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Psoriasis 13, susceptibility to(PSORS13)

MedGen UID:
481384
•Concept ID:
C3279754
•
Finding
Synonym: Psoriasis susceptibility 13
 
Gene (location): TRAF3IP2 (6q21)
 
Monarch Initiative: MONDO:0013554
OMIM®: 614070

Definition

Any psoriasis in which the cause of the disease is a mutation in the TRAF3IP2 gene. [from MONDO]

Professional guidelines

PubMed

Functional Genomics and Insights into the Pathogenesis and Treatment of Psoriasis.
Shellard EM, Rane SS, Eyre S, Warren RB
Biomolecules 2024 May 3;14(5) doi: 10.3390/biom14050548. PMID: 38785955Free PMC Article
Advances in pathogenesis and nanoparticles (NPs)-mediated treatment of psoriasis.
Shen Q, Liu R, Tan S, Xu X, Fang J, Li R
Front Immunol 2022;13:1089262. Epub 2022 Dec 22 doi: 10.3389/fimmu.2022.1089262. PMID: 36618400Free PMC Article
Impact of body composition and genotype on haemodynamics during surgery for pheochromocytoma and paraganglioma.
Pang Y, Li M, Jiang J, Chen X, Fu Y, Wang C, He Y, Zhao Y, Wang Y, Guan X, Zhang L, Xu X, Gan Y, Liu Y, Xie Y, Tang T, Wang J, Xie B, Liang Z, Chen D, Liu H, Chen C, Eisenhofer G, Liu L, Yi X, Chen BT
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2843-2853. Epub 2022 Sep 6 doi: 10.1002/jcsm.13071. PMID: 36068986Free PMC Article

Recent clinical studies

Etiology

IL23R mutations associated with decreased risk of psoriasis lead to the differential expression of genes implicated in the disease.
Rane SS, Shellard E, Adamson A, Eyre S, Warren RB
Exp Dermatol 2024 Sep;33(9):e15180. doi: 10.1111/exd.15180. PMID: 39306854

Therapy

Shared genetic risk factors and causal association between psoriasis and coronary artery disease.
Patrick MT, Li Q, Wasikowski R, Mehta N, Gudjonsson JE, Elder JT, Zhou X, Tsoi LC
Nat Commun 2022 Nov 2;13(1):6565. doi: 10.1038/s41467-022-34323-4. PMID: 36323703Free PMC Article
A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19.
Li S, Yuan S, Schooling CM, Larsson SC
Sci Rep 2022 Oct 21;12(1):17703. doi: 10.1038/s41598-022-22711-1. PMID: 36271292Free PMC Article
The Association Between Psoriasis and Risk of Cardiovascular Disease: A Mendelian Randomization Analysis.
Gao N, Kong M, Li X, Zhu X, Wei D, Ni M, Wang Y, Hong Z, Dong A
Front Immunol 2022;13:918224. Epub 2022 Jun 29 doi: 10.3389/fimmu.2022.918224. PMID: 35844511Free PMC Article
Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.
Li Y, Guo J, Cao Z, Wu J
Front Immunol 2022;13:916645. Epub 2022 Jun 10 doi: 10.3389/fimmu.2022.916645. PMID: 35757704Free PMC Article
Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes.
Tsai YC, Tsai TF
Int J Mol Sci 2022 May 15;23(10) doi: 10.3390/ijms23105518. PMID: 35628327Free PMC Article

Prognosis

Exploring risk factors for autoimmune diseases complicated by non-hodgkin lymphoma through regulatory T cell immune-related traits: a Mendelian randomization study.
Liu Q, Zhou X, Liu K, Wang Y, Liu C, Gao C, Cai Q, Sun C
Front Immunol 2024;15:1374938. Epub 2024 May 28 doi: 10.3389/fimmu.2024.1374938. PMID: 38863695Free PMC Article
So close, and yet so far away: The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis.
Schäbitz A, Eyerich K, Garzorz-Stark N
J Intern Med 2021 Jul;290(1):27-39. Epub 2021 Jan 11 doi: 10.1111/joim.13235. PMID: 33428274
Association between inflammasome-related polymorphisms and psoriatic arthritis.
Juneblad K, Kastbom A, Johansson L, Rantapää-Dahlqvist S, Söderkvist P, Alenius GM
Scand J Rheumatol 2021 May;50(3):206-212. Epub 2020 Dec 10 doi: 10.1080/03009742.2020.1834611. PMID: 33300400
Profile of Patients with Spondyloarthritis in Morocco.
Essouiri J, Abourazzak FE, Kona I, Harzy T
Curr Rheumatol Rev 2018;14(3):258-263. doi: 10.2174/1573397113666170406125338. PMID: 28393709
Skinomics: past, present and future for diagnostic microarray studies in dermatology.
Blumenberg M
Expert Rev Mol Diagn 2013 Nov;13(8):885-94. doi: 10.1586/14737159.2013.846827. PMID: 24151852

Clinical prediction guides

The Association Between Psoriasis and Risk of Cardiovascular Disease: A Mendelian Randomization Analysis.
Gao N, Kong M, Li X, Zhu X, Wei D, Ni M, Wang Y, Hong Z, Dong A
Front Immunol 2022;13:918224. Epub 2022 Jun 29 doi: 10.3389/fimmu.2022.918224. PMID: 35844511Free PMC Article
Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.
Li Y, Guo J, Cao Z, Wu J
Front Immunol 2022;13:916645. Epub 2022 Jun 10 doi: 10.3389/fimmu.2022.916645. PMID: 35757704Free PMC Article
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.
Mitchell BL, Saklatvala JR, Dand N, Hagenbeek FA, Li X, Min JL, Thomas L, Bartels M, Jan Hottenga J, Lupton MK, Boomsma DI, Dong X, Hveem K, Løset M, Martin NG, Barker JN, Han J, Smith CH, Rentería ME, Simpson MA
Nat Commun 2022 Feb 7;13(1):702. doi: 10.1038/s41467-022-28252-5. PMID: 35132056Free PMC Article
A review of antibiotics and psoriasis: induction, exacerbation, and amelioration.
Tsai YC, Tsai TF
Expert Rev Clin Pharmacol 2019 Oct;12(10):981-989. Epub 2019 Sep 30 doi: 10.1080/17512433.2019.1665027. PMID: 31498683
Association of Psoriasis and Metabolic Syndrome in Latin America: A Systematic Review and Meta-Analysis.
Rodríguez-Zúñiga MJM, Cortez-Franco F, Quijano-Gomero E
Actas Dermosifiliogr 2017 May;108(4):326-334. Epub 2017 Jan 20 doi: 10.1016/j.ad.2016.11.009. PMID: 28117050

Recent systematic reviews

Association between Psoriasis and MTHFR polymorphisms: a systematic review and meta-analysis.
Matsuo R, Haught K, Guo W, Na S, Lu K, Kaufmann T, Siamas K
Arch Dermatol Res 2024 May 21;316(5):184. doi: 10.1007/s00403-024-02905-5. PMID: 38771513
Angiotensin-converting enzyme gene insertion/deletion polymorphism and susceptibility to psoriasis: a systematic review and meta-analysis.
Ramezani M, Zavattaro E, Sadeghi M
BMC Med Genet 2020 Jan 8;21(1):8. doi: 10.1186/s12881-019-0943-3. PMID: 31914957Free PMC Article
Association of Psoriasis and Metabolic Syndrome in Latin America: A Systematic Review and Meta-Analysis.
Rodríguez-Zúñiga MJM, Cortez-Franco F, Quijano-Gomero E
Actas Dermosifiliogr 2017 May;108(4):326-334. Epub 2017 Jan 20 doi: 10.1016/j.ad.2016.11.009. PMID: 28117050
The prevalence of culture-confirmed toenail onychomycosis in at-risk patient populations.
Gupta AK, Daigle D, Foley KA
J Eur Acad Dermatol Venereol 2015 Jun;29(6):1039-44. Epub 2014 Nov 21 doi: 10.1111/jdv.12873. PMID: 25413984

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