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Severe dementia

MedGen UID:
781848
Concept ID:
C3494652
Mental or Behavioral Dysfunction
SNOMED CT: Severe dementia (428351000124105)

Professional guidelines

PubMed

Arvanitakis Z, Shah RC, Bennett DA
JAMA 2019 Oct 22;322(16):1589-1599. doi: 10.1001/jama.2019.4782. PMID: 31638686Free PMC Article
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
Volkert D, Chourdakis M, Faxen-Irving G, Frühwald T, Landi F, Suominen MH, Vandewoude M, Wirth R, Schneider SM
Clin Nutr 2015 Dec;34(6):1052-73. Epub 2015 Sep 25 doi: 10.1016/j.clnu.2015.09.004. PMID: 26522922

Recent clinical studies

Etiology

Davies N, Barrado-Martín Y, Vickerstaff V, Rait G, Fukui A, Candy B, Smith CH, Manthorpe J, Moore KJ, Sampson EL
Cochrane Database Syst Rev 2021 Aug 13;8(8):CD013503. doi: 10.1002/14651858.CD013503.pub2. PMID: 34387363Free PMC Article
Birks JS, Harvey RJ
Cochrane Database Syst Rev 2018 Jun 18;6(6):CD001190. doi: 10.1002/14651858.CD001190.pub3. PMID: 29923184Free PMC Article
Sakamoto M, Ando H, Tsutou A
Int Psychogeriatr 2013 May;25(5):775-84. Epub 2013 Jan 8 doi: 10.1017/S1041610212002256. PMID: 23298693Free PMC Article
Svansdottir HB, Snaedal J
Int Psychogeriatr 2006 Dec;18(4):613-21. Epub 2006 Apr 18 doi: 10.1017/S1041610206003206. PMID: 16618375
Birks J
Cochrane Database Syst Rev 2006 Jan 25;2006(1):CD005593. doi: 10.1002/14651858.CD005593. PMID: 16437532Free PMC Article

Diagnosis

Davies N, Barrado-Martín Y, Vickerstaff V, Rait G, Fukui A, Candy B, Smith CH, Manthorpe J, Moore KJ, Sampson EL
Cochrane Database Syst Rev 2021 Aug 13;8(8):CD013503. doi: 10.1002/14651858.CD013503.pub2. PMID: 34387363Free PMC Article
Nakahara S, Takasaki M, Abe S, Kakitani C, Nishioka S, Wakabayashi H, Maeda K
Nutrition 2021 Apr;84:111109. Epub 2020 Dec 10 doi: 10.1016/j.nut.2020.111109. PMID: 33453622
Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229
Arvanitakis Z, Shah RC, Bennett DA
JAMA 2019 Oct 22;322(16):1589-1599. doi: 10.1001/jama.2019.4782. PMID: 31638686Free PMC Article
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article

Therapy

Deardorff WJ, Grossberg GT
Handb Clin Neurol 2019;165:5-32. doi: 10.1016/B978-0-444-64012-3.00002-2. PMID: 31727229
Arvanitakis Z, Shah RC, Bennett DA
JAMA 2019 Oct 22;322(16):1589-1599. doi: 10.1001/jama.2019.4782. PMID: 31638686Free PMC Article
Lyu J, Zhang J, Mu H, Li W, Champ M, Xiong Q, Gao T, Xie L, Jin W, Yang W, Cui M, Gao M, Li M
J Alzheimers Dis 2018;64(4):1347-1358. doi: 10.3233/JAD-180183. PMID: 29991131
Volkert D, Chourdakis M, Faxen-Irving G, Frühwald T, Landi F, Suominen MH, Vandewoude M, Wirth R, Schneider SM
Clin Nutr 2015 Dec;34(6):1052-73. Epub 2015 Sep 25 doi: 10.1016/j.clnu.2015.09.004. PMID: 26522922
Reisberg B, Doody R, Stöffler A, Schmitt F, Ferris S, Möbius HJ; Memantine Study Group
N Engl J Med 2003 Apr 3;348(14):1333-41. doi: 10.1056/NEJMoa013128. PMID: 12672860

Prognosis

Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O'Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley ÉM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA
Neurology 2021 May 4;96(18):848-863. Epub 2021 Mar 15 doi: 10.1212/WNL.0000000000011850. PMID: 33722990Free PMC Article
Eggers C, Arendt G, Hahn K, Husstedt IW, Maschke M, Neuen-Jacob E, Obermann M, Rosenkranz T, Schielke E, Straube E; German Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
J Neurol 2017 Aug;264(8):1715-1727. Epub 2017 May 31 doi: 10.1007/s00415-017-8503-2. PMID: 28567537Free PMC Article
Herr K, Zwakhalen S, Swafford K
Curr Alzheimer Res 2017;14(5):486-500. doi: 10.2174/1567205013666160602234526. PMID: 27335035
Volkert D, Chourdakis M, Faxen-Irving G, Frühwald T, Landi F, Suominen MH, Vandewoude M, Wirth R, Schneider SM
Clin Nutr 2015 Dec;34(6):1052-73. Epub 2015 Sep 25 doi: 10.1016/j.clnu.2015.09.004. PMID: 26522922
Svansdottir HB, Snaedal J
Int Psychogeriatr 2006 Dec;18(4):613-21. Epub 2006 Apr 18 doi: 10.1017/S1041610206003206. PMID: 16618375

Clinical prediction guides

Saito S, Suzuki K, Ohtani R, Maki T, Kowa H, Tachibana H, Washida K, Kawabata N, Mizuno T, Kanki R, Sudoh S, Kitaguchi H, Shindo K, Shindo A, Oka N, Yamamoto K, Yasuno F, Kakuta C, Kakuta R, Yamamoto Y, Hattori Y, Takahashi Y, Nakaoku Y, Tonomura S, Oishi N, Aso T, Taguchi A, Kagimura T, Kojima S, Taketsuna M, Tomimoto H, Takahashi R, Fukuyama H, Nagatsuka K, Yamamoto H, Fukushima M, Ihara M; COMCID Trial Investigator Group
JAMA Netw Open 2023 Dec 1;6(12):e2344938. doi: 10.1001/jamanetworkopen.2023.44938. PMID: 38048134Free PMC Article
Arvanitakis Z, Shah RC, Bennett DA
JAMA 2019 Oct 22;322(16):1589-1599. doi: 10.1001/jama.2019.4782. PMID: 31638686Free PMC Article
Raglio A, Bellandi D, Baiardi P, Gianotti M, Ubezio MC, Zanacchi E, Granieri E, Imbriani M, Stramba-Badiale M
J Am Geriatr Soc 2015 Aug;63(8):1534-9. doi: 10.1111/jgs.13558. PMID: 26289682
Sakamoto M, Ando H, Tsutou A
Int Psychogeriatr 2013 May;25(5):775-84. Epub 2013 Jan 8 doi: 10.1017/S1041610212002256. PMID: 23298693Free PMC Article
Svansdottir HB, Snaedal J
Int Psychogeriatr 2006 Dec;18(4):613-21. Epub 2006 Apr 18 doi: 10.1017/S1041610206003206. PMID: 16618375

Recent systematic reviews

Davies N, Barrado-Martín Y, Vickerstaff V, Rait G, Fukui A, Candy B, Smith CH, Manthorpe J, Moore KJ, Sampson EL
Cochrane Database Syst Rev 2021 Aug 13;8(8):CD013503. doi: 10.1002/14651858.CD013503.pub2. PMID: 34387363Free PMC Article
McCleery J, Sharpley AL
Cochrane Database Syst Rev 2020 Nov 15;11(11):CD009178. doi: 10.1002/14651858.CD009178.pub4. PMID: 33189083Free PMC Article
Birks JS, Harvey RJ
Cochrane Database Syst Rev 2018 Jun 18;6(6):CD001190. doi: 10.1002/14651858.CD001190.pub3. PMID: 29923184Free PMC Article
Kim SK, Park M
Clin Interv Aging 2017;12:381-397. Epub 2017 Feb 17 doi: 10.2147/CIA.S117637. PMID: 28255234Free PMC Article
Birks J
Cochrane Database Syst Rev 2006 Jan 25;2006(1):CD005593. doi: 10.1002/14651858.CD005593. PMID: 16437532Free PMC Article

Supplemental Content

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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