelines

PubMed

Ceftolozane-Tazobactam Versus Ceftazidime-Avibactam for the Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa: a Multicenter Cohort Study.
Almangour TA, Ghonem L, Alassiri D, Aljurbua A, Al Musawa M, Alharbi A, Almohaizeie A, Almuhisen S, Alghaith J, Damfu N, Aljefri D, Alfahad W, Khormi Y, Alanazi MQ, Alsowaida YS
Antimicrob Agents Chemother 2023 Aug 17;67(8):e0040523. Epub 2023 Jul 5 doi: 10.1128/aac.00405-23. PMID: 37404159Free PMC Article
Pathogenicity and treatment of Bartonella infections.
Angelakis E, Raoult D
Int J Antimicrob Agents 2014 Jul;44(1):16-25. Epub 2014 May 9 doi: 10.1016/j.ijantimicag.2014.04.006. PMID: 24933445
Treatment of Acinetobacter infections.
Michalopoulos A, Falagas ME
Expert Opin Pharmacother 2010 Apr;11(5):779-88. doi: 10.1517/14656561003596350. PMID: 20210684

Recent clinical studies

Etiology

Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance.
Amanati A, Sajedianfard S, Khajeh S, Ghasempour S, Mehrangiz S, Nematolahi S, Shahhosein Z
BMC Infect Dis 2021 Jul 2;21(1):636. doi: 10.1186/s12879-021-06243-z. PMID: 34215207Free PMC Article
Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial.
Bassetti M, Echols R, Matsunaga Y, Ariyasu M, Doi Y, Ferrer R, Lodise TP, Naas T, Niki Y, Paterson DL, Portsmouth S, Torre-Cisneros J, Toyoizumi K, Wunderink RG, Nagata TD
Lancet Infect Dis 2021 Feb;21(2):226-240. Epub 2020 Oct 12 doi: 10.1016/S1473-3099(20)30796-9. PMID: 33058795
Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial.
Paul M, Daikos GL, Durante-Mangoni E, Yahav D, Carmeli Y, Benattar YD, Skiada A, Andini R, Eliakim-Raz N, Nutman A, Zusman O, Antoniadou A, Pafundi PC, Adler A, Dickstein Y, Pavleas I, Zampino R, Daitch V, Bitterman R, Zayyad H, Koppel F, Levi I, Babich T, Friberg LE, Mouton JW, Theuretzbacher U, Leibovici L
Lancet Infect Dis 2018 Apr;18(4):391-400. Epub 2018 Feb 16 doi: 10.1016/S1473-3099(18)30099-9. PMID: 29456043
Hospital-acquired infections due to gram-negative bacteria.
Peleg AY, Hooper DC
N Engl J Med 2010 May 13;362(19):1804-13. doi: 10.1056/NEJMra0904124. PMID: 20463340Free PMC Article
Anaerobic bacteremia.
Goldstein EJ
Clin Infect Dis 1996 Dec;23 Suppl 1:S97-101. doi: 10.1093/clinids/23.supplement_1.s97. PMID: 8953114

Diagnosis

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study.
Tabah A, Buetti N, Staiquly Q, Ruckly S, Akova M, Aslan AT, Leone M, Conway Morris A, Bassetti M, Arvaniti K, Lipman J, Ferrer R, Qiu H, Paiva JA, Povoa P, De Bus L, De Waele J, Zand F, Gurjar M, Alsisi A, Abidi K, Bracht H, Hayashi Y, Jeon K, Elhadi M, Barbier F, Timsit JF; EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network
Intensive Care Med 2023 Feb;49(2):178-190. Epub 2023 Feb 10 doi: 10.1007/s00134-022-06944-2. PMID: 36764959Free PMC Article
Diagnosis, management, and outcomes of brain abscess due to gram-negative versus gram-positive bacteria.
Corsini Campioli C, Castillo Almeida NE, O'Horo JC, Wilson WR, Cano E, DeSimone DC, Baddour LM, Sohail MR
Int J Infect Dis 2022 Feb;115:189-194. Epub 2021 Dec 12 doi: 10.1016/j.ijid.2021.12.322. PMID: 34902581
Invasive Nontyphoidal Salmonella Disease in Africa.
Gilchrist JJ, MacLennan CA
EcoSal Plus 2019 Jan;8(2) doi: 10.1128/ecosalplus.ESP-0007-2018. PMID: 30657108
Drug-resistant gram-negative uropathogens: A review.
Khoshnood S, Heidary M, Mirnejad R, Bahramian A, Sedighi M, Mirzaei H
Biomed Pharmacother 2017 Oct;94:982-994. Epub 2017 Aug 12 doi: 10.1016/j.biopha.2017.08.006. PMID: 28810536
Bloodstream infections in older patients.
Yahav D, Eliakim-Raz N, Leibovici L, Paul M
Virulence 2016 Apr 2;7(3):341-52. Epub 2015 Dec 18 doi: 10.1080/21505594.2015.1132142. PMID: 26684392Free PMC Article

Therapy

Klebsiella pneumoniae bacteremia mortality: a systematic review and meta-analysis.
Li D, Huang X, Rao H, Yu H, Long S, Li Y, Zhang J
Front Cell Infect Microbiol 2023;13:1157010. Epub 2023 Apr 20 doi: 10.3389/fcimb.2023.1157010. PMID: 37153146Free PMC Article
Bloodstream infections in adult patients with malignancy, epidemiology, microbiology, and risk factors associated with mortality and multi-drug resistance.
Amanati A, Sajedianfard S, Khajeh S, Ghasempour S, Mehrangiz S, Nematolahi S, Shahhosein Z
BMC Infect Dis 2021 Jul 2;21(1):636. doi: 10.1186/s12879-021-06243-z. PMID: 34215207Free PMC Article
Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial.
Bassetti M, Echols R, Matsunaga Y, Ariyasu M, Doi Y, Ferrer R, Lodise TP, Naas T, Niki Y, Paterson DL, Portsmouth S, Torre-Cisneros J, Toyoizumi K, Wunderink RG, Nagata TD
Lancet Infect Dis 2021 Feb;21(2):226-240. Epub 2020 Oct 12 doi: 10.1016/S1473-3099(20)30796-9. PMID: 33058795
Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial.
Paul M, Daikos GL, Durante-Mangoni E, Yahav D, Carmeli Y, Benattar YD, Skiada A, Andini R, Eliakim-Raz N, Nutman A, Zusman O, Antoniadou A, Pafundi PC, Adler A, Dickstein Y, Pavleas I, Zampino R, Daitch V, Bitterman R, Zayyad H, Koppel F, Levi I, Babich T, Friberg LE, Mouton JW, Theuretzbacher U, Leibovici L
Lancet Infect Dis 2018 Apr;18(4):391-400. Epub 2018 Feb 16 doi: 10.1016/S1473-3099(18)30099-9. PMID: 29456043
Hospital-acquired infections due to gram-negative bacteria.
Peleg AY, Hooper DC
N Engl J Med 2010 May 13;362(19):1804-13. doi: 10.1056/NEJMra0904124. PMID: 20463340Free PMC Article

Prognosis

Incidence and predictors of complications in Gram-negative bloodstream infection.
Mondal U, Warren E, Bookstaver PB, Kohn J, Al-Hasan MN
Infection 2024 Oct;52(5):1725-1731. Epub 2024 Mar 4 doi: 10.1007/s15010-024-02202-3. PMID: 38436912Free PMC Article
Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.
Cernada M, Pinilla-González A, Kuligowski J, Morales JM, Lorente-Pozo S, Piñeiro-Ramos JD, Parra-Llorca A, Lara-Cantón I, Vento M, Serna E
Pediatr Res 2022 Feb;91(3):637-645. Epub 2021 Mar 25 doi: 10.1038/s41390-021-01444-3. PMID: 33767373
Bloodstream infections in the elderly: what is the real goal?
Leibovici-Weissman Y, Tau N, Yahav D
Aging Clin Exp Res 2021 Apr;33(4):1101-1112. Epub 2019 Sep 5 doi: 10.1007/s40520-019-01337-w. PMID: 31486996
Hemodialyzer Reuse and Gram-Negative Bloodstream Infections.
Edens C, Wong J, Lyman M, Rizzo K, Nguyen D, Blain M, Horwich-Scholefield S, Moulton-Meissner H, Epson E, Rosenberg J, Patel PR
Am J Kidney Dis 2017 Jun;69(6):726-733. Epub 2016 Dec 7 doi: 10.1053/j.ajkd.2016.09.022. PMID: 27940061Free PMC Article
Bacterial infection after liver transplantation.
Kim SI
World J Gastroenterol 2014 May 28;20(20):6211-20. doi: 10.3748/wjg.v20.i20.6211. PMID: 24876741Free PMC Article

Clinical prediction guides

Incidence and predictors of complications in Gram-negative bloodstream infection.
Mondal U, Warren E, Bookstaver PB, Kohn J, Al-Hasan MN
Infection 2024 Oct;52(5):1725-1731. Epub 2024 Mar 4 doi: 10.1007/s15010-024-02202-3. PMID: 38436912Free PMC Article
Differences in severity of bacteraemia caused by hypermucoviscous and non-hypermucoviscous Klebsiella pneumoniae.
Namikawa H, Oinuma KI, Yamada K, Kaneko Y, Kakeya H, Shuto T
Int J Antimicrob Agents 2023 May;61(5):106767. Epub 2023 Feb 28 doi: 10.1016/j.ijantimicag.2023.106767. PMID: 36858159
Clinical and Microbiological Characteristics of Recurrent Escherichia coli Bacteremia.
Kobayashi T, Ikeda M, Okada Y, Higurashi Y, Okugawa S, Moriya K
Microbiol Spectr 2021 Dec 22;9(3):e0139921. Epub 2021 Dec 8 doi: 10.1128/Spectrum.01399-21. PMID: 34878318Free PMC Article
Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis.
Liu J, Xie H, Ye Z, Li F, Wang L
BMC Nephrol 2020 Jul 31;21(1):318. doi: 10.1186/s12882-020-01974-8. PMID: 32736541Free PMC Article
Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial.
Paul M, Daikos GL, Durante-Mangoni E, Yahav D, Carmeli Y, Benattar YD, Skiada A, Andini R, Eliakim-Raz N, Nutman A, Zusman O, Antoniadou A, Pafundi PC, Adler A, Dickstein Y, Pavleas I, Zampino R, Daitch V, Bitterman R, Zayyad H, Koppel F, Levi I, Babich T, Friberg LE, Mouton JW, Theuretzbacher U, Leibovici L
Lancet Infect Dis 2018 Apr;18(4):391-400. Epub 2018 Feb 16 doi: 10.1016/S1473-3099(18)30099-9. PMID: 29456043

Recent systematic reviews

Ceftazidime-avibactam and aztreonam combination for Carbapenem-resistant Enterobacterales bloodstream infections with presumed Metallo-β-lactamase production: a systematic review and meta-analysis.
Gupta N, Boodman C, Prayag P, Manesh A, Kumar TP
Expert Rev Anti Infect Ther 2024 Apr;22(4):203-209. Epub 2024 Feb 8 doi: 10.1080/14787210.2024.2307912. PMID: 38258529
Predictors of mortality from extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia.
Namikawa H, Imoto W, Yamada K, Tochino Y, Kaneko Y, Kakeya H, Shuto T
Emerg Microbes Infect 2023 Dec;12(1):2217951. doi: 10.1080/22221751.2023.2217951. PMID: 37219067Free PMC Article
Klebsiella pneumoniae bacteremia mortality: a systematic review and meta-analysis.
Li D, Huang X, Rao H, Yu H, Long S, Li Y, Zhang J
Front Cell Infect Microbiol 2023;13:1157010. Epub 2023 Apr 20 doi: 10.3389/fcimb.2023.1157010. PMID: 37153146Free PMC Article
Differences in severity of bacteraemia caused by hypermucoviscous and non-hypermucoviscous Klebsiella pneumoniae.
Namikawa H, Oinuma KI, Yamada K, Kaneko Y, Kakeya H, Shuto T
Int J Antimicrob Agents 2023 May;61(5):106767. Epub 2023 Feb 28 doi: 10.1016/j.ijantimicag.2023.106767. PMID: 36858159
Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis.
Liu J, Xie H, Ye Z, Li F, Wang L
BMC Nephrol 2020 Jul 31;21(1):318. doi: 10.1186/s12882-020-01974-8. PMID: 32736541Free PMC Article

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