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Hemorrhage, intracerebral, susceptibility to(ICH)

MedGen UID:
482735
•Concept ID:
C3281105
•
Finding
Synonyms: ICH; Stroke, hemorrhagic, susceptibility to
 
Genes (locations): ACE (17q23.3); COL4A1 (13q34); COL4A2 (13q34)
 
Monarch Initiative: MONDO:0100533
OMIM®: 614519

Definition

An inherited susceptibility or predisposition to developing intracerebral hemorrhage. [from MONDO]

Professional guidelines

PubMed

The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
Altintas O, Niftaliyev E, Asil T
Neurol Res 2018 Dec;40(12):1048-1053. Epub 2018 Sep 12 doi: 10.1080/01616412.2018.1517111. PMID: 30207930
Management of intracerebral hemorrhage.
Thabet AM, Kottapally M, Hemphill JC 3rd
Handb Clin Neurol 2017;140:177-194. doi: 10.1016/B978-0-444-63600-3.00011-8. PMID: 28187799
The clinical utility of QSM: disease diagnosis, medical management, and surgical planning.
Eskreis-Winkler S, Zhang Y, Zhang J, Liu Z, Dimov A, Gupta A, Wang Y
NMR Biomed 2017 Apr;30(4) Epub 2016 Dec 1 doi: 10.1002/nbm.3668. PMID: 27906525

Recent clinical studies

Etiology

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients.
Zhao J, Rostgaard K, Lauwers E, Dahlén T, Ostrowski SR, Erikstrup C, Pedersen OB, de Strooper B, Lemmens R, Hjalgrim H, Edgren G
JAMA 2023 Sep 12;330(10):941-950. doi: 10.1001/jama.2023.14445. PMID: 37698562Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Genetic Variants behind Cardiovascular Diseases and Dementia.
Ho WM, Wu YY, Chen YC
Genes (Basel) 2020 Dec 18;11(12) doi: 10.3390/genes11121514. PMID: 33352859Free PMC Article
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.
Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M
BMJ 2018 Oct 24;363:k4168. doi: 10.1136/bmj.k4168. PMID: 30355576Free PMC Article

Diagnosis

Cerebral Amyloid Angiopathy.
Szidonya L, Nickerson JP
Radiol Clin North Am 2023 May;61(3):551-562. Epub 2023 Feb 20 doi: 10.1016/j.rcl.2023.01.009. PMID: 36931769
The Genetic Basis of Moyamoya Disease.
Mertens R, Graupera M, Gerhardt H, Bersano A, Tournier-Lasserve E, Mensah MA, Mundlos S, Vajkoczy P
Transl Stroke Res 2022 Feb;13(1):25-45. Epub 2021 Sep 16 doi: 10.1007/s12975-021-00940-2. PMID: 34529262Free PMC Article
Cerebral amyloid angiopathy-related inflammation: current status and future implications.
Wu JJ, Yao M, Ni J
Chin Med J (Engl) 2021 Feb 23;134(6):646-654. doi: 10.1097/CM9.0000000000001427. PMID: 33625036Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M
Circulation 2019 Jan 8;139(2):256-268. doi: 10.1161/CIRCULATIONAHA.118.035905. PMID: 30586705Free PMC Article

Therapy

Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients.
Zhao J, Rostgaard K, Lauwers E, Dahlén T, Ostrowski SR, Erikstrup C, Pedersen OB, de Strooper B, Lemmens R, Hjalgrim H, Edgren G
JAMA 2023 Sep 12;330(10):941-950. doi: 10.1001/jama.2023.14445. PMID: 37698562Free PMC Article
Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk.
Yuan S, Carter P, Mason AM, Yang F, Burgess S, Larsson SC
Arthritis Rheumatol 2022 Oct;74(10):1638-1647. Epub 2022 Aug 17 doi: 10.1002/art.42239. PMID: 35583917Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M
Circulation 2019 Jan 8;139(2):256-268. doi: 10.1161/CIRCULATIONAHA.118.035905. PMID: 30586705Free PMC Article

Prognosis

Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk.
Yuan S, Carter P, Mason AM, Yang F, Burgess S, Larsson SC
Arthritis Rheumatol 2022 Oct;74(10):1638-1647. Epub 2022 Aug 17 doi: 10.1002/art.42239. PMID: 35583917Free PMC Article
Cerebral amyloid angiopathy-related inflammation: current status and future implications.
Wu JJ, Yao M, Ni J
Chin Med J (Engl) 2021 Feb 23;134(6):646-654. doi: 10.1097/CM9.0000000000001427. PMID: 33625036Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.
Xu Z, Rui YN, Hagan JP, Kim DH
Neuromolecular Med 2019 Dec;21(4):325-343. Epub 2019 May 4 doi: 10.1007/s12017-019-08537-7. PMID: 31055715Free PMC Article

Clinical prediction guides

Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk.
Yuan S, Carter P, Mason AM, Yang F, Burgess S, Larsson SC
Arthritis Rheumatol 2022 Oct;74(10):1638-1647. Epub 2022 Aug 17 doi: 10.1002/art.42239. PMID: 35583917Free PMC Article
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.
Georgakis MK, Gill D, Rannikmäe K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CLM, Malik R, Dichgans M
Circulation 2019 Jan 8;139(2):256-268. doi: 10.1161/CIRCULATIONAHA.118.035905. PMID: 30586705Free PMC Article

Recent systematic reviews

Neurodevelopmental outcomes in preterm or low birth weight infants with germinal matrix-intraventricular hemorrhage: a meta-analysis.
Zhou M, Wang S, Zhang T, Duan S, Wang H
Pediatr Res 2024 Feb;95(3):625-633. Epub 2023 Nov 7 doi: 10.1038/s41390-023-02877-8. PMID: 37935882Free PMC Article
A systematic review on intracranial aneurysm and hemorrhage detection using machine learning and deep learning techniques.
Nafees Ahmed S, Prakasam P
Prog Biophys Mol Biol 2023 Oct;183:1-16. Epub 2023 Jul 25 doi: 10.1016/j.pbiomolbio.2023.07.001. PMID: 37499766
Meta-analysis of the association between RNF213 polymorphisms and clinical features of moyamoya disease in Asian population.
Jiang X, Liu L, Ai S, Xie X, Deng J, Jiang Z, Teng B, Liu C, Huang H
Clin Neurol Neurosurg 2023 Aug;231:107801. Epub 2023 May 30 doi: 10.1016/j.clineuro.2023.107801. PMID: 37267801
Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis.
Paschoal EHA, Yamaki VN, Teixeira RKC, Paschoal Junior FM, Jong-A-Liem GS, Teixeira MJ, Yamada ES, Ribeiro-Dos-Santos Â, Bor-Seng-Shu E
Neurosurg Rev 2018 Jan;41(1):87-94. Epub 2016 Jun 23 doi: 10.1007/s10143-016-0761-4. PMID: 27339197
Systemic thrombolysis for cerebral venous and dural sinus thrombosis: a systematic review.
Viegas LD, Stolz E, Canhão P, Ferro JM
Cerebrovasc Dis 2014;37(1):43-50. Epub 2013 Dec 18 doi: 10.1159/000356840. PMID: 24356180

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